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'3-kinase/Akt-kinase': [16], 'pathway': [17], 'a': [19, 151], 'critical': [20], 'regulator': [21], 'mass.': [24], 'Pancreatic': [25], 'overexpression': [27], 'constitutively': [29], 'active': [30], 'Akt': [31, 146], 'mice': [33, 101, 128, 133], '(caAkt(Tg))': [34], 'resulted': [35], 'marked': [37], 'expansion': [38, 125], 'by': [42, 63, 96, 129, 154], 'increase': [43], 'proliferation': [46, 62, 94, 149], 'and': [47, 78, 81, 140, 161, 187], 'size.': [48], 'The': [49, 110], 'current': [50], 'studies': [51, 114], 'provide': [52], 'new': [53], 'insights': [54], 'into': [55], 'molecular': [57], 'mechanisms': [58], 'involved': [59], 'Akt.': [64], 'beta-cells': [67, 191], 'caAkt(Tg)': [69, 100, 127], 'was': [70], 'associated': [71], 'with': [72], 'increased': [73], 'cyclin': [74, 76, 157, 159], 'D1,': [75, 158], 'D2,': [77, 160], 'p21': [79, 162], 'levels': [80, 171], 'cyclin-dependent': [82], 'kinase-4': [83], '(cdk4)': [84], 'activity.': [85], 'To': [86], 'determine': [87], 'role': [89], 'cdk4': [91, 120, 136], 'induced': [95], 'Akt,': [97], 'we': [98], 'generated': [99], 'that': [102, 116, 145, 168], 'were': [103], 'homozygous,': [104], 'heterozygous,': [105], 'or': [106], 'nullizygous': [107], 'cdk4.': [109], 'results': [111], 'these': [113, 173], 'showed': [115], 'deletion': [117], 'one': [119], 'allele': [121], 'significantly': [122], 'reduced': [123], 'decreased': [130], 'proliferation.': [131], 'CaAkt(Tg)': [132], 'deficient': [134], 'developed': [137], 'failure': [139], 'diabetes.': [141, 197], 'These': [142, 164], 'experiments': [143], 'suggest': [144], 'induces': [147], 'cdk4-dependent': [152], 'manner': [153], 'regulation': [155], 'levels.': [163], 'data': [165], 'also': [166], 'indicate': [167], 'alteration': [169], 'cell': [174], 'cycle': [175], 'components': [176], 'could': [177], 'affect': [178], 'basal': [185], 'states': [186, 194], 'adaptation': [189], 'to': [192], 'pathological': [193], 'resulting': [195]}, 'cited_by_api_url': 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