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1373, 1378, 1419, 1480], 'Late': [16, 622, 678, 979, 995], 'Relapsing': [17], 'Metastatic': [18, 1481, 1504, 1512], 'Renal': [19, 962, 1010, 1482, 1505, 1513], 'Cell': [20, 1483, 1506, 1514], 'Carcinoma': [21, 1515], 'Matteo': [22, 89, 136, 465, 1571, 1623, 2008], 'Santoni,': [23], 'Alessandro': [24, 106, 1591], 'Conti,': [25], 'Camillo': [26, 129, 169, 496, 1617, 1661, 2045], 'Porta,': [27], 'Giuseppe': [28, 54, 143, 337, 1634, 1862], 'Procopio,': [29], 'Cora': [30, 159, 1653], 'N.': [31, 160, 162, 1654], 'Sternberg,': [32], 'Umberto': [33, 176, 1672], 'Basso,': [34], 'Ugo': [35, 189, 1688], 'De': [36, 64, 190, 192, 410, 412, 1689, 1946], 'Giorgi,': [37], 'Sergio': [38, 210, 1711], 'Bracarda,': [39], 'Mimma': [40, 226, 1730], 'Rizzo,': [41], 'Cinzia': [42, 238, 1745], 'Ortega,': [43], 'Francesco': [44, 57, 256, 359, 1766, 1886], 'Massari,': [45], 'Roberto': [46, 271, 1784], 'Iacovelli,': [47], 'Lisa': [48, 287, 1803], 'Derosa,': [49], 'Cristina': [50, 304, 1823], 'Masini,': [51], 'Michele': [52, 323, 1845], 'Milella,': [53], 'Di': [55, 338, 340, 1863], 'Lorenzo,': [56], 'Atzori,': [58], 'Maria': [59, 373, 452, 1903, 1992], 'Pagano,': [60], 'Sebastiano': [61, 396, 1929], 'Buti,': [62], 'Rocco': [63, 409, 1945], 'Vivo,': [65], 'Alessandra': [66, 422, 1960], 'Mosca,': [67], 'Marta': [68, 440, 1981], 'Rossi,': [69], 'Chiara': [70, 458, 2002], 'Paglino,': [71], 'Elena': [72, 330, 472, 1851, 2019], 'Verzoni,': [73], 'Linda': [74, 488, 2038], 'Cerbone,': [75], 'Giovanni': [76, 503, 2056], 'Muzzonigro,': [77], 'Massimo': [78, 526, 2082], 'Falconi,': [79], 'Rodolfo': [80, 542, 2101], 'Montironi,': [81], 'Luciano': [82, 562, 2124], 'Burattini,': [83], 'Daniele': [84, 579, 2144], 'Santini,': [85], 'and': [86, 170, 249, 312, 351, 497, 532, 591, 642, 651, 660, 699, 720, 736, 744, 755, 761, 781, 819, 829, 857, 916, 928, 967, 1002, 1197, 1286, 1294, 1368, 1414, 1462, 1565, 1662, 1755, 1830, 1874, 2046, 2087], 'Stefano': [87, 592, 2159], 'Cascinu': [88, 594, 2160], 'SantoniMatteo': [90], 'Santoni': [91, 1572], 'Clinica': [92, 116, 513, 565, 595, 1573, 1600, 2065, 2126, 2161], 'di': [93, 110, 117, 385, 448, 507, 514, 566, 596, 1574, 1594, 1601, 1914, 1988, 2059, 2066, 2127, 2162], 'Oncologia': [94, 291, 444, 567, 582, 597, 1575, 1806, 1984, 2128, 2146, 2163], 'Medica,': [95, 445, 568, 583, 598, 1576, 1985, 2129, 2147, 2164], 'AOU': [96, 119, 516, 556, 569, 599, 1577, 1603, 2068, 2114, 2130, 2165], 'Ospedali': [97, 120, 517, 557, 570, 600, 1578, 1604, 2069, 2115, 2131, 2166], 'Riuniti,': [98, 121, 518, 558, 571, 601, 1579, 1605, 2070, 2116, 2132, 2167], 'Università': [99, 122, 519, 535, 549, 572, 602, 1580, 1606, 2071, 2090, 2107, 2133, 2168], 'Politecnica': [100, 123, 520, 536, 550, 573, 603, 1581, 1607, 2072, 2091, 2108, 2134, 2169], 'delle': [101, 124, 521, 537, 551, 574, 604, 1582, 1608, 2073, 2092, 2109, 2135, 2170], 'Marche,': [102, 125, 522, 538, 552, 575, 605, 1583, 1609, 2074, 2093, 2110, 2136, 2171], 'Ancona,': [103, 126, 523, 539, 559, 576, 606, 1584, 1610, 2075, 2094, 2117, 2137, 2172], 'Italy': [104, 127, 141, 157, 174, 187, 208, 224, 236, 254, 269, 285, 302, 321, 335, 357, 371, 394, 407, 420, 438, 456, 470, 486, 501, 524, 540, 560, 577, 589, 607, 1585, 1611, 1628, 1647, 1666, 1682, 1705, 1724, 1739, 1760, 1778, 1797, 1817, 1839, 1856, 1880, 1897, 1923, 1939, 1954, 1975, 1996, 2013, 2032, 2050, 2076, 2095, 2118, 2138, 2153, 2173], ',': [105, 128, 142, 158, 175, 188, 209, 225, 237, 255, 270, 286, 303, 322, 336, 358, 372, 395, 408, 421, 439, 457, 471, 487, 502, 525, 541, 561, 578, 590], 'ContiAlessandro': [107], 'Conti': [108, 1592], 'Dipartimento': [109, 506, 1593, 2058], 'Scienze': [111, 508, 1595, 2060], 'Cliniche': [112, 509, 1596, 2061], 'Specialistiche': [113, 510, 1597, 2062], 'ed': [114, 511, 1598, 2063], 'Odontostomatologiche,': [115, 512, 1599, 2064], 'Urologia,': [118, 515, 1602, 2067], 'PortaCamillo': [130], 'Porta': [131, 1618], 'Medical': [132, 148, 166, 179, 231, 259, 276, 326, 345, 362, 414, 425, 461, 477, 493, 1619, 1638, 1658, 1674, 1734, 1768, 1788, 1847, 1868, 1888, 1948, 1962, 2004, 2023, 2042], 'Oncology,': [133, 149, 167, 215, 232, 260, 277, 352, 378, 401, 415, 426, 462, 478, 494, 1620, 1639, 1659, 1715, 1735, 1769, 1789, 1875, 1907, 1933, 1949, 1963, 2005, 2024, 2043], 'IRCCS': [134, 194, 463, 1621, 1691, 2006], 'San': [135, 168, 220, 464, 495, 1622, 1660, 1720, 2007, 2044], 'University': [137, 265, 314, 353, 402, 431, 466, 584, 1624, 1774, 1832, 1876, 1934, 1968, 2009, 2148], 'Hospital': [138, 403, 467, 1625, 1935, 2010], 'Foundation,': [139, 468, 1626, 2011], 'Pavia,': [140, 469, 1627, 2012], 'ProcopioGiuseppe': [144], 'Procopio': [145, 1635], 'Department': [146, 164, 213, 229, 274, 309, 348, 376, 399, 475, 491, 1636, 1656, 1713, 1732, 1786, 1827, 1871, 1905, 1931, 2021, 2040], 'Fondazione': [150, 278, 479, 1640, 1790, 2025], 'IRCCS,': [151, 185, 279, 480, 1641, 1680, 1791, 2026], 'Istituto': [152, 182, 195, 216, 280, 298, 384, 481, 1642, 1677, 1692, 1716, 1792, 1813, 1913, 2027], 'Nazionale': [153, 281, 482, 1643, 1793, 2028], 'dei': [154, 204, 282, 483, 1644, 1701, 1794, 2029], 'Tumori,': [155, 218, 283, 300, 484, 1645, 1718, 1795, 1815, 2030], 'Milan,': [156, 284, 485, 1646, 1796, 2031], 'SternbergCora': [161], 'Sternberg': [163, 1655], 'Forlanini': [171, 498, 1663, 2047], 'Hospitals,': [172, 499, 1664, 2048], 'Rome,': [173, 334, 500, 588, 1665, 1855, 2049, 2152], 'BassoUmberto': [177], 'Basso': [178, 1673], 'Oncology': [180, 241, 307, 311, 327, 346, 363, 379, 1675, 1747, 1825, 1829, 1848, 1869, 1889, 1908], '1,': [181, 1490, 1525, 1543, 1676], 'Oncologico': [183, 1678], 'Veneto,': [184, 1679], 'Padova,': [186, 1681], 'GiorgiUgo': [191], 'Giorgi': [193, 1690], 'Scientifico': [196, 1693], 'Romagnolo': [197, 1694], 'per': [198, 1695], 'lo': [199, 1696], 'Studio': [200, 1697], 'e': [201, 317, 387, 1698, 1835, 1916], 'la': [202, 1699], 'Cura': [203, 1700], 'Tumori-I.R.S.T.,': [205, 1702], 'Meldola': [206, 1703], '(FC),': [207, 1704], 'BracardaSergio': [211], 'Bracarda': [212, 1712], 'Toscano': [217, 299, 1717, 1814], 'Ospedale': [219, 450, 1719, 1990], 'Donato': [221, 1721], 'USL-8,': [222, 1722], 'Arezzo,': [223, 1723], 'RizzoMimma': [227], 'Rizzo': [228, 1731], 'Cardarelli': [233, 1736], 'Hospital,': [234, 264, 418, 430, 1737, 1773, 1952, 1967], 'Napoli,': [235, 356, 1738, 1879], 'OrtegaCinzia': [239], 'Ortega': [240, 1746], 'Foundation': [242, 1748], 'Piedmont,': [244, 1750], 'Institute': [245, 1751], 'Cancer': [247, 332, 343, 1214, 1753, 1853, 1866], 'Research': [248, 1754], 'Treatment,': [250, 1756], 'Laboratory': [251, 1757], 'Medicine,': [252, 555, 1758, 2113], 'Candiolo,': [253, 1759], 'MassariFrancesco': [257], 'Massari': [258, 1767], "'G.B.": [261, 1770], "Rossi'": [262, 1771], 'Academic': [263, 1772], 'Verona,': [267, 268, 1776, 1777], 'IacovelliRoberto': [272], 'Iacovelli': [273, 1785], 'DerosaLisa': [288], 'Derosa': [289, 1804], 'UO': [290, 1805], 'Medica': [292, 1807], '2': [293, 838, 1808], 'Universitaria': [294, 367, 1809, 1893], 'Azienda': [295, 365, 381, 446, 1810, 1891, 1910, 1986], 'Ospedaliero-Universitaria': [296, 1811], 'Pisana': [297, 1812], 'Pisa,': [301, 1816], 'MasiniCristina': [305], 'Masini': [306, 1824], 'Division,': [308, 347, 1826, 1870], 'Hematology,': [313, 1831], 'Modena': [316, 1834], 'Reggio': [318, 392, 1836, 1921], 'Emilia,': [319, 393, 1837, 1922], 'Modena,': [320, 1838], 'MilellaMichele': [324], 'Milella': [325, 1846], 'A,': [328, 1849], 'Regina': [329, 1850], 'National': [331, 1852], 'Institute,': [333, 1854], 'LorenzoGiuseppe': [339], 'Lorenzo': [341, 1864], 'Genitourinary': [342, 1865], 'Section,': [344, 1867], 'Endocrinology': [350, 1873], 'Federico': [354, 1877], 'II,': [355, 1878], 'AtzoriFrancesco': [360], 'Atzori': [361, 1887], 'Unit,': [364, 380, 1890, 1909], 'Ospedaliero': [366, 1892], 'Cagliari,': [369, 370, 1895, 1896], 'PaganoMaria': [374], 'Pagano': [375, 1904], 'Ospedaliera': [382, 447, 1911, 1987], 'AsMN,': [383, 1912], 'Ricovero': [386, 1915], 'cura': [388, 1917], 'a': [389, 630, 801, 924, 1030, 1115, 1141, 1181, 1298, 1309, 1331, 1918], 'carattere': [390, 1919], 'scientifico,': [391, 1920], 'ButiSebastiano': [397], 'Buti': [398, 1930], 'Parma,': [405, 406, 1937, 1938], 'VivoRocco': [411], 'Vivo': [413, 1947], 'S.': [416, 451, 1950, 1991], 'Bortolo': [417, 1951], 'Vicenza,': [419, 1953], 'MoscaAlessandra': [423], 'Mosca': [424, 1961], 'Maggiore': [427, 1964], 'della': [428, 453, 1965, 1993], 'Carità': [429, 1966], 'Eastern': [433, 1970], 'Piedmont': [434, 1971], '"A.': [435, 1972], 'Avogadro",': [436, 1973], 'Novara,': [437, 1974], 'RossiMarta': [441], 'Rossi': [442, 1982], 'S.C.': [443, 1983], 'Perugia,': [449, 455, 1989, 1995], 'Misericordia,': [454, 1994], 'PaglinoChiara': [459], 'Paglino': [460, 2003], 'VerzoniElena': [473], 'Verzoni': [474, 2020], 'CerboneLinda': [489], 'Cerbone': [490, 2039], 'MuzzonigroGiovanni': [504], 'Muzzonigro': [505, 2057], 'FalconiMassimo': [527], 'Falconi': [528, 2083], 'Division': [529, 2084], 'Pancreatic': [531, 2086], 'Digestive': [533, 2088], 'Surgery,': [534, 2089], 'MontironiRodolfo': [543], 'Montironi': [544, 2102], 'Section': [545, 2103], 'Pathological': [547, 2105], 'Anatomy,': [548, 2106], 'School': [553, 2111], 'BurattiniLuciano': [563], 'Burattini': [564, 2125], 'SantiniDaniele': [580], 'Santini': [581, 2145], 'Campus': [585, 2149], 'Bio-Medico': [586, 2150], 'Roma,': [587, 2151], 'CascinuStefano': [593], 'View': [608], 'All': [609, 2180], 'Author': [610], 'Informationhttps://doi.org/10.1016/j.juro.2014.07.011AboutFull': [611], 'TextPDF': [612], 'ToolsAdd': [613], 'to': [614, 757, 799, 1303], 'favoritesDownload': [615], 'CitationsTrack': [616], 'CitationsPermissionsReprints': [617], 'ShareFacebookLinked': [618], 'InTwitterEmail': [619], 'Abstract': [620], 'Purpose:': [621], 'recurrence': [623, 980, 996, 1280, 1306], 'renal': [625, 656, 675, 795, 825, 844, 874, 893, 919, 945, 982, 998, 1027, 1056, 1110, 1137, 1160, 1178, 1206, 1290, 1328, 1345, 1374, 1395, 1423], 'cell': [626, 657, 676, 796, 826, 845, 875, 894, 920, 946, 963, 983, 999, 1028, 1057, 1111, 1138, 1161, 1179, 1207, 1291, 1329, 1346, 1375, 1396, 1424], 'carcinoma': [627, 797, 895, 921, 947, 984, 1139, 1347, 1376, 1425], 'is': [628], 'not': [629], 'rare': [631], 'event.': [632], 'In': [633], 'this': [634, 1589, 1615, 1632, 1651, 1670, 1686, 1709, 1728, 1743, 1764, 1782, 1801, 1821, 1843, 1860, 1884, 1901, 1927, 1943, 1958, 1979, 2000, 2017, 2036, 2054, 2080, 2099, 2122, 2142, 2157, 2177], 'retrospective': [635, 1001], 'study': [636, 1004], 'we': [637], 'investigate': [638], 'clinicopathological': [640], 'features': [641], 'outcome': [644, 1413], 'patients': [646, 696, 714, 869, 913, 1053, 1372, 1418], 'treated': [647, 1377], 'sorafenib,': [649, 817], 'sunitinib': [650, 711, 732, 818, 1442], 'pazopanib': [652, 721, 745], 'late': [654, 793, 968, 1305, 1420], 'relapsing': [655, 794], 'carcinoma.': [658, 677, 846, 876, 1075, 1093, 1162, 1208, 1446], 'Materials': [659, 1554], 'Methods:': [661], 'Data': [662], 'were': [663, 697, 702, 763, 772, 784], 'collected': [664], 'from': [665, 1394, 1399, 1422, 1509], '21': [666, 723, 1257], 'Italian': [667, 1401], 'centers': [668], 'involved': [669], 'in': [670, 704, 712, 717, 722, 811, 843, 868, 1052, 1071, 1090, 1105, 1135, 1176, 1200, 1227, 1327, 1426, 1443, 1476, 1503, 1535], 'treatment': [672, 1024, 1203, 1415], 'metastatic': [674, 805, 873, 1026, 1055, 1091, 1109, 1205, 1325, 1444], 'relapse': [679, 1421], 'was': [680, 710, 728], 'defined': [681], 'as': [682], 'more': [683], 'than': [684], '5': [685, 907, 1282], 'years': [686, 1283], 'after': [687, 985, 1284], 'initial': [688], 'radical': [689], 'nephrectomy.': [690, 986], 'Results:': [691], 'A': [692, 886, 1209, 1469], 'total': [693], '2,490': [695], 'screened': [698], '269': [700], '(11%)': [701], 'included': [703], 'study.': [706], 'First': [707], 'line': [708, 1202], 'therapy': [709], '190': [713], '(71%),': [715], 'sorafenib': [716, 740, 1134], '58': [718], '(21%)': [719], '(8%).': [724], 'Median': [725], 'progression-free': [726, 788, 814], 'survival': [727, 815, 867, 966], '20.0': [729], 'months': [730, 738], '(95%': [733, 741, 746], 'CI': [734, 742, 747], '17.0–25.1),': [735], '14.1': [737], '11.0–29.0)': [743], '11.2–not': [748], 'reported).': [749], 'On': [750], 'multivariate': [751], 'analysis': [752], 'MSKCC': [753, 779], 'score': [754, 780], 'metastases': [756, 771, 783, 1370, 1393], 'lymph': [758], 'nodes,': [759], 'liver': [760, 1369], 'brain': [762, 782], 'associated': [764, 773, 785, 1278], 'worst': [766, 787], 'overall': [767], 'survival,': [768], 'while': [769], 'pancreatic': [770, 1392], 'longer': [775], 'survival.': [776, 789], 'Furthermore,': [777], 'age,': [778], 'Conclusions:': [790], 'seem': [798], 'present': [800], 'characteristic': [802], 'pattern': [803], 'spread': [806], 'without': [807], 'showing': [808], 'significant': [809], 'differences': [810], 'terms': [812], 'among': [816], 'pazopanib.': [820], 'References': [821], '1': [822], ':': [823, 839, 855, 885, 908, 941, 961, 978, 994, 1018, 1042, 1069, 1085, 1103, 1128, 1152, 1172, 1194, 1222, 1243, 1258, 1276, 1322, 1341, 1364, 1388, 1411, 1439], 'Advanced': [824], 'carcinoma:': [827, 964, 1000, 1029, 1058, 1112, 1180, 1292, 1330, 1397], 'current': [828], 'emerging': [830], 'management': [831], 'strategies.': [832], 'Drugs2007;': [833], '67:': [834], '1257.': [835], 'Google': [836, 852, 882, 905, 938, 958, 975, 991, 1015, 1039, 1066, 1082, 1100, 1125, 1149, 1169, 1191, 1219, 1240, 1255, 1273, 1319, 1338, 1361, 1385, 1408, 1436, 1453], 'Scholar': [837, 853, 883, 906, 939, 959, 976, 992, 1016, 1040, 1067, 1083, 1101, 1126, 1150, 1170, 1192, 1220, 1241, 1256, 1274, 1320, 1339, 1362, 1386, 1409, 1437, 1454], 'Evolving': [840], 'therapeutic': [841], 'targets': [842], 'Curr': [847], 'Opin': [848], 'Oncol2013;': [849], '25:': [850], '273.': [851], '3': [854, 1144, 1523], 'Validation': [856], 'extension': [858], 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