Title: Course and outcome in bipolar affective disorder: a longitudinal follow- up study
Abstract: Back to table of contents Previous article Next article No AccessCourse and outcome in bipolar affective disorder: a longitudinal follow- up studyPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.152.3.379AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: A number of recent studies have questioned whether, despite modern treatment, the natural course of bipolar illness today still involves multiple relapses and impaired psychosocial functioning. This prospective follow-up study examined longitudinal outcome in a large group of inpatients with affective disorders. METHOD: Fifty-one bipolar manic patients and 49 unipolar depressed patients were interviewed three times: 1) during hospitalization, 2) approximately 2 years after discharge, and 3) approximately 4.5 years after discharge. Subjects were treated under routine conditions and assessed for global adjustment, rehospitalization, and work and social functioning. RESULTS: Only 41% of the bipolar group had a good overall outcome by the time of the 4.5-year follow-up. The bipolar patients had more severe work impairment than the unipolar group. More than one-half of the bipolar patients were rehospitalized at least once during the 4.5- year follow-up period. Outcome for both diagnostic groups improved significantly over time. CONCLUSIONS: Many contemporary bipolar patients demonstrate gradual improvement in the first several years after hospitalization. However, a subgroup approaching 60% still experience poor posthospital adjustment in one or more areas of functioning. Access content To read the fulltext, please use one of the options below to sign in or purchase access. 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Publication Year: 1995
Publication Date: 1995-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 358
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