Signal Responsiveness of IκB Kinases Is Determined by Cdc37-assisted Transient Interaction with Hsp90

Name: Work Video:
Duration: 3 min 30 s
M. Hinz; Meike Broemer; Seda Çöl Arslan; Albrecht Otto; Eva‐Christina Mueller; R. Dettmer; Claus Scheidereit
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147], 'containing': [5, 148], 'the': [6, 11, 31, 61, 87, 128, 149, 154, 174, 204, 230, 271, 358, 382, 458, 469, 583, 591, 692, 906, 1136, 1312, 1379, 1489, 1862, 1875, 1884, 1895, 1908, 1926, 1946, 1986, 1991, 1995, 2118, 2270, 2405, 2663, 2672, 2683, 2689, 2719, 2746, 2841, 2996, 3026, 3037, 3055, 3061, 3065, 3121, 3154, 3185, 3209, 3213, 3249, 3257, 3274, 3277, 3292, 3297, 3318, 3359, 3402, 3421, 3458, 3528, 3547, 3558, 3631, 3643, 3736, 3887, 3899, 3928, 4031, 4039, 4232, 4339, 4383], 'kinases': [7, 97, 150, 240, 584, 778, 1033, 1484, 1870], 'IKKα,': [8, 151, 1909, 1935, 2148, 2723, 2864, 3672, 3975], 'IKKβ,': [9, 152, 2149, 2724, 2865, 3673], 'and': [10, 30, 153, 173, 293, 298, 306, 373, 454, 463, 474, 581, 586, 636, 892, 909, 955, 959, 1034, 1043, 1115, 1318, 1328, 1485, 1497, 1692, 1871, 1891, 1911, 1936, 1942, 2002, 2004, 2026, 2068, 2150, 2172, 2213, 2219, 2275, 2318, 2374, 2387, 2418, 2572, 2620, 2645, 2657, 2676, 2693, 2725, 2866, 2889, 2985, 3013, 3022, 3034, 3046, 3096, 3167, 3235, 3271, 3308, 3323, 3349, 3399, 3418, 3541, 3544, 3570, 3574, 3601, 3623, 3646, 3674, 3714, 3730, 3895, 3921, 4018, 4036, 4047, 4085, 4101, 4146, 4164, 4192, 4235, 4247, 4264, 4268, 4314], 'scaffold': [12, 155, 594, 726], 'NEMO': [13, 156, 600], '(NF-κB': [14, 157, 601], 'essential': [15, 85, 137, 158, 228, 280, 602, 1950, 3124], 'modifier),': [16, 159], 'mediates': [17, 160, 4352], 'activation': [18, 161, 549, 764, 770, 783, 1393, 1969, 3169, 3283, 4041, 4067, 4166, 4197, 4259], 'of': [19, 81, 89, 102, 140, 162, 224, 232, 245, 283, 365, 471, 518, 578, 634, 698, 737, 791, 864, 916, 948, 1118, 1121, 1129, 1135, 1188, 1316, 1389, 1488, 1682, 1689, 1864, 1868, 1955, 1970, 1997, 2170, 2307, 2340, 2345, 2377, 2383, 2390, 2441, 2674, 2685, 2698, 2711, 2732, 2745, 2843, 3011, 3020, 3032, 3060, 3064, 3075, 3089, 3153, 3184, 3194, 3208, 3212, 3229, 3256, 3279, 3321, 3366, 3371, 3384, 3425, 3437, 3457, 3467, 3531, 3534, 3572, 3583, 3655, 3671, 3826, 3901, 3910, 3930, 3987, 3997, 4001, 4021, 4025, 4034, 4053, 4070, 4079, 4088, 4099, 4178, 4200, 4213, 4266, 4296, 4341, 4354, 4385], 'NF-κB': [20, 163, 286, 513, 548, 1189, 1392, 1490, 1859, 3168, 4165], 'by': [21, 74, 112, 164, 217, 255, 457, 775, 780, 798, 849, 1684, 1939, 2041, 2659, 2860, 3239, 3490, 3578, 3625, 3659, 3683, 3716, 4204, 4274, 4309], 'numerous': [22, 165], 'physiological': [23, 166, 3529], 'stimuli.': [24, 167], 'Heat': [25, 168], 'shock': [26, 169, 941], 'protein': [27, 170, 398, 429, 595, 727, 851, 942, 1032, 1142, 1180, 2311, 2615, 2630, 3591, 4270], '90': [28, 171, 943], '(Hsp90)': [29, 172], 'co-chaperone': [32, 175, 1147, 1260, 3737], 'Cdc37': [33, 57, 83, 176, 200, 226, 910, 1143, 1892, 1922, 2204, 2384, 2677, 2733, 2982, 3012, 3021, 3033, 3045, 3076, 3095, 3111, 3348, 3367, 3380, 3398, 3413, 3426, 3446, 3462, 3468, 3501, 3512, 3575, 3729, 3828, 3940, 3983, 4012, 4037, 4048, 4057, 4065, 4081, 4267, 4297], 'have': [34, 177, 867, 1881], 'been': [35, 178, 730, 868, 3741], 'indicated': [36, 179, 631, 3068, 3230, 3312, 3559, 3644, 4233], 'as': [37, 76, 78, 133, 180, 219, 221, 276, 588, 590, 599, 732, 793, 795, 913, 952, 1031, 1185, 2282, 2416, 2491, 2722, 2737, 2892, 3177, 3605, 3743, 3963, 3965, 4013, 4148, 4307], 'additional': [38, 181, 1919], 'subunits,': [39, 182], 'but': [40, 98, 183, 241, 3260, 3386, 4109], 'their': [41, 184, 1039, 2686, 4220], 'specific': [42, 185, 2716, 3677], 'functions': [43, 186, 289, 1315, 4366], 'in': [44, 64, 187, 207, 290, 468, 550, 691, 876, 1329, 1332, 1929, 1994, 2009, 2063, 2224, 2232, 2333, 2437, 2574, 2667, 2678, 2871, 2877, 3050, 3408, 3497, 3513, 3515, 3630, 3933, 3955, 3993, 4050, 4105, 4169, 4252, 4254, 4288, 4304, 4379], 'signal': [45, 188, 1028], 'transduction': [46, 189], 'are': [47, 190, 1025, 3251], 'indistinct.': [48, 191], 'Using': [49, 192], 'an': [50, 103, 124, 193, 246, 267, 917, 2883, 3178, 3514, 3567, 3651, 3684, 4014, 4149, 4253, 4333], 'RNA': [51, 194, 1899], 'interference': [52, 195], 'approach,': [53, 196, 2855], 'we': [54, 197, 1887, 1905, 2681, 3246, 3732, 3936, 4043, 4374], 'demonstrate': [55, 198, 1906], 'that': [56, 199, 1123, 1261, 1867, 1907, 1985, 3084, 3103, 3120, 3248, 3313, 3394, 3454, 3483, 3500, 3735, 3836, 4325, 4350], 'recruits': [58, 201, 1923], 'Hsp90': [59, 202, 908, 1022, 1037, 1110, 1125, 1264, 1317, 1390, 1480, 1683, 1856, 1890, 1924, 2675, 2979, 3014, 3023, 3035, 3047, 3097, 3104, 3270, 3280, 3350, 3372, 3376, 3400, 3543, 3573, 3841, 3956, 4017, 4035, 4046], 'to': [60, 122, 203, 265, 520, 552, 702, 704, 858, 870, 961, 1126, 1263, 1311, 1853, 1925, 1951, 1966, 2399, 3036, 3108, 3198, 3268, 3273, 3317, 3373, 3401, 3427, 3445, 3526, 3539, 3546, 3589, 3667, 3728, 3886, 3974, 3990, 4003, 4110, 4115, 4294, 4331, 4364], 'IKK': [62, 104, 141, 205, 247, 284, 570, 693, 739, 763, 777, 860, 873, 918, 1690, 1865, 1896, 1927, 1992, 2665, 2679, 2690, 2713, 2747, 2997, 3027, 3038, 3056, 3091, 3155, 3165, 3186, 3258, 3275, 3282, 3298, 3305, 3361, 3403, 3509, 3548, 3562, 3817, 3888, 3904, 3916, 4040, 4093, 4209, 4258, 4302, 4377], 'complex': [63, 206, 462, 571, 1313, 1914, 1928, 1948, 1988, 1993, 2748, 2998, 3039, 3156, 3216, 3259, 3294, 3362, 3563, 3889], 'a': [65, 134, 208, 277, 362, 510, 544, 573, 696, 733, 856, 1119, 1186, 1266, 1387, 1902, 1930, 2175, 2334, 2424, 2438, 2485, 2655, 2668, 2853, 2875, 3029, 3070, 3086, 3099, 3190, 3204, 3220, 3432, 3839, 3994, 4111, 4170, 4176, 4207, 4289, 4359, 4380], 'transitory': [66, 209, 1931], 'manner,': [67, 210, 1932], 'preferentially': [68, 211, 1026, 1933, 3395, 3537], 'via': [69, 212, 1265, 1934, 3110], 'IKKα.': [70, 213, 3896, 3946], 'Binding': [71, 214], 'is': [72, 84, 215, 227, 700, 765, 1111, 1144, 1258, 1851, 1915, 1937, 1949, 1964, 3105, 3151, 3288, 3681, 3838, 3890, 3906, 4175], 'conferred': [73, 216], 'N-terminal': [75, 218, 2156, 2163, 3961], 'well': [77, 220, 589, 794, 3964], 'C-terminal': [79, 222, 516, 3966], 'residues': [80, 223], 'Cdc37.': [82, 225, 3675], 'for': [86, 100, 229, 243, 1391, 2309, 2413, 2530, 2617, 2634, 3189, 3281, 3620, 3679, 3711, 3823, 3903, 4023, 4038, 4126, 4141, 4190, 4338, 4367], 'maturation': [88, 231, 1954, 4353], 'de': [90, 233, 1956, 4345, 4368], 'novo': [91, 234, 1957, 4369], 'synthesized': [92, 235, 1958, 4327, 4370], 'IKKs': [93, 236, 1973, 3109, 3439, 3493, 4123, 4286, 4328, 4357], 'into': [94, 237, 2159, 2166, 2207, 3025, 4358], 'enzymatically': [95, 238], 'competent': [96, 239, 4361], 'not': [99, 242, 1324, 1916, 2838, 3005, 3171, 3174, 3252, 3289, 3387, 3925, 4119], 'assembly': [101, 244], 'holocomplex.': [105, 248, 2691], 'Mature': [106, 249], 'IKKs,': [107, 250, 3476], 'T-loop-phosphorylated': [108, 251], 'after': [109, 252, 2132, 2143], 'stimulation': [110, 253, 1975, 3003], 'either': [111, 254, 774, 3827, 4134, 4154], 'receptor-mediated': [113, 256], 'signaling': [114, 257, 1486, 1876, 3905], 'or': [115, 258, 779, 1880, 1978, 2161, 2201, 2734, 2741, 3201, 3223, 3696, 3829, 4072, 4138, 4160, 4194], 'upon': [116, 259], 'DNA': [117, 260, 553, 1979, 2053, 2128], 'damage,': [118, 261], 'further': [119, 262, 734, 3162], 'require': [120, 263, 4124, 4329], 'Hsp90-Cdc37': [121, 132, 264, 275, 1962, 3391, 4022, 4125, 4330, 4351], 'generate': [123, 266, 521], 'activated': [125, 268], 'state.': [126, 269], 'Thus,': [127, 270, 3834, 4373], 'present': [129, 272, 1885, 3049], 'data': [130, 273, 3082, 3116, 4010], 'denote': [131, 274], 'transiently': [135, 278, 2039, 3410, 3937], 'acting': [136, 279], 'regulatory': [138, 281, 592, 735, 865, 2742, 3182], 'component': [139, 282, 736], 'signaling.': [142, 285], 'maintains': [287], 'key': [288], 'various': [291], 'biological': [292, 1314], 'pathological': [294], 'processes,': [295], 'including': [296, 368, 1492], 'immune': [297], 'inflammatory': [299, 374], 'reactions,': [300], 'development,': [301], 'proliferation,': [302], 'apoptosis,': [303], 'stress': [304], 'responses,': [305], 'oncogenesis': [307], '(1Hayden': [308, 477, 604], 'M.S.': [309, 478, 605, 879], 'Kim': [310, 324, 339, 479, 526, 557, 606, 641, 673, 710, 744, 802, 827, 880, 922, 967, 988, 1051, 1066, 1096, 1150, 1193, 1272, 1287, 1337, 1367, 1396, 1417, 1448, 1463, 1501, 1522, 1589, 1619, 1657, 1696, 1717, 1784, 1799, 1829, 2080, 2180, 2287, 2350, 2496, 2538, 2553, 2751, 2772, 2897, 2929, 2961, 3132, 3327, 3748, 3846, 3861], 'S.': [311, 480, 556, 607, 644, 709, 881, 1210, 1436, 1464, 1539, 1628, 1636, 1662, 1734, 2091, 2499, 2537, 2789, 2900, 2928, 3765], 'Genes': [312, 481, 608, 882], 'Dev.': [313, 482, 609, 883, 1168], '2004;': [314, 483, 530, 610, 755, 884, 1250, 1302, 1453, 1579, 1774, 1789, 2829, 3143, 3805, 3876], '18:': [315, 484, 611, 885, 2299, 2565], '2195-2224Crossref': [316, 485, 612, 886], 'PubMed': [317, 332, 345, 486, 501, 538, 565, 613, 624, 666, 686, 720, 758, 820, 841, 887, 899, 936, 981, 1005, 1019, 1059, 1075, 1089, 1105, 1158, 1172, 1253, 1280, 1305, 1360, 1375, 1410, 1441, 1456, 1515, 1582, 1612, 1650, 1675, 1710, 1777, 1792, 1822, 1844, 2109, 2192, 2301, 2369, 2521, 2546, 2567, 2765, 2832, 2922, 2954, 2971, 3146, 3341, 3808, 3854, 3879], 'Scopus': [318, 333, 346, 487, 502, 539, 566, 614, 625, 667, 687, 721, 759, 821, 842, 888, 900, 937, 982, 1006, 1060, 1076, 1090, 1106, 1159, 1173, 1254, 1281, 1306, 1361, 1411, 1442, 1457, 1516, 1583, 1613, 1651, 1676, 1711, 1778, 1793, 1823, 1845, 2110, 2193, 2302, 2370, 2522, 2547, 2568, 2766, 2833, 2923, 2955, 2972, 3147, 3342, 3809, 3855, 3880], '(3332)': [319, 488, 615, 889], 'Google': [320, 335, 348, 489, 504, 541, 568, 616, 627, 669, 689, 723, 761, 823, 844, 890, 902, 939, 984, 1008, 1020, 1062, 1078, 1092, 1108, 1161, 1175, 1256, 1283, 1308, 1363, 1376, 1413, 1444, 1459, 1478, 1518, 1585, 1615, 1653, 1678, 1713, 1780, 1795, 1825, 1847, 2112, 2195, 2304, 2372, 2524, 2549, 2570, 2768, 2835, 2925, 2957, 2974, 3149, 3344, 3811, 3857, 3882], 'Scholar,': [321, 336, 490, 617, 670, 824, 985, 1009, 1063, 1079, 1093, 1162, 1284, 1364, 1414, 1445, 1460, 1519, 1586, 1616, 1654, 1714, 1781, 1796, 1826, 2769, 2926, 2958, 3858], '2Karin': [322], 'M.': [323, 527, 1149, 1220, 1224, 1447, 1549, 1553, 1630, 1660, 1668, 1744, 1748, 1783, 1832, 2081, 2095, 2185, 2349, 2353, 2799, 2803, 2966, 3775, 3779], 'F.R.': [325], 'Nat.': [326, 493, 835, 1247, 1576, 1771, 2826, 3802], 'Rev.': [327, 494, 1013, 1298, 3872], 'Immunol.': [328, 529, 1840], '2005;': [329, 1169, 1841], '5:': [330], '749-759Crossref': [331], '(2484)': [334], '3Basseres': [337], 'D.S.': [338], 'A.S.': [340], 'Oncogene.': [341, 620, 895, 1452, 1788, 2297, 2563], '2006;': [342, 562, 621, 812, 838, 896, 1357, 1642, 2106, 2543], '25:': [343, 531, 622, 897], '6817-6830Crossref': [344], '(573)': [347], 'Scholar).': [349, 505, 542, 628, 724, 762, 845, 903, 1021, 1109, 1176, 1309, 1479, 1679, 1848, 2113, 2196, 2305, 2975, 3345], 'Three': [350], 'major': [351], 'NF-κB-activating': [352], 'pathways': [353, 1860, 3284], 'can': [354], 'be': [355, 855, 1325, 3042, 3524, 3991], 'distinguished.': [356], 'In': [357, 2729, 3160, 3947, 4007, 4076], 'first,': [359], 'canonical': [360], 'pathway,': [361, 1491], 'broad': [363], 'range': [364], 'extracellular': [366], 'stimuli,': [367], 'bacterial': [369], 'pathogens,': [370], 'antigens,': [371], 'mitogens,': [372], 'cytokines,': [375], 'induce': [376], 'diverse': [377], 'intracellular': [378], 'cascades,': [379], 'which': [380, 945, 3739], 'activate': [381], '4The': [386], 'abbreviations': [387, 418], 'used': [388, 419], 'are:': [389, 420], 'IKK,': [390, 421], 'kinase;': [392, 423], 'UbK63,': [393, 424], 'Lys-63-linked': [394, 425, 788], 'polyubiquitination;': [395, 426], 'FKBP51,': [396, 427, 2735, 3738], 'FK506-binding': [397, 428, 1179], '51;': [399, 430], 'GA,': [400, 431], 'geldanamycin;': [401, 432], 'siRNA,': [402, 433], 'small': [403, 434, 3018, 3087], 'interfering': [404, 435], 'RNA;': [405, 436], 'EMSA,': [406, 437], 'electrophoretic': [407, 438, 2276], 'mobility': [408, 439, 2277], 'shift': [409, 440, 2278], 'assay;': [410, 441], 'TNFα,': [411, 442, 4163], 'tumor': [412, 443], 'necrosis': [413, 444], 'factor': [414, 445], 'α;': [415, 446], 'IP,': [416, 447], 'immunoprecipitation.4The': [417], 'immunoprecipitation.': [448], 'complex.': [449, 3299, 3404, 3549], 'IKK-mediated': [450], 'phosphorylation': [451, 768, 3533, 4069, 4084, 4199], 'triggers': [452], 'p105': [455], 'polyubiquitination': [456, 789], 'SCFβTrCP': [459], 'E3': [460], 'ligase': [461], 'subsequent': [464], 'proteasomal': [465, 1687], 'destruction,': [466], 'resulting': [467], 'release': [470], 'p50-,': [472], 'p65-,': [473], 'c-Rel-containing': [475], 'heterodimers': [476], '4Perkins': [491], 'N.D.': [492], 'Mol.': [495, 714, 810, 926, 1083, 1300, 1354, 1400, 1472, 1505, 1700, 2755, 3331, 3874], 'Cell.': [496, 715, 811, 927, 1054, 1275, 1355, 1401, 1506, 1701, 2756, 2945, 3332, 3849], 'Biol.': [497, 656, 676, 716, 837, 977, 1071, 1099, 1249, 1301, 1356, 1473, 1578, 1602, 1640, 1773, 1812, 2359, 2511, 2828, 2912, 3804, 3875], '2007;': [498], '8:': [499, 839, 1156], '49-62Crossref': [500], '(1902)': [503], 'With': [506, 1901], 'much': [507, 3442, 4290], 'slower': [508], 'kinetics,': [509], 'second,': [511], 'noncanonical': [512], 'pathway': [514, 546], 'induces': [515], 'processing': [517], 'NF-κB2/p100': [519], 'p52-containing': [522], 'complexes': [523, 740, 2320, 3092, 3315, 3510, 3818, 4303], '(5Bonizzi': [524], 'G.': [525, 807, 921, 1200, 1230, 1232, 1238, 1240, 1246, 1395, 1500, 1529, 1559, 1561, 1567, 1569, 1575, 1622, 1695, 1724, 1754, 1756, 1762, 1764, 1770, 2089, 2750, 2779, 2809, 2811, 2817, 2819, 2825, 2930, 2964, 3326, 3755, 3785, 3787, 3793, 3795, 3801], 'Trends': [528], '280-288Abstract': [532], 'Full': [533, 535, 661, 663, 681, 683, 815, 817, 931, 933, 1405, 1407, 1510, 1512, 1607, 1609, 1645, 1647, 1705, 1707, 1817, 1819, 2364, 2366, 2516, 2518, 2760, 2762, 2917, 2919, 2949, 2951, 3336, 3338], 'Text': [534, 536, 662, 664, 682, 684, 816, 818, 932, 934, 1406, 1408, 1511, 1513, 1608, 1610, 1646, 1648, 1706, 1708, 1818, 1820, 2365, 2367, 2517, 2519, 2761, 2763, 2918, 2920, 2950, 2952, 3337, 3339], 'PDF': [537, 665, 685, 819, 935, 1409, 1514, 1611, 1649, 1709, 1821, 2368, 2520, 2764, 2921, 2953, 3340], '(2055)': [540], 'Finally,': [543, 2629], '"nuclear-to-cytoplasmic"': [545], 'promotes': [547, 1038], 'response': [551], 'damage': [554], '(6Janssens': [555], 'J.': [558, 646, 655, 675, 711, 975, 1001, 1052, 1053, 1208, 1222, 1242, 1273, 1274, 1290, 1537, 1551, 1571, 1588, 1601, 1626, 1639, 1669, 1732, 1746, 1766, 1798, 1811, 1836, 1839, 2085, 2103, 2358, 2501, 2510, 2787, 2801, 2821, 2902, 2911, 3763, 3777, 3797, 3847, 3848, 3864], 'Cell': [559, 836, 976, 1082, 1152, 1248, 1577, 1670, 1772, 2827, 3662, 3803], 'Death': [560], 'Differ.': [561], '13:': [563, 2107], '773-784Crossref': [564], '(251)': [567], 'Scholar).The': [569], 'has': [572, 729, 3740], 'large': [574], 'apparent': [575, 2884, 3210], 'molecular': [576, 953, 2885], 'mass': [577, 2886], '700-900': [579], 'kDa': [580], 'contains': [582], 'IKKα': [585, 1941, 2171, 2694, 3195, 3267, 3322, 3385, 3396, 3417, 3428, 3540, 3830, 3979, 4004, 4269], 'IKKβ': [587, 2173, 3078, 3388, 4054, 4073, 4090, 4157], 'nonenzymatic': [593], 'IKKγ,': [596], 'also': [597, 854, 1183, 3634, 3813], 'known': [598, 3840], 'modifier)': [603], '7Scheidereit': [618, 893], 'C.': [619, 654, 713, 894, 989, 1067, 1204, 1212, 1451, 1533, 1541, 1666, 1728, 1736, 1787, 2296, 2509, 2562, 2783, 2791, 2910, 2932, 3759, 3767], '6685-6705Crossref': [623, 898], '(538)': [626, 901], 'Stoichiometric': [629], 'analyses': [630, 3522], 'equimolar': [632], 'content': [633], 'IKKγ': [635, 699, 792, 799, 2151, 2692, 2726, 2844, 2867, 3568, 3652], 'molecules': [638], '(8Krappmann': [639, 2494, 2895], 'D.': [640, 1081, 1151, 1206, 1353, 1449, 1535, 1620, 1634, 1730, 1785, 2286, 2495, 2552, 2785, 2896, 3761], 'E.N.': [642, 2497, 2898], 'Tegethoff': [643, 2498, 2899], 'Li': [645, 829, 2500, 2901], 'Klippel': [647, 2100, 2502, 2903], 'A.': [648, 749, 1194, 1228, 1430, 1437, 1523, 1557, 1590, 1592, 1618, 1632, 1718, 1752, 1800, 1802, 1834, 2079, 2101, 2503, 2773, 2807, 2904, 2944, 3137, 3749, 3783], 'Giese': [649, 2098, 2504, 2905], 'K.': [650, 1050, 1202, 1271, 1531, 1726, 2093, 2099, 2505, 2781, 2906, 3757, 3845], 'Baeuerle': [651, 2506, 2907], 'P.A.': [652, 2507, 2908], 'Scheidereit': [653, 712, 1450, 1786, 2295, 2508, 2561, 2909], 'Chem.': [657, 677, 1603, 1641, 1813, 2360, 2512, 2913], '2000;': [658, 1072, 1372, 1604, 1814, 2513, 2914], '275:': [659, 1605, 1815, 2514, 2915], '29779-29787Abstract': [660, 2515, 2916], '(105)': [668, 2523, 2924], '9Miller': [671], 'B.S.': [672], 'E.': [674, 2292, 2558, 2962], '2001;': [678, 1056, 1277, 3851], '276:': [679], '36320-36326Abstract': [680], '(56)': [688], 'Scholar)': [690, 2571, 2836, 3150], 'complex,': [694], 'where': [695, 4382], 'tetramer': [697], 'thought': [701], 'bind': [703, 3316, 3973], 'two': [705, 3977], 'dimers': [707], '(10Tegethoff': [708], '2003;': [717, 1102, 1155, 1672], '23:': [718, 1454, 1790], '2029-2041Crossref': [719], '(111)': [722], 'ELKS': [728, 3126, 3176], 'proposed': [731, 912, 1386, 3123], 'cellular': [738, 1027, 1047, 3090, 4301], '(11Ducut': [741, 3129], 'Sigala': [742, 3130], 'J.L.': [743, 3131], 'V.': [745, 1292, 2087, 3133, 3866], 'Young': [746, 3134], 'D.B.': [747, 828, 1236, 1565, 1760, 2815, 3135, 3791], 'Shevchenko': [748, 3136], 'Mercurio': [750, 3138], 'F.': [751, 2288, 2554, 2938, 3139], 'Verma': [752, 3140], 'I.M.': [753, 3141], 'Science.': [754, 2188, 3142], '304:': [756, 3144], '1963-1967Crossref': [757, 3145], '(185)': [760, 1652, 3148], 'dependent': [766], 'on': [767, 1990, 2484, 2654, 3982], 'at': [769, 1861, 2626, 3098, 3487], 'loop': [771, 4068, 4198, 4260], '(T-loop)': [772], 'serines,': [773], 'upstream': [776, 1869], 'autophosphorylation.': [781], 'process': [784, 1877, 1996], 'involves': [785], 'catalytic,': [786], 'nondestructive': [787], '(UbK63)': [790], 'UbK63': [796], 'binding': [797, 958, 1117, 3166, 3370, 3424, 3842, 3980, 4000], '(12Ea': [800], 'C.K.': [801], 'L.': [803, 1598, 1664, 1808, 2351], 'Xia': [804], 'Z.P.': [805], 'Pineda': [806], 'Chen': [808], 'Z.J.': [809], '22:': [813], '245-257Abstract': [814], '(794)': [822], '13Wu': [825], 'C.J.': [826], 'T.': [830, 1192, 1348, 1368, 1462, 1466, 1470, 1521, 1716, 2771, 3747], 'Srinivasula': [831], 'S.M.': [832, 991, 1340], 'Ashwell': [833], 'J.D.': [834, 2179], '398-406Crossref': [840], '(500)': [843], 'Moreover,': [846, 1961, 3001, 3506, 4064], 'conformational': [847], 'changes': [848], 'induced': [850], 'interactions': [852], 'may': [853, 1323, 3377], 'mechanism': [857], 'stimulate': [859], 'activity.': [861, 4128], 'A': [862, 3464], 'number': [863], 'proteins': [866, 1024, 1487, 2846, 3067, 3231, 4216, 4234], 'suggested': [869, 1184, 2736, 3742], 'interact': [871, 1893], 'with': [872, 1482, 1894, 1918, 1945, 1976, 2017, 2052, 2076, 2127, 2155, 2162, 2226, 2247, 2324, 2337, 2395, 2409, 2533, 2614, 2622, 2642, 2662, 2688, 2715, 2840, 2874, 2882, 2990, 2995, 3094, 3266, 3296, 3353, 3358, 3390, 3415, 3441, 3448, 3473, 3503, 3555, 3566, 3599, 3614, 3642, 3650, 3691, 3700, 3705, 3815, 3913, 3944, 4056, 4135, 4144, 4156, 4162, 4187, 4206, 4219, 4229, 4239, 4244], 'components': [874, 1691, 2714, 2739, 3255], '(reviewed': [875], 'Refs.': [877], '1Hayden': [878], 'Scholar': [891], 'Among': [904], 'them,': [905], 'chaperones': [907, 1873, 3250], 'were': [911, 2007, 2038, 2050, 2061, 2124, 2139, 2153, 2222, 2230, 2280, 2322, 2331, 2407, 2435, 2528, 2612, 2638, 2858, 2868, 3048, 3351, 3553, 3587, 3597, 3612, 3618, 3633, 3640, 3648, 3665, 3689, 3703, 3709, 3953, 4132, 4153, 4185, 4217, 4226, 4242, 4272], 'stoichiometric': [914, 1920, 2738, 3030, 3191, 3254], 'subunits': [915], 'holocomplex': [919], '(14Chen': [920, 1394, 1499, 1694, 2749, 3325], 'P.': [923, 1344, 1370, 1397, 1422, 1502, 1624, 1697, 2539, 2752, 3328], 'Goeddel': [924, 1398, 1503, 1698, 2186, 2753, 3329], 'D.V.': [925, 1399, 1504, 1699, 2187, 2754, 3330], '2002;': [928, 1086, 1402, 1507, 1702, 2757, 3333], '9:': [929, 1403, 1508, 1703, 2758, 3334], '401-410Abstract': [930, 1404, 1509, 1704, 2759, 3335], '(332)': [938, 1412, 1517, 1712, 2767, 3343], 'Scholar).Heat': [940], '(Hsp90),': [944], 'represents': [946], '1-2%': [947], 'cytosolic': [949], 'protein,': [950], 'acts': [951, 1989], 'chaperone': [954, 1947, 1987, 3293], 'requires': [956], 'ATP': [957], 'hydrolysis': [960], 'maintain': [962], 'its': [963, 1319, 1998, 3832, 3884], 'function': [964, 3530, 3900], '(15Obermann': [965], 'W.M.': [966], 'H.': [968, 1196, 1420, 1468, 1525, 1720, 1830, 2775, 3751], 'Russo': [969], 'A.A.': [970], 'Pavletich': [971, 1423], 'N.P.': [972], 'Hartl': [973], 'F.U.': [974], '1998;': [978, 1002, 2361, 2946, 2968], '143:': [979], '901-910Crossref': [980], '(487)': [983], '16Panaretou': [986], 'B.': [987, 1214, 1244, 1543, 1573, 1738, 1768, 2294, 2560, 2793, 2823, 3769, 3799], 'Roe': [990], "O'Brien": [992], 'R.': [993, 1216, 1545, 1740, 2357, 2795, 2936, 3771], 'Ladbury': [994], 'J.E.': [995], 'Piper': [996], 'P.W.': [997], 'Pearl': [998], 'L.H.': [999, 1065, 1164], 'EMBO': [1000], '17:': [1003], '4829-4836Crossref': [1004], '(613)': [1007], '17Pratt': [1010], 'W.B.': [1011, 1095], 'Annu.': [1012], 'Pharmacol.': [1014], 'Toxicol.': [1015], '1997;': [1016, 2189], '37:': [1017], '297-326Crossref': [1018], 'client': [1023, 1130], 'transducers,': [1029], 'such': [1030, 1146], 'transcription': [1035, 4061], 'factors.': [1036], 'proper': [1040], 'folding,': [1041], 'assembly,': [1042], 'transportation': [1044], 'across': [1045], 'different': [1046, 3221, 3602], 'compartments': [1048], '(18Richter': [1049, 1270, 3844], 'Physiol.': [1055, 1276, 3850], '188:': [1057, 1278, 3852], '281-290Crossref': [1058, 1279, 3853], '(503)': [1061, 1282, 3856], '19Pearl': [1064], 'Curr.': [1068, 1165], 'Opin.': [1069, 1166], 'Struct.': [1070], '10:': [1073], '46-51Crossref': [1074], '(277)': [1077], '20Picard': [1080], 'Life': [1084], 'Sci.': [1085, 1434, 1671], '59:': [1087], '1640-1648Crossref': [1088], '(652)': [1091], '21Pratt': [1094], 'D.O.': [1097], 'Exp.': [1098], 'Med.': [1100], '(Maywood).': [1101], '228:': [1103], '111-133Crossref': [1104], '(1249)': [1107], 'regulated': [1112], 'through': [1113, 3892], 'sequential': [1114], 'cooperative': [1116], 'set': [1120], 'co-chaperones': [1122], 'link': [1124], 'distinct': [1127, 2991], 'classes': [1128], 'proteins.': [1131, 3560], 'mammalian': [1133], 'homologue': [1134], 'budding': [1137], 'yeast': [1138], 'cell': [1139, 2856, 3584], 'cycle': [1140], 'control': [1141, 1874], 'one': [1145], '(22MacLean': [1148], 'Stress': [1153], 'Chaperones.': [1154], '114-119Crossref': [1157], '(113)': [1160], '23Pearl': [1163], 'Genet.': [1167], '15:': [1170], '55-61Crossref': [1171], '(200)': [1174], 'immunophilin': [1178], '51': [1181], '(FKBP51),': [1182], 'regulator': [1187], 'activity': [1190, 1963, 2420, 3917, 4087, 4249, 4378], '(24Bouwmeester': [1191, 3746], 'Ruffner': [1195, 1524, 1719, 2774, 3750], 'Angrand': [1197, 1526, 1721, 2776, 3752], 'P.O.': [1198, 1527, 1722, 2777, 3753], 'Bergamini': [1199, 1528, 1723, 2778, 3754], 'Croughton': [1201, 1530, 1725, 2780, 3756], 'Cruciat': [1203, 1532, 1727, 2782, 3758], 'Eberhard': [1205, 1534, 1729, 2784, 3760], 'Gagneur': [1207, 1536, 1731, 2786, 3762], 'Ghidelli': [1209, 1538, 1733, 2788, 3764], 'Hopf': [1211, 1540, 1735, 2790, 3766], 'Huhse': [1213, 1542, 1737, 2792, 3768], 'Mangano': [1215, 1544, 1739, 2794, 3770], 'Michon': [1217, 1546, 1741, 2796, 3772], 'A.M.': [1218, 1547, 1742, 2797, 3773], 'Schirle': [1219, 1548, 1743, 2798, 3774], 'Schlegl': [1221, 1550, 1745, 2800, 3776], 'Schwab': [1223, 1552, 1747, 2802, 3778], 'Stein': [1225, 1554, 1749, 2804, 3780], 'M.A.': [1226, 1555, 1750, 2805, 3781], 'Bauer': [1227, 1556, 1751, 2806, 3782], 'Casari': [1229, 1558, 1753, 2808, 3784], 'Drewes': [1231, 1560, 1755, 2810, 3786], 'Gavin': [1233, 1562, 1757, 2812, 3788], 'A.C.': [1234, 1563, 1758, 2813, 3789], 'Jackson': [1235, 1564, 1759, 2814, 3790], 'Joberty': [1237, 1566, 1761, 2816, 3792], 'Neubauer': [1239, 1568, 1763, 2818, 3794], 'Rick': [1241, 1570, 1765, 2820, 3796], 'Kuster': [1243, 1572, 1767, 2822, 3798], 'Superti-Furga': [1245, 1574, 1769, 2824, 3800], '6:': [1251, 1580, 1775, 2830, 3806], '97-105Crossref': [1252, 1581, 1776, 2831, 3807], '(851)': [1255, 1584, 1779, 2834, 3810], 'Scholar),': [1257, 2373, 3812, 3883], 'another': [1259], 'binds': [1262, 3538], 'tetratri-copeptide': [1267], 'repeat': [1268], 'domain': [1269, 3434, 3460], '25Riggs': [1285, 3859], 'D.L.': [1286, 3860], 'M.B.': [1288, 3862], 'Cheung-Flynn': [1289, 3863], 'Prapapanich': [1291, 3865], 'Carrigan': [1293, 3867], 'P.E.': [1294, 3868], 'Smith': [1295, 3869], 'D.F.': [1296, 3870], 'Crit.': [1297, 3871], 'Biochem.': [1299, 1471, 3873], '39:': [1303, 3877], '279-295Crossref': [1304, 3878], '(108)': [1307, 3881], 'Due': [1310], 'co-chaperones,': [1320], 'knock-out': [1321], 'studies': [1322, 3407], 'readily': [1326], 'informative': [1327], 'fact': [1330, 4349], 'result': [1331], 'lethal': [1333], 'phenotypes': [1334], '(26Grad': [1335], 'I.': [1336], 'T.A.': [1338], 'Ludwig': [1339], 'Hoyle': [1341], 'G.W.': [1342], 'Ruiz': [1343], 'Wurst': [1345], 'W.': [1346, 1418, 1658, 2097], 'Floss': [1347], 'Miller': [1349, 1591, 1801], 'C.A.': [1350, 1416], 'III': [1351], 'Picard': [1352], '26:': [1358], '8976-8983Crossref': [1359], '(74)': [1362], '27Voss': [1365], 'A.K.': [1366], 'Gruss': [1369], 'Development.': [1371], '127:': [1373], '1-11Crossref': [1374], 'Scholar).Studies': [1377], 'using': [1378, 2045, 2055, 2135, 2423, 3302], 'Hsp90-specific': [1380], 'ATPase': [1381], 'inhibitor': [1382, 2250, 2473, 2606], 'geldanamycin': [1383, 2031], '(GA)': [1384], 'initially': [1385], 'requirement': [1388], '28Byrd': [1415], 'Erdjument-Bromage': [1419], 'Tempst': [1421], 'N.': [1424, 1426, 1656], 'Rosen': [1425], 'Nathan': [1427], 'C.F.': [1428], 'Ding': [1429], 'Proc.': [1431], 'Natl.': [1432], 'Acad.': [1433], 'U.': [1435, 2290, 2556], '1999;': [1438, 1475, 2298, 2564], '96:': [1439], '5645-5650Crossref': [1440], '(175)': [1443], '29Broemer': [1446, 1782], '5378-5386Crossref': [1455, 1791], '(187)': [1458, 1794], '30Sugita': [1461], 'Murakami': [1465], 'Miyoshi': [1467], 'Ohnuki': [1469], 'Int.': [1474], '47:': [1476], '587-595PubMed': [1477], 'interacts': [1481, 3093, 3295, 3502], 'MEKK3,': [1493], 'NIK,': [1494], 'RIP1,': [1495], 'TAK1,': [1496], 'TBK1': [1498], '24Bouwmeester': [1520, 1715, 2770], '31Lewis': [1587, 1797], 'Lin': [1593, 1803], 'Y.': [1594, 1596, 1638, 1804, 1806], 'Rodriguez': [1595, 1805], 'Neckers': [1597, 1807], 'Liu': [1599, 1809], 'Z.G.': [1600, 1810], '10519-10526Abstract': [1606, 1816], '(292)': [1614, 1824], '32Citri': [1617], 'Shohat': [1621], 'Ramakrishnan': [1623], 'Gan': [1625], 'Lavi': [1627], 'Eisenstein': [1629], 'Kimchi': [1631], 'Wallach': [1633], 'Pietrokovski': [1635], 'Yarden': [1637], '281:': [1643], '14361-14369Abstract': [1644], '33Field': [1655], 'Daniels': [1659], 'Howell': [1661], 'Daviet': [1663], 'Boshoff': [1665], 'Collins': [1667], '116:': [1673], '3721-3728Crossref': [1674], '(201)': [1677], 'Prolonged': [1680], 'inhibition': [1681, 1857], 'GA': [1685], 'causes': [1686], 'degradation': [1688, 3920], 'RIP1': [1693], '34Pittet': [1827], 'J.F.': [1828], 'Pespeni': [1831], "O'Mahony": [1833], 'Roux': [1835], 'Welch': [1837], 'W.J.': [1838], '174:': [1842], '384-394Crossref': [1843], '(61)': [1846], 'Hence,': [1849], 'it': [1850, 3287], 'unclear': [1852], 'what': [1854], 'extent': [1855], 'affects': [1858], 'level': [1863], 'versus': [1866], 'if': [1872, 3044], 'per': [1878], 'se': [1879], 'homeostatic': [1882], 'functions.In': [1883], 'study,': [1886], 'investigated': [1888], 'how': [1889, 3291], 'signalosome,': [1897], 'utilizing': [1898], 'interference.': [1900], 'compositional': [1903], 'analysis,': [1904], '-β,': [1910], '-γ': [1912], 'core': [1913], 'associated': [1917, 3181], 'subunits.': [1921], 'phosphorylated': [1938, 1972, 2314, 3486, 3511], 'both': [1940, 3347, 3438, 3504], 'IKKβ.': [1943], 'Interaction': [1944], 'promote': [1952], 'functional': [1953, 4032], 'kinases.': [1960], 'required': [1965], 'trigger': [1967], 'catalytic': [1968], 'T-loop': [1971, 4083], 'following': [1974], 'TNF-α': [1977], 'damage.': [1980], 'These': [1981, 3081], 'results': [1982], 'provide': [1983], 'evidence': [1984], 'activation.EXPERIMENTAL': [1999], 'PROCEDURESCell': [2000], 'Culture': [2001], 'Transfection—HeLa': [2003], '293': [2005, 2036, 3595, 3687, 4130, 4183], 'cells': [2006, 2037, 2049, 2123, 2330, 2406, 2434, 2527, 2701, 2850, 3409, 3552, 3596, 3639, 3688, 4131, 4184, 4225], 'grown': [2008], "Dulbecco's": [2010], 'modified': [2011], "Eagle's": [2012], 'medium': [2013], '(PAA': [2014], 'Laboratories),': [2015], 'supplemented': [2016, 2246], '10%': [2018, 2244, 2468, 2601], 'fetal': [2019], 'calf': [2020], 'serum,': [2021], '1': [2022, 2264, 2453, 2456, 2531, 2586, 2589, 2618], 'mm': [2023, 2234, 2237, 2256, 2259, 2262, 2265, 2443, 2448, 2454, 2457, 2460, 2463, 2466, 2576, 2581, 2587, 2590, 2593, 2596, 2599], 'sodium': [2024], 'pyruvate,': [2025], '100': [2027, 2233], 'units/ml': [2028], 'penicillin/streptomycin.': [2029], '17-Demethoxy': [2030], 'was': [2032, 2073, 2205, 2392, 2421, 2481, 2632, 2652, 3237, 3469, 3485, 3564, 3576, 3657, 4005, 4167, 4202, 4250], 'purchased': [2033], 'from': [2034, 2696, 2847], 'InvivoGen.': [2035], 'transfected': [2040, 2051, 2062, 2126, 2332, 2393, 3554, 3598, 3641, 3690, 4089, 4133, 4186, 4228], 'calcium': [2042], 'phosphate': [2043], 'precipitation': [2044, 2695], 'standard': [2046, 2227], 'protocols.': [2047], 'HeLa': [2048, 2433, 2700, 3551, 3638, 4224], 'constructs': [2054, 2129, 3604, 3698, 3942], 'Lipofectamine': [2056, 2136], '2000': [2057], '(Invitrogen).': [2058], 'Synthetic': [2059], 'siRNAs': [2060, 2717, 4230], 'final': [2064], 'concentrations': [2065], 'between': [2066, 2887, 4016], '0.5': [2067], '10': [2069, 2255, 2459, 2592], 'nm.': [2070], 'Lipid-mediated': [2071], 'transfection': [2072, 2134], 'carried': [2074, 2482], 'out': [2075, 2483], 'atufect01': [2077], '(36Santel': [2078], 'Keil': [2082], 'O.': [2083], 'Endruschat': [2084], 'Esche': [2086], 'Fisch': [2088], 'Dames': [2090], 'Loffler': [2092], 'Fechtner': [2094], 'Arnold': [2096], 'Kaufmann': [2102], 'Gene': [2104, 2328], 'Ther.': [2105], '1222-1234Crossref': [2108], '(324)': [2111], 'For': [2114, 2267], 'sequence': [2115], 'information,': [2116], 'see': [2117, 2269], 'supplemental': [2119, 2271], 'data.': [2120, 2272], 'Where': [2121, 2379], 'indicated,': [2122, 2380, 2417], 'additionally': [2125], '48': [2130, 4236], 'h': [2131, 2142, 2403, 2532, 2619, 4237], 'siRNA': [2133, 2144, 3556], '2000.': [2137], 'Cells': [2138, 2229, 4152], 'lysed': [2140, 2231, 2436, 2573], '72': [2141], 'transfection.': [2145], 'Full-length': [2146], 'human': [2147, 2203], 'cDNAs': [2152], 'cloned': [2154, 2206], 'FLAG': [2157, 3615, 3706, 4245], 'epitope': [2158, 2165], 'pcDNA3': [2160, 2396], 'Myc': [2164], 'pRK5.': [2167], 'Kinase-dead': [2168], 'mutants': [2169, 3307, 3952, 3968], 'carry': [2174], 'K44A': [2176, 3609], 'mutation': [2177], '(37Woronicz': [2178], 'X.': [2181], 'Cao': [2182], 'Z.': [2183], 'Rothe': [2184], '278:': [2190], '866-869Crossref': [2191], '(1063)': [2194], 'N-terminally': [2197], 'FLAG-tagged': [2198, 3412, 3939], 'full-length,': [2199], 'truncated,': [2200], 'point-mutated': [2202], 'pcDNA3.Immunoprecipitation,': [2208], 'Western': [2209, 2220, 3240, 3579, 3626, 3660, 3717, 4275], 'Blotting,': [2210], 'Kinase': [2211, 2273], 'Assay,': [2212], 'Electrophoretic': [2214], 'Mobility': [2215], 'Shift': [2216], 'Assay': [2217], '(EMSA)—Immunoprecipitations': [2218], 'blots': [2221], 'performed': [2223, 2281], 'accordance': [2225], 'procedures.': [2228], 'NaCl,': [2235, 2449, 2582], '25': [2236], 'Tris,': [2238], 'pH': [2239, 2445, 2578], '8,': [2240], '0.2%': [2241], 'Nonidet': [2242], 'P-40,': [2243], 'glycerol,': [2245], 'complete': [2248, 2471, 2604], 'protease': [2249, 2472, 2605], 'mixture': [2251, 2474, 2607], '(Roche': [2252, 2475, 2608], 'Applied': [2253, 2476, 2609], 'Science),': [2254], 'NaF,': [2257, 2461, 2594], '8': [2258, 2462, 2595], 'β-glycerophosphate,': [2260, 2464, 2597], '0,2': [2261], 'Na3VO4,': [2263], 'dithiothreitol.': [2266], 'antibodies,': [2268, 3355], 'assays': [2274, 2279, 4316], 'described': [2283, 2492, 2893], 'previously': [2284, 2493, 3122], '(38Krappmann': [2285, 2551], 'Kordes': [2289, 2555], 'Scharschmidt': [2291, 2557], 'Dorken': [2293, 2559], '943-953Crossref': [2300, 2566], '(237)': [2303, 2569], 'Intensities': [2306], 'signals': [2308], 'IκBα': [2310, 3919], '(Western': [2312], 'blots),': [2313], 'GST-IκBα': [2315], '(kinase': [2316], 'assays),': [2317], 'NF-κB-DNA': [2319], '(EMSA)': [2321], 'quantified': [2323], 'TINA': [2325], 'version': [2326], '2.0.Reporter': [2327], 'Assay—293': [2329], '6-well': [2335], 'plate': [2336], '0.25': [2338], 'μg': [2339, 2376, 2382, 2389], 'pRL-TK': [2341], '(Promega),': [2342], '3': [2343, 2635], 'ng': [2344], '6×': [2346], 'NF-κB-luc': [2347], '(39Bergmann': [2348], 'Lindsay': [2352], 'Barnes': [2354], 'P.J.': [2355], 'Newton': [2356], '273:': [2362], '6607-6610Abstract': [2363], '(167)': [2371], '2.5': [2375, 2400], 'pCDNA3.': [2378], '0.8': [2381], 'expression': [2385, 3368, 3592, 3669, 4094, 4139, 4158, 4188, 4298], 'construct': [2386], '0.7': [2388], 'FLAG-IKKβ': [2391, 4262], 'together': [2394, 3414, 3943, 4055, 4143], 'vector': [2397, 4137, 4140, 4159], 'up': [2398], 'μg.': [2401], '24': [2402], 'post-transfection,': [2404], 'stimulated': [2408, 4161], '40': [2410], 'ng/ml': [2411], 'TNFα': [2412, 3002], '4': [2414, 2627], 'h,': [2415], 'luciferase': [2419, 2426, 4171, 4310], 'determined': [2422, 3635, 4251], 'dual': [2425], 'assay': [2427, 3518], 'kit': [2428], '(Promega).Gel': [2429], 'Filtration—∼2': [2430], '×': [2431], '107': [2432], '500-μl': [2439], 'volume': [2440], '50': [2442, 2575], 'HEPES,': [2444, 2577], '7.5,': [2446, 2579], '150': [2447, 2580], '1%': [2450, 2583], 'Triton': [2451, 2584], 'X-100,': [2452, 2585], 'EDTA,': [2455, 2588], 'dithiothreitol,': [2458, 2591], '0.1': [2465, 2598], 'orthovanadate,': [2467, 2600], 'glycerol': [2469, 2602], 'plus': [2470, 2603], 'Science).': [2477, 2610], 'Gel': [2478], 'filtration': [2479, 3009], 'chromatography': [2480], 'Superose': [2486], '6': [2487], 'column': [2488], '(Amersham': [2489], 'Biosciences)': [2490], 'Scholar).Metabolic': [2525], 'Labeling—HeLa': [2526], 'labeled': [2529, 2849], '70': [2534], 'μCi/ml': [2535], '[35Sharp': [2536], 'Adv.': [2540], 'Cancer': [2541], 'Res.': [2542], '95:': [2544], '323-348Crossref': [2545], '(274)': [2548], 'ScholarS]methionine': [2550], 'Extracts': [2611], 'precleared': [2613], 'A-Sepharose': [2616, 2631], 'incubated': [2621], 'anti-IKKγ': [2623, 3354], 'antibodies': [2624], 'overnight': [2625], '°C.': [2628], 'added': [2633], 'h.': [2636], 'Precipitates': [2637, 3617, 3708], 'washed': [2639], 'five': [2640], 'times': [2641], 'lysis': [2643], 'buffer': [2644], 'boiled': [2646], 'SDS': [2647], 'loading': [2648], 'buffer.': [2649], 'supernatant': [2651], 'applied': [2653], 'SDS-PAGE': [2656], 'analyzed': [2658, 2682, 2859, 3577, 3619, 3658, 3710, 4273, 4375], 'autoradiography.RESULTSHsp90-Cdc37': [2660], 'Interacts': [2661, 3265], 'Core': [2664], 'Complex': [2666], 'Transitory': [2669], 'Manner—To': [2670], 'determine': [2671, 3590, 3668], 'role': [2673, 4033, 4384], 'signaling,': [2680], 'mode': [2684, 3929], 'association': [2687, 3357, 3957], 'lysates': [2697, 2857, 3632, 3647], '[35S]methionine-labeled': [2699], 'revealed': [2702, 3482], 'only': [2703, 3069, 3085], 'three': [2704, 4179], 'prominent': [2705], 'interacting': [2706], 'species': [2707, 2721], '(Fig.': [2708, 2727, 2851, 2880, 2999, 3015, 3079, 3157, 3217, 3232, 3242, 3363, 3429, 3451, 3494, 3519, 3819, 3958, 3984, 4062, 4074, 4096, 4312, 4317], '1A).': [2709], 'Silencing': [2710, 3365], 'single': [2712], 'verified': [2718], 'observed': [2720, 3822], '1B).': [2728], 'contrast,': [2730], 'silencing': [2731, 3193, 4078], '(Hsp90-Cdc37)': [2740], 'co-factor': [2743], '(FKBP51)': [2744], 'did': [2837, 3004], 'interfere': [2839], 'pattern': [2842], 'co-precipitated': [2845, 3352], 'metabolically': [2848], '1B).As': [2852], 'second': [2854], 'size': [2861, 3211], 'exclusion': [2862], 'chromatography.': [2863], 'identically': [2869], 'eluted': [2870, 2989], 'fractions': [2872], '12-16': [2873], 'peak': [2876], 'fraction': [2878, 3088], '14': [2879], '1C)': [2881], '700': [2888], '900': [2890], 'kDa,': [2891], 'before': [2894], '40Yamaoka': [2927], 'Bessia': [2931], 'Whiteside': [2933], 'S.T.': [2934], 'Weil': [2935], 'Agou': [2937], 'Kirk': [2939], 'H.E.': [2940], 'Kay': [2941], 'R.J.': [2942], 'Israel': [2943], '93:': [2947], '1231-1240Abstract': [2948], '(945)': [2956], '41Rothwarf': [2959], 'D.M.': [2960], 'Natoli': [2963], 'Karin': [2965], 'Nature.': [2967], '395:': [2969], '297-300Crossref': [2970], '(842)': [2973], 'Upon': [2976], 'gel': [2977, 3008], 'filtration,': [2978], '(fractions': [2980, 2983, 2987], '18-22),': [2981], '24-28),': [2984], 'FKBP51': [2986, 3272, 3545, 3656, 3680, 3837, 3902, 3911], '22-26)': [2988], 'smaller': [2992], 'sizes': [2993], 'compared': [2994, 3447], '1C).': [3000], 'change': [3006], 'this': [3007], 'profile': [3010], 'S1).': [3016], 'Because': [3017], 'amounts': [3019, 3582], 'trailed': [3024], 'fractions,': [3028], 'contribution': [3031], 'could': [3040, 3173, 3733, 3971], 'still': [3041], 'possible': [3043], 'high': [3051], 'molar': [3052, 3062, 3073], 'excess': [3053, 3074], 'over': [3054, 3077], 'components.': [3057], 'However,': [3058], 'quantification': [3059], 'ratio': [3063], 'endogenous': [3066, 3360, 3508, 3816, 4080, 4371], 'roughly': [3071], '2-3-fold': [3072], 'S2).': [3080], 'reveal': [3083], 'given': [3100, 3835], 'time,': [3101], 'considering': [3102], 'largely': [3106], 'recruited': [3107], '(see': [3112], 'below).': [3113], 'Surprisingly,': [3114, 3960], 'our': [3115], 'gave': [3117], 'no': [3118], 'indication': [3119], 'subunit': [3125, 3183], '(105': [3127], 'kDa)': [3128], 'part': [3152], '1,': [3158, 3233], 'A-C).': [3159], 'fact,': [3161], 'investigations,': [3163], 'addressing': [3164], '(data': [3170, 3924, 4118], 'shown),': [3172], 'support': [3175], 'essential,': [3179], 'generally': [3180], 'complex.As': [3187], 'expected': [3188], 'component,': [3192], '(in': [3196], 'contrast': [3197], 'ELKS,': [3199], 'Cdc37,': [3200, 3894, 3998, 4142], 'FKBP51)': [3202], 'caused': [3203], 'clearly': [3205], 'discernible': [3206], 'decrease': [3207], 'residual': [3214], 'IKKγ-containing': [3215], '1D),': [3218], 'indicating': [3219, 3356, 3976], 'structure': [3222], 'oligomeric': [3224], 'composition.': [3225], 'siRNA-mediated': [3227], 'knockdown': [3228, 4117], 'B': [3234], 'D)': [3236], 'controlled': [3238, 4218], 'blotting': [3241], '1E).': [3243], 'Taken': [3244, 4319], 'together,': [3245, 4320], 'conclude': [3247], 'stable': [3253], 'rather': [3261], 'associate': [3262], 'transiently.Cdc37': [3263], 'Preferentially': [3264], 'Recruit': [3269], 'Complex—Although': [3276], 'importance': [3278], 'seems': [3285, 3989], 'unambiguous,': [3286], 'understood': [3290], 'Previous': [3300], 'studies,': [3301, 3949], 'ectopically': [3303, 3491, 4214, 4355], 'expressed': [3304, 3492, 3938, 4122, 4215, 4285, 4356], 'deletion': [3306, 3697, 3951, 3967], 'GST': [3309], 'pull-down': [3310], 'assays,': [3311], 'Cdc37-Hsp90': [3314], 'domains': [3320], '-β': [3324], 'Indeed,': [3346], '2A).': [3364], 'disrupted': [3369, 3831], 'IKKs.': [3374, 3505, 4372], 'Residual': [3375], 'reflect': [3378], 'incomplete': [3379, 4116], 'depletion.': [3381], 'Notably,': [3382], 'loss': [3383], 'interfered': [3389, 3912], 'recruitment,': [3392], 'suggesting': [3393, 3453, 3477], 'bridges': [3397], 'Protein': [3405], 'interaction': [3406, 3932], 'expressing': [3411], 'Myc-tagged': [3416, 3945], 'Myc-IKKβ': [3419], 'confirmed': [3420], 'highly': [3422], 'preferential': [3423], '2B).': [3430], 'Remarkably,': [3431], 'mutant': [3435, 3941], '(K44A)': [3436], 'bound': [3440], 'higher': [3443], 'affinity': [3444], 'wild': [3449, 3474, 3693], 'type': [3450, 3475, 3694], '2B),': [3452], 'structural': [3455], 'alterations': [3456], 'influence': [3461], 'interaction.': [3463], 'double': [3465], 'band': [3466, 3678], 'detected': [3470, 4203], 'when': [3471], 'cotransfected': [3472], 'IKK-dependent': [3478, 3532], 'phosphorylation.': [3479], 'Further': [3480], 'examination': [3481], 'FLAG-Cdc37': [3484, 3600, 3624, 3692, 3715, 4191], 'serine': [3488], '300': [3489], 'S3,': [3495], 'A-C),': [3496], 'turn': [3498], 'confirming': [3499], 'TNFα-stimulated': [3507], 'vitro': [3516, 4255], 'S3D).': [3520], 'Future': [3521], 'will': [3523], 'important': [3525], 'clarify': [3527], 'Cdc37.FIGURE': [3535], '2Cdc37': [3536], 'connects': [3542], 'A,': [3550, 4129], 'against': [3557, 4231], 'precipitated': [3565, 3613, 3649, 3704], 'antibody,': [3569, 4246], 'co-immunoprecipitation': [3571, 3948], 'blotting.': [3580, 3627, 3661], 'Equal': [3581], 'extracts': [3585, 3663], '(Input)': [3586, 3664], 'immunoblotted': [3588, 3666], 'levels.': [3593], 'B,': [3594, 4182], 'Myc-IKK': [3603], 'indicated.': [3606], 'K/A,': [3607], 'kinase-inactive': [3608], 'mutant.': [3610], 'Lysates': [3611, 3702, 4241], 'antibody.': [3616, 3653, 3707, 4210], 'Myc-IKK,': [3621, 3712], 'Hsp90,': [3622, 3713, 3731, 3824, 3893], 'Expression': [3628, 4211], 'levels': [3629, 3670, 4049, 4095, 4212, 4271], '(Input).': [3636], 'C,': [3637, 4223], 'siRNAs,': [3645], 'Co-immunoprecipitation': [3654], 'marked': [3682], 'asterisk.': [3685], 'D,': [3686], '(WT)': [3695], 'along': [3699], 'Myc-IKKα.': [3701], 'blotting.View': [3718, 4276], 'Large': [3719, 4277], 'Image': [3720, 4278], 'Figure': [3721, 4279], 'ViewerDownload': [3722, 4280], 'Hi-res': [3723, 4281], 'image': [3724, 4282], 'Download': [3725, 4283], '(PPT)In': [3726], 'addition': [3727], 'show': [3734], 'cofactor': [3745], 'co-precipitates': [3814], '2C).': [3820], 'As': [3821], 'down-modulation': [3825, 3909, 4265], 'binding.': [3833], 'partner': [3843], 'recruitment': [3885], 'indirect': [3891], 'At': [3897], 'present,': [3898], 'unclear,': [3907], 'since': [3908, 3999], 'neither': [3914], 'TNFα-induced': [3915, 4305], 'nor': [3918], 'p65': [3922], 'translocation': [3923], 'shown).To': [3926], 'investigate': [3927], 'Hsp90-Cdc37-IKKα': [3931], 'more': [3934, 4291], 'detail,': [3935], 'all': [3950], 'defective': [3954], '2D).': [3959, 3985], '(ΔN)': [3962], '(ΔC1,': [3969], 'ΔC2)': [3970], 'efficiently': [3972], 'independent': [3978, 4180], 'sites': [3981], 'One': [3986], 'these': [3988, 4009, 4321], 'located': [3992], 'central': [3995], 'region': [3996], 'ΔC1': [4002], 'diminished.': [4006], 'sum,': [4008], 'confirm': [4011], 'adaptor': [4015], 'IKKα.Strict': [4019], 'Requirement': [4020], 'Activation': [4024], 'Ectopically': [4026], 'Expressed': [4027], 'Kinases—To': [4029], 'define': [4030], 'process,': [4042], 'directly': [4044], 'manipulated': [4045], 'cells.': [4051], 'Co-transfection': [4052], 'robustly': [4058], 'increased': [4059], 'NF-κB-dependent': [4060], '3A).': [4063], 'amplified': [4066], 'Myc-IKKα': [4071, 4193], '3B).': [4075], 'turn,': [4077], 'abolished': [4082], 'without': [4091], 'affecting': [4092], '3C).': [4097], 'Down-modulation': [4098], 'Hsp90α': [4100], 'Hsp90β': [4102], 'likewise': [4103], 'resulted': [4104], 'reduced': [4106], 'activity,': [4108], 'minor': [4112], 'extent,': [4113], 'due': [4114], 'shown).FIGURE': [4120], '3Ectopically': [4121], 'empty': [4136], '6×NF-κB-luc': [4145], 'pRLTK': [4147], 'internal': [4150], 'standard.': [4151], 'co-transfected': [4155], 'measured': [4168], 'reporter': [4172, 4311], 'assay.': [4173, 4257], 'Shown': [4174], 'representative': [4177], 'experiments.': [4181], 'vectors': [4189], 'Myc-IKKβ.': [4195], 'Myc-IKKs': [4201], 'immunoblotting': [4205], 'phosphospecific': [4208], 'respective': [4221], 'antibodies.': [4222], 'first': [4227], 'later': [4238], 'FLAG-IKKβ.': [4240], 'immunoprecipitated': [4243], 'phosphorylation,': [4261], 'expression,': [4263], '(PPT)Ectopically': [4284], 'respond': [4287], 'sensitive': [4292], 'manner': [4293], 'modulation': [4295], 'than': [4299], 'preformed': [4300], 'cells,': [4306], 'judged': [4308], '3A)': [4313], 'S4).': [4318], 'observations': [4322], 'strongly': [4323], 'suggest': [4324], 'newly': [4326], 'achieve': [4332], 'inducible': [4334], 'conformation.Cdc37': [4335], 'Is': [4336], 'Required': [4337], 'Formation': [4340], 'Functionally': [4342], 'Competent': [4343], 'Endogenous': [4344], 'Novo': [4346], 'Synthesized': [4347], 'IKKs—The': [4348], 'catalytically': [4360], 'conformation': [4362], 'alludes': [4363], 'similar': [4365], 'Hsp90-Cdc37-dependent': [4376], 'situation': [4381]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2152165944', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-12T07:02:36.813475', 'created_date': '2016-06-24'}
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