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441, 499], '5%.': [45], 'Recent': [46], 'evidence': [47], 'suggests': [48], 'that': [49, 70, 103, 414], 'in': [50, 79, 115, 183, 195, 301, 319, 323, 332, 338, 352, 357, 370, 385, 420, 471], 'about': [51, 491], '70%': [52], 'fetuses': [54, 118, 131, 304, 388, 496], 'the': [58, 65, 71, 165, 175, 180, 263, 268, 281, 326, 339, 343, 347, 417, 445, 462], 'nasal': [59, 76, 91, 122, 150, 181, 270, 309, 315, 348, 394, 459], 'bone': [60, 77, 92, 182, 310, 316, 349, 460], 'not': [62, 127], 'visible': [63, 393], 'week': [67], 'scan': [68], 'frequency': [72], 'absence': [74, 178, 266], 'differs': [78], 'different': [80], 'ethnic': [81], 'groups.': [82], 'In': [83, 97, 130], 'addition,': [84], 'there': [85, 138], 'relationship': [88, 454], 'between': [89, 455], 'absent': [90, 121, 149, 306, 318, 351, 457], 'thickness.': [96], 'preliminary': [99], 'study': [100, 157, 204, 220], 'we': [101], 'showed': [102], 'while': [104], 'PAPP-A': [105, 277, 300, 383, 467], 'levels': [106, 112, 463], 'were': [107, 113, 247, 278, 366], 'lower': [108], 'higher': [114], 'an': [120, 148, 222, 456], 'bone,': [123, 395], 'this': [124, 155], 'difference': [125], 'was': [126, 158, 252, 311, 317, 350, 412, 448], 'statistically': [128], 'different.': [129], '13': [134, 199, 246, 324, 402], '18,': [137], 'also': [140, 248], 'high': [142], '(57': [143], '67%)': [145], 'incidence': [146], 'bone.': [151, 271], 'The': [152, 292, 314], 'aim': [153], 'present': [156, 308, 322], 'to': [159, 189], 'extend': [160], 'our': [161, 218], 'examination': [162, 251], 'whether': [164], 'level': [166], 'biochemical': [170, 483], 'markers': [171, 419], 'independent': [173], 'presence': [176, 264], 'or': [177, 265, 403, 468, 477], 'cases': [184, 196, 225, 237, 243, 330, 355, 361, 435, 472], 'ascertain': [190], 'if': [191], 'any': [192], 'differences': [193, 369], 'exist': [194], 'trisomies': [198, 401, 474], '18.': [201, 404], 'Methods': [202], 'This': [203], 'data': [205], 'comprised': [206], '100': [207], 'singleton': [210], 'pregnancies': [211], 'from': [217], 'previous': [219], 'additional': [223], '42': [224], 'analysed': [226], 'as': [227], 'part': [228], 'routine': [230], 'OSCAR': [231], 'screening.': [232], 'A': [233], 'total': [234], '34': [236], '18': [240, 345, 476], '12': [242], 'available.': [249], 'Ultrasound': [250], 'carried': [253], 'out': [254], 'measurement': [256], 'NT': [259, 377], 'assessment': [261], 'Maternal': [272], 'measured': [279], 'using': [280], 'Kryptor': [282], 'rapid': [283], 'random': [284], 'access': [285], 'immunoassay': [286], 'analyser': [287], '(Brahms': [288], 'Diagnostica': [289], 'AG,': [290], 'Berlin).': [291], 'distribution': [293], 'chromosomally': [302], 'abnormal': [303], 'examined.': [312], 'Results': [313], '29': [320], 'new': [327], '98': [333], '(69%)': [334], '44': [336], 'respectively': [337], 'combined': [340], 'series.': [341], 'For': [342, 405, 439], 'cases,': [346], '19': [353], '(55.9%)': [354], '3': [358], '(25%)': [359], '13.': [364], 'There': [365, 451], 'no': [367, 453], 'significant': [368], 'median': [371, 374], 'gestational': [375], 'delta,': [378], 'MoM': [381, 384], 'without': [391], 'similarly': [397], 'those': [399], '5%,': [410], 'it': [411], 'estimated': [413], 'screening': [415], 'four': [418], 'age': [424], 'would': [425], 'be': [426], '96%': [433], '21.': [438, 478], '0.5%,': [444], '88%.': [449], 'Conclusions': [450], '13,': [475], 'An': [479], 'integrated': [480], 'sonographic': [481], 'test': [484], 'can': [488], 'potentially': [489], 'identify': [490], '88%': [492], '0.5%.': [502], 'Copyright': [503], '©': [504], '2005': [505], 'John': [506], 'Wiley': [507], '&': [508], 'Sons,': [509], 'Ltd.': [510]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2148844778', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-13T10:52:19.598693', 'created_date': '2016-06-24'}