Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2146844686', 'doi': 'https://doi.org/10.1128/jvi.00797-11', 'title': 'Highly Pathogenic Avian Influenza Virus Subtype H5N1 Escaping Neutralization: More than HA Variation', 'display_name': 'Highly Pathogenic Avian Influenza Virus Subtype H5N1 Escaping Neutralization: More than HA Variation', 'publication_year': 2011, 'publication_date': '2011-11-17', 'ids': {'openalex': 'https://openalex.org/W2146844686', 'doi': 'https://doi.org/10.1128/jvi.00797-11', 'mag': '2146844686', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22090121', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3264362'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.00797-11', 'pdf_url': 'https://jvi.asm.org/content/jvi/86/3/1394.full.pdf', 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://jvi.asm.org/content/jvi/86/3/1394.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056334251', 'display_name': 'Dirk W. Höper', 'orcid': 'https://orcid.org/0000-0001-8408-2274'}, 'institutions': [{'id': 'https://openalex.org/I1310048521', 'display_name': 'Friedrich-Loeffler-Institut', 'ror': 'https://ror.org/025fw7a54', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I1310048521', 'https://openalex.org/I2801963157']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Dirk Höper', 'raw_affiliation_strings': ['Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany', 'institution_ids': ['https://openalex.org/I1310048521']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108096057', 'display_name': 'Donata Kalthoff', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1310048521', 'display_name': 'Friedrich-Loeffler-Institut', 'ror': 'https://ror.org/025fw7a54', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I1310048521', 'https://openalex.org/I2801963157']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Donata Kalthoff', 'raw_affiliation_strings': ['Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany', 'institution_ids': ['https://openalex.org/I1310048521']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001905405', 'display_name': 'Donata Hoffmann', 'orcid': 'https://orcid.org/0000-0003-4552-031X'}, 'institutions': [{'id': 'https://openalex.org/I1310048521', 'display_name': 'Friedrich-Loeffler-Institut', 'ror': 'https://ror.org/025fw7a54', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I1310048521', 'https://openalex.org/I2801963157']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Bernd Hoffmann', 'raw_affiliation_strings': ['Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany', 'institution_ids': ['https://openalex.org/I1310048521']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036973907', 'display_name': 'Martin Beer', 'orcid': 'https://orcid.org/0000-0002-0598-5254'}, 'institutions': [{'id': 'https://openalex.org/I1310048521', 'display_name': 'Friedrich-Loeffler-Institut', 'ror': 'https://ror.org/025fw7a54', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I1310048521', 'https://openalex.org/I2801963157']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Martin Beer', 'raw_affiliation_strings': ['Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany', 'institution_ids': ['https://openalex.org/I1310048521']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.372, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.855051, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '86', 'issue': '3', 'first_page': '1394', 'last_page': '1404'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11560', 'display_name': 'Animal Disease Management and Epidemiology', 'score': 0.9867, 'subfield': {'id': 'https://openalex.org/subfields/1102', 'display_name': 'Agronomy and Crop Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11243', 'display_name': 'Respiratory viral infections research', 'score': 0.9809, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/antigenic-shift', 'display_name': 'Antigenic shift', 'score': 0.56231946}, {'id': 'https://openalex.org/keywords/h5n1-genetic-structure', 'display_name': 'H5N1 genetic structure', 'score': 0.5456082}, {'id': 'https://openalex.org/keywords/viral-evolution', 'display_name': 'Viral evolution', 'score': 0.5160048}, {'id': 'https://openalex.org/keywords/antigenic-variation', 'display_name': 'Antigenic variation', 'score': 0.5008135}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8922352}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.794682}, {'id': 'https://openalex.org/C7842527', 'wikidata': 'https://www.wikidata.org/wiki/Q575258', 'display_name': 'Antigenic drift', 'level': 4, 'score': 0.77336586}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.7155754}, {'id': 'https://openalex.org/C519248777', 'wikidata': 'https://www.wikidata.org/wiki/Q160122', 'display_name': 'Influenza A virus subtype H5N1', 'level': 3, 'score': 0.68397427}, {'id': 'https://openalex.org/C86282344', 'wikidata': 'https://www.wikidata.org/wiki/Q575314', 'display_name': 'Antigenic shift', 'level': 5, 'score': 0.56231946}, {'id': 'https://openalex.org/C82988372', 'wikidata': 'https://www.wikidata.org/wiki/Q5628866', 'display_name': 'H5N1 genetic structure', 'level': 5, 'score': 0.5456082}, {'id': 'https://openalex.org/C2777546802', 'wikidata': 'https://www.wikidata.org/wiki/Q834390', 'display_name': 'Influenza A virus', 'level': 3, 'score': 0.5164597}, {'id': 'https://openalex.org/C8769409', 'wikidata': 'https://www.wikidata.org/wiki/Q2066554', 'display_name': 'Viral evolution', 'level': 4, 'score': 0.5160048}, {'id': 'https://openalex.org/C191942190', 'wikidata': 'https://www.wikidata.org/wiki/Q4774739', 'display_name': 'Antigenic variation', 'level': 3, 'score': 0.5008135}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.5006633}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.49529734}, {'id': 'https://openalex.org/C14086860', 'wikidata': 'https://www.wikidata.org/wiki/Q337120', 'display_name': 'Neutralization', 'level': 3, 'score': 0.49401575}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.47051635}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.42915392}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2974773}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.28685355}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.19289291}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.1267896}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.07210001}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019267', 'descriptor_name': 'Hemagglutinin Glycoproteins, Influenza Virus', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D053124', 'descriptor_name': 'Influenza A Virus, H5N1 Subtype', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': True}, {'descriptor_ui': 'D009500', 'descriptor_name': 'Neutralization Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000915', 'descriptor_name': 'Antibody Affinity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005455', 'descriptor_name': 'Fluorescent Antibody Technique', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019267', 'descriptor_name': 'Hemagglutinin Glycoproteins, Influenza Virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053124', 'descriptor_name': 'Influenza A Virus, H5N1 Subtype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053124', 'descriptor_name': 'Influenza A Virus, H5N1 Subtype', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D053124', 'descriptor_name': 'Influenza A Virus, H5N1 Subtype', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.00797-11', 'pdf_url': 'https://jvi.asm.org/content/jvi/86/3/1394.full.pdf', 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3264362', 'pdf_url': 'https://europepmc.org/articles/pmc3264362?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264362', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22090121', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.00797-11', 'pdf_url': 'https://jvi.asm.org/content/jvi/86/3/1394.full.pdf', 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.75, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1531358666', 'https://openalex.org/W1538591251', 'https://openalex.org/W1930242224', 'https://openalex.org/W1961024194', 'https://openalex.org/W1965587444', 'https://openalex.org/W1969169898', 'https://openalex.org/W1969867599', 'https://openalex.org/W1972017488', 'https://openalex.org/W1990674671', 'https://openalex.org/W1993663080', 'https://openalex.org/W1997518925', 'https://openalex.org/W2003383506', 'https://openalex.org/W2006542313', 'https://openalex.org/W2006835350', 'https://openalex.org/W2007759731', 'https://openalex.org/W2014805409', 'https://openalex.org/W2015403041', 'https://openalex.org/W2024970913', 'https://openalex.org/W2034767282', 'https://openalex.org/W2037164614', 'https://openalex.org/W2051210160', 'https://openalex.org/W2062209433', 'https://openalex.org/W2063490058', 'https://openalex.org/W2072846173', 'https://openalex.org/W2082194820', 'https://openalex.org/W2085736050', 'https://openalex.org/W2089507691', 'https://openalex.org/W2091570982', 'https://openalex.org/W2097956735', 'https://openalex.org/W2106088492', 'https://openalex.org/W2109723200', 'https://openalex.org/W2127552525', 'https://openalex.org/W2131362286', 'https://openalex.org/W2132823022', 'https://openalex.org/W2135858175', 'https://openalex.org/W2142079260', 'https://openalex.org/W2142734829', 'https://openalex.org/W2151405742', 'https://openalex.org/W2155467153', 'https://openalex.org/W2157062142', 'https://openalex.org/W2160575854', 'https://openalex.org/W2166607097', 'https://openalex.org/W2168988686', 'https://openalex.org/W2170731906'], 'related_works': ['https://openalex.org/W62304571', 'https://openalex.org/W42631778', 'https://openalex.org/W2464109635', 'https://openalex.org/W2278636777', 'https://openalex.org/W2159805061', 'https://openalex.org/W2140347188', 'https://openalex.org/W2134766479', 'https://openalex.org/W2124935992', 'https://openalex.org/W2091436152', 'https://openalex.org/W1989752046'], 'abstract_inverted_index': {'Influenza': [0], 'A': [1, 56, 120, 136], 'viruses': [2, 14, 69, 137], 'are': [3], 'one': [4], 'of': [5, 50, 93, 134], 'the': [6, 27, 43, 89, 94, 107], 'major': [7], 'threats': [8], 'in': [9, 32, 59, 74, 83, 90, 95, 112, 139], 'modern': [10], 'health': [11], 'care.': [12], 'Novel': [13], 'arise': [15], 'due': [16], 'to': [17, 24, 41, 47, 117, 130], 'antigenic': [18, 21, 132], 'drift': [19], 'and': [20, 30, 46, 73, 123], 'shift,': [22], 'leading': [23], 'escape': [25, 44, 68], 'from': [26], 'immune': [28, 64], 'system': [29, 114], 'resulting': [31], 'a': [33], 'serious': [34], 'problem': [35], 'for': [36], 'disease': [37], 'control.': [38], 'In': [39], 'order': [40], 'investigate': [42], 'process': [45], 'enable': [48], 'predictions': [49], 'escape,': [51], 'we': [52], 'serially': [53], 'passaged': [54], 'influenza': [55, 119, 135], 'H5N1': [57], 'virus': [58, 121], 'vitro': [60, 113], '100': [61], 'times': [62], 'under': [63], 'pressure.': [65], 'The': [66], 'generated': [67], 'were': [70, 86, 104], 'characterized': [71], 'phenotypically': [72], 'detail': [75], 'by': [76], 'full-genome': [77], 'deep': [78], 'sequencing.': [79], 'Mutations': [80], 'already': [81], 'found': [82], 'natural': [84], 'isolates': [85], 'detected,': [87], 'evidencing': [88], 'vivo': [91], 'relevance': [92], 'vitro-induced': [96], 'amino': [97], 'acid': [98], 'substitutions.': [99], 'Additionally,': [100], 'several': [101], 'novel': [102], 'alterations': [103], 'triggered.': [105], 'Altogether,': [106], 'results': [108], 'imply': [109], 'that': [110, 124], 'our': [111], 'is': [115], 'suitable': [116], 'study': [118], 'evolution': [122], 'it': [125], 'might': [126], 'even': [127], 'be': [128], 'possible': [129], 'predict': [131], 'changes': [133], 'circulating': [138], 'vaccinated': [140], 'populations.': [141]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2146844686', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-10T07:10:24.817813', 'created_date': '2016-06-24'}