Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2145989199', 'doi': 'https://doi.org/10.1016/j.ijcard.2012.03.137', 'title': 'Contrasting effects of aliskiren versus losartan on hypertensive vascular remodeling', 'display_name': 'Contrasting effects of aliskiren versus losartan on hypertensive vascular remodeling', 'publication_year': 2013, 'publication_date': '2013-08-01', 'ids': {'openalex': 'https://openalex.org/W2145989199', 'doi': 'https://doi.org/10.1016/j.ijcard.2012.03.137', 'mag': '2145989199', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22483258'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ijcard.2012.03.137', 'pdf_url': 'http://www.internationaljournalofcardiology.com/article/S0167527312003440/pdf', 'source': {'id': 'https://openalex.org/S13342628', 'display_name': 'International Journal of Cardiology', 'issn_l': '0167-5273', 'issn': ['0167-5273', '1874-1754'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.internationaljournalofcardiology.com/article/S0167527312003440/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043321177', 'display_name': 'Alisson Martins-Oliveira', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Alisson Martins-Oliveira', 'raw_affiliation_strings': ['Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018979908', 'display_name': 'Michele M. Castro', 'orcid': 'https://orcid.org/0000-0002-3424-6573'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Michele M. Castro', 'raw_affiliation_strings': ['Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068491038', 'display_name': 'Diogo M.M. Oliveira', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Diogo M.M. Oliveira', 'raw_affiliation_strings': ['Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050181613', 'display_name': 'Élen Rizzi', 'orcid': 'https://orcid.org/0000-0002-3823-8845'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Elen Rizzi', 'raw_affiliation_strings': ['Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075437630', 'display_name': 'Carla S. Ceron', 'orcid': 'https://orcid.org/0000-0001-8882-5792'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Carla S. Ceron', 'raw_affiliation_strings': ['Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056754879', 'display_name': 'Danielle Guimarães', 'orcid': 'https://orcid.org/0000-0002-5187-2090'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Danielle Guimaraes', 'raw_affiliation_strings': ['Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090610829', 'display_name': 'Rosana Maria dos Reis', 'orcid': 'https://orcid.org/0000-0001-9631-4167'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Rosana I. Reis', 'raw_affiliation_strings': ['Department of Biochemistry & Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry & Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105827859', 'display_name': 'Frédéric Laigret', 'orcid': 'https://orcid.org/0000-0002-7256-6412'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Claudio M. Costa-Neto', 'raw_affiliation_strings': ['Department of Biochemistry & Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry & Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008620091', 'display_name': 'Dulce Elena Casarini', 'orcid': 'https://orcid.org/0000-0003-1912-4292'}, 'institutions': [{'id': 'https://openalex.org/I88273585', 'display_name': 'Universidade Federal de São Paulo', 'ror': 'https://ror.org/02k5swt12', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I88273585']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Dulce E. Casarini', 'raw_affiliation_strings': ['Department of Medicine – Nephrology Division, Federal University of Sao Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine – Nephrology Division, Federal University of Sao Paulo, Brazil', 'institution_ids': ['https://openalex.org/I88273585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030495411', 'display_name': 'Amanda Ribeiro', 'orcid': 'https://orcid.org/0000-0001-8915-9357'}, 'institutions': [{'id': 'https://openalex.org/I88273585', 'display_name': 'Universidade Federal de São Paulo', 'ror': 'https://ror.org/02k5swt12', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I88273585']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Amanda A. Ribeiro', 'raw_affiliation_strings': ['Department of Medicine – Nephrology Division, Federal University of Sao Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine – Nephrology Division, Federal University of Sao Paulo, Brazil', 'institution_ids': ['https://openalex.org/I88273585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022834761', 'display_name': 'Raquel F. Gerlach', 'orcid': 'https://orcid.org/0000-0002-7031-2128'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Raquel F. Gerlach', 'raw_affiliation_strings': ['Department of Morphology, Estomatology and Physiology, Dental School of Ribeirao Preto, University of Sao Paulo, Brazil.'], 'affiliations': [{'raw_affiliation_string': 'Department of Morphology, Estomatology and Physiology, Dental School of Ribeirao Preto, University of Sao Paulo, Brazil.', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002216895', 'display_name': 'José E. Tanus‐Santos', 'orcid': 'https://orcid.org/0000-0002-9945-9633'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Jose E. Tanus-Santos', 'raw_affiliation_strings': ['Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3340, 'currency': 'USD', 'value_usd': 3340, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.12, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.908529, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '167', 'issue': '4', 'first_page': '1199', 'last_page': '1205'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11839', 'display_name': 'Management of Primary Aldosteronism', 'score': 0.9924, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nurr1/CoREST Pathway in Neuroprotection and Inflammation', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/renin-inhibitor', 'display_name': 'Renin inhibitor', 'score': 0.76818186}, {'id': 'https://openalex.org/keywords/hypertension', 'display_name': 'Hypertension', 'score': 0.516739}, {'id': 'https://openalex.org/keywords/aliskiren', 'display_name': 'Aliskiren', 'score': 0.508218}], 'concepts': [{'id': 'https://openalex.org/C2779838083', 'wikidata': 'https://www.wikidata.org/wiki/Q414904', 'display_name': 'Aliskiren', 'level': 4, 'score': 0.9798026}, {'id': 'https://openalex.org/C2780288358', 'wikidata': 'https://www.wikidata.org/wiki/Q410074', 'display_name': 'Losartan', 'level': 4, 'score': 0.96749616}, {'id': 'https://openalex.org/C2777425892', 'wikidata': 'https://www.wikidata.org/wiki/Q409255', 'display_name': 'Renin inhibitor', 'level': 4, 'score': 0.76818186}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.73955816}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6509827}, {'id': 'https://openalex.org/C198710026', 'wikidata': 'https://www.wikidata.org/wiki/Q898218', 'display_name': 'Renin–angiotensin system', 'level': 3, 'score': 0.6228613}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6218067}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.5814653}, {'id': 'https://openalex.org/C2908929049', 'wikidata': 'https://www.wikidata.org/wiki/Q65963433', 'display_name': 'Angiotensin II', 'level': 3, 'score': 0.541875}, {'id': 'https://openalex.org/C2779869378', 'wikidata': 'https://www.wikidata.org/wiki/Q409747', 'display_name': 'Elastin', 'level': 2, 'score': 0.4206591}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.32075378}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.30440846}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.16789266}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.12948191}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D005650', 'descriptor_name': 'Fumarates', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D019808', 'descriptor_name': 'Losartan', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D020257', 'descriptor_name': 'Ventricular Remodeling', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D005650', 'descriptor_name': 'Fumarates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005650', 'descriptor_name': 'Fumarates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D019808', 'descriptor_name': 'Losartan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019808', 'descriptor_name': 'Losartan', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020257', 'descriptor_name': 'Ventricular Remodeling', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D020257', 'descriptor_name': 'Ventricular Remodeling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ijcard.2012.03.137', 'pdf_url': 'http://www.internationaljournalofcardiology.com/article/S0167527312003440/pdf', 'source': {'id': 'https://openalex.org/S13342628', 'display_name': 'International Journal of Cardiology', 'issn_l': '0167-5273', 'issn': ['0167-5273', '1874-1754'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22483258', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ijcard.2012.03.137', 'pdf_url': 'http://www.internationaljournalofcardiology.com/article/S0167527312003440/pdf', 'source': {'id': 'https://openalex.org/S13342628', 'display_name': 'International Journal of Cardiology', 'issn_l': '0167-5273', 'issn': ['0167-5273', '1874-1754'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation', 'score': 0.63}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1519460332', 'https://openalex.org/W1527824780', 'https://openalex.org/W1605779041', 'https://openalex.org/W1700063422', 'https://openalex.org/W1965883155', 'https://openalex.org/W1972933415', 'https://openalex.org/W1977488948', 'https://openalex.org/W2019310839', 'https://openalex.org/W2027032451', 'https://openalex.org/W2034310547', 'https://openalex.org/W2035493043', 'https://openalex.org/W2037521161', 'https://openalex.org/W2038800901', 'https://openalex.org/W2041269555', 'https://openalex.org/W2042879715', 'https://openalex.org/W2049138684', 'https://openalex.org/W2051451432', 'https://openalex.org/W2052503231', 'https://openalex.org/W2053807731', 'https://openalex.org/W2065901291', 'https://openalex.org/W2070983398', 'https://openalex.org/W2073549750', 'https://openalex.org/W2095634234', 'https://openalex.org/W2106181496', 'https://openalex.org/W2111472663', 'https://openalex.org/W2112178053', 'https://openalex.org/W2127156309', 'https://openalex.org/W2127749087', 'https://openalex.org/W2129484626', 'https://openalex.org/W2135439806', 'https://openalex.org/W2139637918', 'https://openalex.org/W2139757550', 'https://openalex.org/W2145461177', 'https://openalex.org/W2149330078', 'https://openalex.org/W2150441787', 'https://openalex.org/W2151295696', 'https://openalex.org/W2155975134', 'https://openalex.org/W2155997935', 'https://openalex.org/W2157466080', 'https://openalex.org/W2171818587', 'https://openalex.org/W2261108017', 'https://openalex.org/W4252397535'], 'related_works': ['https://openalex.org/W47192733', 'https://openalex.org/W2389396840', 'https://openalex.org/W2145989199', 'https://openalex.org/W2132502769', 'https://openalex.org/W2129554934', 'https://openalex.org/W2116494065', 'https://openalex.org/W2096211964', 'https://openalex.org/W2076433252', 'https://openalex.org/W1984062123', 'https://openalex.org/W1974174019'], 'abstract_inverted_index': {'BackgroundHyperactivation': [0], 'of': [1, 9, 65, 86, 163, 177, 197], 'the': [2, 18, 29, 34, 63, 84, 151, 174, 178, 195, 220], 'renin–angiotensin': [3], 'system': [4], 'contributes': [5], 'to': [6], 'hypertension-induced': [7], 'upregulation': [8, 51, 203], 'vascular': [10, 49, 198, 206], 'matrix': [11], 'metalloproteinases': [12], '(MMPs)': [13], 'and': [14, 52, 54, 72, 130, 147, 149, 161, 166, 186, 201], 'remodeling,': [15, 53], 'especially': [16], 'in': [17, 47, 58, 127, 153, 173, 208], 'two': [19], 'kidney,': [20], 'one': [21], 'clip': [22], '(2K1C)': [23], 'hypertension': [24, 60], 'model.': [25], 'We': [26, 77], 'hypothesized': [27, 79], 'that': [28, 80, 183, 215], 'AT1R': [30], 'antagonist': [31], 'losartan': [32, 96, 185, 193], 'or': [33, 95, 99, 107, 135], 'renin': [35, 125], 'inhibitor': [36], 'aliskiren,': [37, 138], 'given': [38], 'at': [39], 'doses': [40], 'allowing': [41], 'similar': [42, 111, 189], 'antihypertensive': [43, 112, 190], 'effects,': [44, 191], 'could': [45, 82], 'prevent': [46], 'vivo': [48], 'MMPs': [50], 'collagen/elastin': [55, 155], 'deposition': [56], 'found': [57, 172], '2K1C': [59, 209], 'by': [61, 101, 224], 'preventing': [62], 'activation': [64, 196], 'extracellular': [66], 'signal-regulated': [67], 'kinase': [68], '1/2': [69, 165], '(ERK': [70], '1/2)': [71], 'transforming': [73], 'growth': [74], 'factor-β1': [75], '(TGF-β1).': [76], 'also': [78, 213], 'aliskiren': [81, 92, 141, 187, 216], 'enhance': [83, 219], 'effects': [85, 113, 222], 'losartan.Methods2K1C': [87], 'rats': [88, 118], 'were': [89, 171], 'treated': [90, 119], 'with': [91, 116, 120, 137, 205], '(50': [93], 'mg.kg−1.day−1),': [94, 98], '(10': [97], 'both': [100, 108, 128], 'gavage': [102], 'during': [103], '4': [104], 'weeks.ResultsAliskiren,': [105], 'losartan,': [106], 'drugs': [109], 'exerted': [110, 188, 223], 'when': [114], 'compared': [115], '2K-1C': [117, 131], 'water.': [121], 'Aliskiren': [122], 'reduced': [123], 'plasma': [124], 'activity': [126], 'sham': [129], 'rats.': [132], 'Losartan': [133], 'alone': [134], 'combined': [136], 'but': [139], 'not': [140, 218], 'alone,': [142], 'abolished': [143], '2K1C-induced': [144], 'aortic': [145, 154, 175], 'hypertrophy': [146], 'hyperplasia,': [148], 'prevented': [150, 194], 'increases': [152], 'content,': [156], 'MMP-2': [157], 'levels,': [158], 'gelatinolytic': [159], 'activity,': [160], 'expression': [162, 176], 'phospho-ERK': [164], 'TGF-β1.': [167], 'No': [168], 'significant': [169], 'differences': [170], '(pro)renin': [179], 'receptor.ConclusionsThese': [180], 'findings': [181, 212], 'show': [182], 'although': [184], 'only': [192], 'profibrotic': [199], 'mechanisms': [200], 'MMP': [202], 'associated': [204], 'remodeling': [207], 'hypertension.': [210], 'Our': [211], 'suggest': [214], 'does': [217], 'protective': [221], 'losartan.': [225]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2145989199', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}], 'updated_date': '2024-09-15T16:20:28.107975', 'created_date': '2016-06-24'}