Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2145956996', 'doi': 'https://doi.org/10.1086/515673', 'title': 'Effect of High‐Dose Acyclovir on Survival in Allogeneic Marrow Transplant Recipients Who Received Ganciclovir at Engraftment or for Cytomegalovirus pp65 Antigenemia', 'display_name': 'Effect of High‐Dose Acyclovir on Survival in Allogeneic Marrow Transplant Recipients Who Received Ganciclovir at Engraftment or for Cytomegalovirus pp65 Antigenemia', 'publication_year': 1998, 'publication_date': '1998-10-01', 'ids': {'openalex': 'https://openalex.org/W2145956996', 'doi': 'https://doi.org/10.1086/515673', 'mag': '2145956996', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9806049'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1086/515673', 'pdf_url': 'https://academic.oup.com/jid/article-pdf/178/4/1153/2494064/178-4-1153.pdf', 'source': {'id': 'https://openalex.org/S54542293', 'display_name': 'The Journal of Infectious Diseases', 'issn_l': '0022-1899', 'issn': ['0022-1899', '1537-6613'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/jid/article-pdf/178/4/1153/2494064/178-4-1153.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038572943', 'display_name': 'Michael Boeckh', 'orcid': 'https://orcid.org/0000-0003-1538-7984'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Michael Boeckh', 'raw_affiliation_strings': ['Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': 'Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, Washington', 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023949296', 'display_name': 'Ted Gooley', 'orcid': 'https://orcid.org/0000-0002-8182-3652'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ted A. Gooley', 'raw_affiliation_strings': ['Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': 'Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, Washington', 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I201448701']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108286011', 'display_name': 'Raleigh A. Bowden', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Raleigh A. Bowden', 'raw_affiliation_strings': ['Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': 'Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, Washington', 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I201448701']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5038572943'], 'corresponding_institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I201448701'], 'apc_list': {'value': 4320, 'currency': 'USD', 'value_usd': 4320, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.892, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 38, 'citation_normalized_percentile': {'value': 0.757733, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '178', 'issue': '4', 'first_page': '1153', 'last_page': '1157'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10981', 'display_name': 'Cytomegalovirus and herpesvirus research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10981', 'display_name': 'Cytomegalovirus and herpesvirus research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10625', 'display_name': 'Herpesvirus Infections and Treatments', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10685', 'display_name': 'Viral-associated cancers and disorders', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/betaherpesvirinae', 'display_name': 'Betaherpesvirinae', 'score': 0.73514354}, {'id': 'https://openalex.org/keywords/cytomegalovirus', 'display_name': 'Cytomegalovirus', 'score': 0.66992325}, {'id': 'https://openalex.org/keywords/aciclovir', 'display_name': 'Aciclovir', 'score': 0.49469873}], 'concepts': [{'id': 'https://openalex.org/C2777965375', 'wikidata': 'https://www.wikidata.org/wiki/Q417640', 'display_name': 'Ganciclovir', 'level': 4, 'score': 0.96100813}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8187136}, {'id': 'https://openalex.org/C2777662283', 'wikidata': 'https://www.wikidata.org/wiki/Q747711', 'display_name': 'Betaherpesvirinae', 'level': 5, 'score': 0.73514354}, {'id': 'https://openalex.org/C2777732132', 'wikidata': 'https://www.wikidata.org/wiki/Q6946', 'display_name': 'Cytomegalovirus', 'level': 5, 'score': 0.66992325}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.60085523}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.55146}, {'id': 'https://openalex.org/C44249647', 'wikidata': 'https://www.wikidata.org/wiki/Q208498', 'display_name': 'Confidence interval', 'level': 2, 'score': 0.5388597}, {'id': 'https://openalex.org/C2779820661', 'wikidata': 'https://www.wikidata.org/wiki/Q6929', 'display_name': 'Human cytomegalovirus', 'level': 3, 'score': 0.5030295}, {'id': 'https://openalex.org/C2779450786', 'wikidata': 'https://www.wikidata.org/wiki/Q147101', 'display_name': 'Aciclovir', 'level': 5, 'score': 0.49469873}, {'id': 'https://openalex.org/C61511704', 'wikidata': 'https://www.wikidata.org/wiki/Q1671857', 'display_name': 'Incidence (geometry)', 'level': 2, 'score': 0.4583648}, {'id': 'https://openalex.org/C50382708', 'wikidata': 'https://www.wikidata.org/wiki/Q223218', 'display_name': 'Proportional hazards model', 'level': 2, 'score': 0.43189773}, {'id': 'https://openalex.org/C2911091166', 'wikidata': 'https://www.wikidata.org/wiki/Q106419912', 'display_name': 'Transplantation', 'level': 2, 'score': 0.42555186}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.37477773}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.3710396}, {'id': 'https://openalex.org/C2776409557', 'wikidata': 'https://www.wikidata.org/wiki/Q149348', 'display_name': 'Herpesviridae', 'level': 4, 'score': 0.34786242}, {'id': 'https://openalex.org/C2780727368', 'wikidata': 'https://www.wikidata.org/wiki/Q1928978', 'display_name': 'Viral disease', 'level': 3, 'score': 0.3160573}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.18356803}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000212', 'descriptor_name': 'Acyclovir', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D016026', 'descriptor_name': 'Bone Marrow Transplantation', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': True}, {'descriptor_ui': 'D003586', 'descriptor_name': 'Cytomegalovirus Infections', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D015774', 'descriptor_name': 'Ganciclovir', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000212', 'descriptor_name': 'Acyclovir', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000212', 'descriptor_name': 'Acyclovir', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000956', 'descriptor_name': 'Antigens, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000956', 'descriptor_name': 'Antigens, Viral', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016026', 'descriptor_name': 'Bone Marrow Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018890', 'descriptor_name': 'Chemoprevention', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003586', 'descriptor_name': 'Cytomegalovirus Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015774', 'descriptor_name': 'Ganciclovir', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016016', 'descriptor_name': 'Proportional Hazards Models', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016019', 'descriptor_name': 'Survival Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014184', 'descriptor_name': 'Transplantation, Homologous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1086/515673', 'pdf_url': 'https://academic.oup.com/jid/article-pdf/178/4/1153/2494064/178-4-1153.pdf', 'source': {'id': 'https://openalex.org/S54542293', 'display_name': 'The Journal of Infectious Diseases', 'issn_l': '0022-1899', 'issn': ['0022-1899', '1537-6613'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9806049', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1086/515673', 'pdf_url': 'https://academic.oup.com/jid/article-pdf/178/4/1153/2494064/178-4-1153.pdf', 'source': {'id': 'https://openalex.org/S54542293', 'display_name': 'The Journal of Infectious Diseases', 'issn_l': '0022-1899', 'issn': ['0022-1899', '1537-6613'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 15, 'referenced_works': ['https://openalex.org/W129197986', 'https://openalex.org/W152700816', 'https://openalex.org/W1564109452', 'https://openalex.org/W1965003728', 'https://openalex.org/W1993517065', 'https://openalex.org/W2001891624', 'https://openalex.org/W2008262167', 'https://openalex.org/W2041526044', 'https://openalex.org/W2066684881', 'https://openalex.org/W2091704657', 'https://openalex.org/W2096480959', 'https://openalex.org/W2119560215', 'https://openalex.org/W2317836667', 'https://openalex.org/W2412390281', 'https://openalex.org/W2417760721'], 'related_works': ['https://openalex.org/W2411851185', 'https://openalex.org/W2108646699', 'https://openalex.org/W2085663740', 'https://openalex.org/W2062149862', 'https://openalex.org/W2034661738', 'https://openalex.org/W2022553439', 'https://openalex.org/W2006822316', 'https://openalex.org/W1973408299', 'https://openalex.org/W1619468377', 'https://openalex.org/W1519536661'], 'abstract_inverted_index': {'This': [0], 'study': [1], 'sought': [2], 'to': [3, 152], 'determine': [4], 'whether': [5], 'high-dose': [6, 147], 'acyclovir': [7, 40, 70, 148], 'improves': [8], 'posttransplant': [9], 'survival': [10, 99, 154], 'in': [11, 93], 'cytomegalovirus': [12], '(CMV)-seropositive': [13], 'patients': [14], 'when': [15, 155], 'ganciclovir': [16, 35, 49, 64, 156], 'is': [17, 157], 'given': [18, 48, 158], 'for': [19, 50, 112, 163], 'prophylaxis': [20], 'or': [21, 162], 'as': [22], 'early': [23], 'therapy.': [24], 'Three': [25], 'groups': [26, 102], 'were': [27], 'studied:': [28], 'Group': [29], '1': [30], '(n': [31, 44, 60], '=': [32, 45, 61], '112)': [33], 'received': [34, 63], 'from': [36, 76], 'engraftment': [37, 66, 161], 'without': [38, 54], 'prior': [39, 55, 68], 'treatment,': [41], 'group': [42, 58, 114, 117, 125], '2': [43, 106], '114)': [46], 'was': [47, 89, 139], 'CMV': [51, 134, 164], 'pp65': [52, 165], 'antigenemia': [53], 'acyclovir,': [56], 'and': [57, 136], '3': [59], '133)': [62], 'at': [65, 160], 'with': [67], 'intravenous': [69], '(500': [71], 'mg/m2': [72], 'every': [73], '8': [74], 'h)': [75], 'day': [77], '5': [78], 'before': [79], 'transplant': [80, 98, 109], 'until': [81], 'engraftment.': [82], 'In': [83], 'a': [84], 'multivariable': [85], 'Cox': [86], 'model,': [87], 'there': [88], 'no': [90], 'significant': [91], 'difference': [92], 'the': [94, 101, 104, 144], 'adjusted': [95], 'risk': [96, 111], 'of': [97, 133], 'between': [100, 143], 'during': [103], 'first': [105], 'years': [107], 'after': [108], '(relative': [110], 'mortality:': [113], '1,': [115], '1.0;': [116], '2,': [118], '0.75': [119], '(95%': [120, 128], 'confidence': [121], 'interval': [122], '[CI],': [123], '0.52–1.1);': [124], '3,': [126], '1.04': [127], 'CI,': [129], '0.74–1.47).': [130], 'The': [131], 'incidence': [132], 'disease': [135], 'CMV-related': [137], 'mortality': [138], 'not': [140, 150], 'significantly': [141], 'different': [142], 'groups.': [145], 'Thus,': [146], 'does': [149], 'appear': [151], 'improve': [153], 'either': [159], 'antigenemia.': [166]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2145956996', 'counts_by_year': [{'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-10T07:26:43.804483', 'created_date': '2016-06-24'}