Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2148978017', 'doi': 'https://doi.org/10.1016/j.braindev.2011.05.004', 'title': 'Close monitoring of initial enzyme replacement therapy in a patient with childhood-onset Pompe disease', 'display_name': 'Close monitoring of initial enzyme replacement therapy in a patient with childhood-onset Pompe disease', 'publication_year': 2011, 'publication_date': '2011-06-23', 'ids': {'openalex': 'https://openalex.org/W2148978017', 'doi': 'https://doi.org/10.1016/j.braindev.2011.05.004', 'mag': '2148978017', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21676566'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.braindev.2011.05.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S122866201', 'display_name': 'Brain and Development', 'issn_l': '0387-7604', 'issn': ['0387-7604', '1872-7131'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079540484', 'display_name': 'Keiko Ishigaki', 'orcid': 'https://orcid.org/0000-0001-8435-7418'}, 'institutions': [{'id': 'https://openalex.org/I4210136522', 'display_name': "Tokyo Women's Medical University", 'ror': 'https://ror.org/03kjjhe36', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I4210136522']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Keiko Ishigaki', 'raw_affiliation_strings': ["Department of Pediatrics, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatrics, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan", 'institution_ids': ['https://openalex.org/I4210136522']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111572889', 'display_name': 'Terumi Murakami', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136522', 'display_name': "Tokyo Women's Medical University", 'ror': 'https://ror.org/03kjjhe36', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I4210136522']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Terumi Murakami', 'raw_affiliation_strings': ["Department of Pediatrics, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatrics, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan", 'institution_ids': ['https://openalex.org/I4210136522']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067970141', 'display_name': 'Toshio Nakanishi', 'orcid': 'https://orcid.org/0000-0002-7374-9317'}, 'institutions': [{'id': 'https://openalex.org/I4210136522', 'display_name': "Tokyo Women's Medical University", 'ror': 'https://ror.org/03kjjhe36', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I4210136522']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshio Nakanishi', 'raw_affiliation_strings': ["Department of Pediatric Cardiology, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatric Cardiology, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan", 'institution_ids': ['https://openalex.org/I4210136522']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113926540', 'display_name': 'Eri Oda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136522', 'display_name': "Tokyo Women's Medical University", 'ror': 'https://ror.org/03kjjhe36', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I4210136522']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Eri Oda', 'raw_affiliation_strings': ["Department of Pediatrics, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatrics, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan", 'institution_ids': ['https://openalex.org/I4210136522']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028820608', 'display_name': 'Takatoshi Sato', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136522', 'display_name': "Tokyo Women's Medical University", 'ror': 'https://ror.org/03kjjhe36', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I4210136522']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takatoshi Sato', 'raw_affiliation_strings': ["Department of Pediatrics, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatrics, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan", 'institution_ids': ['https://openalex.org/I4210136522']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103438697', 'display_name': 'Makiko Ōsawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136522', 'display_name': "Tokyo Women's Medical University", 'ror': 'https://ror.org/03kjjhe36', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I4210136522']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Makiko Osawa', 'raw_affiliation_strings': ["Department of Pediatrics, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatrics, Heart Institute of Japan, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan", 'institution_ids': ['https://openalex.org/I4210136522']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5079540484'], 'corresponding_institution_ids': ['https://openalex.org/I4210136522'], 'apc_list': {'value': 2810, 'currency': 'USD', 'value_usd': 2810, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.77, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.744147, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '34', 'issue': '2', 'first_page': '98', 'last_page': '102'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12604', 'display_name': 'Glycogen Storage Diseases and Myoclonus', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10890', 'display_name': 'Trypanosoma species research and implications', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2779969927', 'wikidata': 'https://www.wikidata.org/wiki/Q916766', 'display_name': 'Enzyme replacement therapy', 'level': 3, 'score': 0.8951805}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.77247787}, {'id': 'https://openalex.org/C2776735236', 'wikidata': 'https://www.wikidata.org/wiki/Q1365789', 'display_name': 'Glycogen storage disease type II', 'level': 4, 'score': 0.48732838}, {'id': 'https://openalex.org/C187212893', 'wikidata': 'https://www.wikidata.org/wiki/Q123028', 'display_name': 'Pediatrics', 'level': 1, 'score': 0.46119168}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.40350395}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.33396742}], 'mesh': [{'descriptor_ui': 'D056947', 'descriptor_name': 'Enzyme Replacement Therapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D006009', 'descriptor_name': 'Glycogen Storage Disease Type II', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008991', 'descriptor_name': 'Monitoring, Physiologic', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003402', 'descriptor_name': 'Creatine Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003402', 'descriptor_name': 'Creatine Kinase', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D056947', 'descriptor_name': 'Enzyme Replacement Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006009', 'descriptor_name': 'Glycogen Storage Disease Type II', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D006009', 'descriptor_name': 'Glycogen Storage Disease Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006009', 'descriptor_name': 'Glycogen Storage Disease Type II', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008137', 'descriptor_name': 'Longitudinal Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008991', 'descriptor_name': 'Monitoring, Physiologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016138', 'descriptor_name': 'Walking', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016138', 'descriptor_name': 'Walking', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.braindev.2011.05.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S122866201', 'display_name': 'Brain and Development', 'issn_l': '0387-7604', 'issn': ['0387-7604', '1872-7131'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21676566', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.75}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 14, 'referenced_works': ['https://openalex.org/W1973983918', 'https://openalex.org/W1978295655', 'https://openalex.org/W2001805850', 'https://openalex.org/W2019168491', 'https://openalex.org/W2035947437', 'https://openalex.org/W2041506647', 'https://openalex.org/W2042263456', 'https://openalex.org/W2045626394', 'https://openalex.org/W2047627643', 'https://openalex.org/W2061707320', 'https://openalex.org/W2076662962', 'https://openalex.org/W2099289539', 'https://openalex.org/W2152085236', 'https://openalex.org/W2471451792'], 'related_works': ['https://openalex.org/W2976865511', 'https://openalex.org/W2412723576', 'https://openalex.org/W2173022900', 'https://openalex.org/W2150496077', 'https://openalex.org/W2139912313', 'https://openalex.org/W2078718267', 'https://openalex.org/W202703229', 'https://openalex.org/W2022807266', 'https://openalex.org/W2009928958', 'https://openalex.org/W1608471306'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2148978017', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-19T13:04:37.235698', 'created_date': '2016-06-24'}