Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2150111959', 'doi': 'https://doi.org/10.1002/path.1113', 'title': 'Cyclin D1 overexpression in colorectal carcinoma <i>in vivo</i> is dependent on β‐catenin protein dysregulation, but not <i>k‐ras</i> mutation', 'display_name': 'Cyclin D1 overexpression in colorectal carcinoma <i>in vivo</i> is dependent on β‐catenin protein dysregulation, but not <i>k‐ras</i> mutation', 'publication_year': 2002, 'publication_date': '2002-04-10', 'ids': {'openalex': 'https://openalex.org/W2150111959', 'doi': 'https://doi.org/10.1002/path.1113', 'mag': '2150111959', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12081197'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/path.1113', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4394736614', 'display_name': 'The Journal of Pathology', 'issn_l': '0022-3417', 'issn': ['0022-3417', '1096-9896'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083642298', 'display_name': 'Newton A C S Wong', 'orcid': 'https://orcid.org/0000-0002-9537-4106'}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'N. A. C. S. Wong', 'raw_affiliation_strings': ['Department of Pathology, University of Edinburgh Medical School, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Edinburgh Medical School, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016175437', 'display_name': 'Russell E. Morris', 'orcid': 'https://orcid.org/0000-0001-7809-0315'}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'R. G. Morris', 'raw_affiliation_strings': ['Department of Pathology, University of Edinburgh Medical School, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Edinburgh Medical School, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036612411', 'display_name': 'A. McCondochie', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'A. McCondochie', 'raw_affiliation_strings': ['Department of Pathology, University of Edinburgh Medical School, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Edinburgh Medical School, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054515079', 'display_name': 'Scott Bader', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'S. Bader', 'raw_affiliation_strings': ['Department of Pathology, University of Edinburgh Medical School, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Edinburgh Medical School, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071360446', 'display_name': 'Duncan I. Jodrell', 'orcid': 'https://orcid.org/0000-0001-9360-1670'}, 'institutions': [{'id': 'https://openalex.org/I2800150677', 'display_name': 'Western General Hospital', 'ror': 'https://ror.org/009kr6r15', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1324252669', 'https://openalex.org/I2800150677']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'D. I. Jodrell', 'raw_affiliation_strings': ['Department of Oncology, University of Edinburgh, Western General Hospital, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, University of Edinburgh, Western General Hospital, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I2800150677', 'https://openalex.org/I98677209']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064922783', 'display_name': 'David J. Harrison', 'orcid': 'https://orcid.org/0000-0001-9041-9988'}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'D. J. Harrison', 'raw_affiliation_strings': ['Department of Pathology, University of Edinburgh Medical School, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Edinburgh Medical School, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I98677209']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5083642298'], 'corresponding_institution_ids': ['https://openalex.org/I98677209'], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.874, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.76189, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '197', 'issue': '1', 'first_page': '128', 'last_page': '135'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11369', 'display_name': 'Molecular Characterization of Colorectal Cancer', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt Signaling in Development and Disease', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/beta-catenin', 'display_name': 'Beta-catenin', 'score': 0.581158}, {'id': 'https://openalex.org/keywords/cancer-risk', 'display_name': 'Cancer Risk', 'score': 0.498356}], 'concepts': [{'id': 'https://openalex.org/C30145163', 'wikidata': 'https://www.wikidata.org/wiki/Q384104', 'display_name': 'Catenin', 'level': 4, 'score': 0.7501296}, {'id': 'https://openalex.org/C199835354', 'wikidata': 'https://www.wikidata.org/wiki/Q15311861', 'display_name': 'Cyclin D1', 'level': 4, 'score': 0.7335907}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6658253}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.61938}, {'id': 'https://openalex.org/C2779324961', 'wikidata': 'https://www.wikidata.org/wiki/Q1634046', 'display_name': 'Beta-catenin', 'level': 4, 'score': 0.581158}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.5680377}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.56005013}, {'id': 'https://openalex.org/C120089663', 'wikidata': 'https://www.wikidata.org/wiki/Q59250999', 'display_name': 'Cyclin', 'level': 4, 'score': 0.4386032}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4183112}, {'id': 'https://openalex.org/C2777546739', 'wikidata': 'https://www.wikidata.org/wiki/Q33525', 'display_name': 'Carcinoma', 'level': 2, 'score': 0.4106178}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.28791347}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.25753617}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.25016016}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.2179003}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.21239725}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.17926252}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.17648676}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019938', 'descriptor_name': 'Cyclin D1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003598', 'descriptor_name': 'Cytoskeletal Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011905', 'descriptor_name': 'Genes, ras', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D019938', 'descriptor_name': 'Cyclin D1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003598', 'descriptor_name': 'Cytoskeletal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018895', 'descriptor_name': 'Microsatellite Repeats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/path.1113', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4394736614', 'display_name': 'The Journal of Pathology', 'issn_l': '0022-3417', 'issn': ['0022-3417', '1096-9896'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12081197', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'No poverty', 'id': 'https://metadata.un.org/sdg/1', 'score': 0.74}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W116477318', 'https://openalex.org/W1487239501', 'https://openalex.org/W151744451', 'https://openalex.org/W1521591962', 'https://openalex.org/W1535063911', 'https://openalex.org/W1554815317', 'https://openalex.org/W1970064594', 'https://openalex.org/W1978929236', 'https://openalex.org/W1992595726', 'https://openalex.org/W1992772703', 'https://openalex.org/W2009573109', 'https://openalex.org/W2014995450', 'https://openalex.org/W2041922550', 'https://openalex.org/W2043119648', 'https://openalex.org/W2056942951', 'https://openalex.org/W2058879168', 'https://openalex.org/W2066533843', 'https://openalex.org/W2072958478', 'https://openalex.org/W2074023677', 'https://openalex.org/W2074336818', 'https://openalex.org/W2074605890', 'https://openalex.org/W2082722418', 'https://openalex.org/W2085073302', 'https://openalex.org/W2087099184', 'https://openalex.org/W2095597543', 'https://openalex.org/W2097268444', 'https://openalex.org/W2103323335', 'https://openalex.org/W2107570915', 'https://openalex.org/W2109069210', 'https://openalex.org/W2115919351', 'https://openalex.org/W2123127082', 'https://openalex.org/W2124199533', 'https://openalex.org/W2137084288', 'https://openalex.org/W2138103542', 'https://openalex.org/W2140901152', 'https://openalex.org/W2143064763', 'https://openalex.org/W2156241873', 'https://openalex.org/W2157452165', 'https://openalex.org/W2157866949', 'https://openalex.org/W2159594827', 'https://openalex.org/W2168111211', 'https://openalex.org/W2319294235', 'https://openalex.org/W2407900052', 'https://openalex.org/W2409792414', 'https://openalex.org/W2414585151', 'https://openalex.org/W2415192845', 'https://openalex.org/W2965577516', 'https://openalex.org/W4251426261', 'https://openalex.org/W4361773877'], 'related_works': ['https://openalex.org/W4322763886', 'https://openalex.org/W2353902902', 'https://openalex.org/W2095715712', 'https://openalex.org/W2078502999', 'https://openalex.org/W2044192435', 'https://openalex.org/W2040373623', 'https://openalex.org/W2038982615', 'https://openalex.org/W2027969858', 'https://openalex.org/W2008687988', 'https://openalex.org/W1621533677'], 'abstract_inverted_index': {'Abstract': [0], 'Cyclin': [1, 105], 'D1': [2, 42, 65, 87, 106, 133, 154, 175, 181, 207], 'protein': [3, 30, 68, 195], 'overexpression': [4, 23, 88, 107, 134, 155, 176, 182, 208], 'is': [5, 13], 'commonly': [6], 'found': [7], 'in': [8, 44, 46, 50, 110, 140, 186, 209, 212], 'colorectal': [9, 210], 'carcinomas': [10], '(CRCs)': [11], 'and': [12, 32, 48, 66, 70, 73, 121, 137, 156], 'associated': [14, 116], 'with': [15, 71, 91, 98, 117, 142], 'a': [16, 96, 168], 'poorer': [17, 92, 99], 'prognosis,': [18], 'but': [19, 178, 197], 'the': [20, 126], 'mechanism': [21], 'underlying': [22], 'remains': [24], 'uncertain.': [25], 'Both': [26], 'dysregulation': [27], 'of': [28, 95, 129, 145, 171], 'β‐catenin': [29, 67, 190, 194], 'expression': [31, 43, 144], 'k‐ras': [33, 78, 157, 199], 'mutation': [34, 158], 'have': [35], 'recently': [36], 'been': [37], 'shown': [38], 'to': [39, 101, 161, 202], 'promote': [40], 'cyclin': [41, 64, 86, 132, 153, 174, 180, 206], 'human': [45], 'vitro': [47], 'rodent': [49], 'vivo': [51, 213], 'studies.': [52], 'In': [53, 192], 'this': [54], 'study,': [55], '53': [56], 'sporadic': [57], 'CRCs': [58], 'were': [59, 148], 'examined': [60], 'by': [61], 'immunohistochemistry': [62], 'for': [63, 77, 205], 'expression,': [69], 'PCR': [72], 'direct': [74], 'DNA': [75], 'sequencing': [76], 'gene': [79], 'status.': [80], 'The': [81], 'study': [82], 'also': [83], 'addressed': [84], 'whether': [85], 'might': [89], 'associate': [90], 'prognosis': [93], 'because': [94], 'relationship': [97], 'response': [100, 160], '5‐fluorouracil': [102], '(5FU)': [103], 'chemotherapy.': [104], 'was': [108, 114, 122, 135, 183], 'demonstrated': [109], '34/53': [111], '(64%)': [112], 'CRCs,': [113, 167], 'significantly': [115], 'higher': [118], "Dukes'": [119], 'stage,': [120], 'particularly': [123], 'prominent': [124], 'at': [125], 'invasive': [127], 'edges': [128], 'carcinomas.': [130], 'Furthermore,': [131], 'always': [136], 'only': [138, 184], 'seen': [139, 185], 'association': [141], 'nuclear': [143, 189], 'β‐catenin.': [146], 'There': [147], 'no': [149], 'significant': [150], 'associations': [151], 'between': [152], 'or': [159], '5FU.': [162], 'Amongst': [163], '17': [164], 'microsatellite': [165], 'unstable': [166], 'smaller': [169], 'proportion': [170], 'tumours': [172], 'showed': [173], '(18%),': [177], 'again': [179], 'cases': [187], 'showing': [188], 'expression.': [191], 'conclusion,': [193], 'dysregulation,': [196], 'not': [198], 'mutation,': [200], 'appears': [201], 'be': [203], 'required': [204], 'carcinoma': [211], '.': [214], 'Copyright': [215], '©': [216], '2002': [217], 'John': [218], 'Wiley': [219], '&': [220], 'Sons,': [221], 'Ltd.': [222]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2150111959', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-08-16T15:23:55.560148', 'created_date': '2016-06-24'}