Title: 2-Oxo-2-(phen-2-ylpyrrol-2-yl)acetamides as potential anxiolytic agents: Synthesis and affinity at the central benzodiazepine receptor
Abstract: A series of N-substituted 2-hydroxy and 2-oxo-2-(phen-1-ylpyrrol-2-yl)acetamides were synthesized and their affinity at the benzodiazepine receptor tested. Isosteric replacement of the indolyl ring in previously described derivatives by a phen-1-ylpyrrole led to the synthesis of seven compounds 8–9, 12–14, 23 and 26 with benzodiazepine affinity (Ki ≤ 0.90 μM). Among these, 26 exhibits an interesting anxiolytic activity and weak lateral effects.
Publication Year: 1998
Publication Date: 1998-03-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 3
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