Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2145837957', 'doi': 'https://doi.org/10.18632/oncotarget.5995', 'title': 'Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1', 'display_name': 'Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1', 'publication_year': 2015, 'publication_date': '2015-10-19', 'ids': {'openalex': 'https://openalex.org/W2145837957', 'doi': 'https://doi.org/10.18632/oncotarget.5995', 'mag': '2145837957', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27627136', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5078112'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5995', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5995&path%5B%5D=16882', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5995&path%5B%5D=16882', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109463719', 'display_name': 'Yi‐Chen Yen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yi-Chen Yen', 'raw_affiliation_strings': ['National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075579975', 'display_name': 'Jenn‐Ren Hsiao', 'orcid': 'https://orcid.org/0000-0001-8801-3866'}, 'institutions': [{'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Jenn-Ren Hsiao', 'raw_affiliation_strings': ['Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049975962', 'display_name': 'Shih Sheng Jiang', 'orcid': 'https://orcid.org/0000-0003-1909-437X'}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Shih Sheng Jiang', 'raw_affiliation_strings': ['National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062702260', 'display_name': 'Jeffrey S. Chang', 'orcid': 'https://orcid.org/0000-0002-3236-6205'}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey S. Chang', 'raw_affiliation_strings': ['National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009356104', 'display_name': 'Ssu‐Han Wang', 'orcid': 'https://orcid.org/0000-0003-0338-9309'}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Ssu-Han Wang', 'raw_affiliation_strings': ['National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101637164', 'display_name': 'Yingying Shen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Ying-Ying Shen', 'raw_affiliation_strings': ['Pathology Core Laboratory, National Health Research Institutes, Miaoli, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'Pathology Core Laboratory, National Health Research Institutes, Miaoli, Taiwan.', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090036904', 'display_name': 'Chung‐Hsing Chen', 'orcid': 'https://orcid.org/0000-0002-1205-7368'}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chung-Hsing Chen', 'raw_affiliation_strings': ['Institute of Population Health sciences, National Health Research Institutes, Miaoli, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Population Health sciences, National Health Research Institutes, Miaoli, Taiwan.', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108505106', 'display_name': 'I–Shou Chang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'I-Shou Chang', 'raw_affiliation_strings': ['Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan', 'National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.', 'institution_ids': ['https://openalex.org/I165441096']}, {'raw_affiliation_string': 'Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018673219', 'display_name': 'Jang‐Yang Chang', 'orcid': 'https://orcid.org/0000-0002-6515-5930'}, 'institutions': [{'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Jang-Yang Chang', 'raw_affiliation_strings': ['Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan.', 'institution_ids': ['https://openalex.org/I4210158999']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101434360', 'display_name': 'Ya‐Wen Chen', 'orcid': 'https://orcid.org/0000-0002-6080-8859'}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}, {'id': 'https://openalex.org/I184693016', 'display_name': 'China Medical University', 'ror': 'https://ror.org/00v408z34', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I184693016']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Ya-Wen Chen', 'raw_affiliation_strings': ['Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan', 'National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.', 'institution_ids': ['https://openalex.org/I165441096']}, {'raw_affiliation_string': 'Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan', 'institution_ids': ['https://openalex.org/I184693016']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.314, 'has_fulltext': False, 'cited_by_count': 38, 'citation_normalized_percentile': {'value': 0.552171, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '6', 'issue': '39', 'first_page': '41837', 'last_page': '41855'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Research', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6214871}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.5505144}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.48668605}, {'id': 'https://openalex.org/C2780849966', 'wikidata': 'https://www.wikidata.org/wiki/Q170758', 'display_name': 'Lymph node', 'level': 2, 'score': 0.48154265}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.46339136}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.43110323}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42914572}], 'mesh': [{'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006258', 'descriptor_name': 'Head and Neck Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018972', 'descriptor_name': 'Insulin-Like Growth Factor Binding Protein 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009062', 'descriptor_name': 'Mouth Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013002', 'descriptor_name': 'Somatomedins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030541', 'descriptor_name': 'Databases, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006258', 'descriptor_name': 'Head and Neck Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006258', 'descriptor_name': 'Head and Neck Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006258', 'descriptor_name': 'Head and Neck Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018972', 'descriptor_name': 'Insulin-Like Growth Factor Binding Protein 3', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018972', 'descriptor_name': 'Insulin-Like Growth Factor Binding Protein 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008207', 'descriptor_name': 'Lymphatic Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009062', 'descriptor_name': 'Mouth Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009062', 'descriptor_name': 'Mouth Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009062', 'descriptor_name': 'Mouth Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013002', 'descriptor_name': 'Somatomedins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077195', 'descriptor_name': 'Squamous Cell Carcinoma of Head and Neck', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5995', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5995&path%5B%5D=16882', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4747192', 'pdf_url': 'https://europepmc.org/articles/pmc4747192?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747192', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26540630', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5995', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5995&path%5B%5D=16882', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.68, 'display_name': 'No poverty', 'id': 'https://metadata.un.org/sdg/1'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 75, 'referenced_works': ['https://openalex.org/W115790369', 'https://openalex.org/W1499597498', 'https://openalex.org/W1512705899', 'https://openalex.org/W1534699330', 'https://openalex.org/W1606372667', 'https://openalex.org/W1628214385', 'https://openalex.org/W1854589240', 'https://openalex.org/W1968490444', 'https://openalex.org/W1969803665', 'https://openalex.org/W1971398781', 'https://openalex.org/W1972255467', 'https://openalex.org/W1973116504', 'https://openalex.org/W1974624383', 'https://openalex.org/W1975829169', 'https://openalex.org/W1977041069', 'https://openalex.org/W1979597154', 'https://openalex.org/W1989678007', 'https://openalex.org/W1992077614', 'https://openalex.org/W1993535707', 'https://openalex.org/W1998893299', 'https://openalex.org/W2001339111', 'https://openalex.org/W2003500892', 'https://openalex.org/W2004182185', 'https://openalex.org/W2008440424', 'https://openalex.org/W2011369409', 'https://openalex.org/W2016081624', 'https://openalex.org/W2016124553', 'https://openalex.org/W2019629273', 'https://openalex.org/W2022305490', 'https://openalex.org/W2026105810', 'https://openalex.org/W2032038741', 'https://openalex.org/W2037052470', 'https://openalex.org/W2037533802', 'https://openalex.org/W2039553196', 'https://openalex.org/W2041326040', 'https://openalex.org/W2042521915', 'https://openalex.org/W2044671673', 'https://openalex.org/W2054982539', 'https://openalex.org/W2055783995', 'https://openalex.org/W2060654974', 'https://openalex.org/W2061708936', 'https://openalex.org/W2066550173', 'https://openalex.org/W2069352102', 'https://openalex.org/W2070877080', 'https://openalex.org/W2080145523', 'https://openalex.org/W2082668371', 'https://openalex.org/W2093255090', 'https://openalex.org/W2096827608', 'https://openalex.org/W2098547168', 'https://openalex.org/W2100727076', 'https://openalex.org/W2102088808', 'https://openalex.org/W2108713158', 'https://openalex.org/W2115850999', 'https://openalex.org/W2119067365', 'https://openalex.org/W2123916622', 'https://openalex.org/W2124224408', 'https://openalex.org/W2132082330', 'https://openalex.org/W2133289313', 'https://openalex.org/W2133554539', 'https://openalex.org/W2135105302', 'https://openalex.org/W2136917807', 'https://openalex.org/W2138883888', 'https://openalex.org/W2140411792', 'https://openalex.org/W2142650147', 'https://openalex.org/W2149588035', 'https://openalex.org/W2157114696', 'https://openalex.org/W2160923055', 'https://openalex.org/W2162151340', 'https://openalex.org/W2162614357', 'https://openalex.org/W2164766328', 'https://openalex.org/W2345120190', 'https://openalex.org/W2400803738', 'https://openalex.org/W3422088', 'https://openalex.org/W4211025369', 'https://openalex.org/W93935035'], 'related_works': ['https://openalex.org/W4383498154', 'https://openalex.org/W4383498081', 'https://openalex.org/W4302381976', 'https://openalex.org/W4298027456', 'https://openalex.org/W4283831541', 'https://openalex.org/W4243634448', 'https://openalex.org/W3097242330', 'https://openalex.org/W2531913951', 'https://openalex.org/W2186113122', 'https://openalex.org/W1523310174'], 'abstract_inverted_index': {'//': [0], 'Yi-Chen': [1], 'Yen': [2], '1,': [3, 35, 44], '*': [4, 9, 137], ',': [5, 10, 15, 20, 24, 28, 32, 37, 41], 'Jenn-Ren': [6], 'Hsiao': [7], '2,': [8], 'Shih': [11], 'Sheng': [12], 'Jiang': [13], '1': [14, 23, 46], 'Jeffrey': [16], 'S.': [17], 'Chang': [18, 34, 39], '3': [19, 76, 271], 'Ssu-Han': [21], 'Wang': [22], 'Ying-Ying': [25], 'Shen': [26], '4': [27, 88], 'Chung-Hsing': [29], 'Chen': [30, 43], '5': [31, 36, 98], 'I-Shou': [33], 'Jang-Yang': [38], '6': [40, 110], 'Ya-Wen': [42, 148], '7': [45, 125], 'National': [47, 52, 62, 70, 77, 82, 92, 104, 115], 'Institute': [48, 78, 99, 127], 'of': [49, 60, 68, 79, 100, 112, 121, 128, 193, 206, 219, 246, 275, 291, 304, 360, 366, 384, 408, 425], 'Cancer': [50, 80], 'Research,': [51, 81], 'Health': [53, 83, 93, 102, 105], 'Research': [54, 84, 94, 106], 'Institutes,': [55, 85, 95, 107], 'Miaoli,': [56, 96, 108], 'Taiwan': [57, 75, 87, 97, 109, 124, 136], '2': [58], 'Department': [59, 111], 'Otolaryngology,': [61], 'Cheng': [63, 71, 116], 'Kung': [64, 72, 117], 'University': [65, 118], 'Hospital,': [66, 119], 'College': [67, 120], 'Medicine,': [69, 114, 122], 'University,': [73, 134], 'Tainan,': [74, 86, 123], 'Pathology': [89], 'Core': [90], 'Laboratory,': [91], 'Population': [101], 'Sciences,': [103], 'Internal': [113], 'Graduate': [126], 'Basic': [129], 'Medical': [130, 133], 'Science,': [131], 'China': [132], 'Taichung,': [135], 'These': [138, 235], 'authors': [139], 'have': [140], 'contributed': [141], 'equally': [142], 'to': [143, 184, 190, 240, 315, 396, 413], 'this': [144], 'work': [145], 'Correspondence': [146], 'to:': [147], 'Chen,': [149], 'e-mail:': [150], '[email protected]': [151], 'Keywords:': [152], 'oral': [153, 196, 258, 317], 'squamous': [154, 197], 'cell': [155, 198, 398], 'carcinoma,': [156], 'lymph': [157, 187, 207, 217, 242, 335, 357], 'node': [158, 208, 336, 358], 'metastasis,': [159, 209], 'migration,': [160, 353], 'insulin-like': [161, 266], 'growth': [162, 267], 'factor': [163, 268], 'binding': [164, 269], 'protein': [165, 270, 308], '3,': [166], 'integrin': [167, 409, 426], 'β1': [168, 410, 427], 'Received:': [169], 'August': [170], '11,': [171], '2015 ': [172, 176], 'Accepted:': [173], 'October': [174, 178], '05,': [175], 'Published:': [177], '19,': [179], '2015': [180], 'ABSTRACT': [181], 'Frequent': [182], 'metastasis': [183, 359], 'the': [185, 203, 257, 276, 281, 292, 323, 341, 349, 373], 'cervical': [186, 216, 241], 'nodes': [188, 218, 243], 'leads': [189], 'poor': [191], 'survival': [192], 'patients': [194, 333], 'with': [195, 285, 331, 334, 368], 'carcinoma': [199], '(OSCC).': [200], 'To': [201], 'understand': [202], 'underlying': [204], 'mechanisms': [205], 'two': [210, 236], 'sublines': [211, 237, 282, 342], 'were': [212], 'successfully': [213], 'isolated': [214], 'from': [215, 230], 'nude': [220], 'mice': [221], 'through': [222, 387], 'in': [223, 244, 280, 283, 309, 340, 348, 428], 'vivo': [224], 'selection,': [225], 'and': [226, 296, 307, 344, 356, 400, 418], 'identified': [227, 265], 'as': [228, 273], 'originating': [229], 'poorly': [231], 'metastatic': [232], 'parental': [233, 287, 350], 'cells.': [234, 288], 'specifically': [238], 'metastasized': [239], '83%': [245], 'mice,': [247], 'whereas': [248], 'OEC-M1': [249], 'cells': [250, 351, 386], 'did': [251], 'not': [252], 'metastasize': [253], 'after': [254], 'injection': [255], 'into': [256], 'cavity.': [259], 'After': [260], 'gene': [261], 'expression': [262, 327, 347, 365], 'analysis,': [263], 'we': [264], '(IGFBP3)': [272], 'one': [274], 'significantly': [277, 329], 'up-regulated': [278, 324], 'genes': [279], 'comparison': [284], 'their': [286], 'Consistently,': [289], 'meta-analysis': [290], 'public': [293], 'microarray': [294], 'datasets': [295], 'IGFBP3': [297, 305, 325, 338, 346, 367, 380, 393], 'immunohistochemical': [298], 'analysis': [299], 'revealed': [300], 'increased': [301], 'both': [302], 'levels': [303], 'mRNA': [306, 326], 'human': [310], 'OSCC': [311, 332, 385], 'tissues': [312], 'when': [313], 'compared': [314], 'normal': [316], 'or': [318], 'adjacent': [319], 'nontumorous': [320], 'tissues.': [321], 'Interestingly,': [322], 'was': [328, 394, 411], 'associated': [330], 'metastasis.': [337], 'knockdown': [339], 'impaired': [343], 'ectopic': [345, 364], 'promoted': [352], 'transendothelial': [354], 'migration': [355, 417], 'orthotopic': [361], 'transplantation.': [362], 'Additionally,': [363], 'an': [369, 388], 'IGF-binding': [370], 'defect': [371], 'sustained': [372], 'IGFBP3-enhanced': [374], 'biological': [375], 'functions.': [376, 430], 'Results': [377], 'indicated': [378], 'that': [379], 'regulates': [381], 'metastasis-related': [382], 'functions': [383], 'IGF-independent': [389], 'mechanism.': [390], 'Furthermore,': [391], 'exogenous': [392, 415], 'sufficient': [395], 'induce': [397], 'motility': [399], 'extracellular': [401], 'signal-regulated': [402], 'kinase': [403], '(ERK)': [404], 'activation.': [405], 'The': [406], 'silencing': [407], 'able': [412], 'impair': [414], 'IGFBP3-mediated': [416], 'ERK': [419], 'phosphorylation,': [420], 'suggesting': [421], 'a': [422], 'critical': [423], 'role': [424], 'IGFBP3-enchanced': [429]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2145837957', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-12-24T13:39:33.292864', 'created_date': '2016-06-24'}