Title: Congenital diaphragmatic hernia and pulmonary hypoplasia: New insights from developmental biology and genetics
Abstract: American Journal of Medical Genetics Part C: Seminars in Medical GeneticsVolume 145C, Issue 2 p. 105-108 Introduction Congenital diaphragmatic hernia and pulmonary hypoplasia: New insights from developmental biology and genetics† Kate G. Ackerman, Kate G. Ackerman Kate G. Ackerman, M.D. is an Assistant Professor of Pediatrics at Harvard Medical School and a member of the Division of Genetics at Brigham and Women's Hospital and the Division of Emergency Medicine, Department of Medicine at Children's Hospital Boston. Dr. Ackerman is a pediatric intensivist with post-doctoral research training in mouse genetics. Dr. Ackerman's research focuses on understanding the pathophysiology of diaphragmatic defects and pulmonary hypoplasia in humans by investigating mechanisms of development in mouse models.Search for more papers by this authorBarbara R. Pober, Corresponding Author Barbara R. Pober [email protected] [email protected] Center for Human Genetics, Simches Research Building, Room 222, 185 Cambridge Street, Boston, MA 02114. Barbara R. Pober, M.D. is an Associate Professor of Pediatrics at Harvard Medical School, a member of the Department of Surgery and Division of Genetics, Children's Hospital of Boston, and a member of the Department of Pediatrics at the MassGeneral Hospital for Children in Boston, Massachusetts. Dr. Pober's interests include the genetic delineation of congenital diaphragmatic hernia, as well as a longstanding interest in Williams syndrome.Center for Human Genetics, Simches Research Building, Room 222, 185 Cambridge Street, Boston, MA 02114.Search for more papers by this author Kate G. Ackerman, Kate G. Ackerman Kate G. Ackerman, M.D. is an Assistant Professor of Pediatrics at Harvard Medical School and a member of the Division of Genetics at Brigham and Women's Hospital and the Division of Emergency Medicine, Department of Medicine at Children's Hospital Boston. Dr. Ackerman is a pediatric intensivist with post-doctoral research training in mouse genetics. Dr. Ackerman's research focuses on understanding the pathophysiology of diaphragmatic defects and pulmonary hypoplasia in humans by investigating mechanisms of development in mouse models.Search for more papers by this authorBarbara R. Pober, Corresponding Author Barbara R. Pober [email protected] [email protected] Center for Human Genetics, Simches Research Building, Room 222, 185 Cambridge Street, Boston, MA 02114. Barbara R. Pober, M.D. is an Associate Professor of Pediatrics at Harvard Medical School, a member of the Department of Surgery and Division of Genetics, Children's Hospital of Boston, and a member of the Department of Pediatrics at the MassGeneral Hospital for Children in Boston, Massachusetts. Dr. Pober's interests include the genetic delineation of congenital diaphragmatic hernia, as well as a longstanding interest in Williams syndrome.Center for Human Genetics, Simches Research Building, Room 222, 185 Cambridge Street, Boston, MA 02114.Search for more papers by this author First published: 13 April 2007 https://doi.org/10.1002/ajmg.c.30133Citations: 53 † How to cite this article: Ackerman KG, Pober BR. 2007. Congenital diaphragmatic hernia and pulmonary hypoplasia: New insights from developmental biology and genetics. Am J Med Genet Part C Semin Med Genet 145C:105–108. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Ackerman KG, Herron BJ, Vargas SO, Huang H, Tevosian SG, Kochilas L, Rao C, Pober BR, Babiuk RP, Epstein JA, Greer JJ, Beier DR. 2005. Fog2 is required for normal diaphragm and lung development in mice and humans. PLoS Genet 1: 58–65. Ackerman KG, Wang J, Luo L, Fujiwara Y, Orkin SH, Beier DR. 2006. Gata4 is necessary for normal pulmonary lobar development. Am J Respir Cell Mol Biol (in press). Andersen DH. 1941. 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