Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2148646540', 'doi': 'https://doi.org/10.1016/s0092-8674(00)81251-9', 'title': 'The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo', 'display_name': 'The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo', 'publication_year': 1996, 'publication_date': '1996-05-01', 'ids': {'openalex': 'https://openalex.org/W2148646540', 'doi': 'https://doi.org/10.1016/s0092-8674(00)81251-9', 'mag': '2148646540', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8653786'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0092-8674(00)81251-9', 'pdf_url': 'http://www.cell.com/article/S0092867400812519/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.cell.com/article/S0092867400812519/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059507631', 'display_name': 'Thomas M. DeChiara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas M DeChiara', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076469568', 'display_name': 'David C. Bowen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David C Bowen', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046196948', 'display_name': 'David M. Valenzuela', 'orcid': 'https://orcid.org/0000-0002-6955-674X'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David M Valenzuela', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005559847', 'display_name': 'Mary V. Simmons', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mary V Simmons', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079368099', 'display_name': 'William Poueymirou', 'orcid': 'https://orcid.org/0000-0003-3164-7248'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William T Poueymirou', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076020658', 'display_name': 'Susan E. Gibson', 'orcid': 'https://orcid.org/0000-0002-0397-0665'}, 'institutions': [{'id': 'https://openalex.org/I2802849423', 'display_name': 'University Medical Center', 'ror': 'https://ror.org/036pt7h44', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802849423']}, {'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Susan Thomas', 'raw_affiliation_strings': ['Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York, New York 10016, USA'], 'affiliations': [{'raw_affiliation_string': 'Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York, New York 10016, USA', 'institution_ids': ['https://openalex.org/I2802849423', 'https://openalex.org/I57206974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071335717', 'display_name': 'Erika Kinetz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802849423', 'display_name': 'University Medical Center', 'ror': 'https://ror.org/036pt7h44', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802849423']}, {'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Erika Kinetz', 'raw_affiliation_strings': ['Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York, New York 10016, USA'], 'affiliations': [{'raw_affiliation_string': 'Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York, New York 10016, USA', 'institution_ids': ['https://openalex.org/I2802849423', 'https://openalex.org/I57206974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060667137', 'display_name': 'Debra Compton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Debra L Compton', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103478177', 'display_name': 'Eduardo Rojas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eduardo Rojas', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074605256', 'display_name': 'John S. Park', 'orcid': 'https://orcid.org/0000-0003-2151-1160'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John S Park', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085879565', 'display_name': 'Cynthia L. Smith', 'orcid': 'https://orcid.org/0000-0003-3691-0324'}, 'institutions': [{'id': 'https://openalex.org/I2802849423', 'display_name': 'University Medical Center', 'ror': 'https://ror.org/036pt7h44', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802849423']}, {'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cynthia Smith', 'raw_affiliation_strings': ['Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York, New York 10016, USA'], 'affiliations': [{'raw_affiliation_string': 'Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York, New York 10016, USA', 'institution_ids': ['https://openalex.org/I2802849423', 'https://openalex.org/I57206974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089219071', 'display_name': 'Peter S. DiStefano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter S DiStefano', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054558716', 'display_name': 'David J. Glass', 'orcid': 'https://orcid.org/0000-0001-6187-4164'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David J Glass', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082067939', 'display_name': 'Steven J. Burden', 'orcid': 'https://orcid.org/0000-0002-3550-6891'}, 'institutions': [{'id': 'https://openalex.org/I2802849423', 'display_name': 'University Medical Center', 'ror': 'https://ror.org/036pt7h44', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802849423']}, {'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven J Burden', 'raw_affiliation_strings': ['Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York, New York 10016, USA'], 'affiliations': [{'raw_affiliation_string': 'Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York, New York 10016, USA', 'institution_ids': ['https://openalex.org/I2802849423', 'https://openalex.org/I57206974']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085672493', 'display_name': 'George D. Yancopoulos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'George D Yancopoulos', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5085672493'], 'corresponding_institution_ids': ['https://openalex.org/I186523950'], 'apc_list': {'value': 10100, 'currency': 'USD', 'value_usd': 10100, 'provenance': 'doaj'}, 'apc_paid': {'value': 10100, 'currency': 'USD', 'value_usd': 10100, 'provenance': 'doaj'}, 'fwci': 20.86, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 867, 'citation_normalized_percentile': {'value': 0.999773, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '85', 'issue': '4', 'first_page': '501', 'last_page': '512'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10379', 'display_name': 'Cell Mechanics and Extracellular Matrix Interactions', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10379', 'display_name': 'Cell Mechanics and Extracellular Matrix Interactions', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10441', 'display_name': 'Molecular Mechanisms of Muscle Regeneration and Atrophy', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/agrin', 'display_name': 'Agrin', 'score': 0.96645033}, {'id': 'https://openalex.org/keywords/muscle-regeneration', 'display_name': 'Muscle Regeneration', 'score': 0.471544}], 'concepts': [{'id': 'https://openalex.org/C2779024559', 'wikidata': 'https://www.wikidata.org/wiki/Q4694120', 'display_name': 'Agrin', 'level': 4, 'score': 0.96645033}, {'id': 'https://openalex.org/C197341189', 'wikidata': 'https://www.wikidata.org/wiki/Q863533', 'display_name': 'Postsynaptic potential', 'level': 3, 'score': 0.87447405}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8438357}, {'id': 'https://openalex.org/C2777240379', 'wikidata': 'https://www.wikidata.org/wiki/Q776995', 'display_name': 'Neuromuscular junction', 'level': 2, 'score': 0.6768571}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6320502}, {'id': 'https://openalex.org/C127445978', 'wikidata': 'https://www.wikidata.org/wiki/Q187181', 'display_name': 'Synapse', 'level': 2, 'score': 0.595484}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.56091607}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.52324927}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.37389392}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.33992007}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11355069}], 'mesh': [{'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018171', 'descriptor_name': 'Agrin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000831', 'descriptor_name': 'Animals, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017353', 'descriptor_name': 'Gene Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005804', 'descriptor_name': 'Genes, Lethal', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018485', 'descriptor_name': 'Muscle Fibers, Skeletal', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011950', 'descriptor_name': 'Receptors, Cholinergic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013570', 'descriptor_name': 'Synaptic Membranes', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0092-8674(00)81251-9', 'pdf_url': 'http://www.cell.com/article/S0092867400812519/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8653786', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0092-8674(00)81251-9', 'pdf_url': 'http://www.cell.com/article/S0092867400812519/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 67, 'referenced_works': ['https://openalex.org/W1578606547', 'https://openalex.org/W1707332736', 'https://openalex.org/W1919056505', 'https://openalex.org/W1934148756', 'https://openalex.org/W1941310785', 'https://openalex.org/W1965653652', 'https://openalex.org/W1965983162', 'https://openalex.org/W1968739606', 'https://openalex.org/W1968957805', 'https://openalex.org/W1974320708', 'https://openalex.org/W1981850472', 'https://openalex.org/W1982180728', 'https://openalex.org/W1983185480', 'https://openalex.org/W1984734582', 'https://openalex.org/W1986559037', 'https://openalex.org/W1986841892', 'https://openalex.org/W1987098829', 'https://openalex.org/W1990654868', 'https://openalex.org/W1990907625', 'https://openalex.org/W1992628345', 'https://openalex.org/W1996430165', 'https://openalex.org/W1997668305', 'https://openalex.org/W1999880438', 'https://openalex.org/W2000720508', 'https://openalex.org/W2002301530', 'https://openalex.org/W2006298249', 'https://openalex.org/W2006656316', 'https://openalex.org/W2007334456', 'https://openalex.org/W2008256279', 'https://openalex.org/W2015114304', 'https://openalex.org/W2016638288', 'https://openalex.org/W2016828215', 'https://openalex.org/W2018112449', 'https://openalex.org/W2024523695', 'https://openalex.org/W2030204732', 'https://openalex.org/W2034787916', 'https://openalex.org/W2035359717', 'https://openalex.org/W2039162112', 'https://openalex.org/W2042802646', 'https://openalex.org/W2044199827', 'https://openalex.org/W2046516822', 'https://openalex.org/W2046678465', 'https://openalex.org/W2057313033', 'https://openalex.org/W2068836997', 'https://openalex.org/W2075357550', 'https://openalex.org/W2076657715', 'https://openalex.org/W2081082633', 'https://openalex.org/W2083486038', 'https://openalex.org/W2084943582', 'https://openalex.org/W2086874557', 'https://openalex.org/W2087362044', 'https://openalex.org/W2089011655', 'https://openalex.org/W2090473949', 'https://openalex.org/W2103944414', 'https://openalex.org/W2107131583', 'https://openalex.org/W2109547075', 'https://openalex.org/W2113222492', 'https://openalex.org/W2130294004', 'https://openalex.org/W2143395795', 'https://openalex.org/W2148129138', 'https://openalex.org/W2152890178', 'https://openalex.org/W2155080404', 'https://openalex.org/W2156080044', 'https://openalex.org/W2239081232', 'https://openalex.org/W2322962871', 'https://openalex.org/W2415630344', 'https://openalex.org/W261723633'], 'related_works': ['https://openalex.org/W2967536419', 'https://openalex.org/W2038459107', 'https://openalex.org/W2022885740', 'https://openalex.org/W2014987634', 'https://openalex.org/W2001765460', 'https://openalex.org/W1988851138', 'https://openalex.org/W1985460395', 'https://openalex.org/W1971968246', 'https://openalex.org/W1966840510', 'https://openalex.org/W1512382989'], 'abstract_inverted_index': {'Formation': [0], 'of': [1, 7, 23, 59, 89, 96, 122, 127], 'neuromuscular': [2], 'synapses': [3, 76], 'requires': [4], 'a': [5, 24, 30, 56, 64, 84, 107], 'series': [6], 'inductive': [8, 46], 'interactions': [9, 47], 'between': [10], 'growing': [11], 'motor': [12], 'axons': [13], 'and': [14, 41, 112, 133], 'differentiating': [15], 'muscle': [16, 37, 73], 'cells,': [17], 'culminating': [18], 'in': [19, 80, 86, 113], 'the': [20, 35, 60, 71, 87, 94, 128], 'precise': [21], 'juxtaposition': [22], 'highly': [25], 'specialized': [26], 'nerve': [27], 'terminal': [28], 'with': [29, 55, 93], 'complex': [31], 'molecular': [32], 'structure': [33], 'on': [34], 'postsynaptic': [36, 72, 129], 'surface.': [38, 74], 'The': [39], 'receptors': [40], 'signaling': [42, 116], 'pathways': [43], 'mediating': [44], 'these': [45, 81], 'are': [48], 'not': [49, 78], 'known.': [50], 'We': [51], 'have': [52], 'generated': [53], 'mice': [54], 'targeted': [57], 'disruption': [58], 'gene': [61], 'encoding': [62], 'MuSK,': [63], 'receptor': [65], 'tyrosine': [66], 'kinase': [67], 'selectively': [68], 'localized': [69], 'to': [70, 106], 'Neuromuscular': [75], 'do': [77], 'form': [79], 'mice,': [82], 'suggesting': [83], 'failure': [85], 'induction': [88], 'synapse': [90, 123], 'formation.': [91], 'Together': [92], 'results': [95], 'an': [97], 'accompanying': [98], 'manuscript,': [99], 'our': [100], 'findings': [101], 'indicate': [102], 'that': [103], 'MuSK': [104], 'responds': [105], 'critical': [108], 'nerve-derived': [109], 'signal': [110], '(agrin),': [111], 'turn': [114], 'activates': [115], 'cascades': [117], 'responsible': [118], 'for': [119], 'all': [120], 'aspects': [121], 'formation,': [124], 'including': [125], 'organization': [126], 'membrane,': [130], 'synapse-specific': [131], 'transcription,': [132], 'presynaptic': [134], 'differentiation.': [135]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2148646540', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 21}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 30}, {'year': 2020, 'cited_by_count': 34}, {'year': 2019, 'cited_by_count': 28}, {'year': 2018, 'cited_by_count': 27}, {'year': 2017, 'cited_by_count': 23}, {'year': 2016, 'cited_by_count': 19}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 32}, {'year': 2013, 'cited_by_count': 37}, {'year': 2012, 'cited_by_count': 42}], 'updated_date': '2024-09-15T00:14:57.955076', 'created_date': '2016-06-24'}