Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2150842023', 'doi': 'https://doi.org/10.1146/annurev.iy.12.040194.004015', 'title': 'C5A Anaphylatoxin and Its Seven Transmembrane-Segment Receptor', 'display_name': 'C5A Anaphylatoxin and Its Seven Transmembrane-Segment Receptor', 'publication_year': 1994, 'publication_date': '1994-04-01', 'ids': {'openalex': 'https://openalex.org/W2150842023', 'doi': 'https://doi.org/10.1146/annurev.iy.12.040194.004015', 'mag': '2150842023', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8011297'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev.iy.12.040194.004015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S109088427', 'display_name': 'Annual Review of Immunology', 'issn_l': '0732-0582', 'issn': ['0732-0582', '1545-3278'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086198020', 'display_name': 'Craig Gerard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'C Gerard', 'raw_affiliation_strings': ["Ina Sue Perlmutter Laboratory, Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts."], 'affiliations': [{'raw_affiliation_string': "Ina Sue Perlmutter Laboratory, Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.", 'institution_ids': ['https://openalex.org/I1288882113', 'https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112337898', 'display_name': 'N P Gerard', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'N P Gerard', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.616, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 418, 'citation_normalized_percentile': {'value': 0.948441, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '12', 'issue': '1', 'first_page': '775', 'last_page': '808'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lineage', 'display_name': 'Lineage (genetic)', 'score': 0.5428183}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.891524}, {'id': 'https://openalex.org/C51785407', 'wikidata': 'https://www.wikidata.org/wiki/Q2627568', 'display_name': 'Effector', 'level': 2, 'score': 0.6930716}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.581819}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.5730226}, {'id': 'https://openalex.org/C2776817793', 'wikidata': 'https://www.wikidata.org/wiki/Q6553369', 'display_name': 'Lineage (genetic)', 'level': 3, 'score': 0.5428183}, {'id': 'https://openalex.org/C24530287', 'wikidata': 'https://www.wikidata.org/wiki/Q424204', 'display_name': 'Transmembrane protein', 'level': 3, 'score': 0.50774586}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49803185}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.44303817}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.22508726}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.19804618}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14056799}], 'mesh': [{'descriptor_ui': 'D015936', 'descriptor_name': 'Complement C5a', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011951', 'descriptor_name': 'Receptors, Complement', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015936', 'descriptor_name': 'Complement C5a', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015936', 'descriptor_name': 'Complement C5a', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044087', 'descriptor_name': 'Receptor, Anaphylatoxin C5a', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011951', 'descriptor_name': 'Receptors, Complement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011951', 'descriptor_name': 'Receptors, Complement', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev.iy.12.040194.004015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S109088427', 'display_name': 'Annual Review of Immunology', 'issn_l': '0732-0582', 'issn': ['0732-0582', '1545-3278'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8011297', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.77, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 104, 'referenced_works': ['https://openalex.org/W1007663042', 'https://openalex.org/W121092139', 'https://openalex.org/W14378625', 'https://openalex.org/W1482532981', 'https://openalex.org/W1499561687', 'https://openalex.org/W1510824418', 'https://openalex.org/W1521324013', 'https://openalex.org/W1530792946', 'https://openalex.org/W1535481983', 'https://openalex.org/W1541068518', 'https://openalex.org/W1551543540', 'https://openalex.org/W1563846221', 'https://openalex.org/W1564932287', 'https://openalex.org/W1574909924', 'https://openalex.org/W1590050758', 'https://openalex.org/W1595134608', 'https://openalex.org/W1602266368', 'https://openalex.org/W169718174', 'https://openalex.org/W1711579440', 'https://openalex.org/W1751024125', 'https://openalex.org/W1762256219', 'https://openalex.org/W1867704897', 'https://openalex.org/W1900859431', 'https://openalex.org/W1901858952', 'https://openalex.org/W1911780819', 'https://openalex.org/W1943657380', 'https://openalex.org/W1961046981', 'https://openalex.org/W1963610024', 'https://openalex.org/W1963657283', 'https://openalex.org/W1965046685', 'https://openalex.org/W1966055576', 'https://openalex.org/W1971082185', 'https://openalex.org/W1973444197', 'https://openalex.org/W1981821724', 'https://openalex.org/W1985259310', 'https://openalex.org/W1985590866', 'https://openalex.org/W1990894517', 'https://openalex.org/W1991392777', 'https://openalex.org/W1993884809', 'https://openalex.org/W2001118906', 'https://openalex.org/W2005529016', 'https://openalex.org/W2007332219', 'https://openalex.org/W2008509191', 'https://openalex.org/W2009734396', 'https://openalex.org/W2010701203', 'https://openalex.org/W2012982812', 'https://openalex.org/W2013537752', 'https://openalex.org/W2014614869', 'https://openalex.org/W2015999532', 'https://openalex.org/W2023115427', 'https://openalex.org/W2023750079', 'https://openalex.org/W2024875771', 'https://openalex.org/W2025883436', 'https://openalex.org/W2027344845', 'https://openalex.org/W2036259182', 'https://openalex.org/W2037239040', 'https://openalex.org/W2038792816', 'https://openalex.org/W2044090906', 'https://openalex.org/W2048669565', 'https://openalex.org/W2059327659', 'https://openalex.org/W2066092834', 'https://openalex.org/W2069784067', 'https://openalex.org/W2069818304', 'https://openalex.org/W2074651910', 'https://openalex.org/W2077883691', 'https://openalex.org/W2082445308', 'https://openalex.org/W2087825515', 'https://openalex.org/W2088532612', 'https://openalex.org/W2090109532', 'https://openalex.org/W2090762224', 'https://openalex.org/W2091484729', 'https://openalex.org/W2095417745', 'https://openalex.org/W2099233769', 'https://openalex.org/W21061013', 'https://openalex.org/W2108676263', 'https://openalex.org/W2109460872', 'https://openalex.org/W2114919214', 'https://openalex.org/W2114930069', 'https://openalex.org/W2115663586', 'https://openalex.org/W2123884323', 'https://openalex.org/W2133318613', 'https://openalex.org/W2136537674', 'https://openalex.org/W2147355353', 'https://openalex.org/W2149276471', 'https://openalex.org/W2168792260', 'https://openalex.org/W2170159525', 'https://openalex.org/W2172019543', 'https://openalex.org/W2172053715', 'https://openalex.org/W2176220887', 'https://openalex.org/W2182218622', 'https://openalex.org/W2198367915', 'https://openalex.org/W2220511760', 'https://openalex.org/W2286744586', 'https://openalex.org/W2307355608', 'https://openalex.org/W2332263596', 'https://openalex.org/W2339184887', 'https://openalex.org/W2397109931', 'https://openalex.org/W2411292281', 'https://openalex.org/W2412270304', 'https://openalex.org/W2416373453', 'https://openalex.org/W2416827394', 'https://openalex.org/W2418408631', 'https://openalex.org/W2440085321', 'https://openalex.org/W71208058'], 'related_works': ['https://openalex.org/W4361859344', 'https://openalex.org/W4244511512', 'https://openalex.org/W4237190809', 'https://openalex.org/W4231043616', 'https://openalex.org/W2113581200', 'https://openalex.org/W2112070235', 'https://openalex.org/W2038526933', 'https://openalex.org/W2013185554', 'https://openalex.org/W1985830493', 'https://openalex.org/W1966074302'], 'abstract_inverted_index': {'Exhausted': [0], 'CD8': [1], 'T': [2], '(Tex)': [3], 'cells': [4, 23], 'are': [5, 24], 'a': [6], 'distinct': [7], 'cell': [8], 'lineage': [9], 'that': [10], 'arise': [11], 'during': [12], 'chronic': [13], 'infections': [14], 'and': [15, 20, 33], 'cancers': [16], 'in': [17], 'animal': [18], 'models': [19], 'humans.': [21], 'Tex': [22], 'characterized': [25], 'by': [26], 'progressive': [27], 'loss': [28], 'of': [29], 'effector': [30], 'functions,': [31], 'high': [32], 'sustained': [34], 'inhibitory': [35], 'receptor': [36], 'expression,': [37], '...Read': [38], 'More': [39]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2150842023', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 16}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-08T20:45:38.998619', 'created_date': '2016-06-24'}