Title: Photocontrolled Targeted Drug Delivery: Photocaged Biologically Active Folic Acid as a Light‐Responsive Tumor‐Targeting Molecule
Abstract: Angewandte Chemie International EditionVolume 51, Issue 35 p. 8806-8810 Communication Photocontrolled Targeted Drug Delivery: Photocaged Biologically Active Folic Acid as a Light-Responsive Tumor-Targeting Molecule† Nien-Chu Fan, Nien-Chu Fan Department of Chemistry, National Tsing Hua University, Hsinchu 30013 (Taiwan) These authors contributed equally to this work.Search for more papers by this authorProf. Fong-Yu Cheng, Prof. Fong-Yu Cheng Institute of Oral Medicine, National Cheng Kung University, Tainan 701 (Taiwan) These authors contributed equally to this work.Search for more papers by this authorProf. Ja-an Annie Ho, Corresponding Author Prof. Ja-an Annie Ho [email protected] Department of Biochemical Science and Technology, National Taiwan University, Taipei 10167 (Taiwan) Department of Chemistry, National Tsing Hua University, Hsinchu 30013 (Taiwan) Ja-an Annie Ho, Department of Biochemical Science and Technology, National Taiwan University, Taipei 10167 (Taiwan) Chen-Sheng Yeh, Department of Chemistry, Center for Micro/Nano Science and Technology, and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, TaiwanSearch for more papers by this authorProf. Chen-Sheng Yeh, Corresponding Author Prof. Chen-Sheng Yeh [email protected] Department of Chemistry, Center for Micro/Nano Science and Technology, and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, Taiwan Ja-an Annie Ho, Department of Biochemical Science and Technology, National Taiwan University, Taipei 10167 (Taiwan) Chen-Sheng Yeh, Department of Chemistry, Center for Micro/Nano Science and Technology, and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, TaiwanSearch for more papers by this author Nien-Chu Fan, Nien-Chu Fan Department of Chemistry, National Tsing Hua University, Hsinchu 30013 (Taiwan) These authors contributed equally to this work.Search for more papers by this authorProf. Fong-Yu Cheng, Prof. Fong-Yu Cheng Institute of Oral Medicine, National Cheng Kung University, Tainan 701 (Taiwan) These authors contributed equally to this work.Search for more papers by this authorProf. Ja-an Annie Ho, Corresponding Author Prof. Ja-an Annie Ho [email protected] Department of Biochemical Science and Technology, National Taiwan University, Taipei 10167 (Taiwan) Department of Chemistry, National Tsing Hua University, Hsinchu 30013 (Taiwan) Ja-an Annie Ho, Department of Biochemical Science and Technology, National Taiwan University, Taipei 10167 (Taiwan) Chen-Sheng Yeh, Department of Chemistry, Center for Micro/Nano Science and Technology, and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, TaiwanSearch for more papers by this authorProf. Chen-Sheng Yeh, Corresponding Author Prof. Chen-Sheng Yeh [email protected] Department of Chemistry, Center for Micro/Nano Science and Technology, and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, Taiwan Ja-an Annie Ho, Department of Biochemical Science and Technology, National Taiwan University, Taipei 10167 (Taiwan) Chen-Sheng Yeh, Department of Chemistry, Center for Micro/Nano Science and Technology, and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, TaiwanSearch for more papers by this author First published: 25 July 2012 https://doi.org/10.1002/anie.201203339Citations: 178 † This work was supported by the National Science Council of Taiwan. (NSC 100-2627-M-006-007, NSC 100-2119-M-006-021, and 98-2113-M-002-025-MY3). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Light-controlled: Biodegradable nanoparticles encapsulating an anticancer drug (red dots in picture) have been synthesized that carry photocaged folate groups on the surface. Upon irradiation the photocaging group (green) is removed and the free folate group, a tumor-homing agent, binds to folate receptors on cell surfaces, thus leading to specific targeting and cellular uptake. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201203339_sm_miscellaneous_information.pdf4.6 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume51, Issue35August 27, 2012Pages 8806-8810 RelatedInformation
Publication Year: 2012
Publication Date: 2012-07-25
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 194
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot