Title: Chemoselective acylation of some oxidofunctionalised organolithium compounds
Abstract: Once oxidofunctionalised organolithium compounds 1 (easily prepared by reductive ring opening of isochroman and phthalan by DTBB-catalysed lithiation) were transmetallated with ZnBr2/CuCN·2LiCl and reacted successively with a carboxylic acid anhydride and an acyl chloride in THF at 0°C, the corresponding differently acylated compounds 4 were obtained after hydrolysis with water. The anhydride performed the O-acylation exclusively and the acyl chloride carried out the C-acylation.
Publication Year: 2003
Publication Date: 2003-06-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 8
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