Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2147804649', 'doi': 'https://doi.org/10.1089/adt.2011.415', 'title': 'Comparison of Cell Expression Formats for the Characterization of GABA<sub>A</sub> Channels Using a Microfluidic Patch Clamp System', 'display_name': 'Comparison of Cell Expression Formats for the Characterization of GABA<sub>A</sub> Channels Using a Microfluidic Patch Clamp System', 'publication_year': 2012, 'publication_date': '2012-05-10', 'ids': {'openalex': 'https://openalex.org/W2147804649', 'doi': 'https://doi.org/10.1089/adt.2011.415', 'mag': '2147804649', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22574655', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3419985'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1089/adt.2011.415', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76283439', 'display_name': 'Assay and Drug Development Technologies', 'issn_l': '1540-658X', 'issn': ['1540-658X', '1557-8127'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320443', 'host_organization_name': 'Mary Ann Liebert, Inc.', 'host_organization_lineage': ['https://openalex.org/P4310320443'], 'host_organization_lineage_names': ['Mary Ann Liebert, Inc.'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3419985?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024032596', 'display_name': 'Qin Chen', 'orcid': 'https://orcid.org/0000-0001-6409-9300'}, 'institutions': [{'id': 'https://openalex.org/I4210110610', 'display_name': 'Fluxion Biosciences (United States)', 'ror': 'https://ror.org/01rde7a23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210110610']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Qin Chen', 'raw_affiliation_strings': ['Fluxion Biosciences, South San Francisco, California.'], 'affiliations': [{'raw_affiliation_string': 'Fluxion Biosciences, South San Francisco, California.', 'institution_ids': ['https://openalex.org/I4210110610']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064100811', 'display_name': 'Peter D. Yim', 'orcid': 'https://orcid.org/0000-0003-1670-7599'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter D. Yim', 'raw_affiliation_strings': ['The Department of Anesthesiology, Columbia University, New York, New York.'], 'affiliations': [{'raw_affiliation_string': 'The Department of Anesthesiology, Columbia University, New York, New York.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003229724', 'display_name': 'Nina Y. Yuan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43579087', 'display_name': 'University of Wisconsin–Milwaukee', 'ror': 'https://ror.org/031q21x57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43579087']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nina Yuan', 'raw_affiliation_strings': ['The Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.'], 'affiliations': [{'raw_affiliation_string': 'The Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.', 'institution_ids': ['https://openalex.org/I43579087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103494692', 'display_name': 'Juliette Johnson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110610', 'display_name': 'Fluxion Biosciences (United States)', 'ror': 'https://ror.org/01rde7a23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210110610']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Juliette Johnson', 'raw_affiliation_strings': ['Fluxion Biosciences, South San Francisco, California.'], 'affiliations': [{'raw_affiliation_string': 'Fluxion Biosciences, South San Francisco, California.', 'institution_ids': ['https://openalex.org/I4210110610']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021570300', 'display_name': 'James M. Cook', 'orcid': 'https://orcid.org/0000-0001-5512-3022'}, 'institutions': [{'id': 'https://openalex.org/I43579087', 'display_name': 'University of Wisconsin–Milwaukee', 'ror': 'https://ror.org/031q21x57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43579087']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James M. Cook', 'raw_affiliation_strings': ['The Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.'], 'affiliations': [{'raw_affiliation_string': 'The Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.', 'institution_ids': ['https://openalex.org/I43579087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011759109', 'display_name': 'Steven J. Smith', 'orcid': 'https://orcid.org/0000-0003-3248-5607'}, 'institutions': [{'id': 'https://openalex.org/I4210110610', 'display_name': 'Fluxion Biosciences (United States)', 'ror': 'https://ror.org/01rde7a23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210110610']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steve Smith', 'raw_affiliation_strings': ['Fluxion Biosciences, South San Francisco, California.'], 'affiliations': [{'raw_affiliation_string': 'Fluxion Biosciences, South San Francisco, California.', 'institution_ids': ['https://openalex.org/I4210110610']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061327416', 'display_name': 'Cristian Ionescu‐Zanetti', 'orcid': 'https://orcid.org/0000-0002-3123-0699'}, 'institutions': [{'id': 'https://openalex.org/I4210110610', 'display_name': 'Fluxion Biosciences (United States)', 'ror': 'https://ror.org/01rde7a23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210110610']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cristian Ionescu-Zanetti', 'raw_affiliation_strings': ['Fluxion Biosciences, South San Francisco, California.'], 'affiliations': [{'raw_affiliation_string': 'Fluxion Biosciences, South San Francisco, California.', 'institution_ids': ['https://openalex.org/I4210110610']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100453844', 'display_name': 'Zhijian Wang', 'orcid': 'https://orcid.org/0000-0003-2753-3790'}, 'institutions': [{'id': 'https://openalex.org/I43579087', 'display_name': 'University of Wisconsin–Milwaukee', 'ror': 'https://ror.org/031q21x57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43579087']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhi-Jian Wang', 'raw_affiliation_strings': ['The Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.'], 'affiliations': [{'raw_affiliation_string': 'The Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.', 'institution_ids': ['https://openalex.org/I43579087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048457363', 'display_name': 'Leggy A. Arnold', 'orcid': 'https://orcid.org/0000-0003-1411-1572'}, 'institutions': [{'id': 'https://openalex.org/I43579087', 'display_name': 'University of Wisconsin–Milwaukee', 'ror': 'https://ror.org/031q21x57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43579087']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Leggy A. Arnold', 'raw_affiliation_strings': ['The Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.'], 'affiliations': [{'raw_affiliation_string': 'The Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.', 'institution_ids': ['https://openalex.org/I43579087']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108799503', 'display_name': 'Charles W. Emala', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Charles W. Emala', 'raw_affiliation_strings': ['The Department of Anesthesiology, Columbia University, New York, New York.'], 'affiliations': [{'raw_affiliation_string': 'The Department of Anesthesiology, Columbia University, New York, New York.', 'institution_ids': ['https://openalex.org/I78577930']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5108799503'], 'corresponding_institution_ids': ['https://openalex.org/I78577930'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.257, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.553217, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '10', 'issue': '4', 'first_page': '325', 'last_page': '335'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11601', 'display_name': 'Neuroscience and Neural Engineering', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11601', 'display_name': 'Neuroscience and Neural Engineering', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hek-293-cells', 'display_name': 'HEK 293 cells', 'score': 0.88595635}, {'id': 'https://openalex.org/keywords/immortalised-cell-line', 'display_name': 'Immortalised cell line', 'score': 0.6361666}, {'id': 'https://openalex.org/keywords/gamma-aminobutyric-acid', 'display_name': 'Gamma-Aminobutyric Acid', 'score': 0.44555026}], 'concepts': [{'id': 'https://openalex.org/C174510640', 'wikidata': 'https://www.wikidata.org/wiki/Q489618', 'display_name': 'HEK 293 cells', 'level': 3, 'score': 0.88595635}, {'id': 'https://openalex.org/C147944092', 'wikidata': 'https://www.wikidata.org/wiki/Q176366', 'display_name': 'Patch clamp', 'level': 3, 'score': 0.764529}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.7313163}, {'id': 'https://openalex.org/C6045943', 'wikidata': 'https://www.wikidata.org/wiki/Q21014462', 'display_name': 'Immortalised cell line', 'level': 3, 'score': 0.6361666}, {'id': 'https://openalex.org/C50254741', 'wikidata': 'https://www.wikidata.org/wiki/Q62536', 'display_name': 'Ion channel', 'level': 3, 'score': 0.53635746}, {'id': 'https://openalex.org/C185263204', 'wikidata': 'https://www.wikidata.org/wiki/Q1154774', 'display_name': 'Electrophysiology', 'level': 2, 'score': 0.518998}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.508203}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.49027374}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4539258}, {'id': 'https://openalex.org/C166342909', 'wikidata': 'https://www.wikidata.org/wiki/Q845326', 'display_name': 'Allosteric regulation', 'level': 3, 'score': 0.4522614}, {'id': 'https://openalex.org/C2777771985', 'wikidata': 'https://www.wikidata.org/wiki/Q210021', 'display_name': 'gamma-Aminobutyric acid', 'level': 3, 'score': 0.44555026}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.43952438}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.41846645}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.331488}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.29110977}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28898615}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2108596}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.16492218}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.067214966}], 'mesh': [{'descriptor_ui': 'D018682', 'descriptor_name': 'GABA Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D046210', 'descriptor_name': 'Microfluidic Analytical Techniques', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D018408', 'descriptor_name': 'Patch-Clamp Techniques', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D001569', 'descriptor_name': 'Benzodiazepines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001569', 'descriptor_name': 'Benzodiazepines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001640', 'descriptor_name': 'Bicuculline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001640', 'descriptor_name': 'Bicuculline', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003975', 'descriptor_name': 'Diazepam', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003975', 'descriptor_name': 'Diazepam', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018682', 'descriptor_name': 'GABA Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018755', 'descriptor_name': 'GABA Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018755', 'descriptor_name': 'GABA Agonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018756', 'descriptor_name': 'GABA Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018756', 'descriptor_name': 'GABA Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018757', 'descriptor_name': 'GABA Modulators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018757', 'descriptor_name': 'GABA Modulators', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057166', 'descriptor_name': 'High-Throughput Screening Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015640', 'descriptor_name': 'Ion Channel Gating', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015640', 'descriptor_name': 'Ion Channel Gating', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D046210', 'descriptor_name': 'Microfluidic Analytical Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009118', 'descriptor_name': 'Muscimol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009118', 'descriptor_name': 'Muscimol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018408', 'descriptor_name': 'Patch-Clamp Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010852', 'descriptor_name': 'Picrotoxin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010852', 'descriptor_name': 'Picrotoxin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1089/adt.2011.415', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76283439', 'display_name': 'Assay and Drug Development Technologies', 'issn_l': '1540-658X', 'issn': ['1540-658X', '1557-8127'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320443', 'host_organization_name': 'Mary Ann Liebert, Inc.', 'host_organization_lineage': ['https://openalex.org/P4310320443'], 'host_organization_lineage_names': ['Mary Ann Liebert, Inc.'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3419985', 'pdf_url': 'https://europepmc.org/articles/pmc3419985?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419985', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22574655', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3419985', 'pdf_url': 'https://europepmc.org/articles/pmc3419985?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1482497049', 'https://openalex.org/W1563966782', 'https://openalex.org/W1921741715', 'https://openalex.org/W1977666620', 'https://openalex.org/W2006052244', 'https://openalex.org/W2011570269', 'https://openalex.org/W2031844916', 'https://openalex.org/W2036054527', 'https://openalex.org/W2047223439', 'https://openalex.org/W2064465222', 'https://openalex.org/W2064887450', 'https://openalex.org/W2066789664', 'https://openalex.org/W2078927871', 'https://openalex.org/W2090521204', 'https://openalex.org/W2096480261', 'https://openalex.org/W2101268699', 'https://openalex.org/W2101446007', 'https://openalex.org/W2118922355', 'https://openalex.org/W2121584076', 'https://openalex.org/W2125149840', 'https://openalex.org/W2133526968', 'https://openalex.org/W2133636515', 'https://openalex.org/W2133654255', 'https://openalex.org/W2137507678', 'https://openalex.org/W2141631265', 'https://openalex.org/W2161279036', 'https://openalex.org/W2162666247', 'https://openalex.org/W2162699756', 'https://openalex.org/W2235202817', 'https://openalex.org/W2264231063', 'https://openalex.org/W2346482202'], 'related_works': ['https://openalex.org/W2939998722', 'https://openalex.org/W2888470521', 'https://openalex.org/W2195592873', 'https://openalex.org/W2169750653', 'https://openalex.org/W2147804649', 'https://openalex.org/W2046450796', 'https://openalex.org/W2038410823', 'https://openalex.org/W2008959303', 'https://openalex.org/W1972430381', 'https://openalex.org/W1971782741'], 'abstract_inverted_index': {'Ensemble': [0], 'recording': [1, 17, 168], 'and': [2, 15, 51, 95, 132, 148, 199, 217], 'microfluidic': [3], 'perfusion': [4], 'are': [5], 'recently': [6], 'introduced': [7], 'techniques': [8], 'aimed': [9], 'at': [10], 'removing': [11], 'the': [12, 41, 181, 191, 215], 'laborious': [13], 'nature': [14], 'low': [16], 'success': [18, 137, 169, 183], 'rates': [19, 138], 'of': [20, 43, 48, 53, 98, 120, 159, 171, 220, 227], 'manual': [21, 186, 207], 'patch': [22, 187, 208, 236], 'clamp.': [23], 'Here,': [24], 'we': [25], 'present': [26], 'assay': [27], 'characteristics': [28], 'for': [29, 141], 'these': [30], 'features': [31], 'integrated': [32], 'into': [33], 'one': [34], 'automated': [35, 174, 235], 'electrophysiology': [36], 'platform': [37], 'as': [38, 61], 'applied': [39], 'to': [40, 125, 196, 204], 'study': [42], 'GABA(A)': [44, 54, 74, 85, 93, 106, 128, 154, 221], 'channels.': [45, 107, 155], 'A': [46], 'variety': [47, 226], 'cell': [49, 115, 228], 'types': [50, 116], 'methods': [52], 'channel': [55, 121, 129], 'expression': [56, 122], 'were': [57, 110], 'successfully': [58, 111], 'studied': [59, 112], '(defined': [60], 'I(GABA)>500': [62], 'pA),': [63], 'including': [64], 'stably': [65, 144], 'transfected': [66, 88, 145], 'human': [67, 99], 'embryonic': [68], 'kidney': [69], '(HEK)': [70], 'cells': [71, 80, 90, 103, 147, 152, 163], 'expressing': [72, 81, 91, 105, 153], 'α(1)β(3)γ(2)': [73, 82, 92], 'channels,': [75, 86, 94], 'frozen': [76, 149], 'ready-to-assay': [77], '(RTA)': [78], 'HEK': [79, 146, 151], 'or': [83, 143], 'α(3)β(3)γ(2)': [84], 'transiently': [87, 142], 'HEK293T': [89], 'immortalized': [96, 157], 'cultures': [97, 158], 'airway': [100, 160], 'smooth': [101, 161], 'muscle': [102, 162], 'endogenously': [104], 'Current': [108], 'measurements': [109], 'in': [113, 123, 223], 'multiple': [114, 118], 'with': [117], 'modes': [119], 'response': [124], 'several': [126], 'classic': [127], 'agonists,': [130, 197], 'antagonists,': [131, 198], 'allosteric': [133, 200], 'modulators.': [134], 'We': [135], 'obtained': [136], 'above': [139], '95%': [140], 'RTA': [150], 'Tissue-derived': [156], 'exhibited': [164], 'a': [165, 224], 'slightly': [166], 'lower': [167], 'rate': [170, 184], '75%': [172], 'using': [173, 185, 233], 'patch,': [175], 'which': [176], 'was': [177], 'much': [178], 'higher': [179], 'than': [180], '5%': [182], 'clamp': [188, 237], 'technique': [189], 'by': [190], 'same': [192], 'research': [193], 'group.': [194], 'Responses': [195], 'modulators': [201], 'compared': [202], 'well': [203], 'previously': [205], 'reported': [206], 'results.': [209], 'The': [210], 'data': [211], 'demonstrate': [212], 'that': [213], 'both': [214], 'biophysics': [216], 'pharmacologic': [218], 'characterization': [219], 'channels': [222], 'wide': [225], 'formats': [229], 'can': [230], 'be': [231], 'performed': [232], 'this': [234], 'system.': [238]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2147804649', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2025-01-12T19:45:12.313193', 'created_date': '2016-06-24'}