Publication Information

{'id': 'https://openalex.org/W2151772902', 'doi': 'https://doi.org/10.2337/diab.32.10.938', 'title': 'A Controlled Trial of Sorbinil, an Aldose Reductase Inhibitor, in Chronic Painful Diabetic Neuropathy', 'display_name': 'A Controlled Trial of Sorbinil, an Aldose Reductase Inhibitor, in Chronic Painful Diabetic Neuropathy', 'publication_year': 1983, 'publication_date': '1983-10-01', 'ids': {'openalex': 'https://openalex.org/W2151772902', 'doi': 'https://doi.org/10.2337/diab.32.10.938', 'mag': '2151772902', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6225686'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2337/diab.32.10.938', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S129060628', 'display_name': 'Diabetes', 'issn_l': '0012-1797', 'issn': ['0012-1797', '1939-327X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320274', 'host_organization_name': 'American Diabetes Association', 'host_organization_lineage': ['https://openalex.org/P4310320274'], 'host_organization_lineage_names': ['American Diabetes Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012613674', 'display_name': 'Robert J. Young', 'orcid': 'https://orcid.org/0000-0001-7003-3017'}, 'institutions': [{'id': 'https://openalex.org/I2802789809', 'display_name': 'Edinburgh Royal Infirmary', 'ror': 'https://ror.org/009bsy196', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802789809']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Robert J Young', 'raw_affiliation_strings': ['Diabetic and Dietetic Department and University Department of Medicine, The Royal Infirmary, Edinburgh\u2008EH3 9YW, Scotland'], 'affiliations': [{'raw_affiliation_string': 'Diabetic and Dietetic Department and University Department of Medicine, The Royal Infirmary, Edinburgh\u2008EH3 9YW, Scotland', 'institution_ids': ['https://openalex.org/I2802789809']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109932918', 'display_name': 'D J Ewing', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802789809', 'display_name': 'Edinburgh Royal Infirmary', 'ror': 'https://ror.org/009bsy196', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802789809']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David J Ewing', 'raw_affiliation_strings': ['Diabetic and Dietetic Department and University Department of Medicine, The Royal Infirmary, Edinburgh\u2008EH3 9YW, Scotland'], 'affiliations': [{'raw_affiliation_string': 'Diabetic and Dietetic Department and University Department of Medicine, The Royal Infirmary, Edinburgh\u2008EH3 9YW, Scotland', 'institution_ids': ['https://openalex.org/I2802789809']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103515999', 'display_name': 'B F Clarke', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802789809', 'display_name': 'Edinburgh Royal Infirmary', 'ror': 'https://ror.org/009bsy196', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802789809']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Basil F Clarke', 'raw_affiliation_strings': ['Diabetic and Dietetic Department and University Department of Medicine, The Royal Infirmary, Edinburgh\u2008EH3 9YW, Scotland'], 'affiliations': [{'raw_affiliation_string': 'Diabetic and Dietetic Department and University Department of Medicine, The Royal Infirmary, Edinburgh\u2008EH3 9YW, Scotland', 'institution_ids': ['https://openalex.org/I2802789809']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 12.072, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 174, 'citation_normalized_percentile': {'value': 0.978823, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '32', 'issue': '10', 'first_page': '938', 'last_page': '942'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10196', 'display_name': 'Pain Mechanisms and Treatments', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10196', 'display_name': 'Pain Mechanisms and Treatments', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12533', 'display_name': 'Aldose Reductase and Taurine', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11199', 'display_name': 'Pain Management and Opioid Use', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2703', 'display_name': 'Anesthesiology and Pain Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sorbinil', 'display_name': 'Sorbinil', 'score': 0.97845066}, {'id': 'https://openalex.org/keywords/diabetic-neuropathy', 'display_name': 'Diabetic Neuropathy', 'score': 0.65262246}, {'id': 'https://openalex.org/keywords/sural-nerve', 'display_name': 'Sural nerve', 'score': 0.45713034}, {'id': 'https://openalex.org/keywords/crossover-study', 'display_name': 'Crossover study', 'score': 0.45417473}, {'id': 'https://openalex.org/keywords/sensory-nerve', 'display_name': 'Sensory nerve', 'score': 0.45220658}], 'concepts': [{'id': 'https://openalex.org/C2776614240', 'wikidata': 'https://www.wikidata.org/wiki/Q1259458', 'display_name': 'Sorbinil', 'level': 5, 'score': 0.97845066}, {'id': 'https://openalex.org/C2777374081', 'wikidata': 'https://www.wikidata.org/wiki/Q4713968', 'display_name': 'Aldose reductase inhibitor', 'level': 4, 'score': 0.884168}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7791335}, {'id': 'https://openalex.org/C2779178840', 'wikidata': 'https://www.wikidata.org/wiki/Q2046550', 'display_name': 'Diabetic neuropathy', 'level': 3, 'score': 0.65262246}, {'id': 'https://openalex.org/C2776439734', 'wikidata': 'https://www.wikidata.org/wiki/Q414213', 'display_name': 'Aldose reductase', 'level': 3, 'score': 0.51732916}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.51015526}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.46609062}, {'id': 'https://openalex.org/C2780923182', 'wikidata': 'https://www.wikidata.org/wiki/Q6135922', 'display_name': 'Sural nerve', 'level': 2, 'score': 0.45713034}, {'id': 'https://openalex.org/C87813604', 'wikidata': 'https://www.wikidata.org/wiki/Q1242899', 'display_name': 'Crossover study', 'level': 4, 'score': 0.45417473}, {'id': 'https://openalex.org/C2775907655', 'wikidata': 'https://www.wikidata.org/wiki/Q2635510', 'display_name': 'Sensory nerve', 'level': 3, 'score': 0.45220658}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.44674835}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.3875355}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.32218853}, {'id': 'https://openalex.org/C94487597', 'wikidata': 'https://www.wikidata.org/wiki/Q11101', 'display_name': 'Sensory system', 'level': 2, 'score': 0.26938474}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.18415734}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.07108885}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C180747234', 'wikidata': 'https://www.wikidata.org/wiki/Q23373', 'display_name': 'Cognitive psychology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003929', 'descriptor_name': 'Diabetic Neuropathies', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D048289', 'descriptor_name': 'Imidazolidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002908', 'descriptor_name': 'Chronic Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003929', 'descriptor_name': 'Diabetic Neuropathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003875', 'descriptor_name': 'Drug Eruptions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003875', 'descriptor_name': 'Drug Eruptions', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D004890', 'descriptor_name': 'Erythema', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004890', 'descriptor_name': 'Erythema', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D007970', 'descriptor_name': 'Leukopenia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007970', 'descriptor_name': 'Leukopenia', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D008206', 'descriptor_name': 'Lymphatic Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008206', 'descriptor_name': 'Lymphatic Diseases', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2337/diab.32.10.938', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S129060628', 'display_name': 'Diabetes', 'issn_l': '0012-1797', 'issn': ['0012-1797', '1939-327X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320274', 'host_organization_name': 'American Diabetes Association', 'host_organization_lineage': ['https://openalex.org/P4310320274'], 'host_organization_lineage_names': ['American Diabetes Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6225686', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.86, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4234378420', 'https://openalex.org/W2462649681', 'https://openalex.org/W2313945403', 'https://openalex.org/W2161003385', 'https://openalex.org/W2151772902', 'https://openalex.org/W2069723150', 'https://openalex.org/W2059474142', 'https://openalex.org/W2051804183', 'https://openalex.org/W2033373388', 'https://openalex.org/W1990607360'], 'abstract_inverted_index': {'A': [0], 'double-blind,': [1], 'randomized,': [2], 'placebo-controlled': [3], 'cross-over': [4], 'trial': [5], 'of': [6, 46, 71], 'the': [7, 51, 87], 'aldose': [8, 93, 100], 'reductase': [9, 94, 101], 'inhibitor': [10, 95, 102], 'sorbinil': [11, 67, 105], 'was': [12, 26], 'undertaken': [13], 'in': [14, 114], '15': [15], 'patients': [16, 77], '(age': [17], '35-68': [18], 'yr)': [19], 'with': [20, 97, 104], 'chronic': [21], 'painful': [22], 'diabetic': [23, 112], 'neuropathy.': [24], 'Treatment': [25], 'evaluated': [27], 'by': [28], 'subjective': [29], 'pain': [30], 'responses,': [31], 'clinical': [32, 72], 'examination,': [33], 'vibration': [34], 'perception': [35], 'threshold,': [36], 'motor': [37], 'and': [38, 42, 59], 'sensory': [39, 61, 73], 'nerve': [40, 48], 'electrophysiology,': [41], 'cardiovascular': [43], 'reflex': [44, 57], 'tests': [45], 'autonomic': [47], 'function.': [49], 'Among': [50], 'many': [52], 'measurements,': [53], 'only': [54], 'pain,': [55], 'tendon': [56], 'scores,': [58], 'sural': [60], 'potential': [62], 'amplitude': [63], 'improved': [64], 'significantly': [65], 'during': [66], 'administration,': [68], 'while': [69], 'scores': [70], 'examination': [74], 'deteriorated.': [75], 'Four': [76], 'experienced': [78], 'an': [79, 108], 'idiosyncratic': [80], 'reaction': [81], 'that': [82, 92, 99], 'rapidly': [83], 'recovered': [84], 'on': [85, 110], 'discontinuing': [86], 'drug.': [88], 'This': [89], 'study': [90], 'suggests': [91, 98], 'treatment': [96, 103], 'may': [106], 'have': [107], 'effect': [109], 'symptomatic': [111], 'neuropathy': [113], 'man.': [115]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2151772902', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 6}], 'updated_date': '2025-01-08T01:51:14.265187', 'created_date': '2016-06-24'}