Title: Transforming Growth Factor‐β in Rheumatoid Arthritis
Abstract: Annals of the New York Academy of SciencesVolume 593, Issue 1 p. 197-207 Transforming Growth Factor-β in Rheumatoid Arthritis RONALD L. WILDER, RONALD L. WILDER Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland Address reprint requests to Dr. Wilder at National Institutes of Health, Building 10, Room 9N240, Bethesda, MD 20892.Search for more papers by this authorROBERT LAFYATIS, ROBERT LAFYATIS Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MarylandSearch for more papers by this authorANITA B. ROBERTS, ANITA B. ROBERTS Laboratory of Chemoprevention National Cancer Institute National Institutes of Health, Bethesda, MarylandSearch for more papers by this authorJOHN P. CASE, JOHN P. CASE Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MarylandSearch for more papers by this authorGREGORY K. KUMKUMIAN, GREGORY K. KUMKUMIAN Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MarylandSearch for more papers by this authorHAJIME SANO, HAJIME SANO Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MarylandSearch for more papers by this authorMICHAEL B. SPORN, MICHAEL B. SPORN Laboratory of Chemoprevention National Cancer Institute National Institutes of Health, Bethesda, MarylandSearch for more papers by this authorELAINE F. REMMERS, ELAINE F. REMMERS Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MarylandSearch for more papers by this author RONALD L. WILDER, RONALD L. WILDER Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland Address reprint requests to Dr. Wilder at National Institutes of Health, Building 10, Room 9N240, Bethesda, MD 20892.Search for more papers by this authorROBERT LAFYATIS, ROBERT LAFYATIS Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MarylandSearch for more papers by this authorANITA B. ROBERTS, ANITA B. ROBERTS Laboratory of Chemoprevention National Cancer Institute National Institutes of Health, Bethesda, MarylandSearch for more papers by this authorJOHN P. CASE, JOHN P. CASE Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MarylandSearch for more papers by this authorGREGORY K. KUMKUMIAN, GREGORY K. KUMKUMIAN Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MarylandSearch for more papers by this authorHAJIME SANO, HAJIME SANO Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MarylandSearch for more papers by this authorMICHAEL B. SPORN, MICHAEL B. SPORN Laboratory of Chemoprevention National Cancer Institute National Institutes of Health, Bethesda, MarylandSearch for more papers by this authorELAINE F. REMMERS, ELAINE F. REMMERS Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MarylandSearch for more papers by this author First published: June 1990 https://doi.org/10.1111/j.1749-6632.1990.tb16112.xCitations: 29 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Decker, J. L., D. G. Malone, B. Haraoui, S. M. Wahl, L. Schrieber, J. H. Klippel, A. D. Steinberg & R. L. Wilder. 1984. Evolving concepts of pathogenesis and therapy of rheumatoid arthritis. Ann. Intern. Med. 101: 810–824. 10.7326/0003-4819-101-6-810 CASPubMedWeb of Science®Google Scholar 2 P. Utsinger, N. Zvaifler & G. Ehrlich, Eds. 1985. Rheumatoid Arthritis. J. B. Lippincott Co., Philadelphia , PA . Web of Science®Google Scholar 3 Harris E. D. Jr. 1986. Pathogenesis of rheumatoid arthritis. In Textbook of Rheumatology, W. N. Kelley, E. D. Harris, S. Ruddy & C. B. Sledge, Eds.: 886–915. W. B. Saunders Company, Philadelphia , PA . Google Scholar 4 Sporn, M. B., A. B. Roberts, L. M. Wakefield & B. De Combrugghe. 1987. Some recent advances in the chemistry and biology of transforming growth factor-beta. J. Cell Biol. 105: 1039–1045. 10.1083/jcb.105.3.1039 CASPubMedWeb of Science®Google Scholar 5 Kulka, J. P., D. Bocking, M. W. Ropes & W. Bauer. 1955. Early joint lesions of rheumatoid arthritis. Arch Pathol. 59: 129–150. PubMedWeb of Science®Google Scholar 6 Schumacher, H. R. & R. C. Kitridou. 1972. Synovitis of recent onset. A clinicopathologic study during the first month of disease. Arthritis Rheum. 15: 465–485. 10.1002/art.1780150502 CASPubMedWeb of Science®Google Scholar 7 Bromley, M. & D. E. Woolley. 1984. Histopathology of the rheumatoid lesion. Identification of cell types at the sites of cartilage erosion. Arthritis Rheum. 27: 857–863. 10.1002/art.1780270804 CASPubMedWeb of Science®Google Scholar 8 Fassbender, H. G. 1983. Histomorphological basis of articular cartilage destruction in rheumatoid arthritis. Collagen Rel. Res. 3: 141–155. 10.1016/S0174-173X(83)80040-5 CASPubMedWeb of Science®Google Scholar 9 Woolley, D. E., L. C. Tetlow & J. M. Evanston. 1973. Collagenase immunolocalization at sites of cartilage erosion in the rheumatoid joint. Arthritis Rheum. 20: 1231–1239. 10.1002/art.1780200612 Web of Science®Google Scholar 10 Case, J. P., R. Lafyatis, E. F. Remmers & R. L. Wilder. 1989. Transin/stromelysin and erosion of bone and cartilage in rheumatoid arthritis and streptococcal cell wall (SCW) arthritis in LEW/N rats. Arthritis Rheum. 32: 558 (abstract). Google Scholar 11 Fava, R., N. Olsen, J. Keski-Oja, H. Moses & T. Pincus. 1988. Active and latent forms of TGF-beta activity in synovial effusions. J. Exp. Med. 169: 291–296. 10.1084/jem.169.1.291 PubMedWeb of Science®Google Scholar 12 Lafyatis, R., N. Thompson, E. Remmers, K. Flanders, A. Roberts, M. Sporn & R. L. Wilder. 1988. Demonstration of local production of PDGF and TGF-beta by synovial tissue from patients with rheumatoid arthritis. Arthritis Rheum. 31: S62 (abstract). Google Scholar 13 Lafyatis, R., N. L. Thompson, E. F. Remmers, K. C. Flanders, N. S. Roche, S.-J. Kim, J. P. Case, M. B. Sporn, A. B. Roberts & R. L. Wilder. 1989. TGF-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats: studies on secretion by synovial fibroblast-like cells and immunohistologic localization. J. Immunol. 143: 1142–1148. CASPubMedWeb of Science®Google Scholar 14 Chandrasekhar, S. & A. K. Harvey. 1988. Transforming growth factor-beta is a potent inhibitor of IL-1 induced protease activity and cartilage proteoglycan degradation. Biochem. Biophy. Res. Commun. 157: 1352–1359. 10.1016/S0006-291X(88)81024-6 CASPubMedWeb of Science®Google Scholar 15 Edwards, D. R., G. Murphy, J. Reynolds, S. E. Whitham, A. J. P. Docherty, P. Angel & J. K. Heath. 1987. Transforming growth factor-beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J. 6: 1899–1904. 10.1002/j.1460-2075.1987.tb02449.x CASPubMedWeb of Science®Google Scholar 16 Machida, C. M., L. L. Muldoon, K. D. Rodland & B. E. Magun. 1988. Transcriptional modulation of transforming growth factor-beta. Mol. Cell. Biol. 8: 2479–2483. 10.1128/MCB.8.6.2479 CASPubMedWeb of Science®Google Scholar 17 Lafyatis, R., E. F. Remmers, A. S. Roberts, D. E. Yocum, M. B. Sporn & R. L. Wilder. 1989. Anchorage-independent growth of synoviocytes from arthritic and normal joints: Stimulation by exogenous platelet derived growth factor and inhibition by transforming growth factor-beta and retinoids. J. Clin. Invest. 83: 1267–1276. 10.1172/JCI114011 CASPubMedWeb of Science®Google Scholar 18 Remmers, E. F., N. Thompson, R. Lafyatis, K. Flanders, D. Yocum, A. Roberts, M. B. Sporn & R. L. Wilder. 1988. Regulation of rheumatoid synoviocyte proliferation by PDGF, TGF-beta, EGF, IL-1 and TNF-alpha. FASEB J. 2: A1598 (abstract). Web of Science®Google Scholar 19 Brinckerhoff, C. E. 1983. Morphologic and mitogenic responses of rabbit synovial fibroblasts to transforming growth factor beta require transforming growth factor alpha or epidermal growth factor. Arthritis. Rheum. 26: 1370–1379. 10.1002/art.1780261110 CASPubMedWeb of Science®Google Scholar 20 Redini, R., A. Galera, A. Mauviel, G. Layau & J.-P. Pujol. 1988. Transforming growth factor-beta stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes. FEGS Lett. 234: 172–176. 10.1016/0014-5793(88)81327-9 CASPubMedWeb of Science®Google Scholar 21 Morales, T. I. & A. B. Roberts. 1988. Transforming growth factor-beta regulates the metabolism of proteoglycans in bovine cartilage organ cultures. J. Biol. Chem. 263: 12828–12831. CASPubMedWeb of Science®Google Scholar 22 Chenu, C., J. Pfeilschifter, G. R. Mundy & G. D. Roodman. 1988. Transforming growth factor-beta inhibits formation of osteoclast-like cells in long term human marrow cultures. Proc. Natl. Acad. Sci. USA 85: 5683–5687. 10.1073/pnas.85.15.5683 CASPubMedWeb of Science®Google Scholar 23 Canalis, E. & J. B. Lian. 1988. Effects of bone associated growth factors on DNA, collagen and osteocalcin synthesis in cultured rat calvariae. Bone 9: 243–246. 10.1016/8756-3282(88)90037-3 CASPubMedWeb of Science®Google Scholar 24 Pfeilschifter, J., S. M. Seyedin & G. R. Mundy. 1988. Transforming growth factor-beta inhibits bone resorption in fetal rat long bone cultures. J. Clin. Invest. 82: 680–685. 10.1172/JCI113647 CASPubMedWeb of Science®Google Scholar 25 Muller, G., J. Behrens, U. Nussbaumer, P. Bohlen & W. Birchmeier. 1987. Inhibitory action of transforming growth factor beta on endothelial cells. Proc. Natl. Acad. Sci. USA 84: 5600–5604. 10.1073/pnas.84.16.5600 PubMedWeb of Science®Google Scholar 26 Wahl, S. M., D. A. Hunt, L. M. Wakefield, N. McCartney-Francis, L. Wahl, A. B. Roberts & M. B. Sporn. 1987. Transforming growth factor-beta induces monocyte chemotaxis and growth factor production. Proc. Natl. Acad. Sci. USA 84: 5788–5792. 10.1073/pnas.84.16.5788 CASPubMedWeb of Science®Google Scholar 27 Strassman, G., M. D. Cole & W. Newman. 1988. Regulation of colony-stimulating factor 1-dependent macrophage precursor proliferation by type beta transforming growth factor. J. Immunol. 140: 2645–2651. PubMedWeb of Science®Google Scholar 28 Tsunawaki, S., M. Sporn, A. Ding & C. Nathan. 1988. Deactivation of macrophages by transforming growth factor-beta. Nature 334: 260–262. 10.1038/334260a0 CASPubMedWeb of Science®Google Scholar 29 Wahl, S. M., D. A. Hunt, S. Wong, S. Dougherty, N. McCartney-Francis, L. M. Wahl, L. Ellingsworth, J. A. Schmidt, G. Hall, A. B. Roberts & M. B. Sporn. 1988. Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1 dependent lymphocyte proliferation. J. Immunol. 140: 3026–3032. CASPubMedWeb of Science®Google Scholar 30 Mule, J. J., S. L. Schwarz, A. B. Roberts, M. B. Sporn & S. A. Rosenberg. 1988. Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells. Cancer Immunol. Immunother. 26: 95–100. 10.1007/BF00205600 CASPubMedWeb of Science®Google Scholar Citing Literature Volume593, Issue1Transforming Growth Factors: Chemistry, Biology, and TherapeuticsJune 1990Pages 197-207 ReferencesRelatedInformation
Publication Year: 1990
Publication Date: 1990-06-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 39
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot