Publication Information

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'(M.I.),': [67, 71, 115, 119], 'Cardiology': [70, 118], 'Keio': [72, 120, 2269, 4278], 'School': [74, 122, 2271], 'Medicine,': [76, 124, 2273, 3720, 3776, 4127, 4281], 'Shinjuku-ku,': [77, 125, 2276], 'Tokyo,': [78, 126], 'Japan.': [79, 127], 'IedaMasaki': [82], 'Originally': [128, 4498], 'published22': [129], 'Jun': [130], '2012https://doi.org/10.1161/CIRCRESAHA.112.271452Circulation': [131], 'Research.': [132, 831], '2012;111:5–8Cellular': [133], 'reprogramming': [134, 290, 380, 385, 406, 464, 525, 616, 654, 675, 724, 747, 813, 851, 889, 917, 972, 1289, 1362, 1403, 1586, 1612, 1649, 1681, 1759, 1858, 1903, 1943, 1977, 2017, 2052, 2090, 2125, 2143, 2288, 2407, 2434, 2514, 2559, 2588, 2636, 2673, 2707, 2760, 3916, 4021, 4122, 4255], 'achieved': [135, 606, 890, 1354, 1409], 'by': [136, 160, 173, 195, 210, 303, 485, 531, 607, 663, 704, 819, 891, 906, 926, 1084, 1099, 1150, 1155, 1160, 1332, 1410, 1614, 1632, 1841, 1859, 1905, 2091, 2158, 2168, 2293, 2358, 2388, 2440, 2466, 2499, 2521, 2558, 3652, 3917, 4092, 4256, 4405, 4466], 'somatic': [137, 348], 'nuclear': [138], 'transfer': [139], 'or': [140, 309, 423, 662, 956, 1238, 1269, 1480, 1716, 1823, 1861, 2229, 2254, 3522], 'cell': [141, 154, 274, 299, 317, 334, 394, 615, 933, 1214, 1367, 1661, 1937, 1983, 2045, 2330, 2870, 2876, 2997], 'fusion': [142], 'has': [143, 291, 357], 'long': [144], 'been': [145, 358, 1630], 'recognized.1': [146], 'The': [147, 752, 804, 1867, 3188, 3549, 3821, 3925, 4277], 'potency': [148], 'specific': [150, 997], 'transcription': [151, 182, 215, 307, 497, 538, 557, 694, 2028, 2563, 2584], 'factors': [152, 183, 229, 308, 440, 498, 1290, 1317, 1587, 1613, 1904, 2018, 2029, 2053, 2126, 4030], 'as': [153, 180, 243, 324, 396, 432, 716, 1511, 1519, 1534, 1707, 2761], 'fate': [155], 'determinants': [156], 'was': [157, 483, 551, 602, 1086, 1322, 1485, 1562, 2156, 2166], 'first': [158], 'demonstrated': [159, 200, 1808], 'discovery': [162], 'MyoD,': [164], 'a': [165, 285, 314, 328, 399, 433, 494, 542, 559, 680, 686, 856, 860, 864, 976, 1559, 1597, 1691, 1906, 1916, 1926, 1936, 2021, 2200, 2290, 2308, 2762, 3269, 4194, 4314], 'master': [166], 'regulator': [167], 'skeletal': [169], 'muscle': [170], 'differentiation,': [171], 'subsequent': [175, 223], 'identification': [176], 'several': [178, 735, 1516, 1698], 'genes': [179, 1363, 2822], 'lineage-converting': [181], 'in': [184, 225, 407, 429, 447, 449, 465, 467, 500, 512, 517, 523, 568, 629, 644, 673, 816, 826, 838, 867, 878, 1024, 1053, 1088, 1252, 1266, 1364, 1378, 1382, 1392, 1460, 1528, 1575, 1622, 1655, 1666, 1682, 1723, 1737, 1743, 1747, 1757, 1805, 1836, 1911, 1918, 1925, 1958, 1969, 1975, 2008, 2085, 2088, 2113, 2132, 2140, 2219, 2630, 2633, 2736, 2770, 2872, 2958, 3138, 3276, 3553, 3745, 3854, 3863, 3943, 3950, 4154, 4316, 4463], 'blood': [185], 'cells.2,3': [186], 'These': [187], 'pioneering': [188], 'works': [189], 'led': [190], 'landmark': [193], 'study': [194], 'Yamanaka': [197, 2283, 2344, 2377, 3666, 4029], 'laboratory': [198, 1790], 'that': [199, 387, 441, 571, 605, 742, 767, 777, 918, 922, 1005, 1329, 1451, 1551, 1570, 1583, 1638, 1675, 1762, 1834, 1872, 2048, 2061, 2099], 'generation': [202, 1772], 'induced': [204, 252, 277, 598, 612, 620, 624, 2042, 2713], 'pluripotent': [205, 253, 278, 315, 366, 613, 621, 2043, 2291, 2348, 2381], 'stem': [206, 213, 254, 258, 279, 316, 341, 367, 614, 622, 2044, 2349, 2382, 2519, 2875], 'cells': [207, 255, 346, 388, 419, 446, 507, 511, 530, 570, 597, 648, 678, 727, 730, 877, 940, 984, 1041, 1176, 1298, 1328, 1550, 1569, 1637, 1742, 1814, 1871, 1884, 1957, 2106, 2128, 2350, 2383, 2412, 2495, 2520, 2593, 2828, 4027, 4089, 4153], 'from': [208, 276, 347, 487, 1042, 1578, 1783, 1787, 1815, 1886, 2040, 2161, 2170, 2351, 2384, 2496, 2999, 4090, 4313, 4347], 'fibroblasts': [209, 516, 527, 643, 954, 958, 967, 1027, 1074, 1091, 1395, 1755, 1887, 2313, 2387, 2436, 2462, 2498, 2516, 2590, 2639, 2675, 2711, 2824, 3179, 3279, 4024, 4091, 4150, 4192], 'transducing': [211], 'four': [212], 'cell-enriched': [214], 'factors,': [216, 482, 695, 4094, 4258], 'Oct4,': [217], 'Sox2,': [218], 'Klf4,': [219], 'c-Myc.4,5': [221], 'Numerous': [222], 'improvements': [224], 'techniques': [226], 'additional': [228], 'have': [230, 636, 1552, 1629, 2020], 'increased': [231, 1877], 'efficiency': [233, 461, 601, 1096, 1722], 'robustness': [235], 'technology,': [238, 1678, 1944], 'such': [240, 1518], 'enhancements': [241], 'continue,': [242], 'do': [244], 'analyses': [245, 1169, 1251], 'similarities': [248], 'differences': [250, 886], 'embryonic': [257, 376, 2353], 'cells.': [259], 'Increasingly': [260], 'efficient': [261, 782, 2120], 'differentiation': [262, 2871, 2998, 4321], 'protocols': [263], 'now': [264], 'permit': [265], 'us': [266], 'make': [268, 778], 'significant': [269, 758, 1402], 'quantities': [270], 'many': [272, 705, 765, 1446, 1985, 2075, 2092], 'individual': [273], 'types': [275, 1662], 'cells.Article,': [280], 'see': [281, 1002], 'p': [282], '50More': [283], 'recently,': [284, 632], '"next': [286], 'generation"': [287], 'cellular': [289, 355, 463], 'involved': [292, 2139], 'direct': [294, 384, 1679, 2141, 2635, 3475, 4121], 'conversion': [295, 2460], 'one': [297, 1450], 'adult': [298, 1267, 1275, 2355, 2385, 2409], 'type': [300, 934, 1954], 'into': [301, 508, 646, 676, 798, 1760, 2127, 2332, 2437, 2517, 2676, 2712, 2825, 3180, 3715, 3969, 4151, 4222], 'another': [302], 'combinations': [304, 438, 533], 'lineage-specific': [306], 'miRNAs,': [310, 696], 'without': [311, 1092, 1659], 'passing': [312], 'through': [313, 1445, 3162], 'state.': [318], 'Direct': [319, 2433, 2459, 2513, 2913, 2948, 3163, 3206, 3336, 3442, 3496, 3672, 3711, 3965, 3991, 4020, 4217, 4253], 'lineage': [320, 1800], 'reprogramming,': [321, 715, 3140, 3477], 'also': [322], 'known': [323], 'transdifferentiation,': [325], 'can': [326, 2054, 2101], 'yield': [327], 'diverse': [329], 'range': [330], 'medically': [332], 'relevant': [333], 'types,': [335, 1984], 'including': [336], 'pancreatic': [337, 501, 505, 2410, 4320], 'β-cell-like,': [338], 'neuron-like,': [339], 'neural': [340, 2518], 'cell–like,': [342], 'cardiomyocyte-like,': [343], 'hepatocyte-like': [345, 2494], 'cells.6–10': [349], 'In': [350, 491, 962, 1060, 1295, 1369, 1556, 1592, 1797, 1988, 2405, 2705, 2758, 3337, 4397], 'some': [351, 807, 1039, 2051], 'cases,': [352], 'resulting': [354], 'phenotype': [356, 862], 'more': [359, 443, 781, 784, 969, 990, 1007, 1020, 1056, 1144, 1312], 'mature': [360], 'adult-like': [362], 'than': [363, 973, 1057, 1140, 1145, 1318, 1325, 1381, 1396], 'corresponding': [365], 'cell–derived': [368], 'phenotype,': [369], 'likely': [370, 470, 1618, 1718, 1839], 'reflecting': [371], 'lack': [373], 'an': [375, 448], 'intermediate': [377], 'during': [378], 'process.A': [381], 'limitation': [382], 'is': [386, 409, 739, 814, 824, 880, 1509, 1512, 1652, 1684, 2199, 2206], 'appear': [389], 'quickly': [391], 'exit': [392], 'cycle': [395], 'they': [397], 'adopt': [398], 'unique': [400], 'fate.': [401], 'Thus,': [402, 1929], 'utility': [404], 'vitro': [408, 430, 524, 645, 674, 1683, 2086, 2631, 4317], 'limited': [410, 1653], 'given': [411], 'inability': [413], 'generate': [415], 'larger': [416, 1581, 2009], 'numbers': [417], 'potential': [421, 1728], 'therapeutic': [422], 'investigative': [424, 4349], 'use.': [425], 'However,': [426, 1725], 'leveraging': [427], 'system': [431, 1425, 1561, 1939, 2994], 'screening': [434, 1428, 2586], 'tool': [435], 'identify': [437, 707], 'could': [442, 456, 503, 1763, 1893], 'fully': [444, 587, 1008], 'reprogram': [445, 641, 1339, 1741], 'vivo': [450, 468, 1837, 1976, 2089, 2406, 2634, 2706, 2759], 'setting': [451], 'stimulate': [453], 'organ': [454], 'regeneration': [455, 1734], 'be': [457, 627, 718, 792, 924, 1421, 1573, 1948, 1968, 2004, 2037, 2055, 2074, 2102], 'powerful.': [458], 'A': [459, 669, 2580, 3209, 3229, 3375], 'greater': [460, 802, 977, 1139, 1324, 1377, 1391, 1415], 'microenvironment,': [469, 1838], 'involving': [471], 'spatial': [472], 'cues,': [473], 'extracellular': [474, 1847], 'matrix': [475], 'proteins,': [476, 1715], 'tensile': [478], 'forces,': [479, 1851], 'among': [480, 787, 1532], 'other': [481, 634, 1711], 'highlighted': [484, 815], 'work': [486], 'Melton': [488, 2403], 'colleagues.6': [490], 'their': [492, 836, 960, 1370, 1633], 'work,': [493], 'combination': [495, 681, 710], 'enriched': [499, 1840], 'β-cells': [502], 'convert': [504], 'exocrine': [506, 2411], 'insulin-secreting': [509], 'endocrine-like': [510], 'vivo,': [513], 'but': [514, 1245, 1336, 1352, 1473, 1483, 1588, 1745, 2079], 'not': [515, 1001, 1229, 1400, 1736, 1947, 2223], 'vitro.6In': [518], '2010,': [519], 'we': [520, 594, 1535, 1595], 'reported': [521, 637], 'cardiomyocyte-like': [529, 560, 647, 677, 729, 861, 1813, 1883, 1956, 1997, 2105, 2592, 4026, 4088, 4152], 'various': [532], 'core': [535], 'cardiac': [536, 573, 642, 714, 812, 957, 966, 986, 1026, 1204, 1209, 1384, 1394, 1490, 1525, 1680, 1733, 1754, 1857, 1913, 1942, 2142, 2562, 2638, 2710, 2766, 2868, 3080, 3139, 3185, 3476, 3554, 3915, 4195, 4254, 4343], 'developmental': [537], 'factors.': [539, 2360, 2390, 2442, 2468, 2501, 2523, 2564], 'We': [540, 999, 1080, 1433], 'found': [541, 1081], 'minimum': [543], 'cocktail': [544], 'Gata4,': [546, 842, 3808, 4470], 'Mef2c,': [547, 843, 3809, 4471], 'Tbx5': [549, 845, 3811], '(GMT)': [550, 1122], 'sufficient': [552], 'broadly': [554], 'reset': [555], 'gene': [556, 575, 1182, 1576, 1601, 1623, 1656, 1907, 2012], 'toward': [558, 859, 4193], 'state.7': [561], 'Although': [562], 'global': [563], 'transcriptome': [564, 870, 1540], 'changes': [565, 858], 'were': [566, 968, 1006, 1330, 1374, 1388, 1643], 'observed': [567, 1596], 'pooled': [569], 'activated': [572], 'reporter': [574, 1304, 1424, 1471, 1498, 1508, 1560, 2874, 2993], 'expression': [576, 1168, 1283, 1313, 1358, 1408, 1457, 1514, 1521, 1577, 1657, 1820, 3853], '(approximately': [577], '15%': [578], 'cells),': [580], 'only': [581, 855, 1375, 1389], 'approximately': [582, 1100, 1879], '0.5%': [583], 'these': [585, 596, 1798], 'became': [586], 'reprogrammed': [588, 1009, 1299, 1870, 1885], 'with': [589, 649, 655, 667, 679, 764, 801, 900, 910, 975, 1010, 1022, 1029, 1044, 1102, 1174, 1255, 1277, 1404, 1437, 1462, 1676, 1765, 1874, 1896, 2030, 2057, 2561, 3340, 3623, 3818], 'ability': [591, 639, 1012, 1739], 'contract;': [593], 'termed': [595], 'cardiomyocytes.': [599, 1898, 2641, 2714], 'This': [600], 'similar': [603], 'original': [609, 1704], 'set': [610], 'factors;': [617], 'however,': [618], 'unlike': [619], 'cells,': [623, 1998, 2115], 'cardiomyocytes': [625, 1461, 1505, 1761, 1767, 2439, 2677], 'cannot': [626], 'expanded': [628], 'vitro.': [630, 1724], 'More': [631], '2': [633], 'groups': [635, 1699, 2093], 'GMT,': [650, 1222], 'while': [651], 'indicating': [652], 'improved': [653, 1912], 'either': [656], 'GMT': [657, 1023, 1045, 1085, 1244, 1822, 1824, 1860, 1862], 'plus': [658, 1046, 1825, 1863], 'addition': [659, 1047, 1061, 1826, 1864, 1989], 'Hand2,11': [661], 'replacement': [664], 'Gata4': [666, 1386], 'Myocardin.12': [668], 'third': [670], 'group': [671, 1785], 'described': [672, 754, 905], 'cardiac-enriched': [683], 'miRNAs': [684, 1717], 'small': [687, 698, 1712, 2031, 2058], 'molecule': [688], 'inhibitor': [689], 'Jak.13': [691], 'Combinations': [692], 'molecules': [699, 2032], 'are': [700, 748, 941, 1291, 1700, 2144, 2222], 'currently': [701], 'being': [702], 'tried': [703], 'preferred': [709], 'stimuli': [712], 'should': [717, 923], 'expected': [719], 'any': [721, 1003], 'new': [722, 1812, 1882, 2581, 2763], 'technology.Successful': [723], 'fibroblast': [726, 1327, 2356, 3923], 'eluded': [731], 'field': [733, 800, 1709, 2046, 2070], 'decades,': [736], 'so': [737], 'it': [738, 1931, 1945], 'no': [740, 1475], 'surprise': [741], 'conditions': [744, 776, 1994], 'conducive': [745], 'difficult': [749], 'engineer.': [751], 'approaches': [753, 2014, 4350], 'date': [756], 'require': [757, 1544], 'optimization': [759], 'myriad': [761], 'experimental': [762], 'details,': [763], 'pitfalls': [766], 'may': [768, 1946, 2019, 2064], 'lead': [769], 'failure': [771, 1605], 'reprogramming.': [773, 945, 1079], 'Highly': [774], 'standardized': [775], 'process': [780], 'easily': [785], 'transferable': [786], 'different': [788], 'laboratories': [789, 808], 'will': [790, 1429, 1719, 1967, 2003, 2073], 'undoubtedly': [791], 'developed,': [793], 'thereby': [794], 'facilitating': [795], 'successful': [796, 903, 944, 2084], 'entry': [797], 'ease.': [803], 'difficulty': [805, 837], 'successfully': [810], 'achieve': [811, 1971], 'article': [818, 1665, 2221], 'Chen': [820, 832, 907, 946, 1271, 1346, 1411, 1466, 1615, 2646, 2794], 'et': [821, 833, 893, 897, 908, 947, 1017, 1033, 1113, 1116, 1120, 1234, 1258, 1272, 1347, 1412, 1467, 1616, 2511], 'al,14': [822, 909], 'which': [823, 1321], 'published': [825], 'this': [827, 1593, 1667, 1730, 1778, 1795, 2068, 2148, 2220], 'issue': [828], 'Circulation': [830, 1670, 3590, 3675, 3697, 3721, 3994, 4238, 4242, 4474], 'al': [834, 948, 1034, 1114, 1117, 1121, 1235, 1273, 1348, 1413, 1468, 1617], 'report': [835, 1035], 'expressing': [839, 985, 1280, 1506], 'levels': [840, 1284, 1343, 1356, 1373, 1387, 1406, 1416, 1609], 'sufficiently': [846], 'high': [847, 1282, 1355, 1456, 1608], 'promote': [849], 'robust': [850, 1486], 'correspondingly': [853], 'observe': [854], 'few': [857], 'minimal': [865], 'shift': [866], 'overall': [869, 873], 'population': [874, 1582, 1818], 'transduced': [876, 1173, 1379, 1393], 'vitro.It': [879], 'worthwhile': [881], 'consider': [883], 'technical': [885, 1695], 'between': [887, 4342], 'al7': [894], 'Song': [896, 1032, 1257, 2530, 4167], 'al,11': [898], 'compared': [899, 1028, 3817], 'less': [902], 'results': [904], 'objective': [912], 'clarifying': [914], 'aspects': [915], 'remain': [919], 'challenging': [920, 1685], 'addressed': [925], 'future': [927, 2151], 'research': [928, 2159], '(Table).': [929], 'First,': [930], 'starting': [932], 'condition': [937], 'pivotal': [942], 'utilized': [949, 1349, 1469], '3-': [950], '6-week-old': [952], 'tail-tip': [953, 1232], '(TTFs)': [955], 'studies.': [961], 'our': [963, 1296, 1557, 1784], 'experience,': [964, 1297, 1371], 'neonatal': [965, 1025, 1180, 1253, 1319], 'amenable': [970], 'TTFs,': [974, 1030], 'percentage': [978, 1503], 'α-myosin': [980], 'heavy': [981, 1226], 'chain': [982], '(α-MHC)-GFP+': [983], 'troponin': [987, 1210, 1491, 1526], 'T': [988, 1527, 2753, 3201, 3802, 4395], 'complete': [991], 'alteration': [992], 'epigenetic': [994, 2062], 'marks': [995], 'at': [996, 2049, 3615], 'loci.': [998], 'did': [1000], 'TTF': [1004, 1043], 'contract.': [1014], 'Similarly,': [1015], 'Protze': [1016, 2568], 'al12': [1018], 'had': [1019, 1075, 1308, 1340, 1452, 1536], 'success': [1021], 'although': [1031, 1930], 'emergence': [1037, 1810], 'beating': [1040], 'Hand2': [1049], 'after': [1050, 1922, 3347], 'prolonged': [1051], 'periods': [1052], 'culture': [1054, 1938, 1959], '1': [1058, 1148, 1153, 4487], 'month.': [1059], 'source': [1064], 'fibroblasts,': [1066], 'health': [1068], 'senescent': [1070], 'state': [1071, 2292], 'primary': [1073, 1090, 1106], 'major': [1076], 'effects': [1077], 'on': [1078, 1702, 1819, 2207, 3232, 3736, 4031], 'α-MHC-GFP': [1082, 1303], 'induction': [1083], 'best': [1087], 'fresh': [1089], 'passage,': [1093], 'progressively': [1097], 'decreased': [1098], '50%': [1101], 'each': [1103, 1418], 'passage': [1104], 'fibroblasts.Table.': [1107], 'Comparing': [1108], 'Methods': [1109], 'ReprogrammingVectorIeda': [1112], '(GMT)Song': [1115], '(GMHT)': [1118], 'RetrovirusChen': [1119], 'Dox-on': [1123], 'LentivirusRetrovirusDox-on': [1124], 'LentivurusTransgenic': [1125], 'mouseα-MHC-GFPα-MHC-GFPα-MHC-GFPα-MHC-CreNkx2.5-CrecTnT-CreCell': [1126], 'typeNeonatal/adult': [1127], 'CFNeonatal': [1128], 'TTFAdult': [1129], 'TTF/CFAdult': [1130], 'TTF/CFNeonatal': [1131], 'TTFTransduction': [1132], 'efficiency>95%': [1133], '(TTF/CF)80%': [1134], '(TTF)NDND40%': [1135], '(CF)GMT': [1136], 'expression6–8': [1137], 'fold': [1138], 'cardiomyocytesND18-fold': [1141], '1000-fold': [1143], 'fibroblastsToxicityNoYesNoNDCardiac': [1146], 'inductionAfter': [1147], 'wk': [1149, 1154, 1159], 'FACS': [1151, 1156, 1161], '(α-MHC-GFP)After': [1152, 1157], '3': [1158], 'αMHC-GFP15%0.5–1%15–18%0%': [1162], '(α-MHC-Cre': [1163], 'reporter)': [1164], 'cTnT5%ND9%35%': [1165], '(cTnT-Cre': [1166], 'reporter)Gene': [1167], 'Cell': [1170, 2524, 2603, 2771, 2879, 2959, 3062, 3350, 3515, 4329], 'typeαMHC-GFP+': [1171], 'cellsNDCF': [1172], 'GHMTTbx5-expressing': [1175], 'Array': [1177], 'dataSimilar': [1178], 'CMsNDCardiac': [1181], 'upregulationSimilar': [1183], 'TTF/CFImmunohistochemistryα-Actinin+α-Actinin+α-Actinin+NDcTnT+cTnT+ANP+cTnI+FunctionAction': [1185], 'potentialNDAction': [1186], 'potentialCa2': [1187], '+': [1188, 1193, 1195], 'channel–mediated': [1189], 'depolarizationCell': [1190], 'contractionCell': [1191], 'contractionCa2': [1192], 'transientCa2': [1194], 'transientCell': [1196], 'transplantationα-MHC-GFP+NDNDCell': [1197], 'deathα-Actinin+ANP': [1198], 'indicates': [1199], 'atrial': [1200, 3856], 'natriuretic': [1201], 'peptide;': [1202], 'CF,': [1203], 'fibroblast;': [1205], 'CM,': [1206], 'cardiomyocyte;': [1207], 'cTnT,': [1208], 'T;': [1211], 'FACS,': [1212], 'fluorescence-activated': [1213], 'sorting;': [1215], 'GFP,': [1216], 'green': [1217], 'fluorescent': [1218], 'protein;': [1219], 'GMHT,': [1220], 'Gata4/Mef2c/Hand2/Tbx5;': [1221], 'Gata4/Mef2c/Tbx5;': [1223], 'MHC,': [1224], 'myosin': [1225], 'chain;': [1227], 'ND,': [1228], 'determined;': [1230], 'TTF,': [1231], 'fibroblast.Ieda': [1233], 'used': [1236, 1260, 1274, 1426, 1563, 1644], 'retroviral': [1237, 1261, 1306], 'Dox-inducible': [1239], 'lentiviral': [1240, 1278, 1350], 'vectors': [1241, 1262, 1279, 1307, 1335, 1351, 3806], 'express': [1243, 1607], 'performed': [1246], 'most': [1247, 1454], 'experiments': [1248, 1543, 1802], 'in-depth': [1250], 'CFs': [1254, 1268], 'retroviruses.7': [1256], 'al11': [1259], 'GMHT': [1264], 'overexpression': [1265], 'TTFs.': [1270], 'CFs/TTFs': [1276], 'GMT.14Second,': [1281], 'proper': [1286], 'stoichiometry': [1287], 'necessary': [1292, 1949, 2145], 'success.': [1294], 'activate': [1301], 'using': [1305, 2678, 4028], 'six-fold': [1309], 'eight-fold': [1311, 1390], 'all': [1315, 1360, 1636], 'three': [1316, 1361, 2294], 'cardiomyocytes,': [1320, 3002], 'much': [1323, 1580], 'fibroblasts;': [1326, 1385], 'infected': [1331], 'viral': [1334], 'failed': [1337, 1589], 'significantly': [1341, 1852], 'lower': [1342], 'expression.': [1345, 1602], 'never': [1353], 'same': [1366, 1530], 'population.': [1368], 'Mef2c': [1372], '10-fold': [1376], 'TTFs': [1380], 'nontransduced': [1383], 'fibroblasts.': [1397], 'One': [1398], 'would': [1399, 1420, 1628, 2036], 'expect': [1401], 'because': [1414, 1635], 'factor': [1419, 2585], 'required.Third,': [1422], 'affect': [1430], 'results.': [1432], 'generated': [1434], 'transgenic': [1435], 'mice': [1436, 1447], 'α-MHC': [1439, 1523], 'promoter': [1440], 'driving': [1441], 'GFP': [1442, 1459], 'screened': [1444], 'before': [1448], 'selecting': [1449], 'reproducibly': [1455], 'greatest': [1464], 'specificity.': [1465], 'Cre-dependent': [1470], 'systems': [1472, 1499, 2121], 'saw': [1474], 'activation': [1476, 1487, 2819], 'α-MHC-Cre': [1479], 'Nkx2.5-Cre': [1481], 'reporters,': [1482], 'there': [1484, 1651, 2072], 'T-Cre': [1492], 'reporter.': [1493], 'Careful': [1494], 'validation': [1495], 'important,': [1510], 'monitoring': [1513, 2996], 'markers,': [1517], 'cell,': [1531], 'others,': [1533], 'reported.Finally,': [1537], 'whole': [1539], 'analysis,': [1541], 'meaningful': [1542], 'selection': [1545], 'subset': [1548], 'begun': [1553], 'reprogram.': [1555], 'studies,': [1558, 1650, 1799], 'select': [1565], 'fraction': [1567], 'appeared': [1571], 'shifting': [1574], 'received': [1584], 'respond.': [1591], 'setting,': [1594], 'broad': [1598, 1620], 'resetting': [1599, 1627], 'Whereas': [1603, 2011], 'precluded': [1619], 'alterations': [1621], 'expression,': [1624], 'even': [1625], 'partial': [1626], 'undetected': [1631], 'approach': [1634, 1909, 2582, 2764], 'expressed': [1639, 2218], 'Tbx5-expressing': [1641], 'virus': [1642], 'microarray': [1646], 'analysis.': [1647], 'For': [1648], 'value': [1654], 'analysis': [1658], 'purifying': [1660], 'interest.The': [1664], 'issue14': [1668], 'highlights': [1672], 'fact': [1674], 'current': [1677, 3275, 3852], 'requires': [1687], 'scrupulous': [1688], 'attention': [1689], 'great': [1692], 'variety': [1693], 'details.': [1696], 'Already': [1697], 'improving': [1701], 'recipe': [1705], 'and,': [1706], 'develops,': [1710, 2071], 'molecules,': [1713, 2059], 'secreted': [1714, 1842, 2034], 'improve': [1720], 'clinical': [1727, 2152], 'technology': [1731, 2149], 'lies': [1735], 'culture,': [1744], 'rather': [1746], 'harnessing': [1748], 'vast': [1750], 'pool': [1751], 'resident': [1753, 1888], 'situ': [1758], 'integrate': [1764], 'preexisting': [1766, 1897], 'contribute': [1769], 'force': [1771], 'intact': [1775, 1891], 'heart.': [1776], 'To': [1777], 'end,': [1779], 'recent': [1781, 2081], 'articles': [1782], 'Olson': [1789, 2554, 4186], 'indicate': [1791], 'plausibility': [1793], 'approach.11,15': [1796], 'tracing': [1801], 'labeling': [1803], 'nonmyocytes': [1804, 2100], 'heart': [1807, 1892, 2131, 4124], 'nonmyocyte': [1817], 'Hand2.': [1828, 1866], 'Most': [1829, 1899], 'importantly,': [1830, 1900], 'both': [1831], 'studies': [1832, 2112], 'suggest': [1833], 'signals,': [1843], 'components': [1844], 'matrix,': [1848], 'mechanical': [1850], 'enhances': [1853, 3812], 'degree': [1855], 'percent': [1868], 'contract': [1873], 'electric': [1875], 'stimulation': [1876], '50%.11': [1880], 'Furthermore,': [1881], 'within': [1889], 'electrically': [1894], 'couple': [1895], 'adding': [1901], 'therapy': 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[2066], 'As': [2067], 'young': [2069], 'overcome,': [2078], 'reports': [2082], 'firmly': [2094], 'establish': [2095], 'conceptual': [2097], 'advance': [2098, 2147], 'transdifferentiated': [2103], 'capable': [2107], 'contractile': [2109], 'performance.': [2110], 'Future': [2111], 'human': [2114, 2386, 3855, 4087, 4191], 'development': [2116, 3555], 'safe': [2118], 'delivery': [2123], 'situ,': [2133], 'understanding': [2135], 'molecular': [2137], 'mechanisms': [2138, 4352], 'applications.Sources': [2153], 'FundingM.I.': [2155], 'supported': [2157, 2167], 'grants': [2160, 2169], 'JSTCREST': [2162], 'JSPS.': [2164], 'D.S.': [2165], 'National': [2171, 4098, 4200], 'Heart': [2172, 2233, 2556, 2737, 3161, 3213, 3576, 3773, 4269, 4421, 4494], 'Lung': [2173], 'Blood': [2175], 'Institute/National': [2176], 'Institutes': [2177], 'Health,': [2179], 'California': [2181], 'Regenerative': [2184, 3719], 'Medicine': [2185], '(CIRM),': [2186], 'Roddenberry': [2188], 'Foundation,': [2189, 2193], 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'Xue': [4288], 'Nazor': [4292], 'Guo': [4294], 'Trivedi': [4296], 'Peterson': [4298], 'Loring': [4302], 'Laurent': [4305], 'Matched': [4308], 'miRNA': [4309], 'mRNA': [4311], 'signatures': [4312], 'hESC-based': [4315], 'model': [4318], 'reveal': [4322], 'novel': [4323], 'interactions': [4325], 'Science,': [4330], '10.1242/jcs.123570': [4331], 'Su': [4334], 'Mende': [4337], 'U': [4338], 'Cross': [4340], 'talk': [4341], 'myocytes': [4344], 'fibroblasts:': [4346], 'multiscale': [4348], 'consequences,': [4355], '10.1152/ajpheart.01167.2011,': [4363], '303:12,': [4364], '(H1385-H1396),': [4365], '15-Dec-2012.': [4369], 'P.': [4372], 'Lilo': [4377], 'Korman': [4379], 'Fourman': [4381], 'Hackett': [4383], 'Shroyer': [4385], 'Efficacy': [4402], 'Enhanced': [4404], 'Angiogenic': [4406], 'Preconditioning': [4407], 'Infarcted': [4410], 'Myocardium': [4411], 'With': [4412], 'Vascular': [4413], 'Endothelial': [4414], 'Growth': [4415], 'Factor,': [4416], 'Association,': [4422, 4495], '1:6,': [4423], 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