Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2146872605', 'doi': 'https://doi.org/10.1111/j.2042-7158.2011.01279.x', 'title': 'Pharmaceutical applications of cyclodextrins: effects on drug permeation through biological membranes', 'display_name': 'Pharmaceutical applications of cyclodextrins: effects on drug permeation through biological membranes', 'publication_year': 2011, 'publication_date': '2011-04-04', 'ids': {'openalex': 'https://openalex.org/W2146872605', 'doi': 'https://doi.org/10.1111/j.2042-7158.2011.01279.x', 'mag': '2146872605', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21827484'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.2042-7158.2011.01279.x', 'pdf_url': 'https://academic.oup.com/jpp/article-pdf/63/9/1119/36357547/j.2042-7158.2011.01279.x.pdf', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/jpp/article-pdf/63/9/1119/36357547/j.2042-7158.2011.01279.x.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062520026', 'display_name': 'Þorsteinn Loftsson', 'orcid': 'https://orcid.org/0000-0002-9439-1553'}, 'institutions': [{'id': 'https://openalex.org/I165368041', 'display_name': 'University of Iceland', 'ror': 'https://ror.org/01db6h964', 'country_code': 'IS', 'type': 'education', 'lineage': ['https://openalex.org/I165368041']}], 'countries': ['IS'], 'is_corresponding': False, 'raw_author_name': 'Thorsteinn Loftsson', 'raw_affiliation_strings': ['Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata, Reykjavik, Iceland.'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata, Reykjavik, Iceland.', 'institution_ids': ['https://openalex.org/I165368041']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052108006', 'display_name': 'Marcus E. Brewster', 'orcid': 'https://orcid.org/0000-0003-0363-3316'}, 'institutions': [{'id': 'https://openalex.org/I137982388', 'display_name': 'Janssen (Belgium)', 'ror': 'https://ror.org/04yzcpd71', 'country_code': 'BE', 'type': 'company', 'lineage': ['https://openalex.org/I1330063522', 'https://openalex.org/I137982388']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Marcus E Brewster', 'raw_affiliation_strings': ['Pharmaceutical Development and Manufacturing Sciences, Janssen Research and Development, Johnson & Johnson, Scheperstraat, Beerse, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Pharmaceutical Development and Manufacturing Sciences, Janssen Research and Development, Johnson & Johnson, Scheperstraat, Beerse, Belgium', 'institution_ids': ['https://openalex.org/I137982388']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2665, 'currency': 'GBP', 'value_usd': 3268, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 8.086, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 247, 'citation_normalized_percentile': {'value': 0.916309, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '63', 'issue': '9', 'first_page': '1119', 'last_page': '1135'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10256', 'display_name': 'Drug Delivery Systems', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10256', 'display_name': 'Drug Delivery Systems', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10908', 'display_name': 'Chiral Separation in Chromatography', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyclodextrins', 'display_name': 'Cyclodextrins', 'score': 0.608525}, {'id': 'https://openalex.org/keywords/drug-solubility', 'display_name': 'Drug Solubility', 'score': 0.553595}, {'id': 'https://openalex.org/keywords/gastrointestinal-drug-absorption', 'display_name': 'Gastrointestinal Drug Absorption', 'score': 0.517383}, {'id': 'https://openalex.org/keywords/membrane-permeability', 'display_name': 'Membrane permeability', 'score': 0.47440267}], 'concepts': [{'id': 'https://openalex.org/C181389837', 'wikidata': 'https://www.wikidata.org/wiki/Q461809', 'display_name': 'Bioavailability', 'level': 2, 'score': 0.7111173}, {'id': 'https://openalex.org/C2779433975', 'wikidata': 'https://www.wikidata.org/wiki/Q40417805', 'display_name': 'Cyclodextrin', 'level': 2, 'score': 0.70563823}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.691752}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.6587286}, {'id': 'https://openalex.org/C50670333', 'wikidata': 'https://www.wikidata.org/wiki/Q907651', 'display_name': 'Permeation', 'level': 3, 'score': 0.60073286}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.5011978}, {'id': 'https://openalex.org/C2992270614', 'wikidata': 'https://www.wikidata.org/wiki/Q29548', 'display_name': 'Membrane permeability', 'level': 3, 'score': 0.47440267}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.46268952}, {'id': 'https://openalex.org/C183696295', 'wikidata': 'https://www.wikidata.org/wiki/Q2487696', 'display_name': 'Biochemical engineering', 'level': 1, 'score': 0.4410692}, {'id': 'https://openalex.org/C77281830', 'wikidata': 'https://www.wikidata.org/wiki/Q718608', 'display_name': 'Dosage form', 'level': 2, 'score': 0.43239528}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.28334722}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.2789622}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.090932876}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.07909006}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D003505', 'descriptor_name': 'Cyclodextrins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005079', 'descriptor_name': 'Excipients', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010599', 'descriptor_name': 'Pharmacokinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000042', 'descriptor_name': 'Absorption', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000042', 'descriptor_name': 'Absorption', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001682', 'descriptor_name': 'Biological Availability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003505', 'descriptor_name': 'Cyclodextrins', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D003505', 'descriptor_name': 'Cyclodextrins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D003505', 'descriptor_name': 'Cyclodextrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004339', 'descriptor_name': 'Drug Compounding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005079', 'descriptor_name': 'Excipients', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005079', 'descriptor_name': 'Excipients', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005079', 'descriptor_name': 'Excipients', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057927', 'descriptor_name': 'Hydrophobic and Hydrophilic Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010539', 'descriptor_name': 'Permeability', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010539', 'descriptor_name': 'Permeability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014867', 'descriptor_name': 'Water', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.2042-7158.2011.01279.x', 'pdf_url': 'https://academic.oup.com/jpp/article-pdf/63/9/1119/36357547/j.2042-7158.2011.01279.x.pdf', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21827484', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.2042-7158.2011.01279.x', 'pdf_url': 'https://academic.oup.com/jpp/article-pdf/63/9/1119/36357547/j.2042-7158.2011.01279.x.pdf', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'score': 0.87, 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 238, 'referenced_works': ['https://openalex.org/W117984517', 'https://openalex.org/W122760613', 'https://openalex.org/W132053806', 'https://openalex.org/W13604522', 'https://openalex.org/W142151810', 'https://openalex.org/W148175716', 'https://openalex.org/W1499935265', 'https://openalex.org/W1537920356', 'https://openalex.org/W1586111803', 'https://openalex.org/W1592964052', 'https://openalex.org/W160307565', 'https://openalex.org/W1664926220', 'https://openalex.org/W1697337825', 'https://openalex.org/W177460480', 'https://openalex.org/W1919410825', 'https://openalex.org/W1963922088', 'https://openalex.org/W1964003409', 'https://openalex.org/W1964186648', 'https://openalex.org/W1964304331', 'https://openalex.org/W1966132354', 'https://openalex.org/W1966955983', 'https://openalex.org/W1971763487', 'https://openalex.org/W1973154758', 'https://openalex.org/W1973869018', 'https://openalex.org/W1974234151', 'https://openalex.org/W1974284640', 'https://openalex.org/W1976301609', 'https://openalex.org/W1976486969', 'https://openalex.org/W1977593368', 'https://openalex.org/W1977698867', 'https://openalex.org/W1979325424', 'https://openalex.org/W1981751700', 'https://openalex.org/W1983111851', 'https://openalex.org/W1984856535', 'https://openalex.org/W1989511197', 'https://openalex.org/W1989700427', 'https://openalex.org/W1990274870', 'https://openalex.org/W1991042707', 'https://openalex.org/W1992785161', 'https://openalex.org/W1994158919', 'https://openalex.org/W1994315470', 'https://openalex.org/W1994438083', 'https://openalex.org/W1995701699', 'https://openalex.org/W1997094027', 'https://openalex.org/W1997566617', 'https://openalex.org/W1998027699', 'https://openalex.org/W1999307629', 'https://openalex.org/W1999361556', 'https://openalex.org/W1999892352', 'https://openalex.org/W1999987242', 'https://openalex.org/W2001533174', 'https://openalex.org/W2004312574', 'https://openalex.org/W2004844617', 'https://openalex.org/W2005090059', 'https://openalex.org/W2008395289', 'https://openalex.org/W2009483843', 'https://openalex.org/W2009561583', 'https://openalex.org/W2011269257', 'https://openalex.org/W2011382248', 'https://openalex.org/W2011873571', 'https://openalex.org/W2015651852', 'https://openalex.org/W2015911538', 'https://openalex.org/W2016588777', 'https://openalex.org/W2016817093', 'https://openalex.org/W2019526574', 'https://openalex.org/W2020165167', 'https://openalex.org/W2021760892', 'https://openalex.org/W2022132405', 'https://openalex.org/W2022646794', 'https://openalex.org/W2022905205', 'https://openalex.org/W2023758257', 'https://openalex.org/W2023772978', 'https://openalex.org/W2024172578', 'https://openalex.org/W2024897759', 'https://openalex.org/W2024909033', 'https://openalex.org/W2025116918', 'https://openalex.org/W2025931802', 'https://openalex.org/W2025934932', 'https://openalex.org/W2026639014', 'https://openalex.org/W2027593595', 'https://openalex.org/W2028712004', 'https://openalex.org/W2028807431', 'https://openalex.org/W2029667745', 'https://openalex.org/W2030650073', 'https://openalex.org/W2030779032', 'https://openalex.org/W2031384683', 'https://openalex.org/W2033040032', 'https://openalex.org/W2033885904', 'https://openalex.org/W2036325346', 'https://openalex.org/W2037927370', 'https://openalex.org/W2038136276', 'https://openalex.org/W2040562184', 'https://openalex.org/W2041903762', 'https://openalex.org/W2042442239', 'https://openalex.org/W2043096887', 'https://openalex.org/W2043303830', 'https://openalex.org/W2043496047', 'https://openalex.org/W2043961740', 'https://openalex.org/W2044923647', 'https://openalex.org/W2045079561', 'https://openalex.org/W2046017608', 'https://openalex.org/W2047612524', 'https://openalex.org/W2048194104', 'https://openalex.org/W2048384946', 'https://openalex.org/W2049047116', 'https://openalex.org/W2049395613', 'https://openalex.org/W2051050666', 'https://openalex.org/W2051825295', 'https://openalex.org/W2052093873', 'https://openalex.org/W2053369915', 'https://openalex.org/W2053466108', 'https://openalex.org/W2054266330', 'https://openalex.org/W2055091943', 'https://openalex.org/W2055104142', 'https://openalex.org/W2057081246', 'https://openalex.org/W2057618579', 'https://openalex.org/W2058699044', 'https://openalex.org/W2058792513', 'https://openalex.org/W2060774024', 'https://openalex.org/W2061219438', 'https://openalex.org/W2061252347', 'https://openalex.org/W2064410828', 'https://openalex.org/W2064972870', 'https://openalex.org/W2065378691', 'https://openalex.org/W2066322572', 'https://openalex.org/W2066787828', 'https://openalex.org/W2066828592', 'https://openalex.org/W2066847123', 'https://openalex.org/W2068225597', 'https://openalex.org/W2068227848', 'https://openalex.org/W2069506489', 'https://openalex.org/W2069972483', 'https://openalex.org/W2070825233', 'https://openalex.org/W2072813305', 'https://openalex.org/W2072888881', 'https://openalex.org/W2073909306', 'https://openalex.org/W2074084355', 'https://openalex.org/W2074629087', 'https://openalex.org/W2076899651', 'https://openalex.org/W2077180482', 'https://openalex.org/W2077284777', 'https://openalex.org/W2079197876', 'https://openalex.org/W2079551453', 'https://openalex.org/W2081691872', 'https://openalex.org/W2082378475', 'https://openalex.org/W2083676975', 'https://openalex.org/W2084102641', 'https://openalex.org/W2084635208', 'https://openalex.org/W2085118401', 'https://openalex.org/W2088321096', 'https://openalex.org/W2088341612', 'https://openalex.org/W2089348529', 'https://openalex.org/W2089579916', 'https://openalex.org/W2089709899', 'https://openalex.org/W2090280393', 'https://openalex.org/W2090319234', 'https://openalex.org/W2090845410', 'https://openalex.org/W2091001663', 'https://openalex.org/W2091171668', 'https://openalex.org/W2091457816', 'https://openalex.org/W2091807428', 'https://openalex.org/W2092865989', 'https://openalex.org/W2093190900', 'https://openalex.org/W2094486190', 'https://openalex.org/W2099126715', 'https://openalex.org/W2099490683', 'https://openalex.org/W2107707728', 'https://openalex.org/W2109886115', 'https://openalex.org/W2111217646', 'https://openalex.org/W2115820981', 'https://openalex.org/W2117363874', 'https://openalex.org/W2117798770', 'https://openalex.org/W2122956738', 'https://openalex.org/W2123237567', 'https://openalex.org/W2124542589', 'https://openalex.org/W2126307777', 'https://openalex.org/W2127291289', 'https://openalex.org/W2130169412', 'https://openalex.org/W2133004580', 'https://openalex.org/W2135732933', 'https://openalex.org/W2136480820', 'https://openalex.org/W2143963384', 'https://openalex.org/W2148040442', 'https://openalex.org/W2149020328', 'https://openalex.org/W2149659097', 'https://openalex.org/W2150620892', 'https://openalex.org/W2150877602', 'https://openalex.org/W2151560293', 'https://openalex.org/W2157915166', 'https://openalex.org/W2158178542', 'https://openalex.org/W2159728014', 'https://openalex.org/W2160996409', 'https://openalex.org/W2161910756', 'https://openalex.org/W2166471370', 'https://openalex.org/W2168642149', 'https://openalex.org/W2169315622', 'https://openalex.org/W2171802670', 'https://openalex.org/W2184765611', 'https://openalex.org/W2247971996', 'https://openalex.org/W2274369997', 'https://openalex.org/W2279868991', 'https://openalex.org/W2290987125', 'https://openalex.org/W2328408054', 'https://openalex.org/W2328945358', 'https://openalex.org/W2370566290', 'https://openalex.org/W2397443007', 'https://openalex.org/W2397646469', 'https://openalex.org/W2405248020', 'https://openalex.org/W2409893190', 'https://openalex.org/W2411194867', 'https://openalex.org/W2411574823', 'https://openalex.org/W2412043264', 'https://openalex.org/W2412064497', 'https://openalex.org/W2416062726', 'https://openalex.org/W2416232210', 'https://openalex.org/W2425841757', 'https://openalex.org/W2472162670', 'https://openalex.org/W2494097376', 'https://openalex.org/W25105854', 'https://openalex.org/W2522561419', 'https://openalex.org/W2596747802', 'https://openalex.org/W2741706734', 'https://openalex.org/W307898453', 'https://openalex.org/W40909142', 'https://openalex.org/W4232861085', 'https://openalex.org/W4234117485', 'https://openalex.org/W4245294660', 'https://openalex.org/W4247852925', 'https://openalex.org/W4249639739', 'https://openalex.org/W4252827483', 'https://openalex.org/W4255122926', 'https://openalex.org/W43934135', 'https://openalex.org/W53722208', 'https://openalex.org/W59956274', 'https://openalex.org/W640809714', 'https://openalex.org/W89378628', 'https://openalex.org/W89635747', 'https://openalex.org/W98119016'], 'related_works': ['https://openalex.org/W2965827201', 'https://openalex.org/W2567358723', 'https://openalex.org/W2151049431', 'https://openalex.org/W2110192055', 'https://openalex.org/W2099575842', 'https://openalex.org/W2087572532', 'https://openalex.org/W2073177056', 'https://openalex.org/W2046280088', 'https://openalex.org/W2044251933', 'https://openalex.org/W1505739641'], 'abstract_inverted_index': {'Cyclodextrins': [0, 69], 'are': [1, 102, 131], 'useful': [2, 104], 'solubilizing': [3], 'excipients': [4], 'that': [5, 90, 100, 197, 210], 'have': [6], 'gained': [7], 'currency': [8], 'in': [9, 66, 110, 140, 148, 204], 'the': [10, 58, 72, 80, 85, 93, 122, 126, 135, 149, 159, 166, 170, 187, 198, 202, 205, 217, 225, 229, 235, 238, 248], "formulator's": [11], 'armamentarium': [12], 'based': [13], 'on': [14], 'their': [15], 'ability': [16], 'to': [17, 33, 121, 133, 168, 215], 'temporarily': [18], 'camouflage': [19], 'undesirable': [20], 'physicochemical': [21], 'properties.': [22], 'In': [23], 'this': [24], 'context': [25], 'cyclodextrins': [26, 101], 'can': [27, 39, 70], 'increase': [28, 71], 'oral': [29], 'bioavailability,': [30], 'stabilize': [31], 'compounds': [32], 'chemical': [34], 'and': [35, 38, 95, 118, 161, 165, 173, 232], 'enzymatic': [36], 'degradation': [37], 'affect': [40], 'permeability': [41], 'through': [42, 76], 'biological': [43, 77], 'membranes': [44], 'under': [45], 'certain': [46], 'circumstances.': [47], 'This': [48, 98], 'latter': [49], 'property': [50], 'is': [51, 84, 116, 155, 207, 212, 245], 'examined': [52], 'herein': [53], 'as': [54, 61, 63], 'a': [55], 'function': [56], 'of': [57, 74, 125, 138, 151, 158, 163, 201, 237, 242, 251], 'published': [59], 'literature': [60], 'well': [62], 'work': [64], 'completed': [65], 'our': [67], 'laboratories.': [68], 'uptake': [73], 'drugs': [75, 139], 'barriers': [78], 'if': [79], 'limiting': [81], 'barrier': [82, 123], 'component': [83], 'unstirred': [86], 'water': [87], 'layer': [88], '(UWL)': [89], 'exists': [91], 'between': [92], 'membrane': [94], 'bulk': [96], 'water.': [97], 'means': [99], 'most': [103], 'when': [105], 'they': [106], 'interact': [107], 'with': [108, 183], 'lipophiles': [109], 'systems': [111], 'where': [112], 'such': [113, 196], 'an': [114, 156], 'UWL': [115], 'present': [117], 'contributes': [119], 'significantly': [120], 'properties': [124], 'membrane.': [127], 'Furthermore,': [128], 'these': [129], 'principles': [130], 'used': [132], 'direct': [134], 'optimal': [136, 208], 'formulation': [137, 150, 206, 230, 250], 'cyclodextrins.': [141], 'A': [142], 'second': [143], 'related': [144], 'critical': [145], 'success': [146], 'factor': [147], 'cyclodextrin-based': [152], 'drug': [153, 203, 218, 253], 'product': [154], 'understanding': [157, 241], 'kinetics': [160], 'thermodynamics': [162], 'complexation': [164, 244], 'need': [167], 'optimize': [169], 'cyclodextrin': [171, 214, 226, 243], 'amount': [172], 'drug-to-cyclodextrin': [174], 'ratios.': [175], 'Drug': [176], 'formulations,': [177], 'especially': [178], 'those': [179], 'targeting': [180], 'compartments': [181], 'associated': [182], 'limited': [184], 'dissolution': [185], '(i.e.': [186], 'eye,': [188], 'subcutaneous': [189], 'space,': [190], 'etc.),': [191], 'should': [192], 'be': [193], 'carefully': [194], 'designed': [195], 'thermodynamic': [199], 'activity': [200], 'meaning': [209], 'there': [211], 'sufficient': [213], 'solubilize': [216], 'but': [219], 'not': [220], 'more': [221], 'than': [222], 'that.': [223], 'Increasing': [224], 'concentration': [227], 'decreases': [228], "'push'": [231], 'may': [233], 'reduce': [234], 'bioavailability': [236], 'system.A': [239], 'mechanism-based': [240], 'essential': [246], 'for': [247], 'appropriate': [249], 'contemporary': [252], 'candidates.': [254]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2146872605', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 18}, {'year': 2017, 'cited_by_count': 23}, {'year': 2016, 'cited_by_count': 28}, {'year': 2015, 'cited_by_count': 25}, {'year': 2014, 'cited_by_count': 15}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-09-13T06:48:36.185508', 'created_date': '2016-06-24'}