Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90

Name: Work Video:
Duration: 3 min 30 s
Purva Bali; Michael Pranpat; James E. Bradner; Maria E. Balasis; Warren Fiskus; Fei Guo; Kathy Rocha; Sandhya Kumaraswamy; Sandhya Boyapalle; Peter Atadja; Edward Seto; Kapil N. Bhalla
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'https://openalex.org/W2121296685', 'https://openalex.org/W2129890171', 'https://openalex.org/W2132664329', 'https://openalex.org/W2137819605', 'https://openalex.org/W2139306838', 'https://openalex.org/W2140204965', 'https://openalex.org/W2144249142', 'https://openalex.org/W2144332765', 'https://openalex.org/W2146620343', 'https://openalex.org/W2148495272', 'https://openalex.org/W2155045727', 'https://openalex.org/W2157228274', 'https://openalex.org/W2161839272', 'https://openalex.org/W2164065816', 'https://openalex.org/W2175029576'], 'related_works': ['https://openalex.org/W4247607014', 'https://openalex.org/W4244753947', 'https://openalex.org/W4237131491', 'https://openalex.org/W4206101952', 'https://openalex.org/W3163537515', 'https://openalex.org/W3141339723', 'https://openalex.org/W2166899684', 'https://openalex.org/W2071113403', 'https://openalex.org/W2037139350', 'https://openalex.org/W1601558529'], 'abstract_inverted_index': {'The': [0, 225, 1707, 2083, 2313, 2500, 2612, 2798, 2968, 3269, 3967, 4005, 4220], 'hydroxamic': [1, 226, 476, 520, 1316], 'acid': [2, 227, 1317], '(HAA)': [3, 228, 1319], 'analogue': [4, 229, 912, 1318, 3490], 'pan-histone': [5, 230], 'deacetylase': [6, 71, 231, 296, 1715, 3425], '(HDAC)': [7, 232], 'inhibitors': [8, 233, 1321], '(HDIs)': [9, 234, 1322], 'LAQ824': [10, 235, 1323, 1948, 3315, 3335, 3444, 3545, 3581, 3697, 3725, 3755, 3766, 3781, 3891, 3923, 3952, 3986, 4031, 4082, 4111, 4287, 4324, 4371, 4437], 'and': [11, 19, 24, 37, 42, 50, 104, 117, 143, 146, 162, 164, 171, 193, 202, 206, 222, 236, 244, 249, 262, 267, 275, 329, 342, 368, 371, 387, 389, 396, 418, 427, 431, 447, 557, 576, 583, 701, 815, 908, 923, 1019, 1024, 1060, 1070, 1153, 1161, 1210, 1266, 1268, 1324, 1343, 1456, 1461, 1592, 1642, 1654, 1911, 1929, 1947, 1969, 1985, 2000, 2010, 2012, 2015, 2047, 2071, 2153, 2165, 2191, 2194, 2300, 2325, 2354, 2360, 2384, 2486, 2631, 2710, 2755, 2758, 2792, 2808, 2897, 2941, 2987, 2998, 3007, 3086, 3102, 3172, 3316, 3327, 3459, 3470, 3556, 3633, 3756, 3785, 3854, 3876, 3962, 4028, 4045, 4162, 4164, 4182, 4188, 4225, 4299, 4334, 4348, 4358, 4387], 'LBH589': [12, 237, 1325, 1946, 3317, 3376, 3446, 3605, 4084, 4373], 'have': [13, 238, 452, 1259, 3611], 'been': [14, 239, 1260, 1329, 1348, 1836, 3575], 'shown': [15, 240, 1330, 3612, 4067], 'to': [16, 76, 129, 189, 220, 241, 301, 354, 414, 445, 771, 809, 915, 996, 1022, 1141, 1331, 1350, 1574, 1838, 2149, 2172, 2328, 2819, 3235, 3334, 3375, 3399, 3418, 3482, 3508, 3544, 3561, 3572, 3590, 3624, 3871, 4141, 4346, 4390], 'induce': [17, 242, 1332, 1351, 3412], 'acetylation': [18, 114, 159, 190, 243, 339, 384, 415, 1069, 1157, 1192, 1333, 1352, 1591, 1907, 3321, 3383, 3414, 3472, 4025, 4044, 4159, 4311, 4355], 'inhibit': [20, 245, 3400], 'the': [21, 35, 40, 61, 81, 90, 105, 113, 125, 132, 152, 246, 260, 265, 286, 306, 315, 330, 338, 350, 357, 377, 549, 554, 567, 772, 781, 793, 805, 819, 916, 921, 925, 1005, 1015, 1068, 1074, 1078, 1142, 1146, 1149, 1156, 1169, 1191, 1314, 1571, 1577, 1594, 1607, 1655, 1721, 1840, 1848, 1852, 1898, 1906, 1919, 2150, 2157, 2169, 2175, 2303, 2367, 2505, 2621, 2713, 2756, 2805, 2813, 2900, 2995, 3096, 3103, 3188, 3236, 3241, 3312, 3368, 3401, 3423, 3454, 3460, 3488, 3493, 3504, 3525, 3531, 3553, 3557, 3583, 3596, 3614, 3617, 3621, 3625, 3636, 3640, 3646, 3652, 3702, 3712, 3727, 3732, 3768, 3848, 3851, 3864, 3887, 3901, 3919, 3935, 3955, 3973, 3982, 3991, 4011, 4024, 4033, 4048, 4095, 4123, 4132, 4149, 4152, 4183, 4189, 4203, 4235, 4243, 4252, 4265, 4271, 4321, 4366, 4393, 4422, 4430, 4444], 'ATP': [22, 247, 699, 994, 3494], 'binding': [23, 126, 248, 351, 700, 770, 918, 995, 1168, 1209, 3479, 3495, 3505, 3558], 'chaperone': [25, 133, 197, 250, 358, 422, 550, 926, 1595, 1920, 3537, 3584, 3597, 3618, 3865, 4049], 'function': [26, 251, 927, 1596, 1921, 3532, 4050], 'of': [27, 39, 60, 80, 107, 115, 120, 127, 135, 149, 155, 160, 168, 186, 191, 195, 204, 214, 252, 264, 285, 305, 332, 340, 345, 352, 360, 374, 380, 385, 393, 411, 416, 420, 429, 439, 559, 562, 783, 801, 928, 1073, 1077, 1144, 1151, 1159, 1194, 1198, 1201, 1257, 1334, 1337, 1353, 1458, 1576, 1597, 1606, 1611, 1711, 1851, 1886, 1909, 1916, 1922, 1937, 1942, 2059, 2156, 2168, 2174, 2182, 2309, 2315, 2323, 2377, 2493, 2502, 2601, 2603, 2614, 2635, 2706, 2895, 2992, 3070, 3074, 3084, 3089, 3174, 3278, 3299, 3305, 3314, 3332, 3340, 3356, 3370, 3403, 3428, 3440, 3462, 3473, 3480, 3492, 3497, 3506, 3527, 3533, 3541, 3559, 3586, 3620, 3635, 3721, 3729, 3742, 3770, 3850, 3867, 3879, 3890, 3898, 3922, 3932, 3948, 3969, 3985, 4007, 4023, 4026, 4037, 4047, 4051, 4097, 4125, 4134, 4151, 4155, 4160, 4167, 4175, 4186, 4191, 4230, 4246, 4273, 4278, 4305, 4323, 4332, 4351, 4356, 4369], 'heat': [28, 253, 455, 464, 508], 'shock': [29, 254, 456, 465, 509], 'protein': [30, 255, 457, 551, 564, 1854, 2369, 2379, 2496, 2787], '(HSP)': [31, 256, 458], '90.': [32, 257], 'This': [33, 258, 1449, 3101, 3221], 'promotes': [34, 259], 'polyubiquitylation': [36, 145, 201, 261, 370, 426, 1023, 3632, 3728, 3741, 3875], 'degradation': [38, 263, 817, 1026, 3650, 3878], 'pro-growth': [41, 205, 266, 430], 'pro-survival': [43, 207, 268, 432], 'client': [44, 139, 209, 269, 364, 434, 794, 807, 1017, 3622, 3637, 3647], 'proteins': [45, 210, 270, 435, 795, 808, 1018, 1653, 1843, 2193, 2363, 2809, 2993, 3623, 3638, 3648, 3730, 3743], 'Bcr-Abl,': [46, 142, 169, 271, 367, 394, 572, 1459, 2183], 'mutant': [47, 272, 571, 573, 1469], 'FLT-3,': [48, 273, 574], 'c-Raf,': [49, 274, 577, 4001], 'AKT': [51, 276, 3786], 'in': [52, 89, 200, 277, 314, 425, 578, 780, 1463, 1471, 1637, 1894, 1924, 2056, 2073, 2075, 2335, 2504, 2628, 2719, 2804, 3240, 3322, 3358, 3435, 3502, 3595, 3616, 3639, 3701, 3731, 3772, 3856, 3874, 4068, 4071, 4122, 4169, 4179, 4195, 4212, 4217, 4242, 4251, 4257, 4270, 4282, 4297, 4312, 4325, 4339], 'human': [53, 94, 217, 278, 319, 442, 1925, 3323], 'leukemia': [54, 95, 218, 279, 320, 443, 1926, 2045, 2049, 3324], 'cells.': [55, 280, 3329, 4171, 4219, 4301], 'HDAC6': [56, 98, 108, 121, 156, 178, 187, 215, 281, 323, 333, 346, 381, 403, 412, 440, 1599, 1634, 1712, 1833, 1887, 1890, 1904, 1917, 2016, 3075, 3175, 3195, 3242, 3263, 3279, 4038, 4061, 4074, 4098, 4156, 4176, 4192, 4213, 4231, 4293, 4306, 4352, 4419], 'is': [57, 66, 73, 179, 282, 291, 298, 404, 694, 1450, 1579, 1600, 1635, 1718, 4062], 'a': [58, 283, 560, 786, 810, 1199, 1602, 1643, 2052, 2088, 2320, 2514, 2629, 3113, 3223, 3249, 3359, 3378, 3432, 3536, 3857, 4119, 4209, 4227, 4328], 'member': [59, 284, 1605], 'class': [62, 287, 1608, 3404], 'IIB': [63, 288, 1609], 'HDACs.': [64, 289], 'It': [65, 290], 'predominantly': [67, 292, 1601], 'cytosolic,': [68, 293], 'microtubule-associated': [69, 294, 1604], 'α-tubulin': [70, 163, 295, 388, 489, 533, 1714, 1999, 3424, 3853, 4027, 4161, 4275, 4357], 'that': [72, 88, 177, 297, 313, 402, 454, 789, 803, 1008, 1066, 1585, 1648, 1889, 2623, 3348, 3613, 4035, 4099], 'also': [74, 123, 180, 299, 348, 405, 1189, 1346, 1835, 3500, 3600, 3745, 3778, 4307], 'known': [75, 300, 3397], 'promote': [77, 302], 'aggresome': [78, 303], 'inclusion': [79, 304], 'misfolded': [82, 307, 806, 1016, 1652, 1842, 1853], 'polyubiquitylated': [83, 308, 1651, 1841], 'proteins.': [84, 309], 'Here': [85, 310], 'we': [86, 311, 1901, 3523, 4057], 'demonstrate': [87, 312], 'Bcr-abl': [91, 316], 'oncogene': [92, 317], 'expressing': [93, 318], 'K562': [96, 321, 2040, 3110, 3441, 3542, 3722, 3773, 3882, 3914, 3949, 3977, 4072, 4170, 4180, 4207, 4361, 4409], 'cells,': [97, 322, 4181, 4208, 4327], 'can': [99, 324], 'be': [100, 325, 1892, 4040, 4076, 4101, 4233], 'co-immunoprecipitated': [101, 326, 4063, 4077, 4102], 'with': [102, 137, 327, 362, 785, 797, 813, 999, 1313, 1452, 2388, 2608, 2771, 2812, 2822, 2907, 2974, 3187, 3192, 3274, 3345, 3390, 3443, 3457, 3477, 3511, 3577, 3580, 3604, 3693, 3696, 3711, 3724, 3735, 3749, 3754, 3761, 3765, 3886, 3907, 3918, 3940, 3951, 3964, 3981, 3996, 4064, 4078, 4081, 4091, 4103, 4118, 4202, 4264, 4320, 4365, 4375, 4402, 4414, 4434], 'HSP90,': [103, 328, 997, 1583, 2826, 3498, 3509, 4104, 4347], 'knock-down': [106, 331, 3272], 'by': [109, 334, 696, 818, 1137, 1588, 1720, 1951, 2302, 2509, 2619, 2763, 3009, 3078, 3112, 3265, 3343, 3466, 3651, 3709, 4030, 4107], 'its': [110, 138, 196, 335, 363, 421, 909, 1586, 4240], 'siRNA': [111, 336, 3176, 3196, 3251], 'induced': [112, 144, 337, 369], 'HSP90': [116, 128, 136, 161, 182, 192, 208, 341, 353, 361, 386, 407, 417, 433, 697, 777, 784, 929, 1002, 1354, 1895, 1910, 1923, 2324, 2371, 2382, 2487, 2503, 2707, 2772, 3320, 3341, 3357, 3371, 3382, 3413, 3436, 3450, 3463, 3474, 3483, 3534, 3562, 3589, 3870, 4029, 4163, 4310, 4391], 'α-tubulin.': [118, 343], 'Depletion': [119, 213, 344, 438], 'levels': [122, 347, 3369, 3461, 3769, 3787, 3849, 3968, 4006, 4124, 4133, 4254, 4272, 4336], 'inhibited': [124, 157, 349, 382, 1719, 4308], 'ATP,': [130, 355], 'reduced': [131, 165, 356, 390, 3276, 4094], 'association': [134, 359, 3585, 3598, 3619, 3866], 'proteins,': [140, 365], 'e.g.': [141, 366, 566], 'partial': [147, 372], 'depletion': [148, 167, 203, 373, 392, 428, 1457, 1913], 'Bcr-Abl.': [150, 212, 375, 437, 3880], 'Conversely,': [151, 376], 'ectopic': [153, 378, 4153, 4303, 4349], 'overexpression': [154, 379, 4154, 4190, 4229, 4304, 4350], 'LAQ824-induced': [158, 383, 4158, 4309], 'LAQ824-mediated': [166, 391, 4043, 4268, 4330, 4354], 'AKT,': [170, 395, 575, 1460, 2185], 'c-Raf.': [172, 397], 'Collectively,': [173, 398, 1883], 'these': [174, 399, 1187, 1884, 2160, 3528], 'findings': [175, 400], 'indicate': [176, 401], 'an': [181, 406, 798, 3183, 3346], 'deacetylase.': [183, 408], 'Targeted': [184, 409], 'inhibition': [185, 410, 1587, 1915, 4036, 4046], 'leads': [188, 413], 'disruption': [194, 419], 'function,': [198, 423], 'resulting': [199, 424, 779, 3873], 'including': [211, 436], 'sensitized': [216, 441], 'cells': [219, 444, 1465, 1473, 2061, 2084, 2146, 2162, 2332, 2616, 2622, 2638, 2716, 2904, 3111, 3178, 3273, 3333, 3442, 3543, 3723, 3774, 3883, 3915, 3950, 3978, 4073, 4197, 4259, 4284, 4314, 4341, 4362, 4410, 4431], 'HAA-HDIs': [221, 446, 1589], 'proteasome': [223, 448, 822, 3655, 3713], 'inhibitors.': [224, 449], 'Several': [450], 'reports': [451, 3610], 'emphasized': [453], '1The': [459, 503], 'abbreviations': [460, 504], 'used': [461, 505, 2318, 3293], 'are:': [462, 506], 'HSP,': [463, 507], 'protein;': [466, 510], '17-AAG,': [467, 511, 3487, 3578], '17-allylamino-17-demethoxygeldanamycin;': [468, 512], 'HAT,': [469, 513], 'histone': [470, 473, 514, 517, 1061, 1081], 'acetyltransferase;': [471, 515], 'HDAC,': [472, 516], 'deacetylase;': [474, 490, 518, 534], 'HAA,': [475, 519], 'acid;': [477, 521], 'HDI,': [478, 522], 'HDAC': [479, 523, 4137], 'inhibitor;': [480, 524], 'PMSF,': [481, 525, 2739, 2937], 'phenylmethylsulfonyl': [482, 526], 'fluoride;': [483, 527], 'siRNA,': [484, 528], 'small': [485, 529, 1722], 'interfering': [486, 530], 'RNA;': [487, 531], 'TDAC,': [488, 532], 'ITD,': [491, 535], 'internal': [492, 536], 'tandem': [493, 537], 'duplication;': [494, 538], 'CML,': [495, 539], 'chronic': [496, 540], 'myeloid': [497, 501, 541, 545, 2044], 'leukemia;': [498, 542], 'AML,': [499, 543], 'acute': [500, 544, 2043, 2048], 'leukemia.': [502], 'leukemia.90': [546], 'serves': [547], 'as': [548, 1466, 1468, 1573, 2090, 2206, 2319, 2392, 2633, 3288, 3301, 3535, 3972, 4010, 4105, 4318], 'required': [552], 'for': [553, 1581, 2750, 2777, 3262, 3282, 3336, 3407, 3447, 3546, 3649, 3892, 3927, 3987, 4042, 4085, 4378, 4438], 'proper': [555], 'folding': [556], 'maintenance': [558], 'number': [561, 1200, 3246], 'signaling': [563], 'kinases,': [565], 'wild': [568], 'type': [569], 'or': [570, 791, 796, 1914, 2201, 2330, 2708, 2773, 2831, 3193, 3248, 3297, 3393, 3445, 3515, 3751, 3910, 3942, 4002, 4083, 4294, 4372, 4374, 4392, 4405, 4421], 'their': [579, 1207], 'native,': [580], 'mature,': [581], 'stable,': [582], 'functionally': [584], 'active': [585], 'conformations': [586], '(1Hartl': [587], 'F.U.': [588, 975], 'Hayer-Hartl': [589], 'M.': [590, 748, 868, 1091, 1362, 1364, 1481, 1483, 1739, 1800, 2124, 2240, 2402, 2404, 2525, 2527, 2841, 2843, 3019, 3021, 3124, 3126, 3795, 3797], 'Science.': [591], '2002;': [592, 606, 1122, 1673, 1745, 1803, 2139, 2255, 2470, 2593], '295:': [593], '1852-1858Crossref': [594], 'PubMed': [595, 609, 630, 673, 688, 738, 764, 858, 884, 899, 946, 961, 987, 1053, 1096, 1112, 1130, 1181, 1231, 1250, 1288, 1307, 1444, 1563, 1629, 1676, 1702, 1748, 1772, 1806, 1828, 1878, 2278, 2473, 2596, 2664, 2701, 2890, 2963, 3167, 3216, 3672, 3687], 'Scopus': [596, 610, 631, 674, 689, 739, 765, 859, 885, 900, 947, 962, 988, 1054, 1097, 1113, 1131, 1182, 1232, 1251, 1289, 1308, 1445, 1564, 1630, 1677, 1703, 1749, 1773, 1807, 1829, 1879, 2474, 2597, 2665, 2702, 2891, 2964, 3168, 3217, 3673, 3688], '(2767)': [597], 'Google': [598, 612, 633, 646, 676, 691, 741, 767, 861, 887, 902, 949, 964, 990, 1056, 1099, 1115, 1133, 1184, 1234, 1253, 1291, 1310, 1384, 1410, 1447, 1503, 1529, 1566, 1632, 1679, 1705, 1751, 1775, 1809, 1831, 1881, 2117, 2142, 2233, 2258, 2279, 2424, 2450, 2476, 2547, 2573, 2599, 2667, 2704, 2863, 2893, 2966, 3041, 3067, 3146, 3170, 3219, 3675, 3690, 3817, 3843], 'Scholar,': [599, 613, 634, 647, 677, 742, 862, 888, 950, 965, 1100, 1116, 1235, 1292, 1385, 1411, 1504, 1530, 1680, 1752, 1776, 1810, 2118, 2234, 2259, 2425, 2451, 2548, 2574, 2668, 2864, 3042, 3147, 3676, 3818], '2Picard': [600], 'D.': [601, 1762, 1788], 'Cell.': [602, 621, 937, 978, 1044, 1103, 1121, 1176, 1241, 1298, 1693, 1869, 3663], 'Mol.': [603, 682, 955, 1043, 1404, 1523, 2111, 2227, 2444, 2567, 3061, 3681, 3837], 'Life': [604], 'Sci.': [605, 1669, 1824], '59:': [607], '1640-1648Crossref': [608], '(652)': [611], '3Isaacs': [614], 'J.S.': [615, 931, 3657], 'Xu': [616, 932, 3658], 'W.': [617, 933, 1431, 1550, 2688, 3659], 'Neckers': [618, 934, 2458, 2581, 3660], 'L.': [619, 665, 681, 935, 954, 1358, 1368, 1387, 1433, 1477, 1487, 1506, 1552, 2094, 2210, 2398, 2408, 2427, 2459, 2521, 2531, 2550, 2582, 2656, 2690, 2837, 2847, 2880, 3015, 3025, 3044, 3120, 3130, 3661, 3680, 3791, 3801, 3820], 'Cancer': [620, 641, 668, 683, 936, 956, 1240, 1297, 1379, 1405, 1439, 1498, 1524, 1558, 2112, 2137, 2228, 2253, 2419, 2445, 2468, 2542, 2568, 2591, 2659, 2696, 2858, 2885, 3036, 3062, 3141, 3662, 3682, 3812, 3838], '2003;': [622, 756, 876, 896, 938, 1045, 1093, 1242, 1299, 1381, 1407, 1500, 1526, 1621, 1694, 1769, 1825, 1870, 2114, 2230, 2421, 2447, 2544, 2570, 2860, 3038, 3064, 3143, 3664, 3814, 3840], '3:': [623, 686, 939, 959, 3665, 3685], '213-217Abstract': [624, 940, 3666], 'Full': [625, 627, 733, 735, 759, 761, 853, 855, 879, 881, 941, 943, 982, 984, 1048, 1050, 1107, 1109, 1125, 1127, 1245, 1247, 1302, 1304, 1624, 1626, 1697, 1699, 1873, 1875, 3667, 3669], 'Text': [626, 628, 734, 736, 760, 762, 854, 856, 880, 882, 942, 944, 983, 985, 1049, 1051, 1108, 1110, 1126, 1128, 1246, 1248, 1303, 1305, 1625, 1627, 1698, 1700, 1874, 1876, 3668, 3670], 'PDF': [629, 737, 763, 857, 883, 945, 986, 1052, 1111, 1129, 1249, 1306, 1628, 1701, 1877, 3671], '(538)': [632, 948, 3674], '4Nimmanapalli': [635], 'R.': [636, 679, 952, 1220, 1277, 1356, 1374, 1475, 1493, 1731, 2120, 2134, 2236, 2250, 2396, 2414, 2519, 2537, 2835, 2853, 2952, 3013, 3031, 3118, 3136, 3678, 3789, 3807], "O'Bryan": [637, 2121, 2237], 'E.': [638, 714, 722, 834, 842, 1174, 1614, 2122, 2238, 2269, 3161, 3210], 'Bhalla': [639, 666, 1377, 1402, 1436, 1496, 1521, 1555, 2109, 2135, 2225, 2251, 2272, 2417, 2442, 2540, 2565, 2657, 2693, 2856, 2883, 3034, 3059, 3139, 3810, 3835], 'K.': [640, 667, 1378, 1403, 1437, 1497, 1522, 1556, 2110, 2136, 2226, 2252, 2418, 2443, 2541, 2566, 2658, 2694, 2857, 2884, 3035, 3060, 3140, 3811, 3836], 'Res.': [642, 669, 1380, 1440, 1499, 1559, 2138, 2254, 2420, 2543, 2660, 2697, 2859, 2886, 3037, 3142, 3813], '2001;': [643, 1228, 1285, 2960], '61:': [644], '1799-1804PubMed': [645], '5George': [648], 'P.': [649, 651, 653, 708, 746, 828, 866, 1028, 1360, 1376, 1389, 1401, 1413, 1415, 1417, 1435, 1479, 1495, 1508, 1520, 1532, 1534, 1536, 1554, 1766, 2096, 2108, 2126, 2212, 2224, 2242, 2400, 2416, 2429, 2441, 2523, 2539, 2552, 2564, 2640, 2642, 2644, 2670, 2672, 2674, 2692, 2839, 2855, 2872, 2874, 2882, 3017, 3033, 3046, 3058, 3122, 3138, 3793, 3809, 3822, 3834], 'Bali': [650, 1359, 1388, 1478, 1507, 2095, 2125, 2211, 2241, 2399, 2428, 2522, 2551, 2641, 2838, 2871, 3016, 3045, 3121, 3792, 3821], 'Cohen': [652, 1416, 1535, 2643, 2673], 'Tao': [654, 1365, 1418, 1484, 1537, 2405, 2528, 2645, 2675, 2844, 2869, 3022, 3127, 3798], 'J.': [655, 712, 727, 750, 752, 753, 832, 847, 870, 872, 873, 1175, 1366, 1372, 1419, 1485, 1491, 1538, 1768, 1802, 2132, 2248, 2406, 2412, 2466, 2529, 2535, 2589, 2646, 2676, 2845, 2851, 2870, 3023, 3029, 3128, 3134, 3799, 3805], 'Guo': [656, 1394, 1420, 1513, 1539, 2101, 2217, 2434, 2454, 2557, 2577, 2647, 2677, 3051, 3827], 'F.': [657, 1395, 1421, 1514, 1540, 1616, 2102, 2218, 2435, 2558, 2648, 2678, 2866, 3052, 3828], 'Sigua': [658, 1422, 1541, 2649, 2679, 2867], 'C.': [659, 971, 1030, 1034, 1370, 1423, 1489, 1542, 1727, 1758, 2410, 2533, 2650, 2680, 2849, 2868, 3027, 3132, 3803], 'Vishvanath': [660, 1424, 1543, 2651, 2681], 'A.': [661, 1425, 1427, 1544, 1546, 1661, 1672, 1686, 1690, 1729, 1735, 1737, 1778, 1784, 1862, 1866, 2652, 2682, 2684], 'Li': [662, 1755, 2653, 2875], 'Y.': [663, 1682, 1733, 1754, 1782, 1786, 1792, 1858, 2654, 2876, 3151, 3200], 'Moscinski': [664, 1367, 1432, 1486, 1551, 2407, 2530, 2655, 2689, 2846, 2879, 3024, 3129, 3800], '2004;': [670, 685, 958, 1104, 1441, 1560, 2661, 2698, 2887, 3684], '64:': [671, 2662, 2888], '3645-3652Crossref': [672, 2663], '(124)': [675, 2666], '6Bagatell': [678, 951, 3677], 'Whitesell': [680, 953, 3679], 'Ther.': [684, 957, 1406, 1525, 2113, 2229, 2446, 2569, 3063, 3683, 3839], '1021-1030Crossref': [687, 960, 3686], '(35)': [690, 963, 3689], 'Scholar);': [692], 'this': [693, 2784, 3762, 4055, 4442], 'achieved': [695], 'through': [698, 1163], 'hydrolysis': [702], '(7Grenert': [703, 823], 'J.P.': [704, 824], 'Sullivan': [705, 825], 'W.P.': [706, 826], 'Fadden': [707, 827], 'Haystead': [709, 829], 'T.': [710, 830, 1222, 1279, 1780, 2130, 2246, 2954], 'Clark': [711, 831], 'Mimnaugh': [713, 833], 'Krutzsch': [715, 835], 'H.': [716, 744, 836, 864, 1397, 1516, 1790, 2104, 2220, 2437, 2560, 3054, 3153, 3202, 3830], 'Ochel': [717, 837], 'H.J.': [718, 838], 'Schulte': [719, 839], 'T.W.': [720, 840], 'Sausville': [721, 841], 'Nechers': [723, 843], 'L.M.': [724, 844], 'Toft': [725, 845, 891], 'D.O.': [726, 846, 892], 'Biol.': [728, 754, 848, 874, 894], 'Chem.': [729, 755, 849, 875], '1997;': [730, 850, 979], '272:': [731, 851], '23843-23850Abstract': [732, 852], '(506)': [740, 860], '8Wegele': [743, 863], 'Muschler': [745, 865], 'Bunck': [747, 867], 'Reinstein': [749, 869], 'Buchner': [751, 871], '278:': [757, 877], '39303-39310Abstract': [758, 878], '(56)': [766, 886], 'Scholar).': [768, 903, 991, 1134, 1185, 1254, 1311, 1448, 1567, 1633, 1706, 1832, 1882, 2143, 2280, 2477, 2967, 3220, 3691], 'ATP/ADP': [769, 917], 'hydrophobic': [773], 'N-terminal': [774], 'pocket': [775, 3496], 'alters': [776], 'conformation,': [778], 'interaction': [782], 'co-chaperone': [787, 1011], 'complex': [788, 3630], 'protects': [790], 'stabilizes': [792, 1001], 'alternative': [799, 1006], 'subset': [800], 'co-chaperones': [802], 'directs': [804, 1020], 'covalent': [811], 'linkage': [812], 'polyubiquitin': [814], 'subsequent': [816], '26': [820, 3653], 'S': [821, 3654], '9Pratt': [889], 'W.B.': [890], 'Exp.': [893], 'Med.': [895], '228:': [897], '111-133Crossref': [898], '(1249)': [901], 'Benzoquinone': [904], 'ansamycin': [905], 'antibiotic': [906], 'geldanamycin': [907, 3489], 'less': [910], 'toxic': [911], '17-AAG': [913, 1000], 'bind': [914], 'pocket,': [919], 'replacing': [920], 'nucleotide': [922], 'inhibiting': [924, 3503], '(3Isaacs': [930, 3656], '10Stebbins': [966], 'C.E.': [967], 'Russo': [968], 'A.A.': [969], 'Schneider': [970], 'Rosen': [972], 'N.': [973, 1756, 1794, 2267], 'Hartl': [974], 'Pavletich': [976], 'N.P.': [977], '89:': [980], '239-250Abstract': [981], '(1234)': [989], 'By': [992], 'blocking': [993], 'treatment': [998, 3318, 3389, 3439, 3510, 3579, 3603, 3695, 3720, 3748, 3764, 3782, 3947, 4090, 4115, 4288], 'conformation': [1003], 'into': [1004, 1844, 2291, 3095, 3109], 'one': [1007], 'recruits': [1009], 'HSP70-based': [1010], 'complex,': [1012], 'which': [1013, 1204, 1575, 1717, 3420, 3705], 'binds': [1014, 1649, 4345], 'them': [1021], 'proteasomal': [1025, 1454, 3877], '(11Meyer': [1027], 'Prodromou': [1029], 'Hu': [1031], 'B.': [1032, 1038], 'Vaughan': [1033], 'Roe': [1035], 'S.M.': [1036, 1663], 'Panaretou': [1037], 'Piper': [1039], 'P.W.': [1040], 'Pearl': [1041], 'L.H.': [1042], '11:': [1046], '647-658Abstract': [1047], '(367)': [1055], 'Scholar).Histone': [1057], 'acetyltransferases': [1058], '(HATs)': [1059], 'deacetylases': [1062], '(HDACs)': [1063], 'are': [1064, 3396], 'enzymes': [1065, 1188], 'catalyze': [1067], 'deacetylation,': [1071], 'respectively,': [1072], 'N': [1075], 'termini': [1076], 'core': [1079], 'nucleosomal': [1080], 'tails': [1082], 'at': [1083, 2780, 2795], 'evolutionarily': [1084], 'conserved': [1085], 'lysine': [1086, 1196, 1984, 2390, 2830, 3351], 'residues': [1087, 1197, 3352], '(12Felsenfeld': [1088], 'G.': [1089, 1760, 2261], 'Groudine': [1090], 'Nature.': [1092, 1744], '421:': [1094], '448-453Crossref': [1095], '(804)': [1098], '13Khorasanizadeh': [1101], 'S.': [1102, 1391, 1393, 1429, 1510, 1512, 1548, 1671, 1764, 1796, 1798, 2098, 2100, 2214, 2216, 2271, 2431, 2433, 2554, 2556, 2686, 2878, 3048, 3050, 3824, 3826], '116:': [1105], '259-272Abstract': [1106], '(511)': [1114], '14Schreiber': [1117], 'S.L.': [1118, 1820], 'Bernstein': [1119], 'B.E.': [1120, 3159, 3208], '111:': [1123], '771-778Abstract': [1124], '(326)': [1132], 'Following': [1135, 2159, 3438, 3539], 'recruitment': [1136], 'multiprotein': [1138], 'transcriptional': [1139, 1211], 'complexes': [1140], 'promoters': [1143], 'genes,': [1145], 'balance': [1147], 'between': [1148, 4222], 'activities': [1150, 3402], 'HATs': [1152], 'HDACs': [1154, 1258, 1578, 1612], 'regulates': [1155, 1905], 'status': [1158, 1193, 1908], 'chromatin': [1160, 1164], 'transcription': [1162, 1202], 'modification': [1165], 'without': [1166, 3194, 3364], 'directly': [1167], 'DNA': [1170, 1208], '(15Cress': [1171], 'W.D.': [1172], 'Seto': [1173, 3160, 3209], 'Physiol.': [1177], '2000;': [1178, 2275], '184:': [1179], '1-16Crossref': [1180], '(575)': [1183], 'Importantly,': [1186, 4302], 'affect': [1190, 1206, 4292], 'specific': [1195, 2199, 2823], 'factors,': [1203], 'may': [1205, 4039, 4232], 'activity': [1212], '(16Marks': [1213, 1270, 2945], 'P.A.': [1214, 1271, 2946], 'Rifkind': [1215, 1272, 2947], 'R.A.': [1216, 1273, 2948], 'Richon': [1217, 1274, 2949], 'V.M.': [1218, 1275, 2950], 'Breslow': [1219, 1276, 2951], 'Miller': [1221, 1278, 2953], 'Kelly': [1223, 1280, 2955], 'W.K.': [1224, 1281, 2956], 'Nat.': [1225, 1282, 2957], 'Rev.': [1226, 1283, 2958], 'Cancer.': [1227, 1284, 2959], '1:': [1229, 1286, 2961], '194-202Crossref': [1230, 1287, 2962], '(1680)': [1233, 1290, 2965], '17Johnstone': [1236, 1293], 'R.W.': [1237, 1294], 'Licht': [1238, 1295], 'J.D.': [1239, 1296], '4:': [1243, 1300], '13-18Abstract': [1244, 1301], '(436)': [1252, 1309], 'Three': [1255], 'classes': [1256, 1262], 'identified:': [1261], 'I,': [1263], 'II': [1264, 3405], '(A': [1265], 'B),': [1267], 'III': [1269], 'Treatment': [1312, 4080], 'novel': [1315], 'pan-HDAC': [1320], 'not': [1326, 3385, 3398, 3411, 3607, 4089, 4113, 4144, 4277, 4290], 'only': [1327, 3422, 3431, 4226], 'has': [1328, 1347, 1834, 3574], 'histones,': [1335], 'induction': [1336, 4022, 4166], 'p21,': [1338, 2186, 3999], 'cell': [1339, 2479, 3258, 3455, 3554, 3902, 3936, 3992, 4383, 4445], 'cycle': [1340], 'growth': [1341], 'arrest,': [1342], 'apoptosis': [1344], 'but': [1345, 4088, 4112, 4276], 'demonstrated': [1349, 1837], '(18Nimmanapalli': [1355, 1474, 2395, 2518, 2834, 3012, 3117, 3788], 'Fuino': [1357, 1476, 2397, 2520, 2836, 3014, 3119, 3790], 'Gasparetto': [1361, 1480, 2401, 2524, 2840, 3018, 3123, 3794], 'Glozak': [1363, 1482, 2403, 2526, 2842, 3020, 3125, 3796], 'Smith': [1369, 1488, 2409, 2532, 2848, 3026, 3131, 3802], 'Wu': [1371, 1490, 2411, 2534, 2850, 3028, 3133, 3804], 'Jove': [1373, 1492, 2133, 2249, 2413, 2536, 2852, 3030, 3135, 3806], 'Atadja': [1375, 1400, 1434, 1494, 1519, 1553, 2107, 2223, 2415, 2440, 2538, 2563, 2691, 2854, 2881, 3032, 3057, 3137, 3808, 3833], '63:': [1382, 1501, 2422, 2545, 2861, 3039, 3144, 3815], '5126-5135PubMed': [1383, 1502, 2423, 2546, 2862, 3040, 3145, 3816], '19Fuino': [1386, 1505, 2426, 2549, 3043, 3819], 'Wittmann': [1390, 1509, 2097, 2213, 2270, 2430, 2553, 2877, 3047, 3823], 'Donapaty': [1392, 1511, 2099, 2215, 2432, 2555, 3049, 3825], 'Yamaguchi': [1396, 1515, 2103, 2219, 2436, 2559, 3053, 3829], 'Wang': [1398, 1517, 1740, 2105, 2221, 2438, 2561, 3055, 3831], 'H.-G.': [1399, 1518, 2106, 2222, 2439, 2562, 3056, 3832], '2:': [1408, 1527, 2115, 2231, 2448, 2571, 3065, 3841], '971-984PubMed': [1409, 1528, 2116, 2232, 2449, 2572, 3066, 3842], '20Bali': [1412, 1531, 2669], 'George': [1414, 1533, 2671, 2873], 'Scuto': [1426, 1545, 2683], 'Annavarapu': [1428, 1547, 2685], 'Fiskus': [1430, 1549, 2687], 'Clin.': [1438, 1557, 2695], '10:': [1442, 1561, 2699], '4991-4997Crossref': [1443, 1562, 2700], '(118)': [1446, 1565, 2703], 'associated': [1451, 3476, 4117], 'polyubiquitylation,': [1453], 'degradation,': [1455], 'c-Raf': [1462, 3784, 4335], 'CML': [1464, 2039], 'well': [1467], 'FLT-3': [1470], 'AML': [1472], 'These': [1568], 'observations': [1569], 'raised': [1570, 4032], 'issue': [1572], 'responsible': [1580, 4041], 'deacetylating': [1582], 'such': [1584], 'induces': [1590, 3631], 'undermines': [1593], 'HSP90.': [1598, 4052, 4065, 4079, 4359], 'cytoplasmic,': [1603], 'family': [1610], '(21Verdin': [1613], 'Dequiedt': [1615], 'Kasler': [1617], 'H.G.': [1618], 'Trends': [1619], 'Genet.': [1620], '19:': [1622, 3165, 3214], '286-293Abstract': [1623], '(544)': [1631], 'unique': [1636], 'possessing': [1638], 'two': [1639], 'catalytic': [1640, 1709], 'domains': [1641], 'C-terminal': [1644, 1708], 'zinc': [1645], 'finger': [1646], 'domain': [1647, 1710, 3427], 'both': [1650], 'dynein': [1656], 'motor': [1657], '(22Hook': [1658], 'S.S.': [1659], 'Orian': [1660], 'Cowley': [1662], 'Eisenman': [1664], 'R.N.': [1665], 'Proc.': [1666, 1821], 'Natl.': [1667, 1822, 2467, 2590], 'Acad.': [1668, 1823], 'U.': [1670], '99:': [1674], '13425-13430Crossref': [1675], '(169)': [1678], '23Kawaguchi': [1681], 'Kovacs': [1683, 1859], 'J.J.': [1684, 1860], 'McLaurin': [1685, 1861], 'Vance': [1687, 1863], 'J.M.': [1688, 1864], 'Ito': [1689, 1734, 1865], 'Yao': [1691, 1742, 1867], 'T.P.': [1692, 1743, 1868], '115:': [1695, 1871], '727-738Abstract': [1696, 1872], '(1176)': [1704, 1880], 'possesses': [1713], 'activity,': [1716], 'molecule': [1723], 'inhibitor': [1724, 3491, 3714], 'tubacin': [1725, 3516], '(24Hubbert': [1726], 'Guardiola': [1728], 'Shao': [1730], 'Kawaguchi': [1732], 'Nixon': [1736], 'Yoshida': [1738, 1799], 'X.F.': [1741], '417:': [1746], '455-458Crossref': [1747], '(1746)': [1750], '25Zhang': [1753], 'Caron': [1757], 'Matthias': [1759, 1765], 'Hess': [1761], 'Khochbin': [1763, 1795], 'EMBO': [1767, 1801], '22:': [1770], '1168-1179Crossref': [1771], '(563)': [1774], '26Matsuyama': [1777], 'Shimazu': [1779], 'Sumida': [1781], 'Saito': [1783], 'Yoshimatsu': [1785], 'Seigneurin-Berny': [1787], 'Osada': [1789], 'Komatsu': [1791], 'Nishino': [1793], 'Horinouchi': [1797], '21:': [1804], '6820-6831Crossref': [1805], '(569)': [1808], '27Haggarty': [1811], 'S.J.': [1812], 'Koeller': [1813], 'K.M.': [1814], 'Wong': [1815], 'J.C.': [1816], 'Grozinger': [1817], 'C.M.': [1818], 'Schreiber': [1819], '100:': [1826], '4389-4394Crossref': [1827], '(887)': [1830], 'direct': [1839], 'aggresomes,': [1845], 'thus': [1846], 'regulating': [1847], 'cellular': [1849, 2362, 2495, 2759, 3642], 'management': [1850], 'stress': [1855], 'response': [1856], '(23Kawaguchi': [1857], 'features': [1885], 'suggested': [1888], 'might': [1891], 'involved': [1893], 'deacetylation.': [1896], 'In': [1897, 3387], 'present': [1899], 'studies': [1900, 2176], 'determined': [1902, 2618, 3311, 4059, 4148], 'whether': [1903, 1912, 4060], 'affects': [1918], 'cells.EXPERIMENTAL': [1927], 'PROCEDURESReagents': [1928], 'Antibodies—17-AAG': [1930], 'was': [1931, 1960, 2030, 2284, 2317, 2372, 2488, 2507, 3093, 3353, 3362, 3451, 3475, 3499, 3519, 3550, 3565, 3599, 3706, 3744, 4116, 4177, 4215, 4255, 4280, 4337, 4400], 'obtained': [1932, 2063, 3961], 'from': [1933, 1962, 1974, 1991, 2006, 2019, 2032, 2064, 2374, 2490, 2994, 3453, 3552, 3588, 3869, 3900, 3934], 'Developmental': [1934], 'Therapeutics': [1935], 'Branch': [1936], 'CTEP,': [1938], 'NCI,': [1939], 'National': [1940], 'Institutes': [1941, 2308], 'Health': [1943], '(Bethesda,': [1944], 'MD).': [1945, 2312], 'were': [1949, 1972, 1989, 2004, 2017, 2062, 2085, 2147, 2163, 2196, 2333, 2364, 2386, 2481, 2606, 2617, 2717, 2761, 2769, 2790, 2800, 2810, 2905, 2972, 3001, 3106, 3179, 3260, 3280, 3286, 3307, 3464, 3884, 3904, 3916, 3938, 3960, 3979, 3994, 4193, 4363, 4385, 4411, 4432, 4447], 'provided': [1950, 3077], 'Novartis': [1952], 'Pharmaceuticals': [1953], 'Inc.': [1954, 2023, 2034], '(East': [1955], 'Hanover,': [1956], 'NJ).': [1957], 'ATP-Binders': [1958], 'resin': [1959], 'purchased': [1961, 1973, 1990, 2005, 2018, 2031], 'EMD': [1963], 'Biosciences': [1964], '(San': [1965], 'Diego,': [1966], 'CA).': [1967, 2026], 'Anti-HSP90': [1968], '-HSP70': [1970], 'antibodies': [1971, 1988, 2203, 2824], 'StressGen': [1975], 'Biotechnologies': [1976], 'Corp.': [1977], '(Victoria,': [1978], 'British': [1979], 'Columbia,': [1980], 'Canada).': [1981], 'Monoclonal': [1982, 1997, 2008], 'anti-acetyl': [1983, 1998, 2389, 2829, 3997], 'polyclonal': [1986, 2013], 'anti-HDAC3': [1987], 'Cell': [1992, 2765], 'Signaling': [1993], 'Technology': [1994], '(Beverly,': [1995], 'MA).': [1996], 'anti-FLAG': [2001], '(M2)': [2002], 'antibody': [2003, 2029, 2391, 2517, 2776, 2833, 3347, 3737, 4237], 'Sigma-Aldrich.': [2007], 'anti-Abl': [2009, 3736, 3911, 3943, 3965], 'HDAC1': [2011], 'anti-HDAC2': [2014], 'Santa': [2020], 'Cruz': [2021], 'Biotechnology,': [2022], '(Santa': [2024], 'Cruz,': [2025], 'Polyclonal': [2027], 'HDAC10': [2028, 4135, 4253, 4295], 'Biovision': [2033], '(Mountain': [2035], 'View,': [2036], 'CA).Cell': [2037], 'Culture—Human': [2038], '(expressing': [2041], 'Bcr-Abl),': [2042], 'HL-60': [2046, 3328], 'MV4-11': [2050], '(containing': [2051], '30-base': [2053], 'pair-long': [2054], 'ITD': [2055], 'exon': [2057], '14': [2058], 'FLT-3)': [2060], 'American': [2065], 'Type': [2066], 'Culture': [2067], 'Collection': [2068], '(Manassas,': [2069], 'VA)': [2070], 'maintained': [2072], 'culture': [2074], 'RPMI': [2076], 'medium': [2077], 'containing': [2078, 2928, 3627, 4417], '10%': [2079, 2988], 'fetal': [2080], 'bovine': [2081], 'serum.': [2082], 'passaged': [2086], 'twice': [2087], 'week': [2089], 'described': [2091, 2177, 2207, 2393, 3115], 'previously': [2092, 2208, 2394, 3114], '(19Fuino': [2093, 2209], '28Nimmanapalli': [2119, 2235], 'Huang': [2123, 2239], 'Burnette': [2127, 2243], 'P.K.': [2128, 2244], 'Loughran': [2129, 2245], 'Tepperberg': [2131, 2247], '62:': [2140, 2256], '5761-5769PubMed': [2141, 2257], 'Logarithmically': [2144], 'growing': [2145], 'exposed': [2148], 'designated': [2151, 2714, 2901], 'concentrations': [2152, 3921, 3984, 4368], 'exposure': [2154, 3331, 3540], 'intervals': [2155], 'drugs.': [2158], 'treatments,': [2161, 2715, 2903], 'pelleted': [2164], 'washed': [2166, 2786, 2801], 'free': [2167], 'drug(s)': [2170], 'prior': [2171, 2818], 'performance': [2173], 'below.Western': [2178], 'blot': [2179, 2511, 3267], 'Analyses—Western': [2180], 'analyses': [2181, 2821], 'c-Raf-1,': [2184], 'HDAC1,': [2187], '-2,': [2188], '-3,': [2189], '-6,': [2190], '-10': [2192], 'β-actin': [2195, 2316, 3970, 4008], 'performed': [2197, 2285, 4401], 'using': [2198, 2289, 2366, 2380, 2497, 2513], 'antisera': [2200], 'monoclonal': [2202, 2515, 2775], '(see': [2204], 'above)': [2205], '29Fang': [2260], 'Kim': [2262], 'C.N.': [2263], 'Perkins': [2264], 'C.L.': [2265], 'Ramadevi': [2266], 'Winton': [2268], 'K.N.': [2273], 'Blood.': [2274], '96:': [2276], '2246-2256Crossref': [2277], 'Horizontal': [2281], 'scanning': [2282], 'densitometry': [2283, 4108], 'on': [2286, 2753, 3003, 3319, 3367, 3381, 3530, 4157, 4165], 'Western': [2287, 2510, 3010, 3266], 'blots': [2288], 'acquisition': [2290], 'Adobe': [2292], 'PhotoShop': [2293], '(Adobe': [2294], 'Systems': [2295], 'Inc.,': [2296], 'San': [2297, 3091], 'Jose,': [2298], 'CA)': [2299], 'analysis': [2301, 2512, 3298, 4398], 'NIH': [2304], 'Image': [2305, 4015], 'program': [2306], '(National': [2307], 'Health,': [2310], 'Bethesda,': [2311], 'expression': [2314, 3264, 3277, 4185, 4214, 4224, 4296], 'loading': [2321, 2816, 3974, 4012], 'control.Acetylation': [2322], 'Its': [2326], 'Binding': [2327], 'ATP-Sepharose—Untreated': [2329], 'LAQ824-treated': [2331], 'lysed': [2334, 2718, 2906], 'TNESV': [2336], 'buffer': [2337, 2721, 2817, 2909, 2976], '(50': [2338, 2910], 'mm': [2339, 2342, 2348, 2352, 2723, 2738, 2741, 2911, 2916, 2919, 2922, 2936, 2939, 2943, 2978, 2985], 'Tris,': [2340, 2724, 2979], '2': [2341, 2915], 'EDTA,': [2343, 2917], '100': [2344, 2918, 2984], 'nm': [2345, 2728, 4436], 'NaCl,': [2346, 2920], '1': [2347, 2737, 2740, 2778, 2921, 2935], 'sodium': [2349, 2729, 2742, 2923, 3391, 3512, 4092, 4376], 'orthovanadate,': [2350, 2743, 2924], '25': [2351, 2938], 'NaF,': [2353, 2736, 2940], '1%': [2355, 2731, 2925], 'Triton': [2356, 2732], 'X-100,': [2357, 2733], 'pH': [2358, 2725, 2913, 2980], '7.5),': [2359], 'total': [2361, 2378, 2494, 4382], 'quantified': [2365], 'BCA': [2368], 'assay.': [2370], 'immunoprecipitated': [2373, 3551, 4388], '200': [2375, 2491], 'μg': [2376, 2492, 2991], 'mouse': [2381], 'antibody,': [2383], 'immunoprecipitates': [2385, 2799, 3734, 3896, 3931], 'immunoblotted': [2387, 3905, 3939, 3963, 3995], '30Yu': [2452, 2575], 'X.': [2453, 2576, 3149, 3198], 'Z.S.': [2455, 2578], 'Marcu': [2456, 2579], 'M.G.': [2457, 2580], 'Nguyen': [2460, 2583], 'D.M.': [2461, 2584], 'Chen': [2462, 2585], 'G.A.': [2463, 2586], 'Schrump': [2464, 2587], 'D.S.': [2465, 2588], 'Inst.': [2469, 2592], '94:': [2471, 2594], '504-513Crossref': [2472, 2595], '(358)': [2475, 2598], 'Alternatively,': [2478], 'lysates': [2480, 2766, 3259, 3456, 3903, 3937, 3993, 4384, 4446], 'prepared': [2482, 4386], 'after': [2483], 'drug': [2484, 2902, 4129], 'treatment,': [2485, 4443], 'affinity-precipitated': [2489, 3452], 'ATP-Sepharose': [2498, 3481, 3507], 'beads.': [2499], 'concentration': [2501, 3889], 'precipitates': [2506], 'assessed': [2508], 'anti-HSP90': [2516, 4404], 'Scholar).Assessment': [2600], 'Percentage': [2602], 'Nonviable': [2604], 'Cells—Cells': [2605], 'stained': [2607], 'trypan': [2609, 2625], 'blue': [2610, 2626], '(Sigma).': [2611], 'numbers': [2613], 'nonviable': [2615], 'counting': [2620], 'showed': [2624], 'uptake': [2627], 'hemocytometer': [2630], 'reported': [2632, 3779], 'percentage': [2634], 'untreated': [2636], 'control': [2637, 3104, 4206, 4266, 4394], '(5George': [2639], 'Scholar).Immunoprecipitation': [2705], 'Bcr-Abl': [2709, 3549, 3560, 3587, 3699, 3771, 3868, 3899, 3933, 4333], 'Immunoblot': [2711, 4397], 'Analyses—Following': [2712], 'lysis': [2720, 2806], '(20': [2722], '8,': [2726], '150': [2727], 'chloride,': [2730], '0.1': [2734], 'm': [2735], '2.5': [2744], 'μg/ml': [2745, 2748, 2930, 2933], 'leupeptin,': [2746, 2934], '5': [2747, 2942], 'aprotinin)': [2749], '30': [2751], 'min': [2752], 'ice,': [2754], 'nuclear': [2757], 'debris': [2760], 'cleared': [2762], 'centrifugation.': [2764], '(200': [2767], 'μg)': [2768], 'incubated': [2770, 2793], 'Abl-specific': [2774], 'h': [2779, 3255, 3409], '4': [2781, 2796], '°C.': [2782, 2797], 'To': [2783, 4053], 'mixture,': [2785], 'G-agarose': [2788], 'beads': [2789], 'added': [2791], 'overnight': [2794], 'three': [2802], 'times': [2803], 'buffer,': [2807], 'eluted': [2811], 'SDS': [2814, 2975], 'sample': [2815], 'immunoblot': [2820, 3467], 'against': [2825], 'anti-Abl,': [2827], 'HDAC6,': [2828, 3429, 4126], 'anti-ubiquitin': [2832, 3941], '31Guo': [2865], '2580-2589Crossref': [2889], '(197)': [2892], 'Scholar).Preparation': [2894], 'Detergent-soluble': [2896], 'Insoluble': [2898], 'Fractions—After': [2899], 'TNSEV': [2908], 'Tris-HCl,': [2912], '7.5,': [2914], 'Nonidet': [2926, 2996], 'P-40': [2927], '20': [2929, 2932], 'aprotinin,': [2931], 'N-ethylmaleimide)': [2944], 'insoluble': [2969, 2999], 'fractions': [2970, 3000, 3959], '(pellet)': [2971], 'solubilized': [2973], '(80': [2977], '6.8,': [2981], '2%': [2982], 'SDS,': [2983], 'dithiothreitol,': [2986], 'glycerol).': [2989], 'Fifty': [2990], 'P-40-soluble': [2997], 'separated': [3002], '7.5%': [3004], 'SDS-polyacrylamide': [3005], 'gel': [3006], 'analyzed': [3008], 'blotting': [3011], 'Scholar).Ectopic': [3068], 'Overexpression': [3069], 'HDAC6—N-terminal': [3071], 'FLAG-tagged': [3072, 4173, 4244, 4418], 'cDNA': [3073, 4174], '(kindly': [3076], 'Dr.': [3079], 'Eric': [3080], 'Verdin,': [3081], 'Gladstone': [3082], 'Institute': [3083], 'Virology': [3085], 'Immunology,': [3087], 'University': [3088], 'California,': [3090], 'Francisco)': [3092], 'cloned': [3094], 'pcDNA3.1': [3097], 'plasmid': [3098, 3189], 'vector': [3099, 3105, 3190, 4204, 4416, 4423], '(Invitrogen).': [3100], 'transiently': [3107, 3180, 4412], 'transfected': [3108, 3181, 4178, 4413], 'method': [3116], '32Zhang': [3148], 'Ozawa': [3150, 3199], 'Lee': [3152, 3201], 'Wen': [3154, 3203], 'Y.-D.': [3155, 3204], 'Tan': [3156, 3205], 'T.-H.': [3157, 3206], 'Wadzinski': [3158, 3207], 'Genes': [3162, 3211], 'Dev.': [3163, 3212], '2005;': [3164, 3213], '827-839Crossref': [3166, 3215], '(180)': [3169, 3218], 'Scholar).Creation': [3171], 'Transfection': [3173], 'Vector—K562': [3177], 'utilizing': [3182], 'Amaxa': [3184], 'Nucleofector': [3185], 'Electroporator': [3186], 'pBS/U6': [3191], '(32Zhang': [3197], 'had': [3222], '21-nucleotide': [3224], 'sequence': [3225], '(5′-GG': [3226], 'ATG': [3227], 'GAT': [3228], 'CTG': [3229], 'AAC': [3230], 'CTT': [3231], 'GAG': [3232], 'A-3′)': [3233], 'corresponding': [3234], 'targeted': [3237], 'codons': [3238], '200–219': [3239], 'mRNA': [3243], '(GenBank™': [3244], 'accession': [3245], 'BC013737)': [3247], 'nonspecific': [3250], 'encoding': [3252], 'sequence.': [3253], 'Forty-eight': [3254], 'following': [3256, 3602, 3747, 3752, 3946], 'transfection,': [3257], 'screened': [3261], 'analysis.': [3268, 3468], 'most': [3270, 4138], 'efficient': [3271], 'markedly': [3275], 'utilized': [3281], 'further': [3283, 3707], 'studies.Statistical': [3284], 'Analyses—Data': [3285], 'expressed': [3287], 'mean': [3289], '±': [3290], 'S.E.': [3291], 'Comparisons': [3292], "Student's": [3294], 't': [3295], 'test': [3296], 'variance': [3300], 'appropriate.': [3302], 'p': [3303], 'values': [3304], '<0.05': [3306], 'assigned': [3308], 'significance.RESULTSWe': [3309], 'first': [3310, 4058], 'effects': [3313], 'K562,': [3325, 4267], 'MV4–11,': [3326], 'After': [3330, 4441], '16': [3337, 3408, 3448, 3547, 3893, 3928, 3988, 4086, 4379, 4439], 'h,': [3338, 3449, 3548, 4087], 'immunoprecipitation': [3339], 'followed': [3342], 'immunoblotting': [3344], 'recognizes': [3349], 'anti-acetylated': [3350], 'performed.': [3354], 'Acetylation': [3355], 'dose-dependent': [3360, 3858], 'manner': [3361, 3859], 'observed,': [3363], 'significant': [3365, 4249], 'effect': [3366, 3380, 4150, 4322], '(Fig.': [3372, 3415, 3484, 3521, 3717, 3738, 3758, 3775, 3860, 4109, 4198, 4260, 4285, 4315, 4342], '1A).': [3373], 'Exposure': [3374, 3417], 'exerted': [3377], 'similar': [3379, 3571, 3593], '(data': [3384, 3606, 4143], 'shown).': [3386, 3608, 4145], 'contrast,': [3388], 'butyrate': [3392, 4377], 'trapoxin': [3394, 4114], '(which': [3395], 'HDACs)': [3406], 'did': [3410, 4289], '1B).': [3416], 'tubacin,': [3419], 'inhibits': [3421, 4353], '(TDAC)': [3426], 'caused': [3430], 'minimal': [3433], 'increase': [3434, 4121, 4211, 4269], 'acetylation.': [3437], 'ATP-Sepharose,': [3458], 'estimated': [3465, 4106], 'LAQ824-': [3469], 'LBH589-mediated': [3471], 'decreased': [3478], '1C).': [3485], 'While': [3486], 'effective': [3501], 'butyrate,': [3513, 4093], 'trapoxin,': [3514], '(not': [3517], 'shown)': [3518], 'ineffective': [3520], '1C).Next,': [3522], 'evaluated': [3524], 'impact': [3526], 'modifications': [3529], 'protein.': [3538], 'lysates,': [3555], 'versus': [3563], 'HSP70': [3564, 3626], 'determined.': [3566], 'Fig.': [3567, 4069], '2A': [3568], 'demonstrates': [3569], 'that,': [3570], 'what': [3573], 'observed': [3576, 4256, 4338], 'shifted': [3582], 'HSP70.': [3591], 'A': [3592, 4172], 'shift': [3594, 3615], 'seen': [3601, 3746], 'Previous': [3609], 'unstable': [3628], 'multichaperone': [3629], 'accumulation': [3634, 3700], 'detergent-insoluble': [3641, 3703], 'fraction.': [3643], 'Polyubiquitylation': [3644], 'marks': [3645], 'Consistent': [3692, 3760], 'this,': [3694], 'increased': [3698, 3726], 'fraction,': [3704], 'enhanced': [3708], 'co-treatment': [3710, 3753], 'PS341': [3715, 3750, 3757, 3925], '(bortezomib)': [3716, 3926], '2B).': [3718, 3739, 3759], 'Additionally,': [3719, 3945], 'Bcr-Abl-containing': [3733], 'Increased': [3740], 'finding,': [3763], 'depleted': [3767, 3783], '2C).': [3776], 'As': [3777, 4066, 4200, 4262], 'previously,': [3780], 'Scholar),': [3844], 'while': [3845], 'concomitantly': [3846], 'inducing': [3847], 'acetylated': [3852, 4274], 'p21': [3855, 4168, 4279], '2C).Fig.': [3861], '2LAQ824': [3862], 'shifts': [3863], 'HSP70,': [3872], 'A,': [3881, 4360], 'treated': [3885, 3917, 3980, 4364, 4433], 'indicated': [3888, 3920, 3983, 4367], 'h.': [3894, 3929, 3989, 4380, 4428, 4440], 'Then': [3895, 3930, 3990, 4381, 4429], '(IP)': [3897, 4389], '(IB)': [3906, 4399], 'anti-HSP90,': [3908], 'anti-Hsp70,': [3909], 'antibodies.': [3912, 3944], 'B,': [3913, 4408], 'and/or': [3924, 3953], 'PS341,': [3954], 'detergent': [3956], '(Nonidet': [3957], 'P-40)-insoluble': [3958], 'antibody.': [3966, 4004, 4407], 'served': [3971, 4009], 'control.': [3975], 'C,': [3976], 'α-tubulin,': [3998], 'Abl,': [4000], 'anti-AKT': [4003], 'control.View': [4013], 'Large': [4014], 'Figure': [4016], 'ViewerDownload': [4017], 'Hi-res': [4018], 'image': [4019], 'Download': [4020], '(PPT)Simultaneous': [4021], 'possibility': [4034], 'address': [4054], 'issue,': [4056], '3A,': [4070], 'could': [4075, 4100], 'amount': [4096], '3A).': [4110], 'slight': [4120], 'whereas': [4127], 'neither': [4128], 'significantly': [4130, 4291], 'affected': [4131], '(the': [4136], 'closely': [4139], 'related': [4140], 'HDAC6)': [4142], 'We': [4146], 'next': [4147], 'transient': [4184], 'FLAG': [4187, 4223], 'confirmed': [4194], 'K562/HDAC6': [4196, 4218, 4258, 4283, 4298, 4313, 4340], '3B).': [4199, 4261, 4286], 'compared': [4201, 4263, 4319], 'alone-transfected': [4205], '2-fold': [4210, 4228], 'detected': [4216], 'discrepancy': [4221], 'because': [4234], 'anti-HDAC6': [4236, 4406], 'poorly': [4238], 'recognized': [4239], 'epitope': [4241], 'version': [4245], 'HDAC6.': [4247], 'No': [4248], 'change': [4250], 'blunted': [4281], 'K562/control': [4300, 4326], '3C).': [4316], 'Concomitantly,': [4317], 'lesser': [4329], 'attenuation': [4331], '3D).Fig.': [4343], '3HDAC6': [4344], 'HAA-HDI': [4370], 'rat': [4395], 'IgG.': [4396], 'either': [4403], 'pCDNA3.1': [4415], '(K562/HDAC6)': [4420], 'alone': [4424], '(K562/vector)': [4425], 'over': [4426], '48': [4427], '250': [4435], 'immuno': [4448]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2151445954', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 22}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 37}, {'year': 2019, 'cited_by_count': 32}, {'year': 2018, 'cited_by_count': 31}, {'year': 2017, 'cited_by_count': 29}, {'year': 2016, 'cited_by_count': 34}, {'year': 2015, 'cited_by_count': 41}, {'year': 2014, 'cited_by_count': 43}, {'year': 2013, 'cited_by_count': 46}, {'year': 2012, 'cited_by_count': 48}], 'updated_date': '2024-12-24T13:37:13.555811', 'created_date': '2016-06-24'}
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