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[151], 'SCN': [153, 221, 237], 'processes': [154], 'external': [155], 'signals,': [156], 'as': [158, 183, 888, 951, 1088, 1090, 1117], 'ambient': [159], 'light': [160, 191, 211, 318, 1690, 1934], 'inputs': [162], 'from': [163, 361, 600, 620, 628, 635, 679, 753, 770, 801, 1000, 1185, 1273, 1309, 1595, 1674, 1749, 2223, 2521], 'brain,': [165], 'regulate': [167], 'cyclical': [171], 'functions,': [172], 'including': [173, 405, 898, 1563], 'body': [174, 261], 'temperature,': [175, 852, 886], 'sleep/wake': [176], 'cycles,': [177], 'secretion': [179], 'hormones': [181], 'serum': [184], 'cortisol,': [185], 'melatonin,': [186], 'thyroxin,': [187], 'vasopressin.2': [189], 'Ambient': [190], 'can': [192, 218, 229, 465, 581, 1638], 'entrain': [193], 'SCN,': [195, 257, 1463, 1558], 'which': [196, 452, 853, 1218, 1464, 1551], 'then': [197, 837, 1465], 'modulates': [198], 'pathophysiological': [201, 346, 1473], 'processes.': [202], 'In': [203, 234, 414, 505, 980, 1811], 'fact,': [204], 'like': [205], 'modulated': [206, 1502], 'parasystole,3': [207], 'burst': [209, 225], 'striking': [212], 'photoreceptors': [214], 'morning': [217, 323, 437, 449, 460, 485, 490, 1689], 'advance': [219], 'cycle,': [222], 'whereas': [223], 'evening': [228, 1933], 'delay': [230], 'phase-response': [232], 'curve.': [233], 'humans,': [235], 'sets': [238], 'intrinsic': [240, 430], '24-hour': [241], 'cycle': [242], 'accurately': [243], 'average': [245], '≈24': [246], 'hours': [247, 321, 1191], '11': [249], 'minutes.4In': [250], 'addition': [251], 'daily': [253, 851, 865], 'modulation': [254], 'by': [255, 302, 313, 468, 584, 795, 1461, 1550, 1556, 1739, 1746, 2046, 2416, 2449, 2574], 'seasonal': [258, 281, 292, 608, 666, 713, 1080, 1159, 1396, 2138], 'fluctuations': [259, 338, 875], 'occur.': [263], 'For': [264], 'example,': [265], 'plasma': [266, 424, 1899, 1982], 'l-tryptophan': [267], 'competing': [269], 'amino': [270], 'acids': [271], 'are': [272, 358, 1297, 1459, 1651, 1705], 'significantly': [273], 'lower': [274], 'spring,': [277], 'changes': [278, 893, 1458], 'parallel': [280], 'variations': [282, 394], 'prevalence': [285], 'violent': [287, 1907], 'suicide': [288, 1908], 'depression.5': [290], 'affective': [293], 'disorder': [294], 'syndrome': [295, 1281, 1388], '(SADS)': [296], 'well-established': [299], 'entity': [300], 'characterized': [301], 'depression': [303], 'during': [304, 519, 547, 566, 820, 876, 1100, 1217, 1228], 'winter': [306, 673, 1102, 1229, 1286, 1292, 1336, 1444, 1650, 1697, 1939, 2221, 2317], 'months.': [307, 1233], 'Psychiatrists': [308], 'treated': [310], 'SADS': [311], 'patients': [312, 508, 527, 938, 1039, 1937], 'exposing': [314], 'them': [315], 'artificial': [317], '2': [320, 1111], 'each': [322], 'simulate': [325], 'an': [326, 513, 554, 710, 826, 967, 1097, 1118, 1145, 1214, 1518, 1640, 2450], 'earlier': [327], 'sunrise.6We': [328], 'known': [330, 585], 'number': [333, 558, 776, 1221, 2192], 'years': [335, 683, 689], 'affect,': [339], 'perhaps': [341, 1677], 'orchestrate,': [342], 'states.': [347], 'onset': [349, 518, 1957, 2112], 'myocardial': [351, 510, 622, 647, 670, 2114, 2141, 2170, 2225, 2338, 2487], 'infarction,': [352], 'sudden': [353, 450, 533, 1168, 1183, 1260, 1278, 1378, 1385, 1521, 1564, 2008, 2117, 2333, 2346, 2402], 'cardiac': [354, 1504, 1512, 1522, 2009, 2334, 2414, 2431, 2446], 'death,': [355, 451, 1567], 'stroke': [357, 629], 'increased': [360, 375, 514, 676, 899, 1006, 1030, 1072, 1079, 1098, 1238, 1285, 1626, 1654, 2172, 2312], '6': [362], 'am': [363], '12': [365], 'noon.': [366], 'These': [367, 839], 'responses': [368], 'may': [369, 440, 453, 592, 727, 1074, 1135, 1141, 1153, 1476], 'be': [370, 454, 466, 582, 593, 843, 1154, 1408], 'related,': [371], 'part,': [373], 'sympathetic': [376, 1239], 'activity': [377, 432], 'after': [378, 921, 1173, 1192, 1524, 2336], 'getting': [379], 'out': [380], 'bed,': [382], 'with': [383, 387, 471, 488, 677, 696, 715, 817, 939, 966, 1127, 1203, 1231, 1300, 1614, 1620, 1629, 1938], 'subsequent': [384], 'catecholamine': [385, 1242], 'interaction': [386], 'platelets': [388], 'atherosclerotic': [390], 'plaque': [391], 'pathophysiology.7': [392], 'Circadian': [393, 1791, 1952, 2005, 2066, 2088], 'also': [395, 1283, 1390, 1491], 'observed': [398], 'several': [400, 601], 'hemodynamic': [401], 'cardiovascular': [403, 611, 736, 1561, 1655, 1698, 1725, 1960], 'events,': [404, 1322, 1562], 'blood': [406], 'pressure,': [407], 'coronary': [408, 767, 1180, 1193, 1321, 1603, 1627, 1675, 1685, 2250, 2370, 2490, 2522], 'artery': [409, 768, 1194], 'flow,': [410], 'heart': [412, 1314, 1480, 2523], 'rate.': [413], 'addition,': [415], 'alterations': [417, 1601], 'platelet': [419], 'response': [420], 'aggregating': [422], 'stimuli,': [423], 'fibrinogen,': [425], 'coagulation': [426], 'factor': [427, 1257], 'concentration,': [428], 'fibrinolytic': [431], 'documented.': [435], 'Increased': [436, 2220], 'hematocrit': [438], 'levels': [439, 1243], 'contribute.8Changing': [441], 'electrophysiological': [442, 1505], 'conditions': [443], 'accompany': [444], 'greater': [446, 1220], 'frequency': [447, 538], 'due': [455, 594, 765, 1063], 'ventricular': [457, 463, 477, 941, 1186, 1226, 2015, 2043, 2070], 'fibrillation.9': [458], 'A': [459, 550, 1592, 2256], 'peak': [461, 491, 543, 2041], 'tachyarrhythmias': [464, 1187, 2044], 'detected': [467, 2045], 'therapy': [469], 'delivered': [470], 'implantable': [472, 2049], 'cardioverter-defibrillators.10': [473], 'Maximal': [474], 'shortening': [475], 'effective': [478], 'refractory': [479], 'period': [480, 1866], 'occurs': [481], 'early': [484], 'hours,11': [486], 'along': [487], 'defibrillation': [493, 2091], 'threshold': [494], 'failed': [496], 'first': [497, 568, 2201], 'shock': [498], 'frequency.12Weekly': [499], 'death': [500, 534, 756, 764, 991, 1169, 1280, 1387, 1523, 2010, 2251, 2335, 2348, 2404, 2447], 'trends': [501], 'reported.': [504], 'New': [506, 1003, 1393, 2390], 'Zealand,': [507, 1289], 'surviving': [509, 526], 'infarction': [511, 537, 623, 648, 671, 2115, 2226, 2488, 2527], 'showed': [512, 873, 1222], 'incidence': [515, 1166], 'symptom': [517], 'weekend': [521], 'Monday': [524, 2173], 'Saturday': [530], 'high': [531, 1635], 'patients.13': [535], 'Myocardial': [536], 'shown': [541], 'Mondays1415': [545], 'winter.14': [549], 'recent': [551, 602, 1593], 'study': [552, 1148, 1594, 1599, 2308], 'found': [553, 644, 1374], 'increase': [555, 711, 827, 913, 1053, 1519, 2189], 'deaths': [560, 619, 627, 649, 778, 792, 829, 840, 915, 1184, 1353, 1389, 1673, 2194], 'occurring': [561], 'United': [564, 1048, 1302, 2197], 'States': [565, 2198], 'week': [569, 2202], 'month.16': [572], 'Although': [573, 1137], 'influence': [575], 'explained': [583, 844], 'changes,': [587], 'day-of-the-week': [588], 'week-of-the-month': [590], 'peaks': [591], 'more': [595, 1331, 1355], 'environmental': [597, 721], 'work/play': [598], 'influences.Data': [599], 'studies': [603, 1275], 'focused': [605], 'mortality.': [612], 'Sheth': [613, 2212], 'et': [614, 747, 1162, 1305, 1515], 'al17': [615], 'analyzed': [616, 749], '159': [617], '884': [618], 'acute': [621, 646, 669, 735, 1959, 2169, 2224], '136': [625], '157': [626], 'Canadian': [632, 1107], 'mortality': [633, 692, 814, 999, 1032, 1055, 1073, 1099, 1397, 1606, 1628, 1656, 2222, 2300, 2313, 2520, 2544], 'database': [634], '1980': [636], '1982': [638], '1990': [640], '1992.': [642], 'They': [643], 'were': [650, 793, 964, 1244, 1327, 1354, 1373], 'highest': [651], 'January': [653, 785, 922], 'lowest': [655], 'September,': [657], 'producing': [658], 'relative': [660, 703], 'risk': [661, 704, 2174, 2399], 'difference': [662, 705, 986, 1017], '18.6%.': [664], 'This': [665, 1530], 'variation': [667, 714, 1897, 1953, 2006, 2067, 2089, 2167, 2331], 'between': [672, 787, 1197, 1375, 2144], 'summer': [675, 1232], 'age': [678], '5.8%': [680], '<65': [682], 'old': [684], '15.8%': [686], '>85': [688], 'old.': [690], 'Stroke': [691], 'peaked': [693, 831], 'January,': [695, 823], 'trough': [698], 'September': [700], '19.9%,': [707], 'again': [708], 'showing': [709, 1610], 'age.': [716, 2232], 'authors': [718, 880, 1068, 1235], 'suggested': [719, 881], 'factors': [722, 883, 1139, 2400], 'accompanying': [723], 'cold': [725, 1065, 1360], 'weather': [726], 'play': [728, 1142], 'major': [730], 'role': [731], 'triggering': [733], 'these': [734, 877, 957, 1085, 1138, 1415], 'events': [737, 1726], 'determining': [739], 'their': [740], 'outcome.In': [741], 'this': [742, 981, 1455, 1577, 1703], 'issue': [743], 'Circulation,': [745], 'Kloner': [746, 2239, 2443], 'al18': [748], '222': [750], '265': [751], 'reports': [752, 1112], 'monthly': [755], 'certificate': [757], 'data': [758, 1308, 1398, 1585], 'Los': [760, 858, 1527], 'Angeles': [761, 859, 1528], 'County': [762], 'disease': [769, 1315, 2524], '1985': [771, 802], 'through': [772, 946, 1338, 1343], '1996.': [773, 955], 'mean': [775], 'was': [779, 798, 811, 825, 933, 984, 1014, 1033, 1061, 1253, 1735], '33%': [780], 'higher': [781], 'December': [783, 821, 917, 953], 'than': [786, 885, 1345], 'June': [788], 'September.': [790], 'When': [791, 2245], 'plotted': [794], 'year,': [796], 'there': [797, 824, 983], 'decrease': [800], '1996,': [804], 'but': [805, 998, 1616], 'shape': [807], 'curve': [810], 'maintained.': [812], 'Monthly': [813], 'correlated': [815], 'inversely': [816], 'temperature.': [818, 1066], 'However,': [819], 'around': [832, 894], 'holiday': [834, 896, 1031, 1059, 1125, 1269], 'fell.': [838], 'could': [841, 1559, 1682], 'not': [842, 1062, 1092, 1254, 1582, 1706], 'solely': [845], 'basis': [848, 1574], 'generally': [855], 'mild': [856], 'at': [860, 1346], 'minimum': [864], 'temperature': [866, 872, 1116, 1615, 2368, 2480, 2542], 'remained': [867], 'relatively': [868], 'flat,': [869], 'maximum': [871], 'minor': [874], 'times.': [878], 'other': [884, 1110, 1347, 1543, 1678], 'superimposed': [889], 'respiratory': [890], 'infections,': [891], 'behavioral': [892], 'time,': [897, 1729], 'food,': [900, 1132], 'salt,': [901], 'alcohol': [903], 'consumption,': [904], 'emotional': [906, 1083], 'psychological': [908], 'stress,': [909], 'contributed': [910], 'fall': [920, 1980], '1.In': [923], 'Antiarrhythmics': [925, 2303], 'Versus': [926, 2304], 'Implantable': [927, 2305], 'Defibrillators': [928, 2306], '(AVID)': [929, 2307], 'study,19': [930], 'vital': [931], 'status': [932], 'obtained': [934], '4467': [936], 'registered': [937], 'sustained': [940, 1224], 'arrhythmias': [942], 'unexplained': [944], 'syncope': [945], 'National': [948, 1751, 1759], 'Death': [949, 2393], 'Index': [950], '31,': [954], 'Of': [956], 'patients,': [958], '735': [959], 'died,': [960], 'among': [961, 992, 1018], 'whom': [962], '137': [963], 'discharged': [965], 'ICD,': [968], '425': [969], 'received': [970, 974, 978], 'antiarrhythmic': [971], 'drugs,': [972, 1023], '66': [973], 'both,': [975, 1024], '107': [977], 'neither.': [979], 'population,': [982], 'no': [985, 1015], 'pattern': [989, 1028], 'days': [994, 1361, 1648], 'week,': [997, 1731], 'Thanksgiving': [1001], "Year's": [1004], 'Day': [1005], '15%,': [1008], 'versus': [1009], '11%': [1010], 'expected': [1011], '(P=0.002).': [1012], 'There': [1013], 'significant': [1016], 'treatment': [1020, 1935], 'groups': [1021], '(ICD,': [1022], 'neither).': [1026], 'evident': [1034], 'subgroup': [1036], 'analysis': [1037, 2259], 'both': [1041, 1323], 'warmer': [1042, 1369], 'colder': [1044], 'parts': [1045], 'States,': [1049, 2350], 'suggesting': [1050], 'related': [1056, 1077, 1652, 2314], 'concluded': [1069], 'physical': [1081], 'stress.Thus,': [1084], '3': [1086], 'studies,': [1087], 'well': [1089, 1114, 1486], 'others': [1091, 1496], 'mentioned,': [1093], 'point': [1095], 'season.': [1103], 'Except': [1104], 'study,': [1108, 1216], 'fairly': [1113], 'exclude': [1115], 'important': [1119], 'variable': [1120], 'suggest': [1122], 'season,': [1126], 'its': [1128], 'overindulgence': [1129], 'emotions,': [1131], 'beverages,': [1134], 'contribute.': [1136], 'certainly': [1140], 'role,': [1144], 'interesting': [1146], 'animal': [1147], 'suggests': [1149], 'those': [1151, 1708], 'issues': [1152], 'insufficient': [1155], 'explain': [1157], 'differences.': [1160], 'Scherlag': [1161, 2324], 'al20': [1163], 'studied': [1164], '184': [1171], 'dogs': [1172, 1211], 'ligation': [1174, 1195], 'left': [1177], 'anterior': [1178], 'descending': [1179], 'artery.': [1181], 'Forty-six': [1182], '13': [1188], '22': [1190], 'occurred': [1196], 'November': [1198], 'February': [1200], '(42%),': [1201], 'compared': [1202, 1230, 1299], 'only': [1204], '6%': [1205], 'July': [1207], 'August.': [1209], 'Surviving': [1210], '(n=138)': [1212], 'underwent': [1213], 'electrophysiology': [1215], 'inducible': [1223], 'monomorphic': [1225], 'tachycardia': [1227], 'speculated': [1236], 'tone': [1240], 'responsible.': [1245], 'Certainly,': [1246, 1631], 'excessive': [1247], 'emotional,': [1248], 'gustatorial,': [1249], 'alcoholic': [1251], 'intake': [1252], 'likely': [1256, 1332, 1356, 2253], 'canine': [1259], 'deaths.': [1261, 1381], 'Additional': [1262], 'support': [1263], 'minimizing': [1265], 'activities': [1271], 'comes': [1272], 'numerous': [1274], 'infant': [1279, 1386, 2347, 2403], 'show': [1284], 'mortality.21In': [1287], 'Australia/New': [1288], 'same': [1291], 'influences': [1293, 1481], 'occur,': [1294], 'although': [1295], 'seasons': [1296], 'reversed': [1298], 'States.13': [1303], 'Enquselassie': [1304, 2359], 'al,22': [1306], 'using': [1307, 1688], 'community-based': [1311], 'register': [1312], '(WHO': [1316], 'MONICA': [1317, 1598, 2499], 'Project),': [1318], 'demonstrated': [1319, 1498], 'fatal': [1324], 'nonfatal,': [1326], '20%': [1328], '40%': [1330], 'occur': [1334], '(June': [1337], 'August)': [1339], 'spring': [1341], '(September': [1342], 'November)': [1344], 'times': [1348], 'year.': [1351], 'Coronary': [1352], 'happen': [1358], 'much': [1365], 'lesser': [1366], 'extent': [1367], 'days.': [1370], 'No': [1371], 'differences': [1372, 2397], 'patterns': [1376], 'nonsudden': [1380, 1566], 'dominance': [1383], 'exists': [1391], 'Zealand.23': [1394], 'Knowing': [1395], 'equator': [1401], 'North': [1403], 'South': [1405], 'Poles': [1406], 'would': [1407], 'interest.The': [1410], '1': [1411, 1441, 1780], 'constant': [1412, 1442], 'observations': [1416], 'winter,': [1421], 'whether': [1422], 'northern': [1425], 'southern': [1427], 'hemisphere,': [1428], 'animals,': [1430], 'young': [1433], 'older': [1435], 'humans.': [1436], 'And,': [1437], 'course,': [1439], 'decreased': [1446], 'daylight': [1447], 'hours.': [1448], 'As': [1449], 'stated': [1450], 'beginning': [1453], 'editorial,': [1456], 'perceived': [1460], 'signals': [1466], 'myriad': [1468], 'possibly': [1472], 'processes.Although': [1474], 'romanticists': [1475], 'argue': [1477], 'head,': [1483], 'scientists': [1484], 'established': [1487], 'reverse': [1490], 'occurs.': [1492], 'Skinner,24': [1493], 'Lown,25': [1494], 'elegantly': [1497], 'brain': [1501], 'milieu': [1506], 'affect': [1508, 1560], 'generation': [1510], 'arrhythmias.': [1513], 'Leor': [1514, 2439], 'al26': [1516], 'documented': [1517], '1994': [1526], 'earthquake.': [1529, 2451], 'modulation,': [1531], 'via': [1532], 'autonomic': [1534, 1795], 'nervous': [1535, 1796], 'system,': [1536], 'hormone': [1537], 'release,': [1538], 'possible': [1544], 'pathways,': [1545], 'offers': [1546, 1657], 'potential': [1548], 'mechanism': [1549], 'chronobiological': [1553], 'rhythms,': [1554], 'controlled': [1555], 'daily,': [1570], 'weekly,': [1571], 'yearly': [1573], '(Figure).': [1575], 'Naturally,': [1576], 'conclusion': [1578, 1644], 'speculative,': [1580], 'fit': [1586], 'curves': [1588, 1723], 'figure.': [1591], 'Lille-WHO': [1597], 'attributed': [1600], 'morbidity': [1604], 'meteorological': [1608], 'variables,': [1609], 'linear': [1612], 'relationship': [1613, 1619], 'V-shaped': [1618], 'atmospheric': [1621, 2479], 'pressure.27': [1622], 'Others2829': [1623], 'described': [1625], 'heat.': [1630], 'stressful': [1632], 'temperatures,': [1633], 'either': [1634], 'low,': [1637], 'additional': [1641, 1975], 'impact.But': [1642], 'short': [1647], 'hypothesis': [1659], 'test': [1661], 'that,': [1662], 'if': [1663], 'true,': [1664], 'opens': [1665], 'new': [1666], 'approaches': [1667], 'investigating': [1669], 'potentially': [1671], 'reducing': [1672], 'vascular': [1679], 'diseases.': [1680], 'One': [1681], 'envision': [1683], 'future': [1684], 'care': [1686], 'units': [1687], 'treatments': [1691], 'lessen': [1693], 'hazards': [1695], 'mortality!The': [1699], 'opinions': [1700], 'expressed': [1701], 'editorial': [1704], 'necessarily': [1707], 'editors': [1711], 'American': [1715, 2575], 'Heart': [1716, 2150, 2576], 'Association.Download': [1717], 'figureDownload': [1718], 'PowerPoint': [1719], 'Figure': [1720], '1.': [1721], 'Hypothetical': [1722], 'according': [1727], 'day,': [1730], 'season.This': 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