Publication Information

{'id': 'https://openalex.org/W2145745183', 'doi': 'https://doi.org/10.1074/mcp.m113.031567', 'title': 'Identification of Lysine Succinylation Substrates and the Succinylation Regulatory Enzyme CobB in Escherichia coli', 'display_name': 'Identification of Lysine Succinylation Substrates and the Succinylation Regulatory Enzyme CobB in Escherichia coli', 'publication_year': 2013, 'publication_date': '2013-11-01', 'ids': {'openalex': 'https://openalex.org/W2145745183', 'doi': 'https://doi.org/10.1074/mcp.m113.031567', 'mag': '2145745183', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24176774', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3861704'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m113.031567', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1074/mcp.m113.031567', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016229715', 'display_name': 'Gozde Colak', 'orcid': 'https://orcid.org/0000-0002-2450-9165'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gozde Colak', 'raw_affiliation_strings': ['Ben May Department of Cancer Research, University of Chicago, Chicago, Illinois 60637'], 'affiliations': [{'raw_affiliation_string': 'Ben May Department of Cancer Research, University of Chicago, Chicago, Illinois 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077042154', 'display_name': 'Zhongyu Xie', 'orcid': 'https://orcid.org/0000-0001-5394-8282'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhongyu Xie', 'raw_affiliation_strings': ['Ben May Department of Cancer Research, University of Chicago, Chicago, Illinois 60637'], 'affiliations': [{'raw_affiliation_string': 'Ben May Department of Cancer Research, University of Chicago, Chicago, Illinois 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034869187', 'display_name': 'Anita Y. 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200, 400, 1816, 2030, 2100, 2410, 2533, 2634], 'succinylation': [1, 18, 42, 60, 78, 119, 180, 201, 218, 242, 260, 278, 319, 380, 1255, 1288, 1865, 1988, 2031, 2101, 2378, 2411, 2440, 2858, 4191, 4204, 4229, 4239, 4260, 4271], 'is': [2, 175, 202, 375, 453, 463, 816, 939, 1221, 1378, 2009, 2245, 2269, 2351, 2441, 2535, 2659, 2828], 'a': [3, 114, 127, 145, 203, 314, 327, 345, 454, 940, 1106, 1222, 1304, 1314, 1353, 1379, 1533, 1604, 1990, 2127, 2139, 2246, 2262, 2270, 2283, 2380, 2477, 2536, 2630, 2834, 2871, 2905, 2936, 2951, 3220, 3236, 3366, 3379, 3396, 3428, 3518, 3554, 3595, 3737, 3788, 3823, 3871, 3875, 3896, 3908, 3916, 3954, 3992, 4001, 4024, 4166, 4222, 4265, 4304], 'newly': [4, 204], 'identified': [5, 125, 205, 325, 1474, 1878, 2461, 2697, 4374, 4420], 'protein': [6, 206, 647, 676, 703, 800, 1224, 1315, 1676, 1741, 1819, 1847, 2248, 2499, 2662, 3322, 3463, 4069, 4094, 4150, 4299, 4423], 'post-translational': [7, 207, 459, 1258, 1291, 1992, 2382, 3765], 'modification': [8, 208, 460, 815, 1259, 1292, 1316, 2542, 4168, 4224, 4267, 4353], 'pathway': [9, 209, 2458], 'present': [10, 210, 2010], 'in': [11, 44, 53, 67, 82, 189, 211, 244, 253, 267, 282, 389, 425, 450, 468, 510, 713, 1266, 1299, 1479, 1490, 1778, 1850, 1882, 2011, 2035, 2060, 2076, 2105, 2142, 2145, 2292, 2356, 2361, 2415, 2446, 2462, 2467, 2484, 2502, 2543, 2636, 2664, 2743, 2807, 2836, 2839, 2847, 2883, 2892, 2901, 2915, 2922, 2925, 3085, 3246, 3290, 3328, 3365, 3413, 3621, 3787, 3810, 3816, 3865, 3867, 3907, 3924, 3934, 3962, 3980, 4246, 4278, 4310], 'both': [12, 212, 1883], 'prokaryotic': [13, 136, 213, 336, 1042, 2953], 'and': [14, 20, 47, 62, 79, 98, 151, 184, 214, 220, 247, 262, 279, 298, 351, 384, 415, 440, 456, 480, 485, 492, 513, 590, 639, 678, 715, 718, 841, 860, 958, 1043, 1063, 1070, 1075, 1080, 1093, 1096, 1108, 1168, 1227, 1251, 1284, 1344, 1419, 1450, 1454, 1481, 1484, 1493, 1525, 1559, 1565, 1596, 1624, 1668, 1782, 1821, 1867, 1879, 1885, 1907, 1955, 2032, 2102, 2144, 2192, 2251, 2276, 2299, 2412, 2473, 2539, 2601, 2787, 2798, 2859, 2889, 2918, 2971, 2982, 2998, 3017, 3021, 3058, 3069, 3116, 3159, 3178, 3190, 3194, 3205, 3209, 3229, 3305, 3309, 3333, 3341, 3363, 3438, 3456, 3472, 3510, 3546, 3587, 3700, 3782, 3808, 3886, 3927, 4029, 4067, 4080, 4120, 4136, 4149, 4158, 4186, 4189, 4225, 4227, 4251, 4326, 4352, 4364, 4369], 'eukaryotic': [15, 157, 215, 357, 1044], 'cells.': [16, 216], 'However,': [17, 217], 'substrates': [19, 81, 219, 281, 1167, 1343, 1781, 1954, 2191, 2483, 2855], 'regulatory': [21, 187, 221, 387, 1170, 1957, 2194, 2272, 2861], 'enzyme(s)': [22, 222], 'remain': [23, 223, 2469], 'largely': [24, 224, 2470], 'unknown,': [25, 225], 'hindering': [26, 226], 'the': [27, 36, 57, 63, 76, 100, 134, 156, 227, 236, 257, 263, 276, 300, 334, 356, 469, 511, 645, 835, 848, 903, 1101, 1345, 1412, 1629, 1674, 1774, 2081, 2130, 2300, 2447, 2456, 2660, 2703, 2961, 2974, 2987, 3092, 3131, 3144, 3232, 3260, 3646, 3710, 3723, 3925, 3935, 4030, 4038, 4133, 4137, 4201, 4290, 4311], 'biological': [28, 228], 'study': [29, 229], 'of': [30, 38, 75, 102, 141, 230, 238, 275, 302, 341, 413, 438, 471, 515, 552, 644, 735, 740, 796, 813, 821, 856, 895, 902, 961, 983, 1041, 1088, 1103, 1121, 1164, 1249, 1282, 1307, 1340, 1347, 1356, 1411, 1415, 1456, 1476, 1488, 1528, 1563, 1599, 1673, 1737, 1776, 1846, 1896, 1951, 1986, 2129, 2134, 2188, 2274, 2285, 2376, 2434, 2449, 2455, 2498, 2594, 2633, 2678, 2683, 2705, 2720, 2725, 2780, 2844, 2856, 2963, 3091, 3136, 3143, 3243, 3321, 3431, 3513, 3590, 3653, 3764, 3878, 3947, 3956, 3996, 4027, 4037, 4140, 4175, 4323, 4330, 4336, 4418], 'this': [31, 231, 814, 2867], 'modification.': [32, 232], 'Here': [33, 233], 'we': [34, 234, 1623, 2265, 2869, 2947], 'report': [35, 235, 2870], 'identification': [37, 140, 237, 340, 1163, 1339, 1950, 2187, 4061, 4095], '2,580': [39, 239, 2912], 'bacterial': [40, 130, 142, 240, 330, 342, 1884, 2744, 2893], 'lysine': [41, 49, 59, 77, 131, 149, 166, 179, 194, 241, 249, 259, 277, 331, 349, 366, 379, 394, 801, 827, 836, 843, 1165, 1225, 1237, 1254, 1270, 1287, 1309, 1357, 1529, 1600, 1742, 1848, 1864, 1868, 1952, 1987, 2033, 2103, 2189, 2249, 2329, 2377, 2413, 2439, 2500, 2845, 2857, 2894, 2899, 2967, 2976, 3014, 3187, 3202, 3514, 3591, 4190, 4203, 4238, 4259, 4270], 'sites': [43, 52, 243, 252, 2057, 2072, 2914, 2921, 4242, 4274], '670': [45, 245, 2916], 'proteins': [46, 97, 246, 297, 1478, 1492, 1891, 2279, 2917, 2924, 3389], '2,803': [48, 248, 2919], 'acetylation': [50, 195, 250, 395, 401, 677, 859, 901, 1122, 1238, 1271, 1310, 1358, 1530, 1601, 1817, 1849, 2501, 2534, 2806, 2846, 3515, 3592, 4152], '(Kac)': [51, 251, 402], '782': [54, 254, 2923], 'proteins,': [55, 255], 'representing': [56, 256], 'first': [58, 135, 258, 335, 1162, 1471, 1949, 2186], 'dataset': [61, 66, 261, 266], 'largest': [64, 264], 'Kac': [65, 80, 108, 265, 280, 308, 1342, 1489, 1554, 2482, 2827, 2920, 3539, 3547, 3730, 3783], 'wild-type': [68, 268], 'E.': [69, 269, 478, 672, 706, 1156, 1439, 1943, 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1971, 2002, 2050, 2120, 2208, 2259, 2347, 2392, 2430, 2513, 2559, 2610, 2653, 2692, 2734, 2796, 2821, 3533, 3610, 3777, 4078, 4110], 'Scholar,': [501, 524, 572, 602, 662, 693, 722, 750, 871, 889, 919, 950, 976, 1006, 1185, 1389, 1437, 1691, 1751, 1799, 1833, 1972, 2209, 2393, 2514, 2560, 2611], '2Finkel': [502], 'T.': [503, 666, 762, 1323, 1509, 1580, 1703, 2625, 3494, 3571], 'Deng': [504], 'C.X.': [505], 'Mostoslavsky': [506], 'R.': [507, 925, 1364, 1403, 1499, 1570, 2518, 2584, 2770, 3484, 3561], 'Recent': [508], 'progress': [509], 'biology': [512], 'physiology': [514], 'sirtuins.Nature.': [516], '2009;': [517, 1826, 2548], '460:': [518], '587-591Crossref': [519], '(1187)': [522], '3Finley': [525], 'L.W.': [526], 'Carracedo': [527], 'A.': [528, 532, 534, 923, 929, 931, 1362, 1368, 1370], 'Lee': [529], 'J.': [530, 536, 538, 764, 774, 784, 1154, 1187, 1199, 1201, 1215, 1507, 1578, 1705, 1715, 1725, 1941, 2017, 2087, 2178, 2211, 2223, 2225, 2239, 2305, 2397, 2516, 2520, 2572, 2758, 3492, 3569, 3746, 4054], 'Souza': [531], 'Egia': [533], 'Zhang': [535, 761, 1137, 1210, 1702, 1924, 2161, 2234, 2318, 2563, 2749], 'Teruya-Feldstein': [537], 'Moreira': [539], 'P.I.': [540], 'Cardoso': [541], 'S.M.': [542, 778, 1719], 'Clish': [543], 'C.B.': [544], 'Pandolfi': [545], 'P.P.': [546], 'Haigis': [547], 'M.C.': [548], 'SIRT3': [549, 583, 640, 673, 1669], 'opposes': [550], 'reprogramming': [551, 643, 1672], 'cancer': [553], 'through': [556], 'HIF1alpha': [557], 'destabilization.Cancer': [558], 'Cell.': [559, 649, 1172, 1424, 1461, 1536, 1607, 1678, 1785, 1959, 2037, 2107, 2196, 2335, 2417, 2546, 2639, 3521, 3598], '2011;': [560, 595, 686, 1174, 1229, 1961, 1996, 2198, 2253, 2386, 2815], '19:': [561], '416-428Abstract': [562], 'Full': [563, 565, 653, 655, 910, 912, 967, 969, 997, 999, 1177, 1179, 1428, 1430, 1540, 1542, 1611, 1613, 1682, 1684, 1790, 1792, 1964, 1966, 2042, 2044, 2112, 2114, 2201, 2203, 2339, 2341, 2422, 2424, 2551, 2553, 2646, 2648, 3525, 3527, 3602, 3604, 3940], 'Text': [564, 566, 654, 656, 911, 913, 968, 970, 998, 1000, 1178, 1180, 1429, 1431, 1541, 1543, 1612, 1614, 1683, 1685, 1791, 1793, 1965, 1967, 2043, 2045, 2113, 2115, 2202, 2204, 2340, 2342, 2423, 2425, 2552, 2554, 2647, 2649, 3526, 3528, 3603, 3605], 'PDF': [567, 657, 914, 971, 1001, 1181, 1432, 1544, 1615, 1686, 1794, 1968, 2046, 2116, 2205, 2343, 2426, 2555, 2650, 3529, 3606], '(611)': [570], '4Smith': [573], 'B.C.': [574, 952], 'Settles': [575], 'B.': [576, 670, 1207, 1397, 2231, 2621], 'Hallows': [577, 953], 'W.C.': [578, 954], 'Craven': [579], 'M.W.': [580, 3754], 'Denu': [581, 633, 874, 955, 1662], 'J.M.': [582, 634, 875, 956, 1443, 1663], 'substrate': [584, 1477, 1890], 'specificity': [585], 'determined': [586, 3254], 'peptide': [588, 3721, 3795, 4060, 4384], 'arrays': [589], 'machine': [591], 'learning.ACS': [592], 'Chem.': [593, 1994, 2384], 'Biol.': [594, 685, 963, 1022, 1460, 1995, 2385], '6:': [596], '146-157Crossref': [597], '(60)': [600], '5Hebert': [603], 'A.S.': [604, 1633], 'Dittenhafer-Reed': [605, 1634], 'K.E.': [606, 1635], 'Yu': [607, 757, 1192, 1636, 1698, 2216], 'W.': [608, 754, 756, 758, 776, 891, 1140, 1209, 1637, 1695, 1697, 1699, 1717, 1755, 1767, 1927, 2164, 2233, 2578, 2764], 'Bailey': [609, 1638], 'D.J.': [610, 626, 1639, 1655, 4088], 'Selen': [611, 1640], 'E.S.': [612, 1641], 'Boersma': [613, 1642], 'M.D.': [614, 664, 852, 1643], 'Carson': [615, 1644], 'J.J.': [616, 636, 1193, 1645, 1665, 2217], 'Tonelli': [617, 1646], 'M.': [618, 854, 933, 1134, 1372, 1519, 1590, 1647, 1765, 1809, 1815, 1921, 1976, 2021, 2091, 2158, 2313, 2366, 2401, 3504, 3581, 4056], 'Balloon': [619, 1648], 'A.J.': [620, 622, 1649, 1651], 'Higbee': [621, 1650], 'Westphall': [623, 1652], 'M.S.': [624, 1653], 'Pagliarini': [625, 1654], 'Prolla': [627, 1656], 'T.A.': [628, 1399, 1657], 'Assadi-Porter': [629, 1658], 'F.': [630, 780, 1659, 1721, 1805], 'Roy': [631, 1660], 'S.': [632, 708, 752, 978, 1195, 1211, 1393, 1661, 1693, 1837, 2219, 2235, 2489, 2524, 2590, 2776], 'Coon': [635, 1664], 'Calorie': [637, 1666], 'restriction': [638, 1667], 'trigger': [641, 1670], 'global': [642, 1671], 'mitochondrial': [646, 675, 1482, 1491, 1675, 2286], 'acetylome.Mol.': [648, 1677], '2013;': [650, 1679, 1855, 2336, 2507, 2640, 3771], '49:': [651, 1680], '186-199Abstract': [652, 1681], '(477)': [660, 1689], '6Hirschey': [663], 'Shimazu': [665], 'Huang': [667], 'J.Y.': [668, 1441], 'Schwer': [669], 'Verdin': [671, 1155, 1942, 2179], 'regulates': [674], 'intermediary': [679], 'metabolism.Cold': [680], 'Spring': [681], 'Harb.': [682], 'Symp.': [683], 'Quant.': [684], '76:': [687, 865], '267-277Crossref': [688], '(139)': [691], '7Lombard': [694], 'D.B.': [695, 2325], 'Tishkoff': [696, 1145, 1932, 2169, 2308], 'D.X.': [697, 2309], 'Zwaans': [698, 1143, 1930, 2167, 2320], 'B.M.': [699, 1144, 1407, 1931, 2168, 2321], 'Mitochondrial': [700, 711], 'acetylation.in:': [704], 'Cadenas': [705], 'Orrenius': [707], 'Packer': [709], 'L.': [710, 766, 782, 980, 1148, 1515, 1586, 1707, 1723, 1935, 1980, 2019, 2089, 2172, 2315, 2370, 2399, 2576, 2762, 3500, 3577], 'Signaling': [712], 'Health': [714], 'Disease.': [716], 'Taylor': [717], 'Francis,': [719], 'London2012:': [720], '269-298Google': [721], '8Starai': [723], 'V.J.': [724, 2667, 2709], 'Celic': [725, 2668, 2710], 'I.': [726, 1447, 2669, 2711], 'Cole': [727, 2670, 2712], 'R.N.': [728, 2671, 2713], 'Boeke': [729, 2026, 2096, 2406, 2672, 2714], 'J.D.': [730, 2027, 2097, 2407, 2673, 2715, 3758], 'Escalante-Semerena': [731, 2674, 2716], 'J.C.': [732, 1445, 2675, 2717], 'Sir2-dependent': [733, 2676, 2718], 'activation': [734, 2677, 2704, 2719], 'acetyl-CoA': [736, 2679, 2706, 2721], 'synthetase': [737, 2680, 2707, 2722], 'active': [741, 2684, 2726], 'lysine.Science.': [742, 2685, 2727], '2002;': [743, 943, 1382, 2686, 2728], '298:': [744, 2687, 2729], '2390-2392Crossref': [745, 2688, 2730], '(469)': [748, 2691, 2733], '9Zhao': [751, 1692], 'Xu': [753, 1502, 1573, 1694, 3487, 3564], 'Jiang': [755, 1196, 1696, 2220], 'Lin': [759, 1218, 1700, 2242, 2569, 2755], 'Y.': [760, 768, 772, 792, 927, 1132, 1138, 1158, 1160, 1189, 1366, 1501, 1503, 1511, 1523, 1572, 1574, 1582, 1594, 1701, 1709, 1713, 1733, 1753, 1769, 1841, 1919, 1925, 1945, 1947, 1982, 1984, 2025, 2029, 2095, 2099, 2156, 2162, 2182, 2184, 2213, 2307, 2319, 2327, 2372, 2374, 2405, 2409, 2493, 2532, 2564, 2570, 2580, 2586, 2750, 2756, 2766, 2772, 3486, 3488, 3496, 3508, 3563, 3565, 3573, 3585, 4406, 4412], 'Yao': [763, 936, 1324, 1375, 1704, 2571, 2579, 2757, 2765], 'Zhou': [765, 1188, 1706, 2212], 'Zeng': [767, 1708, 2583, 2769], 'Li': [769, 771, 1710, 1712, 2573, 2759], 'H.': [770, 1136, 1197, 1219, 1405, 1505, 1513, 1576, 1584, 1711, 1761, 1923, 2160, 2221, 2243, 2526, 2568, 2574, 2754, 2760, 3490, 3498, 3567, 3575], 'Shi': [773, 1714], 'An': [775, 1716], 'Hancock': [777, 1718], 'He': [779, 1139, 1151, 1206, 1720, 1926, 1938, 2163, 2175, 2230], 'Qin': [781, 1722], 'Chin': [783, 1724], 'Yang': [785, 1141, 1520, 1591, 1726, 1756, 1838, 1928, 2165, 2490, 2565, 2751, 3505, 3582], 'P.': [786, 1727, 2623, 3742], 'Chen': [787, 1131, 1208, 1500, 1571, 1728, 1840, 1918, 1981, 2155, 2232, 2306, 2371, 2492, 3485, 3562], 'X.': [788, 1191, 1729, 2215, 2522], 'Lei': [789, 1730], 'Q.': [790, 1217, 1731, 2241, 2562, 2748, 2802], 'Xiong': [791, 1732, 2567, 2585, 2753, 2771], 'Guan': [793, 1734, 2587, 2773], 'K.L.': [794, 1735, 2588, 2774], 'Regulation': [795, 1736], 'acetylation.Science.': [802, 1743], '2010;': [803, 994, 1744, 2604, 2790], '327:': [804, 1745, 2605, 2791], '1000-1004Crossref': [805, 1746], '(1458)': [808, 1749], 'Scholar).': [810, 1030, 1236, 1337, 1469, 1549, 1620, 1862, 2003, 2051, 2121, 2260, 2348, 2431, 2654, 2693, 2735, 2822, 3534, 3611, 3778, 4111], 'status': [812], 'controlled': [817], 'two': [819, 1872, 2964], 'groups': [820, 4363], 'opposing': [824], 'activities,': [826], 'acetyltransferases': [828], 'add': [830], 'an': [831, 2443, 2699, 2829, 3843, 3889, 3912, 3928, 3944, 4318], 'acetyl': [832, 849, 2970], 'group': [833, 850, 2284], '(Lys': [837], 'or': [838, 3029, 3099, 3108, 3123, 3197, 3337, 3538, 3659, 4004, 4382], 'K)': [839], 'residue,': [840], 'histone': [842, 858, 1241, 1274], 'deacetylases': [844], '(HDACs)': [845], 'remove': [847, 3636], '(10Shahbazian': [851], 'Grunstein': [853], 'Functions': [855], 'site-specific': [857], 'deacetylation.Annu.': [861], 'Rev.': [862, 880, 1019], 'Biochem.': [863, 881], '75-100Crossref': [866], '(1207)': [869], '11Roth': [872], 'S.Y.': [873], 'Allis': [876], 'C.D.': [877], 'Histone': [878, 1011], 'acetyltransferases.Annu.': [879], '2001;': [882], '70:': [883], '81-120Crossref': [884], '(1596)': [887], '12Gu': [890], 'Roeder': [892], 'R.G.': [893], 'Activation': [894], 'p53': [896, 904], 'sequence-specific': [897], 'DNA': [898], 'binding': [899], 'C-terminal': [905, 4383], 'domain.Cell.': [906], '1997;': [907], '90:': [908], '595-606Abstract': [909], '(2168)': [917], '13Hubbert': [920], 'C.': [921, 1124, 1360, 1401, 1801, 1803, 1911, 2148, 2311, 2566, 2619, 2752], 'Guardiola': [922, 1361], 'Shao': [924, 1363], 'Kawaguchi': [926, 1365], 'Ito': [928, 1367], 'Nixon': [930, 1369], 'Yoshida': [932, 1371], 'Wang': [934, 1373], 'X.F.': [935, 1374], 'T.P.': [937, 1325, 1376], 'HDAC6': [938, 1377], 'microtubule-associated': [941, 1380], 'deacetylase.Nature.': [942, 1381], '417:': [944, 1383], '455-458Crossref': [945, 1384], '(1778)': [948, 1387], '14Smith': [951], 'Mechanisms': [957], 'molecular': [959], 'probes': [960], 'sirtuins.Chem.': [962], '2008;': [964, 4072], '15:': [965], '1002-1013Abstract': [966], '(126)': [974], '15Imai': [977], 'Guarente': [979], 'Ten': [981], 'years': [982], 'NAD-dependent': [984, 1223, 2247], 'SIR2': [985], 'family': [986, 2133], 'deacetylases:': [987], 'implications': [988], 'metabolic': [990, 1494, 2333, 2595, 2602, 2781, 2788], 'diseases.Trends': [991], 'Pharmacol.': [992], 'Sci.': [993], '31:': [995], '212-220Abstract': [996], '(347)': [1004], '16Lee': [1007], 'K.K.': [1008], 'Workman': [1009], 'J.L.': [1010], 'acetyltransferase': [1012], 'complexes:': [1013], 'one': [1014], 'size': [1015], "doesn't": [1016], 'fit': [1017], 'all.Nat.': [1018], 'Mol.': [1020], 'Cell': [1021], '8:': [1024, 2549], '284-295Crossref': [1025], '(784)': [1028], 'HDACs': [1031, 1090, 1349], 'are': [1032, 1119, 1871, 2058, 2280, 2289, 2459, 2863], 'grouped': [1033], 'into': [1034, 3181, 3392, 3441, 3888], 'several': [1035], 'categories': [1036], '(17Frye': [1037], 'R.A.': [1038, 1213, 2237], 'Phylogenetic': [1039], 'classification': [1040], 'proteins.Biochem.': [1046], 'Biophys.': [1047, 2812], 'Res.': [1048, 1854, 2506, 2813, 4431], 'Commun.': [1049, 2814], '2000;': [1050], '273:': [1051], '793-798Crossref': [1052], '(1153)': [1055], 'Scholar):': [1057], 'class': [1058, 1065, 1072, 1077, 1081, 2131], 'I': [1059], '(HDAC1,': [1060], '-2,': [1061], '-3,': [1062], '-8),': [1064], 'IIA': [1066], '(HDAC4,': [1067], '-5,': [1068, 1095], '-7,': [1069], '-9),': [1071], 'IIB': [1073], '(HDAC6': [1074], '-10),': [1076], 'III': [1078, 2132], '(Sirt1–7),': [1079], 'IV': [1082], '(HDAC11).': [1083], 'weak': [1085], '(e.g.': [1091], 'Sirt4–7': [1092], 'HDAC4,': [1094], '-7–11),': [1097], 'well': [1099, 2897], 'demonstration': [1102], 'Sirt5': [1104, 1220, 2244, 2268], 'demalonylation': [1109], 'enzyme,': [1110, 4135], 'suggest': [1111, 1352, 2437], 'HDAC': [1114], 'independent': [1120], '(18Peng': [1123, 1910, 2147], 'Lu': [1125, 1762, 1912, 2149], 'Z.': [1126, 1128, 1130, 1759, 1763, 1843, 1913, 1915, 1917, 1974, 1978, 2015, 2023, 2085, 2093, 2150, 2152, 2154, 2317, 2364, 2368, 2395, 2403, 2495], 'Xie': [1127, 1914, 1977, 2151, 2316, 2367, 2575, 2761], 'Cheng': [1129, 1508, 1579, 1758, 1842, 1916, 2022, 2092, 2153, 2402, 2494, 3493, 3570], 'Tan': [1133, 1764, 1920, 1975, 2020, 2090, 2157, 2312, 2365, 2400, 2521], 'Luo': [1135, 1760, 1922, 2159], 'K.': [1142, 1835, 1929, 2166, 2487], 'D.': [1146, 1150, 1933, 1937, 2170, 2174], 'Ho': [1147, 1934, 2171], 'Lombard': [1149, 1936, 2173, 2324], 'T.C.': [1152, 1811, 1939, 2176], 'Dai': [1153, 1940, 1979, 2016, 2018, 2086, 2088, 2177, 2314, 2369, 2396, 2398], 'Ye': [1157, 1944, 2181], 'Zhao': [1159, 1522, 1593, 1754, 1768, 1946, 1983, 2028, 2098, 2183, 2326, 2373, 2408, 2531, 2577, 2589, 2591, 2763, 2775, 2777, 3507, 3584, 4411], 'malonylation': [1166, 1869, 1953, 2034, 2104, 2190, 2414], 'its': [1169, 1956, 2193], 'enzyme.Mol.': [1171, 1958, 2195], 'Proteomics.': [1173, 1786, 1960, 2038, 2108, 2197, 2418, 2547], '10': [1175, 1962, 2199, 3273, 3357, 3442, 3633], '(M111.012658)Abstract': [1176, 1963, 2200], '(511)': [1183, 1970, 2207], '19Du': [1186, 2210], 'Su': [1190, 2214], 'Khan': [1194, 2218], 'Kim': [1198, 1202, 2222, 2226, 2523, 4409], 'Woo': [1200, 2224], 'J.H.': [1203, 2227], 'Choi': [1204, 2228], 'B.H.': [1205, 2229], 'Cerione': [1212, 2236], 'Auwerx': [1214, 2238], 'Hao': [1216, 2240], 'demalonylase': [1226, 2250], 'desuccinylase.Science.': [1228, 2252], '334:': [1230, 2254], '806-809Crossref': [1231, 2255], '(954)': [1234, 2258], 'gene': [1239, 1272, 2077], 'ontology': [1240, 1273], 'deacetylase': [1242, 1275, 2663], 'heavy/light': [1243, 1276], 'high-performance': [1244, 1277], 'chromatography': [1246, 1279], 'Kyoto': [1247, 1280], 'Genomes': [1252, 1285], 'knockout': [1253, 1286], 'mass': [1256, 1289, 3256, 3893, 3901, 4065, 4101, 4115, 4321, 4328, 4428], 'spectrometry': [1257, 1290, 3257, 4102], 'stable': [1260, 1293, 2877], 'culture': [1268, 1301, 2885, 3158], 'sirtuin.': [1269, 1302], 'For': [1303], 'long': [1305], 'period': [1306], 'time,': [1308], 'was': [1311, 1318, 2695, 2738, 3001, 3041, 3128, 3151, 3249, 3280, 3352, 3361, 3447, 3641, 3904, 3969, 4018, 4033, 4130, 4143, 4163, 4182, 4214, 4254, 4285], 'considered': [1312], 'restricted': [1319], 'nuclei': [1321, 1351], '(20Cohen': [1322], 'AcK-knowledge': [1326], 'reversible': [1327], 'acetylation.Sci.': [1328], 'STKE.': [1329], '2004;': [1330, 1425], '2004:': [1331], 'pe42Crossref': [1332], '(46)': [1335], 'cytosolic': [1341, 1480], 'localization': [1346], 'outside': [1350], 'non-nuclear': [1354, 1557], '(13Hubbert': [1359], '21Cohen': [1390], 'H.Y.': [1391], 'Lavu': [1392], 'Bitterman': [1394], 'K.J.': [1395], 'Hekking': [1396], 'Imahiyerobo': [1398], 'Miller': [1400], 'Frye': [1402], 'Ploegh': [1404], 'Kessler': [1406], 'Sinclair': [1408], 'D.A.': [1409], 'Acetylation': [1410, 2593, 2635, 2779], 'C': [1413], 'terminus': [1414], 'Ku70': [1416], 'CBP': [1418], 'PCAF': [1420], 'controls': [1421], 'Bax-mediated': [1422], 'apoptosis.Mol.': [1423], '13:': [1426], '627-638Abstract': [1427], '(507)': [1435], '22Michishita': [1438], 'Park': [1440], 'Burneskis': [1442], 'Barrett': [1444], 'Horikawa': [1446], 'Evolutionarily': [1448], 'nonconserved': [1451], 'localizations': [1453], 'functions': [1455, 1562], 'human': [1457], 'SIRT': [1458], 'proteins.Mol.': [1459], '2005;': [1462, 4432], '16:': [1463], '4623-4635Crossref': [1464], '(1064)': [1467], 'proteomic': [1472, 2873, 3762], 'screening': [1473, 2910], 'hundreds': [1475], 'fractions': [1483, 3394, 3435, 3796], 'demonstrated': [1485], '(23Kim': [1496, 1567, 3481, 3558], 'S.C.': [1497, 1568, 3482, 3559, 4410], 'Sprung': [1498, 1569, 2517, 3483, 3560], 'Ball': [1504, 1575, 3489, 3566], 'Pei': [1506, 1577, 2519, 3491, 3568], 'Kho': [1510, 1581, 3495, 3572], 'Xiao': [1512, 1514, 1583, 1585, 3497, 3499, 3574, 3576], 'Grishin': [1516, 1587, 2529, 3501, 3578], 'N.V.': [1517, 1588, 2530, 3502, 3579], 'White': [1518, 1589, 3503, 3580], 'Substrate': [1524, 1595, 3509, 3586], 'functional': [1526, 1597, 3511, 3588], 'diversity': [1527, 1598, 3512, 3589], 'revealed': [1531, 1602, 2266, 3516, 3593], 'proteomics': [1534, 1605, 1908, 2478, 2930, 3261, 3519, 3596], 'survey.Mol.': [1535, 1606, 3520, 3597], '2006;': [1537, 1608, 3522, 3599], '23:': [1538, 1609, 3523, 3600], '607-618Abstract': [1539, 1610, 3524, 3601], '(1217)': [1547, 1618, 3532, 3609], 'This': [1550], 'result': [1551], 'implies': [1552], 'can': [1560, 2136], 'regulate': [1561], 'mitochondria': [1566], 'Since': [1621], 'then,': [1622], 'others': [1625, 2474], 'extensively': [1627], 'characterized': [1628], 'acetylome': [1631, 1771], '(5Hebert': [1632], '24Chen': [1752], 'J.S.': [1757, 1839, 2491, 4092], 'Gu': [1766], 'Quantitative': [1770], 'analysis': [1772, 1903, 1909, 3763, 3903, 4177], 'reveals': [1773], 'SIRT1': [1777], 'regulating': [1779], 'pathways.Mol.': [1784, 2334], '2012;': [1787, 2039, 2109, 2419], '11:': [1788, 2040, 2110, 2420], '1048-1062Abstract': [1789], '(155)': [1797], '25Choudhary': [1800], 'Kumar': [1802], 'Gnad': [1804], 'Nielsen': [1806], 'M.L.': [1807], 'Rehman': [1808], 'Walther': [1810], 'Olsen': [1812], 'J.V.': [1813], 'Mann': [1814, 4055], 'targets': [1818], 'complexes': [1820], 'co-regulates': [1822], 'major': [1823, 2906], 'functions.Science.': [1825], '325:': [1827], '834-840Crossref': [1828], '(3152)': [1831], '26Zhang': [1834], 'Zheng': [1836, 2488], 'Comprehensive': [1844, 2496], 'profiling': [1845, 2497], 'Escherichia': [1851, 2503, 2544, 2926], 'coli.J.': [1852, 2504], 'Proteome': [1853, 2505, 4430], '12:': [1856, 2508], '844-851Crossref': [1857, 2509], '(179)': [1860, 2512], '(Ksucc)': [1866], 'pathways': [1870, 1874], 'PTM': [1873, 2445, 2832, 3075], 'were': [1876, 2984, 3024, 3049, 3060, 3072, 3083, 3113, 3163, 3172, 3214, 3266, 3288, 3345, 3390, 3436, 3465, 3550, 3619, 3628, 3678, 3707, 3726, 3785, 3797, 3819, 3854, 3883, 3951, 3985, 4009, 4046, 4124, 4153, 4178, 4194, 4340, 4355, 4386, 4394], 'recently': [1877, 3738], 'comprehensively': [1880], 'validated': [1881], 'mammalian': [1886, 2357, 2463], 'cells,': [1887, 2358, 2464], 'multiple': [1889], 'identified,': [1892], 'using': [1893, 1904, 3378, 3395, 3450, 3553, 3732, 3799, 3920, 3931, 4100, 4287, 4400], 'HPLC-MS/MS,': [1894], 'co-elution': [1895], 'synthetic': [1897], 'isotopic': [1899], 'labeling,': [1900], 'Western': [1901, 3117], 'blotting': [1902], 'pan-anti-Ksucc': [1905], 'antibodies,': [1906], '27Zhang': [1973], 'Identification': [1985, 2375], 'new': [1991, 2381], 'modification.Nat.': [1993, 2383], '7:': [1997, 2387], '58-63Crossref': [1998, 2388], '(569)': [2001, 2391], 'also': [2005, 2360], 'Ksucc': [2008, 2056, 2071, 2275, 2278, 2350, 2457, 2941, 3537, 3544, 3705, 3720, 3781], 'core': [2012], 'histones': [2013, 2063], '(29Xie': [2014, 2084], 'Wu': [2024, 2094, 2404], 'histones.Mol.': [2036, 2106, 2416], '100-107Abstract': [2041, 2111, 2421], '(413)': [2049, 2119, 2429], 'yeast': [2053], 'histones,': [2054], 'located': [2059], 'regions': [2061], 'where': [2062], 'make': [2064], 'close': [2065], 'contact': [2066], 'DNA,': [2068], 'changing': [2080], 'chromatin': [2082], 'structure': [2083], 'then': [2123, 3473, 3820], 'found': [2124, 2948], 'Sirt5,': [2126], 'member': [2128], 'HDACs,': [2135], 'vitro': [2143], 'vivo': [2146], 'recent': [2263], 'study,': [2264], 'key': [2271, 2453], 'abundant': [2281, 2538], 'among': [2282], 'predominantly': [2290], 'fatty': [2293], 'acid': [2294, 2297, 2302, 3453, 3815, 3864], 'metabolism,': [2295], 'degradation,': [2298], 'tricarboxylic': [2301], 'cycle': [2303], '(28Park': [2304], 'Peng': [2310], 'Skinner': [2322], 'M.E.': [2323], 'SIRT5-mediated': [2328], 'impacts': [2331], '50:': [2337], '919-930Abstract': [2338], '(618)': [2346], 'Importantly,': [2349], 'not': [2354, 2850, 2864], 'only': [2355], 'but': [2359], 'bacteria': [2362, 2468, 2485, 2665, 2848], '(27Zhang': [2363], '29Xie': [2394], 'These': [2432], 'lines': [2433], 'evidence': [2435], 'strongly': [2436], 'important': [2444], 'functions.': [2451], 'Although': [2452], 'elements': [2454], 'being': [2460], 'their': [2465, 2860], 'counterparts': [2466], 'unknown.': [2471], 'approach': [2479, 2874, 3740, 4414], 'identify': [2481, 2888, 4237, 4269], '(26Zhang': [2486], '30Zhang': [2515], 'Zhu': [2525], 'Liu': [2527], 'C.F.': [2528], 'coli.Mol.': [2545], '215-225Abstract': [2550], '(382)': [2558], '31Wang': [2561], 'Ning': [2581, 2767], 'Z.B.': [2582, 2768], 'G.P.': [2592, 2778], 'coordinates': [2597, 2783], 'carbon': [2598, 2784], 'source': [2599, 2785], 'utilization': [2600, 2786], 'flux.Science.': [2603, 2789], '1004-1007Crossref': [2606, 2792], '(791)': [2609, 2795], '52Weinert': [2612], 'B.T.': [2613], 'Iesmantavicius': [2614], 'V.': [2615], 'Wagner': [2616], 'S.A.': [2617, 3760], 'Schölz': [2618], 'Gummesson': [2620], 'Beli': [2622], 'Nyström': [2624], 'Choudhary': [2626], 'C.R.': [2627], "'Acetyl-Phosphate": [2628], 'Is': [2629], 'Critical': [2631], 'Determinant': [2632], "coli.'.Molecular": [2638], 'vol': [2641], '51': [2642], '(no.': [2643], '2):': [2644], '265-272Abstract': [2645], '(301)': [2652], 'best-studied': [2661], '(8Starai': [2666, 2708], 'initially': [2696], 'required': [2701], 'Recently,': [2736], 'shown': [2739], 'play': [2741], 'energy': [2745, 2837, 2907, 3995], '(31Wang': [2747], 'Scholar)': [2797, 4079], 'stress': [2799, 2810], '(32Ma': [2801], 'Wood': [2803], 'T.K.': [2804], 'Protein': [2805], 'prokaryotes': [2808], 'increases': [2809], 'resistance.Biochem.': [2811], '410:': [2816], '846-851Crossref': [2817], '(61)': [2820], 'Those': [2823], 'studies': [2824], 'indicated': [2825], 'role': [2835], 'prokaryotes.': [2840], 'Nevertheless,': [2841], 'been': [2851], 'studied.': [2852], 'known.': [2865], 'paper,': [2868], 'quantitative': [2872, 2929], 'based': [2875], '(SILAC)': [2886], 'quantify': [2890], 'succinylation,': [2895], 'acetylation,': [2900], 'glucose,': [2904], 'source.': [2908, 3899], 'detected': [2911], 'show': [2932], 'had': [2935, 2955], 'Kac.': [2944], 'dual': [2956, 3936], 'catalyze': [2960], 'removal': [2962], 'structurally': [2965], 'acyl': [2968], 'groups,': [2969], 'succinyl,': [2972], 'modified': [2975], 'residues.': [2977], 'coli': [2979, 3081, 3155, 3264, 3326, 4294], 'strains': [2980], 'MG1655': [2981], 'AT713': [2983], 'obtained': [2985, 3002, 3061], 'Coli': [2988], 'Genetic': [2989], 'Stock': [2990], 'Center': [2991], 'at': [2992, 3096, 3148, 3216, 3270, 3275, 3316, 3354, 3424, 3427, 3630, 3667, 3874, 3958, 3966, 4145, 4357], 'Yale': [2993], 'University': [2994], '(New': [2995], 'Haven,': [2996], 'CT),': [2997], 'BL21': [2999], '(DE3)': [3000], 'Novagen': [3004], '(Millipore': [3005], 'Corporation,': [3006], 'Billerica,': [3007], 'MA).': [3008, 3055, 3067, 3852], 'M9': [3009, 3086, 3100, 3137, 3176, 3183, 3198], 'minimal': [3010], 'salts,': [3011], 'isotopically': [3012], 'labeled': [3013], '(l-lysine-13C6,15N2': [3015], 'hydrochloride)': [3016], 'arginine': [3018, 3191, 3206], '(l-arginine-13C6,15N4': [3019], 'hydrochloride),': [3020], 'other': [3022], 'chemicals': [3023], 'purchased': [3025, 3042, 3050, 3073], 'purity': [3028], 'analytical': [3030], 'grade': [3031], 'Sigma-Aldrich,': [3033], 'Inc.': [3034, 3077], '(St.': [3035], 'Louis,': [3036], 'MO).': [3037], 'Modified': [3038], 'sequencing-grade': [3039], 'trypsin': [3040, 3476], 'Promega': [3044], '(Madison,': [3045], 'WI).': [3046], 'C18': [3047, 3801], 'ZipTips': [3048], 'Millipore': [3052], 'Corporation': [3053], '(Billerica,': [3054], 'MS-grade': [3056], 'water': [3057], 'acetonitrile': [3059], 'Thermo': [3063], 'Fisher': [3064], 'Scientific': [3065], '(Waltham,': [3066], 'Pan-anti-acetyllysine': [3068], 'anti-succinyllysine': [3070, 3658], 'antibodies': [3071], 'Biolabs,': [3076], '(Chicago,': [3078], 'IL).': [3079], 'cells': [3082, 3112, 3213, 3244, 3265, 3287, 4244, 4276], 'cultured': [3084, 3245], 'medium': [3087, 3101, 3139, 3177, 3184, 3199], '(supplemented': [3088, 3140], 'each': [3090, 3142, 3616, 3981], '20': [3093, 3145, 3297, 3649, 3976, 4381], '100': [3097, 3149, 3622, 3694], 'mg/l)': [3098, 3150], 'supplemented': [3102], '0.8%': [3104, 3106, 3109, 3210], 'pyruvate,': [3105], 'succinate,': [3107], 'harvested,': [3114], 'lysed,': [3115], 'blotted': [3118], 'pan-antibodies': [3120], 'against': [3121, 4289], 'acetyllysine': [3122], 'succinyllysine.': [3124], 'Coomassie': [3125], 'Blue': [3126], 'staining': [3127], 'loading': [3132], 'controls.': [3133], '300': [3134], 'ml': [3135], 'growth': [3138], 'inoculated': [3152], '(strain': [3156], 'AT713)': [3157], 'grown': [3160, 3327, 4245, 4277], 'overnight.': [3161], 'Cells': [3162], 'harvested': [3164, 3230, 3267], 'when': [3165], 'A600': [3166], 'reached': [3167], '0.8.': [3168], 'pellets': [3171, 3464], 'washed': [3173, 3281, 3467, 3679], 'twice': [3174, 3282, 3468, 3685], 'subsequently': [3179], 'transferred': [3180], 'either': [3182, 3329, 4000], 'containing': [3185, 3200, 3536], 'light': [3186, 3338, 4279], '(12C614N2': [3188, 3339], 'Lys)': [3189, 3204], '(12C614N4': [3192], 'Arg)': [3193, 3208, 3335, 3343], 'no': [3195], 'heavy': [3201, 3247, 3330, 4247], '(13C615N2': [3203, 3331], '(13C615N4': [3207], 'incubated': [3215], '37': [3217], '°C': [3218, 3426], 'rotary': [3221], 'shaker': [3222], '(225': [3223], 'rpm)': [3224], 'about': [3226], '5': [3227, 3312], 'h': [3228, 3672], 'during': [3231], 'exponential': [3233], 'phase': [3234], 'comparable': [3237], 'OD': [3238], 'value.': [3239], 'efficiency': [3242], 'media': [3248, 3336, 3344, 4248, 4280], 'greater': [3250], '98%': [3252], 'prior': [3258, 3790, 4388], 'experiment.': [3262], 'via': [3268], 'centrifugation': [3269], '2,000g': [3271], 'min': [3274, 3313, 3634], '4': [3276, 3425, 3671], '°C.': [3277], 'pellet': [3279], 'ice-cold': [3284, 3291, 3470], 'PBS.': [3285], 'resuspended': [3289], 'NETN': [3292, 3683], 'buffer': [3293, 3403, 3414, 3688], '(100': [3294, 3829], 'mm': [3295, 3298, 3303, 3406, 3409, 3417, 3422, 3623, 3690, 3695, 3698, 3830], 'NaCl,': [3296, 3410, 3696], 'Tris-Cl,': [3299, 3691], 'pH': [3300, 3411, 3419, 3692], '8.0,': [3301, 3693], '0.5': [3302, 4331], 'EDTA,': [3304], '0.5%': [3306], 'Nonidet': [3307], 'P-40)': [3308], 'sonicated': [3310], 'cooling': [3315], '1-min': [3317], 'intervals.': [3318], 'Equal': [3319], 'amounts': [3320], 'lysate': [3323], 'Lys': [3332, 3340], '13C615N4': [3334], '12C614N4': [3342], 'mixed': [3346], '(40': [3347], 'mg': [3348], 'each).': [3349], 'mixture': [3351], 'centrifuged': [3353, 3629], '100,000g': [3355], 'min.': [3358], 'supernatant': [3360], 'removed': [3362, 4387], 'separated': [3364, 3391], 'mixed-bed': [3367], 'ion': [3368, 3898, 3938, 4378], 'exchange': [3369], 'column': [3370, 3828], '(polyCAT/WAX': [3371], '(250': [3372], '×': [3373, 3831], '21.2': [3374], 'mm),': [3375], 'PolyLC,': [3376], 'Inc.)': [3377], 'Discovery': [3380], 'VP': [3381], 'preparative': [3382], 'HPLC': [3383, 3617, 3847], 'system': [3384, 3848], '(Shimadzu,': [3385], 'Kyoto,': [3386], 'Japan).': [3387], '62': [3393], 'salt': [3397], 'gradient': [3398, 3873], '0%': [3400], '100%': [3402], 'B': [3404, 3861], '(10': [3405, 3416], 'MES,': [3407, 3418], '800': [3408], '6.0)': [3412], 'A': [3415, 3812, 3869], '6.0,': [3420], '50': [3421], 'NaCl)': [3423], 'flow': [3429, 3876], 'rate': [3430, 3877, 4347], '16': [3432], 'ml/min.': [3433], 'Adjacent': [3434], 'pooled': [3437], 'finally': [3439], 'combined': [3440], 'final': [3443], 'fractions.': [3444], 'Each': [3445], 'fraction': [3446, 3618], 'precipitated': [3448], '10%': [3451], 'trichloroacetic': [3452], '(final': [3454, 3460], 'volume)': [3455], '1%': [3457], 'sodium': [3458], 'deoxycholate': [3459], 'concentration).': [3461], 'collected,': [3466], 'acetone,': [3471], 'subjected': [3474], 'digestion': [3477], 'described': [3479, 3556], 'previously': [3480, 3557, 4403], 'Peptides': [3535, 3853], '(hereinafter': [3540], 'referred': [3541], 'respectively)': [3549], 'sequentially': [3551, 3986], 'enriched': [3552, 3728], 'procedure': [3555], 'Briefly,': [3612], 'tryptic': [3613], 'resolubilized': [3620], 'NH4HCO3': [3624], '(pH': [3625], '8.0).': [3626], 'Samples': [3627, 3818], '50,000g': [3631], 'insoluble': [3637], 'particles.': [3638], 'Affinity': [3639], 'purification': [3640], 'carried': [3642, 3905], 'out': [3643, 3906], 'incubating': [3645], '40': [3651], 'μl': [3652], 'agarose': [3654], 'beads': [3655, 3677, 3711], 'conjugated': [3656], 'anti-acetyllysine': [3660], 'antibody': [3661], '(PTM': [3662], 'Biolabs': [3663], 'Inc.,': [3664], 'Chicago,': [3665], 'IL)': [3666], 'room': [3668], 'temperature': [3669], 'gentle': [3674], 'rotation.': [3675], 'three': [3680, 3713, 4334], 'times': [3681], 'buffer,': [3684], 'ETN': [3687], '(50': [3689], '1': [3697], 'EDTA),': [3699], 'once': [3701], 'water.': [3703], 'Enriched': [3704], 'eluted': [3708, 3780, 3855], 'washes': [3714], '0.1%': [3716], 'trifluoroacetic': [3717], 'acid.': [3718], 'After': [3719], 'enrichment,': [3722], 'remnant': [3724], 'supernatants': [3725], 'anti-Kac': [3733], 'antibody,': [3734], 'similar': [3735], 'reported': [3739, 4404], '(33Mertins': [3741], 'Qiao': [3743], 'J.W.': [3744], 'Patel': [3745], 'Udeshi': [3747], 'N.D.': [3748], 'Clauser': [3749], 'K.R.': [3750], 'Mani': [3751], 'D.R.': [3752], 'Burgess': [3753], 'Gillette': [3755], 'M.A.': [3756], 'Jaffe': [3757], 'Carr': [3759], 'Integrated': [3761, 4413], 'modifications': [3766, 4198, 4235, 4385], 'serial': [3768], 'enrichment.Nat.': [3769], 'Methods.': [3770], '10:': [3772], '634-637Crossref': [3773], '(432)': [3776], 'dried': [3786], 'SpeedVac': [3789], 'nano-HPLC-MS/MS': [3792], 'analysis.': [3793, 3974, 4391], 'desalted': [3798], 'OMIX': [3800], 'tips': [3802], '(Agilent': [3803], 'Technologies,': [3804], 'Santa': [3805], 'Clara,': [3806], 'CA)': [3807, 3840], 'dissolved': [3809], 'solvent': [3811, 3860, 3868], '(0.1%': [3813, 3862], 'formic': [3814, 3863], 'water).': [3817], 'injected': [3821], 'onto': [3822], 'manually': [3824], 'packed': [3825], 'reversed-phase': [3826], 'C12': [3827], '75': [3832], 'μm,': [3833], '4-μm': [3834], 'particle': [3835], 'size,': [3836], 'Phenomenex,': [3837], 'St.': [3838], 'Torrance,': [3839], 'connected': [3841], 'Eksigent': [3844], 'NanoLC-1D': [3845], 'plus': [3846], '(AB': [3849], 'SCIEX,': [3850], 'Framingham,': [3851], '5%': [3857], '80%': [3859], 'acetonitrile)': [3866], '2-h': [3872], '200': [3879], 'nl/min.': [3880], 'analytes': [3882], 'directly': [3884], 'ionized': [3885], 'sprayed': [3887], 'LTQ': [3890], 'Orbitrap': [3891, 3926], 'Velos': [3892], 'spectrometer': [3894], 'nanospray': [3897], 'spectrometric': [3902], 'data-dependent': [3909], 'mode': [3910], 'automatic': [3913], 'switch': [3914], 'between': [3915], 'full': [3917, 3972, 3982], 'MS': [3918, 3923, 3941, 3973, 3983, 4043], 'scan': [3919, 3930], 'Fourier': [3921], 'transform': [3922], 'MS/MS': [3929, 3989, 4012], 'collision-induced': [3932], 'dissociation': [3933], 'linear': [3937], 'trap.': [3939], 'spectra': [3942], 'm/z': [3945, 3959, 3967], 'range': [3946], '350': [3948], '1500': [3950], 'acquired': [3952, 4042], 'resolution': [3955], '60,000': [3957], '=': [3960], '400': [3961], 'profile': [3963], 'mode.': [3964], 'Lockmass': [3965], '445.120024': [3968], 'enabled': [3970], 'most': [3977], 'intense': [3978], 'ions': [3979], 'spectrum': [3984], 'isolated': [3987], 'fragmentation': [3990], 'normalized': [3993], 'collision': [3994], '35%.': [3997], 'Ions': [3998], 'single': [4002], 'charge': [4003], 'four': [4007], 'charges': [4008], 'excluded': [4010], 'fragmentation.': [4013], 'exclusion': [4016, 4031], 'duration': [4017], 'set': [4019, 4034, 4144], '36': [4021], 's': [4022], 'repeat': [4025], 'count': [4026], '2,': [4028], 'window': [4032], '0.01%': [4036], 'reference': [4039], 'mass.': [4040], 'raw': [4044], 'processed': [4047, 4342], 'MaxQuant': [4049, 4057, 4127, 4359], 'software': [4050, 4082, 4360], '(version': [4051, 4083], '1.0.13.13)': [4052], '(34Cox': [4053], 'enables': [4058], 'rates,': [4062], 'individualized': [4063], 'p.p.b.-range': [4064], 'accuracies': [4066], 'proteome-wide': [4068], 'quantification.Nat.': [4070], 'Biotechnol.': [4071], '1367-1372Crossref': [4074], '(9154)': [4077], 'Mascot': [4081, 4288, 4337, 4377], '2.1)': [4084], '(35Perkins': [4085], 'D.N.': [4086], 'Pappin': [4087], 'Creasy': [4089], 'D.M.': [4090], 'Cottrell': [4091], 'Probability-based': [4093], 'searching': [4097, 4284, 4422], 'sequence': [4098, 4300, 4424], 'databases': [4099, 4425], 'data.Electrophoresis.': [4103], '1999;': [4104], '20:': [4105], '3551-3567Crossref': [4106], '(6763)': [4109], 'Peaklist': [4112], 'generation,': [4113], 'precursor': [4114, 4320], 'recalibration,': [4116], 'SILAC': [4117, 4121, 4181, 4213, 4253, 4370], 'pair': [4118, 4210], 'extraction,': [4119], 'ratio': [4122], 'calculation': [4123], 'generated': [4125], 'software.': [4128], 'Trypsin': [4129], 'specified': [4131, 4154, 4164, 4195, 4220, 4232, 4263], 'cleavage': [4134], 'maximum': [4138], 'number': [4139], 'missed': [4141], 'cleavages': [4142], '2.': [4146], 'Methionine': [4147], 'oxidation': [4148], 'N-terminal': [4151], 'variable': [4156, 4197, 4234, 4266], 'modifications,': [4157], 'cysteine': [4159], 'alkylation': [4160], 'iodoacetamide': [4162], 'fixed': [4167, 4223, 4356], 'all': [4170], 'database': [4171, 4301, 4307], 'searching.': [4172], 'Three': [4173], 'sets': [4174, 4335], 'performed:': [4179], '(1)': [4180], 'selected': [4183, 4215, 4255], '"doublets"': [4185], 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