Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2150196410', 'doi': 'https://doi.org/10.1093/jac/dkn319', 'title': 'Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug design', 'display_name': 'Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug design', 'publication_year': 2008, 'publication_date': '2008-08-11', 'ids': {'openalex': 'https://openalex.org/W2150196410', 'doi': 'https://doi.org/10.1093/jac/dkn319', 'mag': '2150196410', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18694906'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/dkn319', 'pdf_url': 'https://academic.oup.com/jac/article-pdf/62/5/998/16862392/dkn319.pdf', 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/jac/article-pdf/62/5/998/16862392/dkn319.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113688768', 'display_name': 'Pragya Misra', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Pragya Misra', 'raw_affiliation_strings': ['Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070437118', 'display_name': 'Tanvir Khaliq', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Tanvir Khaliq', 'raw_affiliation_strings': ['Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009132569', 'display_name': 'Anshuman Dixit', 'orcid': 'https://orcid.org/0000-0001-8063-7893'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Anshuman Dixit', 'raw_affiliation_strings': ['Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073122376', 'display_name': 'Souvik Sengupta', 'orcid': 'https://orcid.org/0000-0001-7452-979X'}, 'institutions': [{'id': 'https://openalex.org/I160344538', 'display_name': 'Indian Institute of Chemical Biology', 'ror': 'https://ror.org/01kh0x418', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I160344538', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Souvik SenGupta', 'raw_affiliation_strings': ['Department of Molecular Parasitology, Indian Institute of Chemical Biology, Kolkata 700032, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Parasitology, Indian Institute of Chemical Biology, Kolkata 700032, India', 'institution_ids': ['https://openalex.org/I160344538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005116678', 'display_name': 'Mukesh Samant', 'orcid': 'https://orcid.org/0000-0002-0154-2421'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Mukesh Samant', 'raw_affiliation_strings': ['Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100860500', 'display_name': 'Shraddha Kumari', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Shraddha Kumari', 'raw_affiliation_strings': ['Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004422727', 'display_name': 'Awanish Kumar', 'orcid': 'https://orcid.org/0000-0001-8735-479X'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Awanish Kumar', 'raw_affiliation_strings': ['Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091112687', 'display_name': 'Pramod Kumar Kushawaha', 'orcid': 'https://orcid.org/0000-0002-6186-0456'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Pramod K. Kushawaha', 'raw_affiliation_strings': ['Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055196554', 'display_name': 'Hemanta K. Majumder', 'orcid': 'https://orcid.org/0000-0001-5438-6779'}, 'institutions': [{'id': 'https://openalex.org/I160344538', 'display_name': 'Indian Institute of Chemical Biology', 'ror': 'https://ror.org/01kh0x418', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I160344538', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'H. K. Majumder', 'raw_affiliation_strings': ['Department of Molecular Parasitology, Indian Institute of Chemical Biology, Kolkata 700032, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Parasitology, Indian Institute of Chemical Biology, Kolkata 700032, India', 'institution_ids': ['https://openalex.org/I160344538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101687710', 'display_name': 'Anil K. Saxena', 'orcid': 'https://orcid.org/0000-0002-0212-7246'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Anil K. Saxena', 'raw_affiliation_strings': ['Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075946768', 'display_name': 'Tadigoppula Narender', 'orcid': 'https://orcid.org/0000-0002-2290-2764'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'T. Narender', 'raw_affiliation_strings': ['Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076603228', 'display_name': 'Anuradha Dube', 'orcid': 'https://orcid.org/0000-0002-5122-400X'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'Anuradha Dube', 'raw_affiliation_strings': ['Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5076603228'], 'corresponding_institution_ids': ['https://openalex.org/I185249246'], 'apc_list': {'value': 2627, 'currency': 'GBP', 'value_usd': 3222, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.576, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 46, 'citation_normalized_percentile': {'value': 0.870982, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '62', 'issue': '5', 'first_page': '998', 'last_page': '1002'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13188', 'display_name': 'Synthesis and bioactivity of alkaloids', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13188', 'display_name': 'Synthesis and bioactivity of alkaloids', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10823', 'display_name': 'Research on Leishmaniasis Studies', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13160', 'display_name': 'Synthesis and Biological Evaluation', 'score': 0.9893, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.7719043}, {'id': 'https://openalex.org/C2781333301', 'wikidata': 'https://www.wikidata.org/wiki/Q1950752', 'display_name': 'Leishmania donovani', 'level': 4, 'score': 0.7467671}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.67949927}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.58135647}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.48693192}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.4228537}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.39868054}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34442943}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.34073046}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.097284466}, {'id': 'https://openalex.org/C2776555147', 'wikidata': 'https://www.wikidata.org/wiki/Q331283', 'display_name': 'Leishmaniasis', 'level': 2, 'score': 0.076393366}, {'id': 'https://openalex.org/C2778689377', 'wikidata': 'https://www.wikidata.org/wiki/Q2046113', 'display_name': 'Visceral leishmaniasis', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000470', 'descriptor_name': 'Alkaloids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000981', 'descriptor_name': 'Antiprotozoal Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007893', 'descriptor_name': 'Leishmania donovani', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000470', 'descriptor_name': 'Alkaloids', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D000470', 'descriptor_name': 'Alkaloids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000981', 'descriptor_name': 'Antiprotozoal Agents', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D000981', 'descriptor_name': 'Antiprotozoal Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007893', 'descriptor_name': 'Leishmania donovani', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059004', 'descriptor_name': 'Topoisomerase I Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/dkn319', 'pdf_url': 'https://academic.oup.com/jac/article-pdf/62/5/998/16862392/dkn319.pdf', 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18694906', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/dkn319', 'pdf_url': 'https://academic.oup.com/jac/article-pdf/62/5/998/16862392/dkn319.pdf', 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.76, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1973934517', 'https://openalex.org/W2014662504', 'https://openalex.org/W2018026783', 'https://openalex.org/W2030686695', 'https://openalex.org/W2030690248', 'https://openalex.org/W2037082550', 'https://openalex.org/W2045203645', 'https://openalex.org/W2063993053', 'https://openalex.org/W2064182879', 'https://openalex.org/W2069131106', 'https://openalex.org/W2084944743', 'https://openalex.org/W2093871819'], 'related_works': ['https://openalex.org/W2890574245', 'https://openalex.org/W2400412854', 'https://openalex.org/W2141064514', 'https://openalex.org/W2100049223', 'https://openalex.org/W2097697790', 'https://openalex.org/W2094941924', 'https://openalex.org/W2047893495', 'https://openalex.org/W2020684201', 'https://openalex.org/W1996910582', 'https://openalex.org/W1954622523'], 'abstract_inverted_index': {'The': [0, 166], 'aim': [1], 'of': [2, 36, 41, 53, 65, 87, 127, 132, 148, 153], 'this': [3], 'study': [4], 'was': [5, 43, 102, 118], 'to': [6, 83, 120], 'resolve': [7], 'the': [8, 69, 85, 125], 'putative': [9], 'pathway': [10], 'responsible': [11], 'for': [12], 'death': [13], 'induced': [14], 'by': [15, 98], 'peganine': [16, 88, 99], 'hydrochloride': [17, 89, 100, 113], 'dihydrate': [18, 90, 101], 'isolated': [19], 'from': [20], 'Peganum': [21], 'harmala': [22], 'seeds': [23], 'at': [24], 'cellular,': [25], 'structural': [26], 'and': [27, 57, 73, 180], 'molecular': [28, 74], 'level': [29], 'in': [30, 58, 68, 123, 164, 177], 'Leishmania': [31], 'donovani,': [32], 'a': [33, 141, 157, 161], 'causative': [34], 'agent': [35], 'fatal': [37], 'visceral': [38], 'leishmaniasis.The': [39], 'mode': [40], 'action': [42], 'assessed': [44, 104], 'using': [45, 105], 'various': [46], 'biochemical': [47], 'approaches': [48], 'including': [49], 'phosphatidylserine': [50], 'exposure,': [51], 'estimation': [52], 'mitochondrial': [54, 133], 'transmembrane': [55, 134], 'potential': [56], 'situ': [59], 'dUTP': [60], 'nick': [61], 'end': [62], 'labelling': [63], 'staining': [64], 'nicked': [66], 'DNA': [67, 80, 94, 145, 182], 'parasite.': [70], 'Molecular': [71, 136], 'modelling': [72], 'dynamics': [75], 'studies': [76, 138], 'were': [77], 'conducted': [78], 'with': [79, 144], 'topoisomerase': [81, 95, 109, 146, 172, 183], 'I': [82, 96, 110, 147], 'identify': [84], 'target': [86], 'mediating': [91], 'apoptosis.': [92, 165], 'Further,': [93], 'inhibition': [97], 'also': [103, 168], 'an': [106], 'L.': [107, 128, 149, 170, 178], 'donovani': [108, 129, 150, 171, 179], 'relaxation': [111], 'assay.Peganine': [112], 'dihydrate,': [114], 'besides': [115], 'being': [116], 'safe,': [117], 'found': [119], 'induce': [121], 'apoptosis': [122, 176], 'both': [124], 'stages': [126], 'via': [130], 'loss': [131], 'potential.': [135], 'docking': [137], 'suggest': [139], 'that': [140], 'binding': [142], 'interaction': [143], '(binding': [151], 'energy': [152], '-79': [154], 'kcal/mol)': [155], 'forms': [156], 'stable': [158], 'complex,': [159], 'indicating': [160], 'possible': [162], 'role': [163], 'compound': [167, 174], 'inhibits': [169, 181], 'I.The': [173], 'induces': [175], 'I.': [184]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2150196410', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-07T08:10:49.811684', 'created_date': '2016-06-24'}