Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2151475042', 'doi': 'https://doi.org/10.1159/000083980', 'title': 'Multi-Glycoside of <i>Tripterygium wilfordii</i> Hook f. Ameliorates Proteinuria and Acute Mesangial Injury Induced by Anti-Thy1.1 Monoclonal Antibody', 'display_name': 'Multi-Glycoside of <i>Tripterygium wilfordii</i> Hook f. Ameliorates Proteinuria and Acute Mesangial Injury Induced by Anti-Thy1.1 Monoclonal Antibody', 'publication_year': 2005, 'publication_date': '2005-02-22', 'ids': {'openalex': 'https://openalex.org/W2151475042', 'doi': 'https://doi.org/10.1159/000083980', 'mag': '2151475042', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15722645'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1159/000083980', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S143355720', 'display_name': 'Nephron Experimental Nephrology', 'issn_l': '1660-2129', 'issn': ['1660-2129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317820', 'host_organization_name': 'Karger Publishers', 'host_organization_lineage': ['https://openalex.org/P4310317820'], 'host_organization_lineage_names': ['Karger Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087481751', 'display_name': 'Yi‐Gang Wan', 'orcid': 'https://orcid.org/0000-0002-5278-2695'}, 'institutions': [{'id': 'https://openalex.org/I4210111013', 'display_name': 'Nanjing Drum Tower Hospital', 'ror': 'https://ror.org/026axqv54', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111013']}, {'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['CN', 'JP'], 'is_corresponding': False, 'raw_author_name': 'Yigang Wan', 'raw_affiliation_strings': ['Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan', 'Department of Traditional Chinese Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, and'], 'affiliations': [{'raw_affiliation_string': 'Department of Traditional Chinese Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, and', 'institution_ids': ['https://openalex.org/I4210111013']}, {'raw_affiliation_string': 'Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071912533', 'display_name': 'Liya Gu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I881766915', 'display_name': 'Nanjing University', 'ror': 'https://ror.org/01rxvg760', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I881766915']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liubao Gu', 'raw_affiliation_strings': ['Department of Graduate School, Nanjing University of Traditional Chinese Medicine, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Graduate School, Nanjing University of Traditional Chinese Medicine, Nanjing, China', 'institution_ids': ['https://openalex.org/I881766915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077483738', 'display_name': 'Koichi Suzuki', 'orcid': 'https://orcid.org/0000-0001-8659-4660'}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Koichi Suzuki', 'raw_affiliation_strings': ['Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033004877', 'display_name': 'Tamaki Karasawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tamaki Karasawa', 'raw_affiliation_strings': ['Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032007444', 'display_name': 'Yumiko Fujioka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yumiko Fujioka', 'raw_affiliation_strings': ['Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013046172', 'display_name': 'Gi Dong Han', 'orcid': 'https://orcid.org/0000-0002-8209-931X'}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Gi Dong Han', 'raw_affiliation_strings': ['Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106733417', 'display_name': 'Hiroko Koike', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroko Koike', 'raw_affiliation_strings': ['Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057301328', 'display_name': 'Hiroshi Kawachi', 'orcid': 'https://orcid.org/0000-0002-8270-791X'}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Kawachi', 'raw_affiliation_strings': ['Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102222262', 'display_name': 'Fujio Shimizu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fujio Shimizu', 'raw_affiliation_strings': ['Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.87, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.923317, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '99', 'issue': '4', 'first_page': 'e121', 'last_page': 'e129'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13026', 'display_name': 'Therapeutic Potential of Herbal Medicines', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13026', 'display_name': 'Therapeutic Potential of Herbal Medicines', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12429', 'display_name': 'Mechanisms and Renoprotective Strategies for Cisplatin Nephrotoxicity', 'score': 0.9512, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tripterygium-wilfordii', 'display_name': 'Tripterygium wilfordii', 'score': 0.9314938}, {'id': 'https://openalex.org/keywords/tripterygium', 'display_name': 'Tripterygium', 'score': 0.6169994}, {'id': 'https://openalex.org/keywords/mesangial-proliferative-glomerulonephritis', 'display_name': 'Mesangial proliferative glomerulonephritis', 'score': 0.57653683}, {'id': 'https://openalex.org/keywords/triptolide', 'display_name': 'Triptolide', 'score': 0.47925}], 'concepts': [{'id': 'https://openalex.org/C2780695664', 'wikidata': 'https://www.wikidata.org/wiki/Q1424919', 'display_name': 'Tripterygium wilfordii', 'level': 3, 'score': 0.9314938}, {'id': 'https://openalex.org/C2779561371', 'wikidata': 'https://www.wikidata.org/wiki/Q570197', 'display_name': 'Proteinuria', 'level': 3, 'score': 0.73674554}, {'id': 'https://openalex.org/C2781079059', 'wikidata': 'https://www.wikidata.org/wiki/Q5226910', 'display_name': 'Tripterygium', 'level': 3, 'score': 0.6169994}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5914695}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.58884203}, {'id': 'https://openalex.org/C2780688133', 'wikidata': 'https://www.wikidata.org/wiki/Q3772406', 'display_name': 'Mesangial proliferative glomerulonephritis', 'level': 4, 'score': 0.57653683}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5028}, {'id': 'https://openalex.org/C2780368995', 'wikidata': 'https://www.wikidata.org/wiki/Q605006', 'display_name': 'Glomerulonephritis', 'level': 3, 'score': 0.47045246}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.37134498}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.30828643}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.24757114}, {'id': 'https://openalex.org/C194671627', 'wikidata': 'https://www.wikidata.org/wiki/Q192639', 'display_name': 'Glycoside', 'level': 2, 'score': 0.15645647}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.107495636}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D005920', 'descriptor_name': 'Glomerular Mesangium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015432', 'descriptor_name': 'Glomerulonephritis, Membranoproliferative', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D006027', 'descriptor_name': 'Glycosides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011507', 'descriptor_name': 'Proteinuria', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D011507', 'descriptor_name': 'Proteinuria', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018800', 'descriptor_name': 'Thy-1 Antigens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000208', 'descriptor_name': 'Acute Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077214', 'descriptor_name': 'Becaplermin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018932', 'descriptor_name': 'Chemokine CCL2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018932', 'descriptor_name': 'Chemokine CCL2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005920', 'descriptor_name': 'Glomerular Mesangium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005920', 'descriptor_name': 'Glomerular Mesangium', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005920', 'descriptor_name': 'Glomerular Mesangium', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015432', 'descriptor_name': 'Glomerulonephritis, Membranoproliferative', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015432', 'descriptor_name': 'Glomerulonephritis, Membranoproliferative', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015432', 'descriptor_name': 'Glomerulonephritis, Membranoproliferative', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006027', 'descriptor_name': 'Glycosides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010982', 'descriptor_name': 'Platelet-Derived Growth Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010982', 'descriptor_name': 'Platelet-Derived Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011507', 'descriptor_name': 'Proteinuria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020574', 'descriptor_name': 'Proto-Oncogene Proteins c-sis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018800', 'descriptor_name': 'Thy-1 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1159/000083980', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S143355720', 'display_name': 'Nephron Experimental Nephrology', 'issn_l': '1660-2129', 'issn': ['1660-2129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317820', 'host_organization_name': 'Karger Publishers', 'host_organization_lineage': ['https://openalex.org/P4310317820'], 'host_organization_lineage_names': ['Karger Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15722645', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.77, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W177301814', 'https://openalex.org/W1969348313', 'https://openalex.org/W1972674756', 'https://openalex.org/W1984650546', 'https://openalex.org/W1994342907', 'https://openalex.org/W2009185981', 'https://openalex.org/W2013161860', 'https://openalex.org/W2014323100', 'https://openalex.org/W2019621141', 'https://openalex.org/W2029489668', 'https://openalex.org/W2032130427', 'https://openalex.org/W2033465719', 'https://openalex.org/W2038329844', 'https://openalex.org/W2040513423', 'https://openalex.org/W2043212350', 'https://openalex.org/W2052765919', 'https://openalex.org/W2053097440', 'https://openalex.org/W2072099230', 'https://openalex.org/W2076321944', 'https://openalex.org/W2078772718', 'https://openalex.org/W2085295620', 'https://openalex.org/W2085382182', 'https://openalex.org/W2091614482', 'https://openalex.org/W2115102903', 'https://openalex.org/W2117811540', 'https://openalex.org/W2122954841', 'https://openalex.org/W2136625782', 'https://openalex.org/W2148802230', 'https://openalex.org/W2152063538', 'https://openalex.org/W2396515077', 'https://openalex.org/W2401078146', 'https://openalex.org/W2410531896'], 'related_works': ['https://openalex.org/W3140661854', 'https://openalex.org/W2752417151', 'https://openalex.org/W2391090572', 'https://openalex.org/W2388158478', 'https://openalex.org/W2371272686', 'https://openalex.org/W2368389542', 'https://openalex.org/W2366583396', 'https://openalex.org/W2350082124', 'https://openalex.org/W2035101957', 'https://openalex.org/W1994342907'], 'abstract_inverted_index': {'Multi-glycoside': [0], 'from': [1, 128], 'Tripterygium': [2], 'wilfordii': [3], 'Hook': [4], 'f.': [5], '(GTW)': [6], 'is': [7, 46], 'used': [8], 'for': [9, 262], 'various': [10, 93], 'immune': [11], 'and': [12, 65, 70, 76, 121, 152, 155, 185, 195, 202, 216, 227, 247, 265], 'inflammatory': [13, 294], 'diseases': [14, 17], 'including': [15], 'renal': [16], 'represented': [18], 'by': [19, 88, 104, 234, 280], 'mesangial': [20, 63, 210, 228, 245, 273], 'proliferative': [21], 'glomerulonephritis': [22, 73], '(MsPGN)': [23], 'in': [24, 67, 96, 102, 140, 160, 167, 187, 197, 250, 275, 296], 'China.': [25], 'However,': [26], 'there': [27], 'have': [28], 'been': [29], 'no': [30], 'fundamental': [31], 'studies': [32], 'on': [33, 39, 57, 92, 157, 164, 178, 191, 292], 'the': [34, 50, 53, 80, 136, 257], 'operating': [35], 'mechanism': [36, 82], 'of': [37, 43, 55, 83, 112, 119, 133, 138, 172, 220, 260, 283], 'GTW': [38, 56, 84, 120, 235, 240, 288], 'MsPGN.': [40], 'The': [41], 'aim': [42], 'this': [44, 97], 'study': [45], 'to': [47, 78, 135], 'examine': [48], 'as': [49, 62, 123], 'first': [51], 'step': [52], 'effects': [54, 91, 291], 'acute': [58, 69, 293], 'injurious': [59, 94, 284], 'process': [60], 'such': [61], 'injury': [64], 'proteinuria': [66, 226, 270], 'an': [68], 'reversible': [71], 'Thy.1.1': [72], '(Thy1.1GN)': [74], 'model': [75], 'then': [77], 'clarify': [79], 'action': [81], 'at': [85, 205], 'molecular': [86], 'level': [87], 'examining': [89], 'its': [90], 'factors': [95], 'model.Thy1.1': [98], 'GN': [99, 277], 'was': [100, 126, 176], 'induced': [101], 'rats': [103, 144], 'a': [105, 124], 'single': [106], 'intravenous': [107], 'injection': [108, 132], 'with': [109], '500': [110], 'microg': [111], 'anti-Thy1.1': [113], 'mAb': [114, 134], '1-22-3.': [115], 'Daily': [116], 'oral': [117], 'administration': [118], 'vehicle': [122], 'control': [125], 'started': [127], '3': [129], 'days': [130, 179], 'before': [131], 'day': [137, 158, 165], 'sacrifice': [139], 'each': [141], 'experiment.': [142], 'Fourteen': [143], 'were': [145, 222, 231], 'randomly': [146], 'divided': [147], 'into': [148], '2': [149, 169], 'groups,': [150, 154], 'GTW-treated': [151], 'vehicle-treated': [153], 'sacrificed': [156], '14': [159, 186], 'experiment': [161, 168, 188, 198, 224, 238], '1': [162, 189], 'or': [163, 190], '7': [166, 196], 'after': [170], 'induction': [171], 'Thy1.1': [173, 276], 'GN.': [174], 'Proteinuria': [175], 'determined': [177], '1,': [180, 192, 225], '3,': [181, 193], '5,': [182], '7,': [183], '10': [184], '5': [194], '2.': [199], 'From': [200], 'blood': [201, 207], 'kidneys': [203], 'taken': [204], 'sacrifice,': [206], 'biochemical': [208], 'parameters,': [209], 'morphological': [211], 'changes,': [212], 'glomerular': [213, 217, 258], 'macrophage': [214, 248], 'infiltration,': [215], 'mRNA': [218, 261], 'expression': [219, 259, 282], 'cytokines': [221], 'examined.In': [223], 'matrix': [229], 'expansion': [230], 'significantly': [232, 242, 255], 'attenuated': [233], 'treatment.': [236], 'In': [237, 252], '2,': [239], 'treatment': [241], 'ameliorated': [243, 267], 'proteinuria,': [244], 'lesions': [246], 'accumulation': [249], 'glomerulus.': [251], 'addition,': [253], 'it': [254], 'reduced': [256], 'PDGF,': [263], 'MCP-1': [264], 'IL-2.GTW': [266], 'not': [268], 'only': [269], 'but': [271], 'also': [272], 'alterations': [274], 'most': [278], 'likely': [279], 'reducing': [281], 'cytokines,': [285], 'indicating': [286], 'that': [287], 'has': [289], 'suppressive': [290], 'changes': [295], 'glomeruli.': [297]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2151475042', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-08-27T22:33:34.227714', 'created_date': '2016-06-24'}