Publication Information

{'id': 'https://openalex.org/W2150943858', 'doi': 'https://doi.org/10.1136/thx.2004.026336', 'title': 'Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF', 'display_name': 'Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF', 'publication_year': 2004, 'publication_date': '2004-10-31', 'ids': {'openalex': 'https://openalex.org/W2150943858', 'doi': 'https://doi.org/10.1136/thx.2004.026336', 'mag': '2150943858', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15516475', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1746860'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/thx.2004.026336', 'pdf_url': 'https://thorax.bmj.com/content/thoraxjnl/59/11/977.full.pdf', 'source': {'id': 'https://openalex.org/S106546978', 'display_name': 'Thorax', 'issn_l': '0040-6376', 'issn': ['0040-6376', '1468-3296'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://thorax.bmj.com/content/thoraxjnl/59/11/977.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103627020', 'display_name': 'William E. Lawson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'W E Lawson', 'raw_affiliation_strings': ['Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA', 'Department of Veterans Affairs Medical Center, Nashville, TN, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Veterans Affairs Medical Center, Nashville, TN, USA', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA', 'institution_ids': ['https://openalex.org/I200719446']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5103627020'], 'corresponding_institution_ids': ['https://openalex.org/I200719446'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.657, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 267, 'citation_normalized_percentile': {'value': 0.969263, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '59', 'issue': '11', 'first_page': '977', 'last_page': '980'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10870', 'display_name': 'Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10870', 'display_name': 'Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10549', 'display_name': 'Neonatal Respiratory Health Research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11356', 'display_name': 'Pleural and Pulmonary Diseases', 'score': 0.977, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/surfactant-protein-c', 'display_name': 'Surfactant protein C', 'score': 0.9360555}], 'concepts': [{'id': 'https://openalex.org/C2778729956', 'wikidata': 'https://www.wikidata.org/wiki/Q7646058', 'display_name': 'Surfactant protein C', 'level': 3, 'score': 0.9360555}, {'id': 'https://openalex.org/C2778341716', 'wikidata': 'https://www.wikidata.org/wiki/Q2290446', 'display_name': 'Idiopathic pulmonary fibrosis', 'level': 3, 'score': 0.6775892}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6421575}, {'id': 'https://openalex.org/C2781244666', 'wikidata': 'https://www.wikidata.org/wiki/Q32446', 'display_name': 'Pulmonary fibrosis', 'level': 3, 'score': 0.58930624}, {'id': 'https://openalex.org/C2777543607', 'wikidata': 'https://www.wikidata.org/wiki/Q1153419', 'display_name': 'Interstitial lung disease', 'level': 3, 'score': 0.5549986}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.46206933}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.45537505}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.41370106}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.36671686}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.32725665}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23408386}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.22080678}, {'id': 'https://openalex.org/C2780559512', 'wikidata': 'https://www.wikidata.org/wiki/Q605709', 'display_name': 'Fibrosis', 'level': 2, 'score': 0.21648186}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.13562623}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017563', 'descriptor_name': 'Lung Diseases, Interstitial', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D037721', 'descriptor_name': 'Pulmonary Surfactant-Associated Protein C', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005784', 'descriptor_name': 'Gene Amplification', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006579', 'descriptor_name': 'Heterozygote', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017563', 'descriptor_name': 'Lung Diseases, Interstitial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037721', 'descriptor_name': 'Pulmonary Surfactant-Associated Protein C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/thx.2004.026336', 'pdf_url': 'https://thorax.bmj.com/content/thoraxjnl/59/11/977.full.pdf', 'source': {'id': 'https://openalex.org/S106546978', 'display_name': 'Thorax', 'issn_l': '0040-6376', 'issn': ['0040-6376', '1468-3296'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1746860', 'pdf_url': 'https://europepmc.org/articles/pmc1746860?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1746860', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15516475', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/thx.2004.026336', 'pdf_url': 'https://thorax.bmj.com/content/thoraxjnl/59/11/977.full.pdf', 'source': {'id': 'https://openalex.org/S106546978', 'display_name': 'Thorax', 'issn_l': '0040-6376', 'issn': ['0040-6376', '1468-3296'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.73, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1966959414', 'https://openalex.org/W1996682753', 'https://openalex.org/W1998579506', 'https://openalex.org/W2011788706', 'https://openalex.org/W2029074080', 'https://openalex.org/W2037443445', 'https://openalex.org/W2071746055', 'https://openalex.org/W2106672926', 'https://openalex.org/W2107367358', 'https://openalex.org/W2129682060', 'https://openalex.org/W2133937594', 'https://openalex.org/W2136114918', 'https://openalex.org/W2144017344', 'https://openalex.org/W2150448842', 'https://openalex.org/W2151119895', 'https://openalex.org/W2160856572', 'https://openalex.org/W2165871186', 'https://openalex.org/W2315096416', 'https://openalex.org/W2321791250', 'https://openalex.org/W2416914730', 'https://openalex.org/W2626588662', 'https://openalex.org/W2740355891', 'https://openalex.org/W313369389', 'https://openalex.org/W4256033448'], 'related_works': ['https://openalex.org/W4367606959', 'https://openalex.org/W4327934586', 'https://openalex.org/W4311503197', 'https://openalex.org/W4309181476', 'https://openalex.org/W3190722030', 'https://openalex.org/W3028948813', 'https://openalex.org/W2921455299', 'https://openalex.org/W2883658117', 'https://openalex.org/W2743918347', 'https://openalex.org/W2149476949'], 'abstract_inverted_index': {'While': [0], 'idiopathic': [1], 'pulmonary': [2, 26, 53, 86], 'fibrosis': [3, 27], '(IPF)': [4], 'is': [5, 20], 'one': [6, 56, 142, 185], 'of': [7, 12, 18, 25, 35, 52, 63, 79, 85, 96, 99, 143, 173, 211, 236, 241], 'the': [8, 16, 36, 73, 129, 174, 182, 188, 234, 239], 'most': [9], 'common': [10], 'forms': [11, 34, 51], 'interstitial': [13, 70, 103], 'lung': [14], 'disease,': [15], 'aetiology': [17], 'IPF': [19, 135, 237], 'poorly': [21], 'understood.': [22], 'Familial': [23], 'cases': [24, 84, 98], 'suggest': [28], 'a': [29, 61, 94, 151, 160, 167, 208, 212], 'genetic': [30, 42], 'basis': [31], 'for': [32, 90, 107], 'some': [33], 'disease.': [37], 'Recent': [38], 'reports': [39], 'have': [40], 'linked': [41], 'mutations': [43, 92, 229], 'in': [44, 59, 82, 93, 111, 128, 134, 139, 150, 153, 166, 169, 187, 215, 220, 238], 'surfactant': [45], 'protein': [46, 176], 'C': [47, 163], '(SFTPC)': [48], 'with': [49, 68, 115, 119], 'familial': [50, 83], 'fibrosis,': [54, 87], 'including': [55], 'large': [57], 'family': [58, 64], 'which': [60], 'number': [62], 'members': [65], 'were': [66, 132, 192, 202], 'diagnosed': [67, 114], 'usual': [69], 'pneumonitis': [71, 104], '(UIP),': [72], 'pathological': [74], 'correlate': [75], 'to': [76, 162, 179, 233], 'IPF.': [77], 'Because': [78], 'this': [80, 158, 221], 'finding': [81], 'we': [88], 'searched': [89], 'SFTPC': [91, 108, 130, 216, 228], 'cohort': [95], 'sporadic': [97, 242], 'UIP': [100], 'and': [101, 121, 137, 200], 'non-specific': [102], '(NSIP).The': [105], 'gene': [106], 'was': [109, 186], 'sequenced': [110], '89': [112], 'patients': [113, 118, 136], 'UIP,': [116], '46': [117], 'NSIP,': [120], '104': [122], 'normal': [123], 'controls.Ten': [124], 'single': [125], 'nucleotide': [126], 'polymorphisms': [127], 'sequence': [131, 198], 'found': [133], 'not': [138, 231], 'controls.': [140], 'Only': [141], 'these': [144], 'created': [145], 'an': [146], 'exonic': [147, 193], 'change': [148, 152, 168], 'resulting': [149], 'amino': [154, 170, 196], 'acid': [155, 171, 197], 'sequence.': [156], 'In': [157], 'case,': [159], 'T': [161], 'substitution': [164], 'resulted': [165], '73': [172], 'precursor': [175], 'from': [177], 'isoleucine': [178], 'threonine.': [180], 'Of': [181], 'remaining': [183], 'polymorphisms,': [184], "5'": [189], 'UTR,': [190], 'two': [191], 'without': [194], 'predicted': [195], 'changes,': [199], 'six': [201], 'intronic.': [203], 'One': [204], 'intronic': [205], 'mutation': [206], 'suggested': [207], 'potential': [209], 'enhancement': [210], 'splicing': [213], 'site.Mutations': [214], 'are': [217], 'identified': [218], 'infrequently': [219], 'patient': [222], 'population.': [223], 'These': [224], 'findings': [225], 'indicate': [226], 'that': [227], 'do': [230], 'contribute': [232], 'pathogenesis': [235], 'majority': [240], 'cases.': [243]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2150943858', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-12-15T08:35:20.128428', 'created_date': '2016-06-24'}