Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2147381249', 'doi': 'https://doi.org/10.1113/jphysiol.2007.132647', 'title': 'Regulation of KCNQ channels by manipulation of phosphoinositides', 'display_name': 'Regulation of KCNQ channels by manipulation of phosphoinositides', 'publication_year': 2007, 'publication_date': '2007-04-06', 'ids': {'openalex': 'https://openalex.org/W2147381249', 'doi': 'https://doi.org/10.1113/jphysiol.2007.132647', 'mag': '2147381249', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17412763', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2075235'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1113/jphysiol.2007.132647', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/jphysiol.2007.132647', 'source': {'id': 'https://openalex.org/S2090548', 'display_name': 'The Journal of Physiology', 'issn_l': '0022-3751', 'issn': ['0022-3751', '1469-7793'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/jphysiol.2007.132647', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003536922', 'display_name': 'Byung‐Chang Suh', 'orcid': 'https://orcid.org/0000-0003-0278-2459'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Byung‐Chang Suh', 'raw_affiliation_strings': ['Department of Physiology and Biophysics. University of Washington School of Medicine. Seattle, WA 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Biophysics. University of Washington School of Medicine. Seattle, WA 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049507794', 'display_name': 'Bertil Hille', 'orcid': 'https://orcid.org/0000-0002-7266-1671'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bertil Hille', 'raw_affiliation_strings': ['Department of Physiology and Biophysics. University of Washington School of Medicine. Seattle, WA 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Biophysics. University of Washington School of Medicine. Seattle, WA 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.04, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 68, 'citation_normalized_percentile': {'value': 0.876241, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '582', 'issue': '3', 'first_page': '911', 'last_page': '916'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/second-messenger-system', 'display_name': 'Second messenger system', 'score': 0.7773651}], 'concepts': [{'id': 'https://openalex.org/C163235415', 'wikidata': 'https://www.wikidata.org/wiki/Q899814', 'display_name': 'Second messenger system', 'level': 3, 'score': 0.7773651}, {'id': 'https://openalex.org/C2780610907', 'wikidata': 'https://www.wikidata.org/wiki/Q2273248', 'display_name': 'Phosphatidylinositol', 'level': 3, 'score': 0.65627396}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.55633956}, {'id': 'https://openalex.org/C2778597717', 'wikidata': 'https://www.wikidata.org/wiki/Q420248', 'display_name': 'Phospholipase C', 'level': 3, 'score': 0.5351957}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5215673}, {'id': 'https://openalex.org/C33789571', 'wikidata': 'https://www.wikidata.org/wiki/Q410959', 'display_name': 'Muscarinic acetylcholine receptor', 'level': 3, 'score': 0.4582824}, {'id': 'https://openalex.org/C50254741', 'wikidata': 'https://www.wikidata.org/wiki/Q62536', 'display_name': 'Ion channel', 'level': 3, 'score': 0.453363}, {'id': 'https://openalex.org/C80631254', 'wikidata': 'https://www.wikidata.org/wiki/Q407438', 'display_name': 'G protein', 'level': 3, 'score': 0.44754755}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.42552364}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.40878743}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.366104}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.365133}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27649838}], 'mesh': [{'descriptor_ui': 'D051656', 'descriptor_name': 'KCNQ Potassium Channels', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010716', 'descriptor_name': 'Phosphatidylinositols', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D019870', 'descriptor_name': '1-Phosphatidylinositol 4-Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019870', 'descriptor_name': '1-Phosphatidylinositol 4-Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051656', 'descriptor_name': 'KCNQ Potassium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019269', 'descriptor_name': 'Phosphatidylinositol 4,5-Diphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019269', 'descriptor_name': 'Phosphatidylinositol 4,5-Diphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010716', 'descriptor_name': 'Phosphatidylinositols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015290', 'descriptor_name': 'Second Messenger Systems', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015290', 'descriptor_name': 'Second Messenger Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010738', 'descriptor_name': 'Type C Phospholipases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010738', 'descriptor_name': 'Type C Phospholipases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1113/jphysiol.2007.132647', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/jphysiol.2007.132647', 'source': {'id': 'https://openalex.org/S2090548', 'display_name': 'The Journal of Physiology', 'issn_l': '0022-3751', 'issn': ['0022-3751', '1469-7793'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075235', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17412763', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1113/jphysiol.2007.132647', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/jphysiol.2007.132647', 'source': {'id': 'https://openalex.org/S2090548', 'display_name': 'The Journal of Physiology', 'issn_l': '0022-3751', 'issn': ['0022-3751', '1469-7793'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.51, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1969429227', 'https://openalex.org/W1983769291', 'https://openalex.org/W2000702625', 'https://openalex.org/W2012951702', 'https://openalex.org/W2048894410', 'https://openalex.org/W2052082800', 'https://openalex.org/W2052454481', 'https://openalex.org/W2055659589', 'https://openalex.org/W2059690890', 'https://openalex.org/W2066489411', 'https://openalex.org/W2070189344', 'https://openalex.org/W2071786252', 'https://openalex.org/W2072459093', 'https://openalex.org/W2079373480', 'https://openalex.org/W2090469070', 'https://openalex.org/W2091884933', 'https://openalex.org/W2094069152', 'https://openalex.org/W2103687341', 'https://openalex.org/W2106699401', 'https://openalex.org/W2118141613', 'https://openalex.org/W2123505183', 'https://openalex.org/W2153841101', 'https://openalex.org/W2171553829', 'https://openalex.org/W4253230296'], 'related_works': ['https://openalex.org/W967991370', 'https://openalex.org/W859989218', 'https://openalex.org/W3084225630', 'https://openalex.org/W273099659', 'https://openalex.org/W2401625263', 'https://openalex.org/W2156132993', 'https://openalex.org/W2081610379', 'https://openalex.org/W2040399427', 'https://openalex.org/W2027294752', 'https://openalex.org/W2016066140'], 'abstract_inverted_index': {'Activation': [0, 34], 'of': [1, 12, 35, 57, 66, 94, 99, 101, 123, 138], 'phospholipase': [2], 'C': [3], '(PLC)': [4], 'through': [5], 'G-protein-coupled': [6], 'receptors': [7], 'produces': [8], 'a': [9, 50, 64, 116], 'large': [10], 'number': [11], 'second': [13], 'messengers': [14], 'and': [15, 76, 119, 129], 'regulates': [16], 'many': [17], 'physiological': [18], 'processes.': [19], 'Many': [20], 'membrane': [21, 112, 140], 'proteins': [22], 'including': [23], 'ion': [24], 'channels': [25, 73, 81], 'require': [26, 74], 'the': [27, 45, 54, 80, 110], 'phosphoinositide': [28, 102], 'phosphatidylinositol': [29], '4,5-bisphosphate': [30], '(PIP(2))': [31], 'to': [32, 69, 107, 109, 115, 133], 'function.': [33], 'PLC': [36, 86], 'can': [37, 130], 'shut': [38], 'down': [39], 'their': [40], 'activity': [41], 'if': [42], 'it': [43], 'depletes': [44, 87], 'PIP(2)': [46, 75, 136], 'pool': [47], 'strongly.': [48], 'Such': [49], 'mechanism': [51], 'accounts': [52], 'for': [53, 135], 'muscarinic': [55], 'suppression': [56], 'current': [58, 78], 'in': [59, 79, 113], 'KCNQ': [60], 'channels.': [61], 'We': [62], 'describe': [63], 'variety': [65], 'methods': [67, 90], 'used': [68, 132], 'show': [70], 'that': [71, 77], 'these': [72, 105], 'is': [82], 'suppressed': [83], 'when': [84], 'receptor-activated': [85], 'PIP(2).': [88], 'The': [89], 'include': [91], 'observing': [92], 'translocation': [93], 'lipid-sensitive': [95], 'protein': [96], 'domains,': [97], 'overexpression': [98], 'enzymes': [100, 106], 'metabolism,': [103], 'engineering': [104], 'move': [108], 'plasma': [111], 'response': [114], 'chemical': [117, 121], 'signal,': [118], 'direct': [120], 'analysis': [122], 'phospholipids.': [124], 'These': [125], 'approaches': [126], 'are': [127], 'general': [128], 'be': [131], 'test': [134], 'requirements': [137], 'other': [139], 'proteins.': [141]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2147381249', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-09T09:27:53.915583', 'created_date': '2016-06-24'}