Carboxylation of NH/CH Bonds Using N‐Heterocyclic Carbene Copper(I) Complexes

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Duration: 3 min 30 s
Description: Greenhouse gas makes good: A simple copper-mediated protocol has been developed where NH or CH bonds can be directly functionalized using an easily prepared catalyst. The novel [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) hydroxide, [Cu(IPr)(OH)], permits the facile activation and carboxylation of NH and CH bonds with pKa values of less than 27.7 (see scheme).
Inẽ I. F. Boogaerts; George C. Fortman; Marc R. L. Furst; Catherine S. J. Cazin; Steven P. Nolan
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