Publication Information

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984, 1056, 1364, 1398, 1434, 1657, 2391, 2454, 2567, 2634, 2697, 2736, 2826, 3058, 3071, 3130, 3192, 3251, 3275, 3283, 3339, 3352, 3401, 3486, 3504, 3511, 3531, 3541, 3570, 3660, 3681, 3711, 3853, 3889, 4105, 4134, 4145, 4191], 'are': [4, 252, 623, 780, 3265, 4039, 4082], 'mediated': [5, 253, 1052], 'by': [6, 44, 78, 84, 149, 233, 254, 292, 326, 332, 397, 481, 782, 1053, 1408, 1429, 1536, 1568, 1950, 2139, 2184, 2327, 2389, 2423, 2428, 2576, 2586, 2593, 2677, 2705, 2872, 2879, 2896, 2938, 2976, 3250, 3351, 3361, 3405, 3428, 3465, 3473, 3583, 3602, 3609, 3617, 3867, 3930, 3968], 'activation': [7, 255, 1048, 1089, 1415, 2640, 3221, 3234, 3348, 3358, 3386, 3458, 3490, 3614, 3622, 3716, 3941, 4212, 4356], 'endothelial': [9, 198, 257, 446, 497, 505, 636, 718, 769, 1756, 1762, 1886, 1901, 3771, 3824, 3901], 'nitric-oxide': [10, 258, 498, 770, 4397], 'synthase': [11, 259, 499, 771, 4398], '(eNOS)': [12, 260], 'and': [13, 20, 261, 268, 607, 734, 776, 817, 980, 1168, 1422, 1445, 1453, 1547, 1565, 1617, 1688, 1705, 1737, 1759, 1816, 1914, 1953, 2058, 2094, 2179, 2217, 2310, 2332, 2402, 2407, 2496, 2511, 2554, 2613, 2651, 2655, 2752, 2774, 2812, 2834, 2843, 2904, 2932, 2983, 3013, 3062, 3085, 3096, 3109, 3215, 3231, 3258, 3276, 3336, 3371, 3384, 3487, 3503, 3510, 3530, 3569, 3593, 3680, 3710, 3715, 3736, 3768, 3784, 3788, 3880, 3894, 3932, 3950, 4107, 4114, 4122, 4144, 4197, 4210, 4370], 'subsequent': [14, 262, 810, 3300, 3506], 'production': [15, 30, 54, 77, 100, 140, 263, 278, 302, 325, 348, 388, 535, 630, 1339, 2181, 2501, 2515, 2547, 2700, 2820, 2924, 2963, 2997, 3033, 3289, 3306, 3395, 3423, 3549, 3585, 3654, 3790, 3837, 3918, 4150, 4385], 'NO.': [17, 265], 'Phosphatidylinositol': [18, 266], '3-kinase': [19, 267], 'Akt': [21, 112, 190, 269, 360, 438, 608, 1228, 1332, 1352, 1430, 1531, 1578, 1609, 1745, 2342, 2798, 2857, 3080, 3124, 3186, 3240, 3374, 3381, 3410, 3610, 3624, 3719, 3727, 3931, 3949, 4198, 4214], 'play': [22, 270, 4199], 'important': [23, 271, 4200], 'roles': [24, 272, 4201], 'in': [25, 33, 55, 63, 66, 95, 120, 134, 143, 172, 206, 273, 281, 303, 311, 314, 343, 368, 382, 391, 420, 454, 524, 540, 633, 683, 714, 717, 1067, 1092, 1235, 1239, 1333, 1342, 1353, 1361, 1396, 1579, 1610, 1690, 1712, 1764, 1774, 1897, 1958, 1974, 2043, 2055, 2159, 2214, 2394, 2462, 2476, 2488, 2504, 2520, 2530, 2548, 2574, 2615, 2618, 2665, 2717, 2802, 2823, 2827, 2846, 2881, 2890, 2923, 2992, 3003, 3032, 3040, 3081, 3127, 3137, 3141, 3156, 3189, 3228, 3292, 3315, 3382, 3398, 3520, 3523, 3550, 3573, 3577, 3638, 3643, 3657, 3661, 3773, 3798, 3820, 3840, 3873, 3886, 3900, 3903, 3911, 3921, 3961, 3973, 4141, 4153, 4202, 4388], 'insulin-signaling': [26, 274, 1335], 'pathways': [27, 275, 4136, 4147, 4209], 'leading': [28, 276], 'to': [29, 50, 122, 127, 131, 145, 160, 174, 203, 277, 298, 370, 375, 379, 393, 408, 422, 451, 526, 628, 688, 721, 727, 757, 814, 934, 988, 1363, 1435, 1829, 1879, 1948, 1976, 2153, 2201, 2221, 2247, 2266, 2365, 2381, 2590, 2668, 2804, 2825, 2863, 2935, 2974, 3191, 3286, 3376, 3390, 3400, 3421, 3525, 3534, 3552, 3599, 3645, 3659, 3734, 3757, 3795, 3842, 3852, 3875, 3888, 4117, 4138, 4149, 4349, 4363, 4381], 'NO': [32, 53, 65, 76, 102, 119, 142, 280, 301, 313, 324, 350, 367, 390, 632, 942, 1341, 1962, 1980, 2180, 2478, 2503, 2517, 2546, 2702, 2822, 2926, 2962, 2999, 3035, 3291, 3308, 3397, 3425, 3522, 3548, 3578, 3587, 3640, 3656, 3792, 3839, 3872, 3920, 4152, 4387], 'vascular': [34, 197, 282, 445, 542, 635, 684, 3922, 4154], 'endothelium.': [35, 283, 1068], 'Here': [36, 284], 'we': [37, 285, 1325, 1392, 1439, 2211, 2398, 2570, 2884, 2918, 2956, 3027, 3113, 3495, 3619, 3762, 4187], 'dissected': [38, 286], 'mechanisms': [39, 237, 287, 485, 761, 1201, 1395, 2388, 3244, 3260, 3475, 4353], 'whereby': [40, 288, 762], 'activates': [42, 290, 2392], 'eNOS': [43, 166, 223, 232, 240, 291, 414, 471, 480, 488, 773, 802, 822, 1050, 1072, 1091, 1203, 1232, 1241, 1360, 1400, 1407, 1417, 1426, 1449, 1513, 1735, 2337, 2393, 2401, 2420, 2510, 2553, 2612, 2637, 2642, 2792, 2808, 2845, 2870, 2875, 2894, 2903, 2994, 3145, 3223, 3236, 3248, 3263, 3319, 3350, 3360, 3370, 3460, 3464, 3471, 3492, 3608, 3616, 3699, 3754, 3927, 3943, 3953, 3960, 3974, 4079, 4110, 4358], 'using': [45, 225, 293, 473, 1747, 2239, 2278, 3441, 3766], 'the': [46, 89, 96, 108, 125, 158, 211, 214, 294, 337, 344, 356, 373, 406, 459, 462, 541, 600, 729, 759, 766, 815, 931, 935, 939, 1334, 1348, 1389, 1481, 1530, 1540, 1548, 1574, 1832, 1923, 1959, 1977, 2056, 2205, 2215, 2254, 2271, 2311, 2372, 2382, 2387, 2411, 2542, 2621, 2666, 2694, 2727, 2741, 2847, 2856, 2891, 2988, 3074, 3083, 3123, 3166, 3170, 3173, 3210, 3288, 3378, 3408, 3417, 3429, 3454, 3468, 3515, 3518, 3544, 3558, 3589, 3653, 3662, 3666, 3676, 3781, 3803, 3807, 3850, 3969, 4190, 4351, 4365], 'fluorescent': [47, 295, 513, 1494, 2413, 4374], 'dye': [48, 296, 1925, 2207, 2414, 4375], 'DAF-2': [49, 297, 508, 1939, 1949, 2113, 2128, 2206, 2415, 2624, 4376], 'directly': [51, 299], 'measure': [52, 300], 'single': [56, 304], 'cells.': [57, 305], 'Insulin': [58, 306, 520], 'caused': [59, 307, 2455], 'a': [60, 226, 308, 474, 783, 1059, 1077, 1083, 1328, 1561, 1713, 1942, 1955, 2064, 2070, 2160, 2197, 2222, 2267, 2395, 2456, 2474, 2562, 2580, 2587, 2627, 2920, 2958, 2965, 3029, 3118, 3138, 3574, 3595, 3758, 3912, 4389], 'rapid': [61, 309, 2588, 2921, 3575, 3596], 'increase': [62, 310, 2461, 2573, 3031, 3140, 3637], 'intracellular': [64, 312, 808, 990, 1065, 1951, 2477, 2882, 2916, 3229, 3521, 3639, 3936, 4384], 'NIH-3T3IR': [67, 208, 315, 456, 1838, 2405, 2549, 2616, 2645, 2899, 3267, 3629, 3749, 3800], 'cells': [68, 87, 106, 135, 188, 199, 316, 335, 354, 383, 436, 447, 506, 637, 719, 1757, 1763, 1824, 1839, 1887, 1918, 2038, 2156, 2213, 2406, 2409, 2446, 2489, 2505, 2522, 2531, 2550, 2558, 2617, 2646, 2672, 2718, 2768, 2789, 2794, 2805, 2828, 2851, 2900, 2950, 3004, 3021, 3041, 3164, 3195, 3268, 3294, 3316, 3330, 3366, 3500, 3630, 3664, 3750, 3772, 3825, 3902], 'transiently': [69, 317, 1724, 1884, 2132, 2399, 2507, 2647, 3751], 'transfected': [70, 207, 318, 455, 1885, 2133, 2155, 2258, 2532, 2719, 2767, 3752, 3799], 'with': [71, 88, 176, 180, 319, 336, 424, 428, 694, 983, 1539, 1696, 1716, 1726, 1850, 1908, 1922, 2049, 2063, 2083, 2112, 2127, 2172, 2334, 2371, 2410, 2449, 2509, 2533, 2552, 2561, 2579, 2620, 2649, 2720, 2793, 2902, 2908, 2954, 2964, 2987, 3006, 3025, 3037, 3044, 3117, 3274, 3302, 3312, 3334, 3338, 3368, 3393, 3501, 3505, 3528, 3537, 3744, 3753, 3833, 3908], 'eNOS.': [72, 138, 193, 320, 386, 441, 1437, 3388, 3738], 'The': [73, 321, 1456, 1487, 1509, 1571, 1606, 3956, 4033, 4372], 'stimulation': [74, 322, 2737, 2960, 3193, 3498, 3647, 3682, 3725, 3877, 3890], 'lysophosphatidic': [79, 327, 515, 2174], 'acid': [80, 328, 511, 516, 2175, 2376], '(LPA)': [81, 329], 'was': [82, 103, 129, 147, 162, 169, 216, 330, 351, 377, 395, 410, 417, 464, 1480, 1505, 1520, 1534, 1566, 1581, 1619, 1874, 2106, 2124, 2137, 2182, 2237, 2379, 2485, 2498, 2518, 2703, 2738, 2817, 3000, 3059, 3065, 3154, 3284, 3310, 3403, 3426, 3532, 3611, 3641, 3731, 3809], 'abrogated': [83, 331], 'pretreatment': [85, 333, 3830], 'calcium': [90, 338, 3937], 'chelator': [91, 339], '1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic': [92, 340, 510], 'acid.': [93, 341], 'Remarkably,': [94, 342], 'same': [97, 345, 2949, 3663], 'cells,': [98, 209, 346, 457, 2134, 3801], 'insulin-stimulated': [99, 347, 1047, 1414, 3163, 3220, 3457, 3789, 3917, 4355], 'unaffected.': [104, 163, 352, 411], 'However,': [105, 353, 1041, 3467, 3543], 'expressing': [107, 136, 355, 384, 1655, 2419, 2790, 2795, 2806, 2829, 3165, 3196, 3269, 3317, 3631], 'eNOS-S1179A': [109, 357, 2658, 2724, 2757, 2796, 2830, 3200, 3270, 3863], 'mutant': [110, 154, 358, 402, 1526, 1576, 2844, 3167, 3409, 3431, 3445], '(disrupted': [111, 359, 2797], 'phosphorylation': [113, 230, 361, 478, 1355, 1405, 1424, 1532, 2799, 2858, 3075, 3125, 3142, 3462, 3606, 3697, 3714, 3925, 3951], 'site)': [114, 362], 'did': [115, 363, 3101, 3683], 'not': [116, 179, 192, 364, 427, 440, 1044, 1058, 1346, 2486, 2506, 2537, 3042, 3068, 3102, 3133, 3341, 3355, 3449, 3477, 3684, 3689, 3694, 3732, 3827, 3885, 4216], 'produce': [117, 365], 'detectable': [118, 366, 2500, 2819], 'response': [121, 126, 144, 159, 173, 369, 374, 392, 407, 421, 1362, 2824, 3190, 3399, 3524, 3551, 3644, 3658, 3808, 3841, 3851, 3874, 3887], 'insulin,': [123, 177, 371, 425, 597, 2173, 2955, 3026, 3618, 3692], 'whereas': [124, 157, 372, 405, 3098, 3416, 3652, 4078, 4207], 'LPA': [128, 161, 376, 409, 2909, 3063, 3099, 3134, 3303, 3335, 3420, 3488, 3502, 3509, 3529, 3539, 3568, 3843, 3876], 'similar': [130, 202, 378, 450, 3055, 3533, 3794], 'that': [132, 220, 238, 380, 468, 486, 532, 589, 779, 1088, 1227, 1413, 1423, 1442, 1945, 1963, 2483, 2607, 2914, 2927, 3038, 3219, 3232, 3309, 3313, 3456, 3535, 4035, 4104, 4129, 4189, 4394], 'observed': [133, 170, 381, 418, 2519, 2571, 2919, 2957, 3028, 3054, 3536, 3642], 'wild-type': [137, 385, 2791, 2807, 2842, 3144, 3318, 3369, 3632], 'Moreover,': [139, 387, 712, 3111, 3939], 'blocked': [148, 396, 3002, 3404], 'coexpression': [150, 398, 2424, 3406, 3868], 'an': [152, 400, 1734, 1744, 2084, 2572], 'inhibitory': [153, 401, 3430, 3444], 'Akt,': [156, 404], 'Phosphorylation': [164, 412], 'at': [167, 415, 1233, 1709, 1720, 1818, 1889, 1966, 1971, 2060, 2148, 2164, 2193, 2433, 2438, 2451, 2465, 2491, 2582, 2686, 2714, 2860, 2929, 2970, 3146, 3579, 3700, 3954], 'Ser1179': [168, 416, 1428, 2861, 3344, 3701, 3929], 'only': [171, 419, 2218, 3129], 'treatment': [175, 186, 423, 434, 3064, 3072, 3100, 3301, 3402, 3527, 3554, 3571], 'but': [178, 191, 426, 439, 1344, 3132, 3353, 3693, 3884, 3946], 'LPA.': [181, 429, 3277, 3362], 'Interestingly,': [182, 430, 3070, 3514], 'platelet-derived': [183, 431, 517], 'growth': [184, 432, 518, 2912], 'factor': [185, 433, 519, 2913], 'activated': [189, 437], 'Results': [194, 442], 'from': [195, 245, 443, 493, 821, 930, 943, 1497, 1516, 1904, 2766, 3162, 3212], 'human': [196, 444, 502, 634, 1231, 1656], 'were': [200, 448, 1675, 1723, 1772, 1825, 1840, 1892, 1919, 2039, 2157, 2169, 2264, 2276, 2325, 2421, 2447, 2559, 2661, 2675, 2906, 2951, 3022, 3187, 3271, 3327, 3331, 3439, 3493, 3755, 3793, 3818], 'qualitatively': [201, 449, 3907], 'those': [204, 452, 3796], 'obtained': [205, 453, 1496, 3328, 3392, 3440, 3743, 3797, 3819], 'although': [210, 458, 3802], 'magnitude': [212, 460, 3516, 3805], 'responses': [215, 463], 'smaller.': [217, 465], 'We': [218, 466, 586, 2539, 2786, 3053, 3363, 4125], 'conclude': [219, 467], 'regulates': [222, 470, 765, 1399, 2636], 'activity': [224, 241, 472, 489, 767, 803, 1204, 1242, 1358, 1401, 2871, 2895, 3249, 3264, 3472, 3728, 4111], 'Ca2+-independent': [227, 475, 1200], 'mechanism': [228, 476], 'requiring': [229, 477], 'Akt.': [234, 482, 1409, 3466], 'Importantly,': [235, 483, 1438, 3829], 'phosphorylation-dependent': [236, 484, 1443, 3259], 'enhance': [239, 487], 'can': [242, 490, 1229], 'operate': [243, 491], 'independently': [244, 492], 'Ca2+-dependent': [246, 494, 1446, 3257, 3474], 'mechanisms.': [247, 495], 'phosphatidylinositol': [496], 'wild': [500], 'type': [501], 'umbilical': [503, 1754], 'vein': [504, 1755], '4,5-diaminofluorescein': [507, 1926], 'diacetate': [509, 1927], 'red': [512, 1493, 1860, 2142, 2431, 2680], 'protein': [514, 1495], 'has': [521, 985, 3964, 4377], 'vasodilator': [522], 'effects,': [523], 'addition': [525, 2695, 3507, 3556], 'its': [527], 'well': [528], 'known': [529], 'metabolic': [530, 594, 695, 722, 4121], 'actions,': [531], 'depend': [533], 'on': [534, 1427, 2069, 3489, 3928], 'nitric': [537], 'oxide': [538], '(NO)': [539], 'endothelium': [543, 685, 1093, 1343, 3923, 4155], '(1Steinberg': [544], 'H.O.': [545], 'Brechtel': [546], 'G.': [547, 639, 654, 904, 1131, 1366, 1779, 1794, 4218, 4233], 'Johnson': [548], 'A.': [549, 1176, 1189, 1279, 1663, 4024, 4297, 4334], 'Fineberg': [550], 'N.': [551, 1985, 2009, 4003, 4044, 4056, 4403], 'Baron': [552, 4092], 'A.D.': [553, 4093], 'J.': [554, 575, 642, 831, 857, 881, 900, 909, 966, 1025, 1153, 1174, 1180, 1271, 1642, 1782, 4052, 4067, 4091, 4221], 'Clin.': [555, 576, 643, 967, 1783, 4068, 4222], 'Invest.': [556, 577, 644, 968, 1784, 4069, 4223], '1994;': [557, 578, 1116, 4335], '94:': [558, 579], '1172-1179Crossref': [559], 'PubMed': [560, 581, 618, 648, 671, 707, 746, 795, 842, 868, 892, 920, 957, 972, 1008, 1036, 1122, 1143, 1163, 1193, 1216, 1259, 1286, 1383, 1475, 1603, 1647, 1670, 1788, 1811, 2003, 2031, 3995, 4028, 4073, 4098, 4165, 4180, 4227, 4250, 4279, 4309, 4338, 4421], 'Scopus': [561, 582, 619, 649, 672, 708, 747, 796, 843, 869, 893, 921, 958, 973, 1009, 1037, 1123, 1144, 1164, 1194, 1217, 1260, 1287, 1320, 1384, 1476, 1648, 1671, 1789, 1812, 2004, 2032, 3996, 4029, 4074, 4099, 4166, 4181, 4228, 4251, 4280, 4310, 4339, 4422], '(1092)': [562], 'Google': [563, 584, 621, 651, 674, 710, 749, 798, 845, 871, 895, 923, 960, 975, 1011, 1039, 1125, 1146, 1166, 1196, 1219, 1262, 1289, 1322, 1386, 1478, 1604, 1650, 1673, 1791, 1814, 2006, 2034, 3998, 4031, 4076, 4101, 4168, 4183, 4230, 4253, 4282, 4312, 4341], 'Scholar,': [564, 652, 846, 872, 896, 1012, 1263, 1290, 1792, 2007, 3999, 4169, 4231, 4254, 4283, 4313], '2Scherrer': [565], 'U.': [566, 1187, 4022, 4332], 'Randin': [567], 'D.': [568, 828, 1178, 1265, 2019], 'Vollenweider': [569, 571], 'P.': [570, 574, 854, 1133], 'L.': [572, 660, 1372, 1591, 1628, 1800, 4239, 4291], 'Nicod': [573], '2511-2515Crossref': [580], '(684)': [583], 'Scholar).': [585, 675, 711, 750, 799, 924, 976, 1040, 1197, 1220, 1323, 1387, 1605, 1651, 2035, 4032, 4184, 4342], 'previously': [587, 3669, 4378], 'demonstrated': [588, 2769, 3279, 3967], 'key': [590, 3764], 'signaling': [591, 716, 764, 2635, 4106, 4135, 4146], 'molecules': [592], 'mediating': [593], 'such': [598, 1101], 'as': [599, 1076, 1102, 1582, 1620, 1776, 2663, 2740], 'receptor': [602, 4192], 'tyrosine': [603, 4193], 'kinase,': [604, 4194], 'PI1': [605], '3-kinase,': [606, 4196], '(3Nystrom': [609, 4156], 'F.H.': [610, 656, 1368, 1796, 4157, 4235], 'Quon': [611, 640, 665, 699, 738, 1377, 1596, 1636, 1780, 1805, 4158, 4172, 4219, 4244], 'M.J.': [612, 641, 666, 700, 739, 1378, 1597, 1637, 1661, 1781, 1806, 4159, 4173, 4220, 4245, 4256, 4264, 4285, 4293, 4315, 4319], 'Cell.': [613, 1470, 4160, 4274], 'Signal.': [614, 4161], '1999;': [615, 792, 954, 1190, 1213, 1256, 1283, 1312, 4162], '11:': [616, 1473, 1601, 4163], '563-574Crossref': [617, 4164], '(157)': [620, 4167], 'Scholar),': [622, 1126, 1147, 1167], 'also': [624, 1440, 2888], 'necessary': [625, 1432, 3612], 'for': [626, 1062, 1099, 1331, 1338, 1433, 1484, 1492, 1511, 1573, 1608, 1842, 1894, 2097, 2227, 2230, 2261, 2631, 2749, 2756, 2867, 3245, 3261, 3347, 3357, 3562, 3613, 3786], 'stimulate': [629, 3287, 3422], '(4Zeng': [638, 1778, 4217], '1996;': [645, 1785, 4025, 4224, 4306], '98:': [646, 1786, 4225], '894-898Crossref': [647, 1787, 4226], '(662)': [650, 1790, 4229], '5Zeng': [653, 1793, 4232], 'Nystrom': [655, 1367, 1795, 4234], 'Ravichandran': [657, 1369, 1797, 4236], 'L.V.': [658, 1370, 1798, 4237], 'Cong': [659, 1371, 1624, 1799, 4238], 'Kirby': [661, 1373, 1801, 4240], 'M.': [662, 698, 737, 1374, 1464, 1802, 4050, 4066, 4171, 4241, 4268, 4317, 4323], 'Mostowski': [663, 1375, 1803, 4242], 'H.': [664, 1105, 1376, 1587, 1804, 1983, 1993, 2011, 2015, 3982, 4042, 4060, 4089, 4243, 4258, 4287, 4401, 4411], 'Circulation.': [667, 1379, 1807, 4246], '2000;': [668, 704, 743, 912, 1028, 1380, 1644, 1808, 4095, 4177, 4247], '101:': [669, 1381, 1809, 4071, 4248], '1539-1545Crossref': [670, 1382, 1810, 4249], '(651)': [673, 1385, 1813, 4252], 'Thus,': [676, 1198, 2855, 3242, 3343, 3724, 3897, 4343], 'one': [677], 'physiological': [678, 3759], 'role': [679, 1330, 3379, 3958], 'action': [682], 'may': [686, 725, 1094, 1205, 1450, 4112, 4361], 'be': [687, 1095, 1451, 2864, 3626], 'couple': [689], 'regulation': [690, 1444, 1447, 2868, 2892, 3246, 3469, 4108, 4118], 'hemodynamic': [692, 3962], 'homeostasis': [693, 696, 3963], '(6Montagnani': [697, 736], 'Diabetes': [701, 740, 4174], 'Obes.': [702, 741, 4175], 'Metab.': [703, 742, 4176], '2:': [705, 744, 4178], '285-292Crossref': [706, 745, 4179], '(91)': [709, 748, 4182], 'abnormalities': [713], 'related': [720, 4137, 4148], 'resistance': [724], 'help': [726], 'explain': [728], 'frequent': [730], 'association': [731], 'between': [732, 4133, 4368], 'hypertension': [733, 3972], 'diabetes': [735, 4369], 'Therefore,': [751], 'it': [752, 1042, 4344], 'is': [753, 1043, 1051, 1057, 1073, 1082, 1418, 1431, 1941, 1946, 2626, 2876, 3224, 3237, 3345, 3354, 3933, 3944, 4345], 'great': [755, 4347], 'interest': [756, 4348], 'elucidate': [758], 'precise': [760, 4352], '(eNOS).': [772], 'contains': [774], 'reductase': [775, 932], 'oxygenase': [777, 936], 'domains': [778], 'joined': [781], 'calmodulin': [784], 'binding': [785, 811], 'site': [786, 1533, 1564, 2859, 3126], '(7Stuehr': [787], 'D.J.': [788, 950], 'Biochim.': [789, 951], 'Biophys.': [790, 952, 4303], 'Acta.': [791, 953], '1411:': [793, 955], '217-230Crossref': [794, 956], '(806)': [797, 959], 'Regulation': [800], 'typically': [804, 2877], 'involves': [805], 'mobilization': [806], 'Ca2+,': [809, 1054, 2883], 'Ca2+/calmodulin': [813], 'enzyme,': [816, 1080], 'displacement': [818], 'caveolin-1': [820], '(8Michel': [823], 'J.B.': [824, 848, 878], 'Feron': [825, 849, 964], 'O.': [826, 850, 874, 965, 4017], 'Sacks': [827], 'Michel': [829, 855, 877, 879], 'T.': [830, 856, 880, 963, 1129, 1300, 1462, 1633, 1997, 2023, 2025, 4048, 4058, 4415], 'Biol.': [832, 858, 882, 910, 1026, 1311, 1471, 4275], 'Chem.': [833, 859, 883, 911, 1027, 1999, 4417], '1997;': [834, 860, 969, 1005, 1140, 1600], '272:': [835, 861], '15583-15586Abstract': [836], 'Full': [837, 839, 863, 865, 887, 889, 915, 917, 1031, 1033, 1119, 1315, 1317], 'Text': [838, 840, 864, 866, 888, 890, 916, 918, 1032, 1034, 1120, 1316, 1318], 'PDF': [841, 867, 891, 919, 1035, 1121, 1319], '(510)': [844], '9Michel': [847], 'Sase': [851], 'K.': [852, 1275, 1987, 2013, 4046, 4266, 4405], 'Prabhakar': [853], '25907-25912Abstract': [862], '(270)': [870], '10Feron': [873], 'Saldana': [875], 'F.': [876, 1623, 4054], '1998;': [884, 1160, 2000, 2028, 4070, 4418], '273:': [885], '3125-3128Abstract': [886], '(312)': [894], '11Gratton': [897], 'J.P.': [898, 1267], 'Fontana': [899, 1270], "O'Connor": [901], 'D.S.': [902], 'Garcia-Cardena': [903, 1130], 'McCabe': [905, 1268], 'T.J.': [906, 1269], 'Sessa': [907, 1134, 1280, 4014], 'W.C.': [908, 1135, 1281, 4015], '275:': [913, 1029], '22268-22272Abstract': [914], '(272)': [922], 'This': [925, 1558], 'promotes': [926], 'transfer': [927], 'electrons': [929], 'domain': [933], 'domain,': [937], 'catalyzing': [938], 'formation': [940], 'l-arginine': [944, 1871], '(for': [945], 'reviews,': [946], 'see': [947], 'Refs.': [948], '7Stuehr': [949], 'Scholarand': [961], '12Michel': [962], '100:': [970], '2146-2152Crossref': [971], '(846)': [974], 'Treatment': [977], 'neurons': [979], 'pancreatic': [981], 'β-cells': [982], 'been': [986, 3965, 4379], 'reported': [987, 1226], 'mobilize': [989], 'Ca2+stores': [991], '(13Jonas': [992], 'E.A.': [993], 'Knox': [994], 'R.J.': [995], 'Smith': [996], 'T.C.': [997], 'Wayne': [998], 'N.L.': [999], 'Connor': [1000], 'J.A.': [1001, 3988], 'Kaczmarek': [1002], 'L.K.': [1003], 'Nature.': [1004, 1255, 1282, 3991], '385:': [1006], '343-346Crossref': [1007], '(109)': [1010], '14Aspinwall': [1013], 'C.A.': [1014], 'Qian': [1015], 'W.J.': [1016], 'Roper': [1017], 'M.G.': [1018], 'Kulkarni': [1019], 'R.N.': [1020], 'Kahn': [1021], 'C.R.': [1022], 'Kennedy': [1023], 'R.T.': [1024], '22331-22338Abstract': [1030], '(141)': [1038], 'clear': [1045], 'whether': [1046, 1394, 2886, 3256, 3483, 3621, 3741], 'because': [1055, 4359], 'classical': [1060], 'agonist': [1061], 'modulation': [1063], 'Ca2+': [1066, 1098, 1403, 1421, 2991, 3230], 'Furthermore,': [1069, 2513], 'even': [1070], 'though': [1071], 'often': [1074], 'regarded': [1075], 'strictly': [1078], 'Ca2+/calmodulin-dependent': [1079], 'there': [1081, 2497, 2816], 'growing': [1084], 'body': [1085], 'evidence': [1087], 'independent': [1096, 1419, 2747, 2754, 3225, 3238, 3934, 3947], 'stimuli': [1100], 'IGF-1': [1103], '(15Tsukahara': [1104], 'Gordienko': [1106], 'D.V.': [1107], 'Tonshoff': [1108], 'B.': [1109, 1155, 1248], 'Gelato': [1110], 'M.C.': [1111, 3990], 'Goligorsky': [1112], 'M.S.': [1113], 'Kidney': [1114], 'Int.': [1115], '45:': [1117], '598-604Abstract': [1118], '(294)': [1124], 'estrogen': [1127], '(16Caulin-Glaser': [1128], 'Sarrel': [1132], 'Bender': [1136], 'J.R.': [1137], 'Circ.': [1138, 1158], 'Res.': [1139, 1159, 1212, 4304], '81:': [1141], '885-892Crossref': [1142], '(438)': [1145], 'shear': [1148], 'stress': [1149], '(17Fleming': [1150], 'I.': [1151, 1172, 1208, 1246, 1298], 'Bauersachs': [1152, 1173], 'Fisslthaler': [1154, 1247], 'Busse': [1156, 1181, 1209, 1251], 'R.': [1157, 1182, 1210, 1252, 1468, 4295], '82:': [1161], '686-695Crossref': [1162], '(225)': [1165], 'isometric': [1169], 'contraction': [1170], '(18Fleming': [1171], 'Schafer': [1175], 'Scholz': [1177], 'Aldershvile': [1179], 'Proc.': [1183, 4018, 4328], 'Natl.': [1184, 4019, 4329], 'Acad.': [1185, 4020, 4330], 'Sci.': [1186, 4021, 4331], 'S.': [1188, 1244, 1302, 1989, 4023, 4062, 4333, 4407], '96:': [1191], '1123-1128Crossref': [1192], '(102)': [1195], 'additional': [1199], 'regulating': [1202, 1354, 2993, 3262], 'exist': [1206, 4132], '(19Fleming': [1207], 'Cardiovasc.': [1211], '43:': [1214], '532-541Crossref': [1215], '(354)': [1218], 'Indeed,': [1221], 'several': [1222], 'groups': [1223, 2849], 'have': [1224, 4126], 'recently': [1225, 4127], 'phosphorylate': [1230, 3735], 'Ser1177(Ser1179': [1234], 'bovine': [1236, 1512, 1699, 1760, 1868, 3769, 3822], 'eNOS),': [1237], 'resulting': [1238], 'increased': [1240], '(20Dimmeler': [1243], 'Fleming': [1245], 'Hermann': [1249], 'C.': [1250, 1466], 'Zeiher': [1253], 'A.M.': [1254], '399:': [1257, 1284], '601-605Crossref': [1258], '(3022)': [1261], '21Fulton': [1264], 'Gratton': [1266], 'Fujio': [1272], 'Y.': [1273, 1589, 1991, 1995, 2017, 2021, 4064, 4087, 4409, 4413], 'Walsh': [1274], 'Franke': [1276], 'T.F.': [1277], 'Papapetropoulos': [1278], '597-601Crossref': [1285], '(2214)': [1288], '22Michell': [1291], 'B.J.': [1292], 'Griffiths': [1293], 'J.E.': [1294], 'Mitchelhill': [1295], 'K.I.': [1296], 'Rodriguez-Crespo': [1297], 'Tiganis': [1299], 'Bozinovski': [1301], 'de': [1303], 'Montellano': [1304], 'P.R.': [1305], 'Kemp': [1306], 'B.E.': [1307], 'Pearson': [1308], 'R.B.': [1309], 'Curr.': [1310], '12:': [1313], '845-848Abstract': [1314], '(411)': [1321], 'Previously,': [1324], 'had': [1326, 1345], 'identified': [1327, 2158, 2422, 2676], 'critical': [1329, 3346, 3957], 'pathway': [1336], 'responsible': [1337], 'studied': [1347], 'direct': [1349, 1569], 'effects': [1350, 3484], 'or': [1356, 1404, 1743, 1883, 2052, 2177, 2356, 2529, 2657, 2723, 3199, 3540, 3864], 'enzymatic': [1357], '(5Zeng': [1365], 'In': [1388, 2100, 2115, 3628, 3778, 4185], 'present': [1390, 1981], 'study,': [1391], 'investigated': [1393], 'which': [1397, 2390], 'involve': [1402], 'Our': [1410], 'results': [1411, 3056, 3211, 3326, 3391, 3438, 3687, 3742, 3817, 3899, 3910], 'suggest': [1412, 2606, 3218, 4103], 'activate': [1436, 3737], 'found': [1441, 4188], 'separable': [1452], 'functionally': [1454], 'independent.': [1455], 'pCIS2': [1457, 1580, 1611, 1742], 'mammalian': [1458], 'expression': [1459, 2136, 2771, 2840], 'vector': [1460, 1483], '(23Choi': [1461], 'Huang': [1463, 3979], 'Gorman': [1465], 'Jaenisch': [1467], 'Mol.': [1469, 1598, 4273], '1991;': [1472], '3070-3074Crossref': [1474], '(305)': [1477], 'Scholar)': [1479, 1674, 1815, 4077, 4102], 'parent': [1482], 'all': [1485, 2251], 'constructs.': [1486], 'XhoI/NotI': [1488], 'fragment': [1489], 'containing': [1490, 1612], 'cDNA': [1491, 1510, 1572, 1607], 'pDsRed1–1': [1498], '(CLONTECH': [1499], 'Laboratories': [1500], 'Inc.,': [1501, 1685, 2079, 2091, 2244, 2345], 'Palo': [1502], 'Alto,': [1503], 'CA)': [1504, 1771], 'subcloned': [1506, 1521], 'into': [1507, 1522, 1677, 2404], 'pCIS2.': [1508, 1523], '(a': [1514, 2910], 'gift': [1515], 'Dr.': [1517], 'Thomas': [1518], 'Michel)': [1519], 'A': [1524], 'point': [1525, 1613], 'eNOS-WT': [1528, 2653, 2721, 2750, 2773, 3198], 'disrupting': [1529], 'constructed': [1535], 'site-directed': [1537], 'mutagenesis': [1538], 'MORPH': [1541], 'kit': [1542], '(Eppendorf-5': [1543], 'Prime,': [1544], 'Boulder,': [1545], 'CO)': [1546], 'mutagenic': [1549], 'oligonucleotide': [1550], '(5′-CGT': [1551], 'ACC': [1552], 'CAG': [1553], 'GCC': [1554], 'TTT': [1555], 'TCC': [1556], 'CTG-3′).': [1557], 'mutation': [1559], 'introduced': [1560], 'new': [1562], 'StuI': [1563], 'confirmed': [1567], 'sequencing.': [1570], 'kinase-inactive': [1575], 'described': [1583, 1621, 1777, 2664], '(24Cong': [1584], 'L.N.': [1585, 1625], 'Chen': [1586, 4257, 4286], 'Li': [1588], 'Zhou': [1590, 4290], 'McGibbon': [1592], 'M.A.': [1593, 3986], 'Taylor': [1594, 1664, 4271, 4300, 4326], 'S.I.': [1595, 1665, 4272, 4301, 4327], 'Endocrinol.': [1599], '1881-1890Crossref': [1602], 'mutations': [1614], 'K179A,': [1615], 'T308A,': [1616], 'S473A': [1618], '(25Ahmad': [1622], 'Stenson': [1626], 'Holst': [1627], 'Wang': [1629], 'L.M.': [1630], 'Rahn': [1631], 'Landstrom': [1632], 'Pierce': [1634], 'J.H.': [1635, 4009], 'Degerman': [1638], 'E.': [1639], 'Manganiello': [1640], 'V.C.': [1641], 'Immunol.': [1643], '164:': [1645], '4678-4688Crossref': [1646], '(57)': [1649], 'NIH-3T3': [1652], 'fibroblasts': [1653], 'stably': [1654], 'receptors': [1658], '(NIH-3T3IR)': [1659], '(26Quon': [1660], 'Cama': [1662], 'Biochemistry.': [1666], '1992;': [1667], '31:': [1668], '9947-9954Crossref': [1669], '(23)': [1672], 'seeded': [1676], '35-mm': [1678], 'tissue': [1679, 4143], 'culture': [1680, 1766, 3775, 3905], 'dishes': [1681], '(Delta': [1682], 'TC3,': [1683], 'Bioptechs,': [1684], 'Butler,': [1686], 'PA)': [1687], 'grown': [1689, 1773, 1888], "Dulbecco's": [1691, 1851, 2044], 'modified': [1692, 1852, 1856, 2045], "Eagle's": [1693, 1853, 1857, 2046], 'medium': [1694, 1858], 'supplemented': [1695, 1907, 2048], '10%': [1697], 'fetal': [1698], 'serum,': [1700], 'penicillin': [1701], 'G': [1702], '(100': [1703, 1707, 1872, 2104, 2284, 2377], 'units/ml),': [1704], 'streptomycin': [1706], 'µg/ml)': [1708], '37': [1710, 1937, 2061], '°C': [1711, 2062], 'humid': [1714], 'atmosphere': [1715], '5%': [1717], 'CO2.': [1718], 'Cells': [1719, 2168, 2418], '60%': [1721], 'confluence': [1722, 1891], 'cotransfected': [1725, 2400, 2508, 2521, 2551, 2648, 2901, 3367], '0.1': [1727], 'µg': [1728, 1732, 1739, 2321], 'pCIS2-RFP,': [1730], '0.45': [1731, 1738], 'construct,': [1736], 'either': [1741, 2652, 3197, 3538, 3862], 'construct': [1746], 'LipofectAMINE': [1748], 'Plus': [1749], '(Life': [1750], 'Technologies,': [1751], 'Inc.).': [1752], 'Human': [1753], '(HUVEC)': [1758], 'aortic': [1761, 3770, 3823], 'primary': [1765, 3774, 3904], '(Clonetics': [1767], 'Corp.,': [1768], 'San': [1769], 'Diego,': [1770], 'EGM-2': [1775], 'used': [1817], 'passages': [1819], '3–4.': [1820], 'For': [1821, 2368], 'immunoblotting': [1822, 2369], 'experiments,': [1823, 2102, 2117], 'serum-starved': [1826, 1841, 1893], 'overnight': [1827], 'prior': [1828, 1878], 'initiation': [1830], 'experiments.': [1833], 'One': [1834], 'day': [1835], 'after': [1836, 1845, 2693, 2735], 'transfection,': [1837], '2': [1843, 1895, 2583, 2853, 2971], 'h': [1844, 1877, 1896], 'being': [1846], 'washed': [1847], 'three': [1848, 2041], 'times': [1849, 2042, 3811], 'medium-A': [1854, 2047], "(Dulbecco's": [1855], 'without': [1859, 3848], 'phenol,': [1861], '15': [1862], 'mm': [1863, 2285, 2288, 2296, 2302, 2308], 'Hepes,': [1864, 2289], 'pH': [1865, 2290], '7.4,': [1866], '0.1%': [1867], 'serum': [1869, 1912], 'albumin).': [1870], 'µm)': [1873, 2105], 'added': [1875, 2107, 2125, 2380, 3060], '1': [1876, 2295, 2304, 2442], 'each': [1880, 2231, 2257, 2262], 'study.': [1881], 'Untransfected': [1882], '95%': [1890], 'EBM-A': [1898], '(red': [1899], 'phenol-free': [1900], 'basal': [1902, 2272, 2591, 2936, 2975, 3600], 'media': [1903], 'Clonetics': [1905], 'Corp': [1906], '1%': [1909, 2292], 'platelet-deprived': [1910], 'horse': [1911], '(Sigma)': [1913], '100': [1915, 2050, 2279], 'µml-arginine).': [1916], 'Serum-starved': [1917], 'first': [1920, 3061, 3333], 'loaded': [1921, 2408], 'NO-reactive': [1924], '(DAF-2': [1928], 'DA;': [1929], 'Calbiochem)': [1930], '(final': [1931], 'concentration,': [1932], '3': [1933, 2228, 2594, 2939, 2977, 3090, 3104, 3214], 'µm;': [1934], '20': [1935, 2108, 2287], 'min,': [1936, 2972], '°C).': [1938], 'DA': [1940, 2625], 'cell-permeable': [1943], 'compound': [1944], 'converted': [1947], 'esterases': [1952], 'forms': [1954], 'triazole': [1956], 'derivative': [1957], 'presence': [1960, 3086, 3970], 'emits': [1964], 'light': [1965, 2143, 2188, 2223, 2432, 2450, 2681, 2709], '515': [1967, 2466], 'nm': [1968, 1973, 2195, 2435, 2467, 2493, 2688, 2716], 'upon': [1969, 2146, 2191, 2436, 2684, 2712], 'excitation': [1970, 2147, 2192, 2437, 2685, 2713], '489': [1972, 2194, 2452, 2492, 2715], 'proportion': [1975], 'amount': [1978], '(27Kojima': [1982, 4400], 'Nakatsubo': [1984, 4402], 'Kikuchi': [1986, 2012, 4404], 'Kawahara': [1988, 4406], 'Kirino': [1990, 4408], 'Nagoshi': [1992, 2014, 4410], 'Hirata': [1994, 2016, 4412], 'Nagano': [1996, 2024, 4414], 'Anal.': [1998, 4416], '70:': [2001, 4419], '2446-2453Crossref': [2002, 4420], '(1178)': [2005], '28Nakatsubo': [2008], 'Kojima': [2010], 'Maeda': [2018, 4002], 'Imai': [2020], 'Irimura': [2022], 'FEBS': [2026], 'Lett.': [2027], '427:': [2029], '263-266Crossref': [2030], '(337)': [2033], 'After': [2036], 'loading,': [2037], 'rinsed': [2040], 'µml-arginine': [2051], 'EBM-A,': [2053], 'kept': [2054], 'dark,': [2057], 'maintained': [2059, 2212], 'warming': [2065], 'stage': [2066], '(Bioptechs,': [2067], 'Inc.)': [2068], 'Zeiss': [2071, 2078], 'Axiovert': [2072], 'S100': [2073], 'TV': [2074], 'inverted': [2075], 'microscope': [2076], '(Carl': [2077], 'Thornwood,': [2080], 'NY)': [2081], 'equipped': [2082], 'argon': [2085], 'laser,': [2086], 'PentaMAX': [2087], 'camera': [2088], '(Princetown': [2089], 'Instruments': [2090], 'Trenton,': [2092], 'NJ),': [2093], 'appropriate': [2095], 'filters': [2096], 'fluorescence': [2098, 2235, 2464, 2575, 2733], 'microscopy.': [2099], 'some': [2101], 'l-NAME': [2103], 'min': [2109, 2584, 2595, 2692, 2940], 'before': [2110], 'loading': [2111], 'DA.': [2114, 2129], 'other': [2116], '10': [2118, 2301, 2307], 'µm': [2119], 'BAPTA': [2120, 3007, 3045, 3088, 3834], 'tetrakis(acetoxymethyl': [2121], 'ester)': [2122], '(Calbiochem)': [2123], 'along': [2126], 'To': [2130, 2385, 3254, 3481, 3739], 'identify': [2131], 'RFP': [2135, 2403, 2426, 2484, 2534, 2614, 2905], 'visualized': [2138, 2183, 2704], 'emission': [2140, 2185, 2429, 2678, 2706], '(583': [2144, 2682], 'nm)': [2145, 2190, 2378, 2440, 2683, 2711], '558': [2149, 2439, 2687], 'nm.': [2150], 'Typically,': [2151], 'two': [2152, 2848, 3559], 'five': [2154], 'field': [2161], 'view': [2163], '×': [2165], '32': [2166], 'magnification.': [2167], 'then': [2170, 3337, 3594], 'treated': [2171, 2560, 2662, 2907, 2953, 3273, 3332], '(LPA),': [2176], 'PDGF-BB,': [2178], 'green': [2187, 2463, 2708, 2732], '(515': [2189, 2710], 'over': [2196, 2250, 3588], 'period': [2198], 'up': [2200], '9': [2202], 'min.': [2203, 3604], 'Because': [2204, 2874, 3605], 'undergoes': [2208], 'significant': [2209, 3030, 3139, 3305], 'photobleaching,': [2210], 'dark': [2216], 'exposed': [2219], 'them': [2220], 'intensity': [2224, 2236, 2249, 2734], '20%': [2226], 's': [2229, 2931, 3581, 3592], 'image': [2232, 2269, 2783], 'captured.': [2233], 'Green': [2234], 'quantified': [2238], 'IP': [2240], 'Labs': [2241], 'Software': [2242], '(Scanalytics': [2243], 'Fairfax,': [2245], 'VA)': [2246], 'integrate': [2248], 'pixels': [2252], 'within': [2253], 'boundary': [2255], 'cell.': [2259], 'Data': [2260], 'experiment': [2263], 'normalized': [2265], 'reference': [2268], 'state.': [2273], 'Cell': [2274, 2351], 'lysates': [2275, 2764, 3116, 3160], 'prepared': [2277], 'µl': [2280], 'lysis': [2282, 2383], 'buffer': [2283], 'NaCl,': [2286], '7.9,': [2291], 'Triton': [2293], 'X-100,': [2294], 'Na3VO4,': [2297], '4': [2298, 3206, 3216], 'mmsodium': [2299], 'pyrophosphate,': [2300], 'EDTA,': [2303], 'mmphenylmethylsulfonyl': [2305], 'fluoride,': [2306], 'NaF,': [2309], 'complete': [2312], 'protease': [2313], 'inhibitor': [2314, 2526], 'mixture': [2315], '(Roche': [2316], 'Molecular': [2317], 'Biochemicals).': [2318], 'Samples': [2319], '(45': [2320], 'total': [2323], 'protein)': [2324], 'separated': [2326], '8%': [2328], 'SDS-polyacrylamide': [2329], 'gel': [2330], 'electrophoresis': [2331], 'immunoblotted': [2333, 3114], 'antibodies': [2335], 'against': [2336, 3122], '(Transduction': [2338], 'Laboratories,': [2339], 'Lexington,': [2340], 'KY),': [2341], '(Upstate': [2343], 'Biotechnology,': [2344], 'Lake': [2346], 'Placid,': [2347], 'NY),': [2348], 'phospho-eNOS': [2349, 2373, 3174], '(P-Ser1177,': [2350], 'Signaling': [2352], 'Technology,': [2353], 'Beverly,': [2354, 2362], 'MA),': [2355], 'phospho-Akt': [2357], '(P-Ser473,': [2358], 'New': [2359], 'England': [2360], 'Biolabs,': [2361], 'MA)': [2363], 'according': [2364], 'standard': [2366], 'methods.': [2367], 'experiments': [2370, 2748, 2755, 3765], 'antibody,': [2374], 'okadaic': [2375], 'buffer.': [2384], 'study': [2386, 4383], 'minimal': [2396, 3746, 3913], 'system,': [2397], 'NO-specific': [2412, 4373], '(Fig.1': [2416, 2494], 'A).': [2417, 3815], '(detected': [2427], '583': [2434], '(Fig.': [2441, 2479, 2831, 2852, 2941, 2979, 3010, 3046, 3089, 3103, 3176, 3201, 3281, 3320, 3411, 3432, 3702, 3720, 3776, 3813, 3844, 3854, 3891], 'B).': [2443], 'When': [2444, 2556, 2898, 2947], 'these': [2445, 2557, 2604, 2948, 3019, 3293, 3686, 4205], 'excited': [2448, 2490], 'nm,': [2453], 'rapid,': [2457], 'dose-dependent,': [2458], 'saturable': [2459], '∼50-fold': [2460], '(ED50': [2468], '∼50': [2470], 'nm),': [2471, 2569, 2699], 'indicative': [2472], 'rise': [2475, 2922, 3519, 3576], '1,': [2480], 'C–I).': [2481], 'Note': [2482], 'visible': [2487], 'C),': [2495], 'no': [2499, 2514, 2818], 'RFP.': [2512, 2555], 'pretreated': [2523, 3005, 3043], 'withl-NAME': [2524], '(competitive': [2525], 'eNOS)': [2528], 'alone': [2535, 3512], '(data': [2536, 3067, 3340, 3448, 3688, 3826], 'shown).': [2538, 3069, 3342, 3450, 3690, 3828], 'next': [2540, 2787, 3364, 3590], 'examined': [2541, 3365], 'time': [2543, 2728, 2967, 3545, 3560, 3667, 3782], 'course': [2544, 2729, 2968, 3546, 3668, 3783], 'maximally': [2563], 'stimulating': [2564], 'concentration': [2565], '(500': [2568, 2698], '30': [2577, 2930, 3580], 's,': [2578], 'peak': [2581], 'followed': [2585, 3582], 'return': [2589], 'levels': [2592, 2937, 3183, 3601], '(Fig.2,': [2596, 2809], 'A,': [2597, 2810, 3296, 3322, 3649, 3672], 'C,': [2598, 2811], 'andE,': [2599], 'closed': [2600, 2814, 2945, 3414, 3435, 3650, 3673, 3857, 3882], 'triangles).': [2601, 2985, 3052, 3298, 3674, 3858, 3896], 'Taken': [2602, 3208], 'together,': [2603, 3209], 'data': [2605], 'our': [2608, 3745, 3898, 3909], 'strategy': [2609], 'coexpressing': [2611], 'conjunction': [2619], 'use': [2622], 'useful': [2628], 'model': [2629], 'system': [2630, 3747], 'understanding': [2632, 4364], 'how': [2633], 'activity.Figure': [2638], '2Insulin-stimulated': [2639], 'requires': [2643, 3461, 3924], 'Ser1179.': [2644, 3955], 'pCIS2-RFP': [2650], '(A': [2654, 2689], 'C)': [2656], '(B': [2659], 'andD)': [2660], 'legend': [2667], 'Fig.': [2669], '1.': [2670], 'Transfected': [2671], '(expressing': [2673], 'RFP)': [2674, 3870], 'andB).': [2690], 'Two': [2691], '(C)': [2722], '(D).': [2725], 'E,': [2726, 2813, 2835, 2982], 'relative': [2731], 'plotted': [2739], 'mean': [2742], '±': [2743], 'S.E.': [2744], '12': [2746], '(▴)': [2751], '7': [2753, 3703, 3721], '(▵).': [2758], 'F,': [2759], 'anti-eNOS': [2760], 'immunoblot': [2761], 'cell': [2763, 3115, 3760, 4392], 'derived': [2765, 3161], 'comparable': [2770, 2839, 2959, 3036, 3311, 3713], 'eNOS-S1179A.': [2775], 'Ctrl,': [2776], 'control.View': [2777], 'Large': [2778], 'Image': [2779], 'Figure': [2780], 'ViewerDownload': [2781], 'Hi-res': [2782], 'Download': [2784], '(PPT)': [2785], 'compared': [2788, 3496], 'site).': [2800], 'Strikingly,': [2801], 'contrast': [2803], 'triangles),': [2815, 2837, 3415], '2,': [2832, 3106], 'B,D,': [2833], 'open': [2836, 3015, 3051, 3297, 3323], 'despite': [2838], 'F).': [2854], 'appears': [2862], 'absolutely': [2865], 'essential': [2866], 'insulin.': [2873, 2897], 'regulated': [2878], 'changes': [2880, 3227], 'inquired': [2885], 'Ca2+is': [2887], 'involved': [2889], 'phospholipid': [2911], 'mobilizes': [2915], 'Ca2+),': [2917], 'peaked': [2928], 'slowly': [2933], 'decreased': [2934], '3,': [2942, 2980, 3011, 3047, 3107], 'B–D': [2943], 'andK,': [2944, 3050], 'circles).': [2946, 3016, 3324, 3436], 'subsequently': [2952, 3023], 'distinct': [2966], '(peak': [2969], 'back': [2973, 3598], 'min)': [2978], 'D,': [2981, 3881], 'K,closed': [2984], 'Consistent': [2986], 'importance': [2989], 'activity,': [2995], 'LPA-induced': [2996], 'completely': [3001], '(calcium': [3008], 'chelator)': [3009], 'G–I': [3012], 'K,': [3014], 'Nevertheless,': [3017, 3299, 3707], 'when': [3018, 3057, 3112, 3329], 'BAPTA-treated': [3020], 'stimulated': [3024, 3073, 3304, 3696, 3712], 'seen': [3039, 3314], 'I,': [3048], 'J,': [3049], 'second': [3066], '(and': [3076], 'presumably': [3077], 'activation)': [3078], 'both': [3082, 3708, 4120, 4203], 'absence': [3084], 'L,': [3091], 'lanes': [3092, 3205], '4,': [3093, 3148, 3177, 3202], '5,': [3094], '8,': [3095, 3892], '9)': [3097], 'L,lanes': [3105], '6,': [3108], '7).': [3110], 'phosphospecific': [3119], 'antibody': [3120, 3175], 'directed': [3121], 'eNOS,': [3128, 3633], 'treatment,': [3131, 3135], 'resulted': [3136, 3572], 'Ser1179(Fig.': [3147], 'top': [3149, 3178], 'panel,lanes': [3150], '2–4).': [3151], 'No': [3152], 'band': [3153], 'detected': [3155, 3188], 'anti-phospho-eNOS': [3157], 'immunoblots': [3158], 'eNOS-S1179A,': [3168, 3394], 'demonstrating': [3169], 'specificity': [3171], 'panel,': [3179, 3204], 'lane': [3180], '5).': [3181], 'Comparable': [3182], 'phosphorylated': [3185], 'lower': [3203, 3812], 'and5).': [3207], 'Figs.': [3213], 'strongly': [3217], 'LPA-stimulated': [3233], 'activation.': [3241], 'alternative': [3243], 'must': [3252], 'exist.': [3253], 'determine': [3255, 3377, 3482, 3740, 4350], 'separable,': [3266], 'sequentially': [3272], 'As': [3278], 'above': [3280], '2),': [3282], 'unable': [3285], '(Fig.5': [3295], '5': [3321, 3412, 3433], 'Similar': [3325, 3389, 3437, 3816], 'required': [3356], 'Akt-K179A': [3372], '(inhibitory': [3373], 'mutant)': [3375], 'LPA-': [3383, 3787], 'insulin-mediated': [3385], 'B,': [3413, 3434, 3704, 3856], 'ability': [3418], 'unaffected': [3427], 'Akt-AAA': [3442], '(another': [3443], 'Akt)': [3447], 'These': [3451], 'findings': [3452], 'support': [3453], 'concept': [3455], 'does': [3476], 'require': [3478], 'this': [3479, 4360], 'phosphorylation.': [3480], 'synergistic,': [3494], 'simultaneous': [3497, 3567], '(Fig.6).': [3513], 'concurrent': [3526], 'alone.': [3542], 'combination': [3553], 'resembled': [3555, 3665], 'courses': [3561], 'individual': [3563], 'treatment.': [3564], 'That': [3565, 3915], 'is,': [3566, 3916], 'sustained': [3584], '90': [3591], 'decrease': [3597], '2.5': [3603], 'wondered': [3620], 'would': [3625], 'sufficient.': [3627], 'little,': [3634], 'if': [3635], 'any,': [3636], 'PDGF': [3646, 3679, 3709], '(Fig.7': [3648, 3671], 'squares),': [3651, 3847], 'illustrated': [3670], 'Interchanging': [3675], 'order': [3677], 'alter': [3685], 'Similarly,': [3691], 'PDGF,': [3695], 'upper': [3705], 'panel).': [3706], 'endogenous': [3718], 'B,lower': [3722], 'panels).': [3723], 'per': [3729], 'se': [3730], 'sufficient': [3733], 'relevant': [3756], 'type,': [3761], 'repeated': [3763], 'HUVEC': [3767, 3832, 3860], '8).': [3777], 'untransfected': [3779, 3821], 'HUVEC,': [3780], 'dynamics': [3785], 'absolute': [3804], '6–7': [3810], '8': [3814, 3845, 3855], 'significantly': [3835], 'inhibited': [3836], 'B,closed': [3846], 'affecting': [3849], 'Finally,': [3859], 'overexpressing': [3861], 'AKT-AAA': [3865], '(identified': [3866], 'produced': [3871], '(Fig.8,': [3878], 'C': [3879, 3893], 'squares)': [3883], 'D,closed': [3895], 'agree': [3906], 'system.': [3914], 'mobilization.': [3938], 'LPA-mediated': [3940], 'calcium-dependent': [3945], 'unequivocally': [3966], '"knockout"': [3975], 'mice': [3976, 4038, 4081], '(29Huang': [3977], 'P.L.': [3978], 'Z.': [3980], 'Mashimo': [3981], 'Bloch': [3983], 'K.D.': [3984], 'Moskowitz': [3985], 'Bevan': [3987], 'Fishman': [3989], '1995;': [3992, 4276], '377:': [3993], '239-242Crossref': [3994], '(1769)': [3997], '30Shesely': [4000], 'E.G.': [4001], 'Kim': [4004], 'H.S.': [4005], 'Desai': [4006], 'K.M.': [4007], 'Krege': [4008], 'Laubach': [4010], 'V.E.': [4011], 'Sherman': [4012], 'P.A.': [4013], 'Smithies': [4016], '93:': [4026], '13176-13181Crossref': [4027], '(783)': [4030], 'observations': [4034], 'IRS-1': [4036], 'knockout': [4037, 4080], 'hypertensive': [4040], '(31Abe': [4041], 'Yamada': [4043], 'Kamata': [4045], 'Kuwaki': [4047], 'Shimada': [4049], 'Osuga': [4051], 'Shionoiri': [4053], 'Yahagi': [4055], 'Kadowaki': [4057], 'Tamemoto': [4059], 'Ishibashi': [4061], 'Yazaki': [4063], 'Makuuchi': [4065], '1784-1788Crossref': [4072], '(203)': [4075], 'insulin-resistant': [4083], '(32Shankar': [4084], 'R.R.': [4085], 'Wu': [4086], 'Shen': [4088], 'Zhu': [4090], 'Diabetes.': [4094], '49:': [4096], '684-687Crossref': [4097], '(245)': [4100], 'intersect': [4113], 'contribute': [4115, 4362], 'importantly': [4116], 'cardiovascular': [4123], 'physiology.': [4124], 'shown': [4128], 'striking': [4130], 'parallels': [4131], 'glucose': [4139], 'uptake': [4140], 'adipose': [4142], '6Montagnani': [4170], 'particular,': [4186], 'PI': [4195], 'processes,': [4206], 'Ras': [4208], 'PDGF-stimulated': [4211], 'do': [4215], '33Quon': [4255], 'Ing': [4259], 'B.L.': [4260], 'Liu': [4261], 'M.L.': [4262], 'Zarnowski': [4263, 4292, 4318], 'Yonezawa': [4265], 'Kasuga': [4267], 'Cushman': [4269, 4298, 4324], 'S.W.': [4270, 4299, 4325], '15:': [4277], '5403-5411Crossref': [4278], '(143)': [4281], '34Quon': [4284], 'Lin': [4288], 'C.H.': [4289], 'Klinghoffer': [4294], 'Kazlauskas': [4296], 'Biochem.': [4302], 'Commun.': [4305], '226:': [4307], '587-594Crossref': [4308], '(30)': [4311], '35Quon': [4314], 'Guerre-Millo': [4316], 'Butte': [4320], 'A.J.': [4321], 'Em': [4322], '91:': [4336], '5587-5591Crossref': [4337], '(86)': [4340], 'underlying': [4354], 'pathophysiological': [4366], 'relationships': [4367], 'hypertension.': [4371], 'employed': [4380], 'quantitatively': [4382], 'variety': [4390], 'types': [4393], 'normally': [4395], 'express': [4396], 'isoforms': [4399], '(1178': [4423]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2149098481', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 22}, {'year': 2014, 'cited_by_count': 30}, {'year': 2013, 'cited_by_count': 35}, {'year': 2012, 'cited_by_count': 38}], 'updated_date': '2024-12-29T05:24:10.029920', 'created_date': '2016-06-24'}