Title: Reaction of the 2-(bromodifluoromethyl)benzoxazole with tetrakis(dimethylamino)ethylene (TDAE) in the presence of aldehydes. A convenient synthesis of 2-(difluoromethyl)benzoxazole alcohols
Abstract: Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of the 2-(bromodifluoromethyl)benzoxazole 1. The generated 2-(difluoromethyl) benzoxazole anion was trapped with several aldehydes 2 – 9, under mild conditions, to give the corresponding 2-(difluoromethyl)benzoxazole alcohols 10 – 17, in moderate to good yields.
Publication Year: 1997
Publication Date: 1997-02-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 25
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