Publication Information

{'id': 'https://openalex.org/W2147438194', 'doi': 'https://doi.org/10.1371/journal.pone.0003525', 'title': 'The Specificity and Polymorphism of the MHC Class I Prevents the Global Adaptation of HIV-1 to the Monomorphic Proteasome and TAP', 'display_name': 'The Specificity and Polymorphism of the MHC Class I Prevents the Global Adaptation of HIV-1 to the Monomorphic Proteasome and TAP', 'publication_year': 2008, 'publication_date': '2008-10-23', 'ids': {'openalex': 'https://openalex.org/W2147438194', 'doi': 'https://doi.org/10.1371/journal.pone.0003525', 'mag': '2147438194', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18949050', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2645794'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0003525', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003525&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003525&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046769596', 'display_name': 'Boris V. Schmid', 'orcid': 'https://orcid.org/0000-0003-0452-623X'}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Boris Schmid', 'raw_affiliation_strings': ['Institute of Theoretical Biology, Utrecht University, Utrecht, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Institute of Theoretical Biology, Utrecht University, Utrecht, the Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073950969', 'display_name': 'Can Keşmir', 'orcid': 'https://orcid.org/0000-0002-8756-1171'}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}, {'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Can Keşmir', 'raw_affiliation_strings': ['Academic Biomedical Centre, Utrecht University, Utrecht, the Netherlands', 'Institute of Theoretical Biology, Utrecht University, Utrecht, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Academic Biomedical Centre, Utrecht University, Utrecht, the Netherlands', 'institution_ids': ['https://openalex.org/I193662353', 'https://openalex.org/I3018483916']}, {'raw_affiliation_string': 'Institute of Theoretical Biology, Utrecht University, Utrecht, the Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5053694044', 'display_name': 'Rob J. de Boer', 'orcid': 'https://orcid.org/0000-0002-2130-691X'}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Rob J. de Boer', 'raw_affiliation_strings': ['Institute of Theoretical Biology, Utrecht University, Utrecht, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Institute of Theoretical Biology, Utrecht University, Utrecht, the Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5046769596', 'https://openalex.org/A5073950969', 'https://openalex.org/A5053694044'], 'corresponding_institution_ids': ['https://openalex.org/I193662353', 'https://openalex.org/I193662353', 'https://openalex.org/I3018483916', 'https://openalex.org/I193662353'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 0.715, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.653281, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '3', 'issue': '10', 'first_page': 'e3525', 'last_page': 'e3525'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12576', 'display_name': 'vaccines and immunoinformatics approaches', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ctl*', 'display_name': 'CTL*', 'score': 0.602033}], 'concepts': [{'id': 'https://openalex.org/C195616568', 'wikidata': 'https://www.wikidata.org/wiki/Q128711', 'display_name': 'Epitope', 'level': 3, 'score': 0.9286822}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7877351}, {'id': 'https://openalex.org/C207936829', 'wikidata': 'https://www.wikidata.org/wiki/Q423163', 'display_name': 'Major histocompatibility complex', 'level': 3, 'score': 0.6217461}, {'id': 'https://openalex.org/C147969180', 'wikidata': 'https://www.wikidata.org/wiki/Q5014579', 'display_name': 'CTL*', 'level': 4, 'score': 0.602033}, {'id': 'https://openalex.org/C170627219', 'wikidata': 'https://www.wikidata.org/wiki/Q13218497', 'display_name': 'MHC class I', 'level': 4, 'score': 0.5787572}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.5708821}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.5695106}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.5042697}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.41169262}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.41022134}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.108282566}, {'id': 'https://openalex.org/C149923435', 'wikidata': 'https://www.wikidata.org/wiki/Q37732', 'display_name': 'Demography', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C144024400', 'wikidata': 'https://www.wikidata.org/wiki/Q21201', 'display_name': 'Sociology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005805', 'descriptor_name': 'Genes, MHC Class I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D037182', 'descriptor_name': 'T-Cell Antigen Receptor Specificity', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000220', 'descriptor_name': 'Adaptation, Biological', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000220', 'descriptor_name': 'Adaptation, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017951', 'descriptor_name': 'Antigen Presentation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017951', 'descriptor_name': 'Antigen Presentation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D017951', 'descriptor_name': 'Antigen Presentation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019295', 'descriptor_name': 'Computational Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007108', 'descriptor_name': 'Immune Tolerance', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007108', 'descriptor_name': 'Immune Tolerance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011153', 'descriptor_name': 'Population', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011153', 'descriptor_name': 'Population', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037182', 'descriptor_name': 'T-Cell Antigen Receptor Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013602', 'descriptor_name': 'T-Lymphocytes, Cytotoxic', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D013602', 'descriptor_name': 'T-Lymphocytes, Cytotoxic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0003525', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003525&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/61459e3be54741ada872a34e1ba63c1a', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2569417', 'pdf_url': 'https://europepmc.org/articles/pmc2569417?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569417', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18949050', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0003525', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003525&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.69}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 77, 'referenced_works': ['https://openalex.org/W14031296', 'https://openalex.org/W1502735160', 'https://openalex.org/W1527289043', 'https://openalex.org/W1547978013', 'https://openalex.org/W1559325378', 'https://openalex.org/W1606271020', 'https://openalex.org/W1664174075', 'https://openalex.org/W1674505922', 'https://openalex.org/W1969761972', 'https://openalex.org/W1978563162', 'https://openalex.org/W1980888764', 'https://openalex.org/W1985514943', 'https://openalex.org/W1995453338', 'https://openalex.org/W1999152416', 'https://openalex.org/W2006556166', 'https://openalex.org/W2006877285', 'https://openalex.org/W2012625502', 'https://openalex.org/W2013851631', 'https://openalex.org/W2014578768', 'https://openalex.org/W2018535220', 'https://openalex.org/W2018855162', 'https://openalex.org/W2019582266', 'https://openalex.org/W2029353650', 'https://openalex.org/W2031352213', 'https://openalex.org/W2046208887', 'https://openalex.org/W2058894986', 'https://openalex.org/W2061531912', 'https://openalex.org/W2061870048', 'https://openalex.org/W2063485002', 'https://openalex.org/W2072334833', 'https://openalex.org/W2073533360', 'https://openalex.org/W2086013059', 'https://openalex.org/W2086831001', 'https://openalex.org/W2087137589', 'https://openalex.org/W2087484510', 'https://openalex.org/W2088129901', 'https://openalex.org/W2092297539', 'https://openalex.org/W2092434970', 'https://openalex.org/W2094706980', 'https://openalex.org/W2095983332', 'https://openalex.org/W2097398162', 'https://openalex.org/W2100600596', 'https://openalex.org/W2100928031', 'https://openalex.org/W2102054691', 'https://openalex.org/W2102760333', 'https://openalex.org/W2103498243', 'https://openalex.org/W2107186721', 'https://openalex.org/W2107666854', 'https://openalex.org/W2108446353', 'https://openalex.org/W2110574412', 'https://openalex.org/W2111077677', 'https://openalex.org/W2112111895', 'https://openalex.org/W2115673224', 'https://openalex.org/W2116296845', 'https://openalex.org/W2118619247', 'https://openalex.org/W2118619556', 'https://openalex.org/W2122638950', 'https://openalex.org/W2124728662', 'https://openalex.org/W2124861675', 'https://openalex.org/W2124969212', 'https://openalex.org/W2131098197', 'https://openalex.org/W2131174506', 'https://openalex.org/W2139257243', 'https://openalex.org/W2141459466', 'https://openalex.org/W2142831360', 'https://openalex.org/W2144882745', 'https://openalex.org/W2148845590', 'https://openalex.org/W2151831732', 'https://openalex.org/W2153163225', 'https://openalex.org/W2158240501', 'https://openalex.org/W2158626262', 'https://openalex.org/W2166831581', 'https://openalex.org/W2169628767', 'https://openalex.org/W2169692131', 'https://openalex.org/W2170327206', 'https://openalex.org/W2171750584', 'https://openalex.org/W4229880569'], 'related_works': ['https://openalex.org/W2977793531', 'https://openalex.org/W2168688111', 'https://openalex.org/W2150433660', 'https://openalex.org/W2126139339', 'https://openalex.org/W2070684866', 'https://openalex.org/W2023967363', 'https://openalex.org/W1939527068', 'https://openalex.org/W1928100000', 'https://openalex.org/W1840653008', 'https://openalex.org/W1574776422'], 'abstract_inverted_index': {'The': [0], 'large': [1], 'diversity': [2], 'in': [3, 8, 146, 197], 'MHC': [4, 28, 79, 175, 183], 'class': [5], 'I': [6], 'molecules': [7], 'a': [9, 15, 18, 191, 198, 215, 218], 'population': [10, 130], 'lowers': [11], 'the': [12, 27, 42, 48, 55, 78, 91, 107, 129, 137, 155, 170, 174, 178, 194, 223], 'chance': [13], 'that': [14, 53, 98, 117, 161, 204, 211, 225], 'virus': [16, 216], 'infects': [17], 'host': [19, 199, 220], 'to': [20, 25, 61, 73, 101, 217], 'which': [21], 'it': [22], 'is': [23], 'pre-adapted': [24, 72], 'escape': [26, 63, 123], 'binding': [29], 'of': [30, 47, 77, 93, 111, 140, 164, 173, 181, 186, 193, 214, 222], 'CTL': [31, 38, 103], 'epitopes.': [32], 'However,': [33, 127], 'viruses': [34, 59, 84], 'can': [35, 166], 'also': [36], 'lose': [37], 'epitopes': [39, 142], 'by': [40, 169], 'escaping': [41], 'monomorphic': [43, 67], 'antigen': [44, 112], 'processing': [45, 113], 'components': [46], 'pathway': [49], '(proteasome': [50], 'and': [51, 105, 109, 121, 143, 177, 203], 'TAP)': [52], 'create': [54], 'epitope': [56, 144, 195, 227], 'precursors.': [57], 'If': [58], 'were': [60], 'accumulate': [62], 'mutations': [64, 124, 224], 'affecting': [65], 'these': [66, 132, 187], 'components,': [68], 'they': [69], 'would': [70], 'become': [71], 'all': [74], 'hosts': [75], 'regardless': [76], 'polymorphism.': [80], 'To': [81], 'assess': [82], 'whether': [83], 'exploit': [85], 'this': [86, 162], 'apparent': [87], 'vulnerability,': [88], 'we': [89], 'study': [90], 'evolution': [92], 'HIV-1': [94, 147], 'with': [95], 'bioinformatic': [96], 'tools': [97], 'allow': [99], 'us': [100], 'predict': [102], 'epitopes,': [104, 202], 'quantify': [106], 'frequency': [108], 'accumulation': [110], 'escapes.': [114], 'We': [115, 159, 209], 'found': [116], 'within': [118], 'hosts,': [119], 'proteasome': [120], 'TAP': [122], 'occur': [125], 'frequently.': [126], 'on': [128], 'level': [131], 'escapes': [133, 229], 'do': [134], 'not': [135], 'accumulate:': [136], 'total': [138], 'number': [139], 'predicted': [141], 'precursors': [145, 196], 'clade': [148], 'B': [149], 'has': [150], 'remained': [151], 'relatively': [152], 'constant': [153], 'over': [154], 'last': [156], '30': [157], 'years.': [158], 'argue': [160], 'lack': [163], 'adaptation': [165], 'be': [167], 'explained': [168], 'combined': [171], 'effect': [172], 'polymorphism': [176], 'high': [179], 'specificity': [180], 'individual': [182], 'molecules.': [184], 'Because': [185], 'two': [188], 'properties,': [189], 'only': [190], 'subset': [192, 205], 'are': [200, 230], 'potential': [201], 'differs': [206], 'between': [207], 'hosts.': [208], 'estimate': [210], 'upon': [212], 'transmission': [213], 'new': [219], '39%-66%': [221], 'caused': [226], 'precursor': [228], 'released': [231], 'from': [232], 'immune': [233], 'selection': [234], 'pressure.': [235]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2147438194', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-15T13:42:46.838783', 'created_date': '2016-06-24'}