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'but': [74], 'not': [75], 'physiological': [77], 'bicarbonate': [78], 'buffer,': [79], 'yet': [80], 'concentrations': [84], 'were': [85, 99, 161, 175], 'higher': [86], 'under': [87], 'both': [88, 92], 'conditions.': [89], 'addition,': [91], 'diastolic': [93], 'systolic': [95], 'Ca': [96, 108, 118, 122, 140, 148, 153], '2+': [97, 109, 119, 123, 141, 149, 154], 'levels': [98], 'increased': [100, 213], 'consequence': [103], '-induced': [107], 'overload;': [110], 'this': [111], 'accompanied': [113], 'by': [114, 178], 'enhanced': [115], 'sarcoplasmic': [116], 'reticulum': [117], 'loading': [120], 'via': [121], '/calmodulin-dependent': [124], 'protein': [125], 'kinase': [126], '(CaMK)II-dependent': [127], 'phosphorylation': [128], 'phospholamban.': [130], 'Negative': [131], 'force–frequency': [132], 'dependence': [133], 'observed': [135, 169], 'preservation': [137], ',': [142], 'suggesting': [143, 211], 'decrease': [145], 'myofibril': [147], 'sensitivity.': [150], 'Furthermore,': [151], '-dependent': [155], 'prohypertrophic': [156], 'molecules': [157], 'calcineurin': [158], 'CaMKII': [160], 'highly': [162], 'activated': [163, 201], 'These': [167], 'effects': [168], 'vivo': [171], 'vitro': [174], 'largely': [176], 'prevented': [177], 'inhibitor': [181], 'cariporide.': [182], 'Interestingly,': [183], 'overexpression': [184], 'neonatal': [188], 'rat': [189], 'ventricular': [190], 'myocytes': [191], 'induced': [192], 'cariporide-sensitive': [193], 'nuclear': [194, 205], 'translocation': [195, 232], 'NFAT': [197, 237, 254], '(nuclear': [198], 'factor': [199], 'T': [202], 'cells)': [203], 'export': [206], 'histone': [208, 234], 'deacetylase': [209, 235, 276], '4,': [210, 236], 'exchange': [218], 'can': [220], 'alter': [221], 'hypertrophy-associated': [222], 'gene': [223], 'expression.': [224], 'contrary': [229], 'exclusive': [231], 'only': [238], 'partially': [239], 'translocated': [240], 'nucleus,': [242], 'possibly': [243], 'because': [244], 'marked': [246], 'p38,': [249], 'negative': [251], 'regulator': [252], 'signaling.': [255], 'conclude': [257], 'initiate': [265], 'failure': [270], 'mainly': [271], 'through': [272], 'CaMKII–histone': [275], 'pathway.': [277]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2151354922', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 26}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2025-01-06T04:22:41.168915', 'created_date': '2016-06-24'}