Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2148743079', 'doi': None, 'title': 'Role of histamine H3 receptors in the regulation of gastric functions.', 'display_name': 'Role of histamine H3 receptors in the regulation of gastric functions.', 'publication_year': 2001, 'publication_date': '2001-12-01', 'ids': {'openalex': 'https://openalex.org/W2148743079', 'mag': '2148743079', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11787757'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11787757', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028163528', 'display_name': 'Gabriella Coruzzi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I124601658', 'display_name': 'University of Parma', 'ror': 'https://ror.org/02k7wn190', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I124601658']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Coruzzi G', 'raw_affiliation_strings': ['Institute of Pharmacology, Medical Faculty, University of Parma, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacology, Medical Faculty, University of Parma, Italy.', 'institution_ids': ['https://openalex.org/I124601658']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024362933', 'display_name': 'Giuseppina Morini', 'orcid': 'https://orcid.org/0000-0002-6975-0235'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Morini G', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103202663', 'display_name': 'Maristella Adami', 'orcid': 'https://orcid.org/0000-0002-3807-8650'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Adami M', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5091516367', 'display_name': 'Daniela Grandi', 'orcid': 'https://orcid.org/0000-0003-3133-8496'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Grandi D', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.506, 'has_fulltext': False, 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.696523, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '52', 'issue': '4 Pt 1', 'first_page': '539', 'last_page': '53'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11346', 'display_name': 'Mast cells and histamine', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11346', 'display_name': 'Mast cells and histamine', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11584', 'display_name': 'Biochemical Analysis and Sensing Techniques', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10971', 'display_name': 'Olfactory and Sensory Function Studies', 'score': 0.989, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dimaprit', 'display_name': 'Dimaprit', 'score': 0.9322232}, {'id': 'https://openalex.org/keywords/pentagastrin', 'display_name': 'Pentagastrin', 'score': 0.50379485}], 'concepts': [{'id': 'https://openalex.org/C2776166919', 'wikidata': 'https://www.wikidata.org/wiki/Q5277162', 'display_name': 'Dimaprit', 'level': 5, 'score': 0.9322232}, {'id': 'https://openalex.org/C1122143', 'wikidata': 'https://www.wikidata.org/wiki/Q61233', 'display_name': 'Histamine', 'level': 2, 'score': 0.8172877}, {'id': 'https://openalex.org/C63180777', 'wikidata': 'https://www.wikidata.org/wiki/Q288395', 'display_name': 'Histamine H3 receptor', 'level': 4, 'score': 0.6759136}, {'id': 'https://openalex.org/C2777504413', 'wikidata': 'https://www.wikidata.org/wiki/Q846270', 'display_name': 'Gastric acid', 'level': 3, 'score': 0.6246641}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5837703}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.5727468}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.56290734}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5587846}, {'id': 'https://openalex.org/C34400551', 'wikidata': 'https://www.wikidata.org/wiki/Q311568', 'display_name': 'Histamine H2 receptor', 'level': 4, 'score': 0.5533219}, {'id': 'https://openalex.org/C2779377912', 'wikidata': 'https://www.wikidata.org/wiki/Q423586', 'display_name': 'Pentagastrin', 'level': 4, 'score': 0.50379485}, {'id': 'https://openalex.org/C159545944', 'wikidata': 'https://www.wikidata.org/wiki/Q424228', 'display_name': 'Histamine receptor', 'level': 4, 'score': 0.47538128}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.42623365}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.420271}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.27952302}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.25107545}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.21143481}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.16167772}], 'mesh': [{'descriptor_ui': 'D018100', 'descriptor_name': 'Receptors, Histamine H3', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D013270', 'descriptor_name': 'Stomach', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019610', 'descriptor_name': 'Cytoprotection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019610', 'descriptor_name': 'Cytoprotection', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005744', 'descriptor_name': 'Gastric Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005744', 'descriptor_name': 'Gastric Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005748', 'descriptor_name': 'Gastric Fundus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005748', 'descriptor_name': 'Gastric Fundus', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005748', 'descriptor_name': 'Gastric Fundus', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D005753', 'descriptor_name': 'Gastric Mucosa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005753', 'descriptor_name': 'Gastric Mucosa', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005753', 'descriptor_name': 'Gastric Mucosa', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016481', 'descriptor_name': 'Helicobacter Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016481', 'descriptor_name': 'Helicobacter Infections', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D016480', 'descriptor_name': 'Helicobacter pylori', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016480', 'descriptor_name': 'Helicobacter pylori', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006632', 'descriptor_name': 'Histamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006632', 'descriptor_name': 'Histamine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017442', 'descriptor_name': 'Histamine Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017442', 'descriptor_name': 'Histamine Agonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018100', 'descriptor_name': 'Receptors, Histamine H3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018100', 'descriptor_name': 'Receptors, Histamine H3', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013270', 'descriptor_name': 'Stomach', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11787757', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 88, 'referenced_works': ['https://openalex.org/W139697878', 'https://openalex.org/W1558123896', 'https://openalex.org/W1594704683', 'https://openalex.org/W1664200544', 'https://openalex.org/W1847746464', 'https://openalex.org/W1870330756', 'https://openalex.org/W1914965533', 'https://openalex.org/W1930515007', 'https://openalex.org/W1964392920', 'https://openalex.org/W1967843166', 'https://openalex.org/W1968005191', 'https://openalex.org/W1969352938', 'https://openalex.org/W1975870401', 'https://openalex.org/W1979976473', 'https://openalex.org/W1981727295', 'https://openalex.org/W1985411297', 'https://openalex.org/W1992649591', 'https://openalex.org/W2002717770', 'https://openalex.org/W2004573492', 'https://openalex.org/W2010673774', 'https://openalex.org/W2013538870', 'https://openalex.org/W2019732156', 'https://openalex.org/W2022231826', 'https://openalex.org/W2022236955', 'https://openalex.org/W2023191079', 'https://openalex.org/W2026225820', 'https://openalex.org/W2027522579', 'https://openalex.org/W2029227863', 'https://openalex.org/W2031533928', 'https://openalex.org/W2034837885', 'https://openalex.org/W2039031830', 'https://openalex.org/W2042180023', 'https://openalex.org/W2043391766', 'https://openalex.org/W2046207475', 'https://openalex.org/W2048733609', 'https://openalex.org/W2049563041', 'https://openalex.org/W2053950040', 'https://openalex.org/W2055195187', 'https://openalex.org/W2057388590', 'https://openalex.org/W2057777434', 'https://openalex.org/W2062555302', 'https://openalex.org/W2067866223', 'https://openalex.org/W2069933091', 'https://openalex.org/W2071596004', 'https://openalex.org/W2074949244', 'https://openalex.org/W2074988523', 'https://openalex.org/W2077687762', 'https://openalex.org/W2085577426', 'https://openalex.org/W2091486123', 'https://openalex.org/W2092361519', 'https://openalex.org/W2093224248', 'https://openalex.org/W2097836571', 'https://openalex.org/W2099553607', 'https://openalex.org/W2102773142', 'https://openalex.org/W2104462181', 'https://openalex.org/W2106903382', 'https://openalex.org/W2111140103', 'https://openalex.org/W2113935353', 'https://openalex.org/W2123652062', 'https://openalex.org/W2125991290', 'https://openalex.org/W2135612996', 'https://openalex.org/W2136804172', 'https://openalex.org/W2140994013', 'https://openalex.org/W2156174515', 'https://openalex.org/W2163641477', 'https://openalex.org/W2167216302', 'https://openalex.org/W2186316037', 'https://openalex.org/W2201091350', 'https://openalex.org/W2217155966', 'https://openalex.org/W2257594985', 'https://openalex.org/W2258309671', 'https://openalex.org/W2270927659', 'https://openalex.org/W2284016712', 'https://openalex.org/W2303823775', 'https://openalex.org/W2408955837', 'https://openalex.org/W2410291466', 'https://openalex.org/W2414917160', 'https://openalex.org/W2418875693', 'https://openalex.org/W2461229023', 'https://openalex.org/W2470257851', 'https://openalex.org/W2952817331', 'https://openalex.org/W317868860', 'https://openalex.org/W329871679', 'https://openalex.org/W346645064', 'https://openalex.org/W583784964', 'https://openalex.org/W639473593', 'https://openalex.org/W93761348', 'https://openalex.org/W945745145'], 'related_works': ['https://openalex.org/W2464352043', 'https://openalex.org/W2230382798', 'https://openalex.org/W2148743079', 'https://openalex.org/W2075755628', 'https://openalex.org/W2071638221', 'https://openalex.org/W2062288238', 'https://openalex.org/W1999967818', 'https://openalex.org/W1998377389', 'https://openalex.org/W1964700033', 'https://openalex.org/W147020135'], 'abstract_inverted_index': {'The': [0, 22, 49, 120], 'role': [1], 'of': [2, 12, 24, 30, 91, 94, 104, 146], 'central': [3, 89, 144], 'and': [4, 16, 42, 118], 'peripheral': [5, 28], 'histamine': [6, 76, 92, 147], 'H3': [7, 25, 95], 'receptors': [8, 26, 155], 'in': [9, 38, 47, 86], 'the': [10, 31, 99, 110, 128, 157], 'regulation': [11], 'gastric': [13, 17, 161], 'acid': [14, 36, 82], 'secretion': [15, 37], 'mucosal': [18], 'integrity': [19], 'is': [20], 'reviewed.': [21], 'activation': [23], 'by': [27, 113], 'administration': [29, 90, 103, 145], 'selective': [32], 'agonist': [33], '(R)alpha-methylhistamine': [34, 105], 'reduced': [35], 'cats,': [39], 'dogs,': [40], 'rats': [41, 87], 'rabbits,': [43], 'while': [44], 'increasing': [45], 'it': [46], 'mice.': [48], 'antisecretory': [50], 'effects': [51, 80, 108, 137, 159], 'were': [52, 84, 140], 'observed': [53, 85, 142], 'against': [54, 75, 109, 138], 'indirect': [55], 'stimuli': [56], 'that': [57, 153], 'act': [58], 'on': [59, 63, 81, 160], 'vagal': [60], 'pathways': [61], 'or': [62, 71, 77, 93, 148], 'enterochromaffin-like': [64], '(ECL)': [65], 'cells,': [66], 'such': [67], 'as': [68], '2-deoxy-D-glucose,': [69], 'food': [70], 'pentagastrin,': [72], 'but': [73], 'not': [74], 'dimaprit.': [78], 'Inhibitory': [79], 'production': [83], 'after': [88, 143], 'receptor': [96], 'agonists.': [97], 'In': [98], 'conscious': [100], 'rat': [101], 'intragastric': [102], 'caused': [106], 'gastroprotective': [107], 'damage': [111], 'induced': [112], 'absolute': [114], 'ethanol,': [115], 'HCl,': [116], 'aspirin': [117], 'stress.': [119], 'mechanism': [121], 'involved': [122], 'seems': [123], 'to': [124, 127], 'be': [125], 'related': [126], 'increased': [129], 'mucus': [130], 'production,': [131], 'via': [132], 'nitric': [133], 'oxide-independent': [134], 'mechanisms.': [135], 'Gastroprotective': [136], 'ethanol': [139], 'also': [141], 'its': [149], 'metabolite': [150], 'N(alpha)-methylhistamine,': [151], 'suggesting': [152], 'brain': [154], 'participate': [156], 'histamine-mediated': [158], 'functions.': [162]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2148743079', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-17T11:23:42.841278', 'created_date': '2016-06-24'}