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1662, 1687, 1712, 1742, 1764, 1790, 1826, 1848, 1870, 1906, 1936, 1978, 1998, 2018, 2047, 2085, 2115, 2149, 2181, 2210, 2850, 3005, 3086, 3122, 3350], 'metabolomics': [10, 2706, 2885, 3180], 'Rui': [11, 15, 1112, 1116, 2215], 'Wang-Sattler': [12, 16, 1113, 1117, 2216], 'Corresponding': [13, 1114], 'Author': [14, 1115, 2213], 'Research': [17, 38, 70, 210, 267, 288, 309, 350, 487, 630, 824, 964, 1087, 1118, 1139, 1171, 1311, 1368, 1389, 1410, 1451, 1588, 1731, 1925, 2065, 2188, 2327, 2503, 2622, 2728, 3286], 'Unit': [18, 39, 211, 268, 289, 310, 351, 1088, 1119, 1140, 1312, 1369, 1390, 1411, 1452, 2189, 2307, 2623], 'of': [19, 40, 91, 111, 115, 141, 153, 169, 189, 212, 248, 269, 290, 311, 331, 352, 372, 392, 412, 435, 455, 524, 528, 532, 569, 594, 622, 649, 681, 705, 717, 733, 737, 755, 759, 784, 793, 816, 843, 854, 860, 885, 905, 925, 934, 992, 1001, 1022, 1026, 1059, 1068, 1089, 1120, 1141, 1192, 1212, 1216, 1242, 1254, 1270, 1290, 1313, 1349, 1370, 1391, 1412, 1432, 1453, 1473, 1493, 1513, 1536, 1556, 1625, 1629, 1633, 1670, 1695, 1723, 1750, 1782, 1806, 1818, 1834, 1838, 1856, 1860, 1885, 1894, 1917, 1944, 1955, 1961, 1986, 2006, 2026, 2035, 2093, 2102, 2123, 2127, 2160, 2169, 2190, 2308, 2335, 2344, 2348, 2363, 2375, 2380, 2389, 2416, 2425, 2434, 2446, 2455, 2459, 2463, 2478, 2495, 2511, 2532, 2537, 2546, 2552, 2566, 2584, 2624, 2650, 2660, 2712, 2732, 2801, 2859, 2893, 2897, 2937, 2976, 2994, 3027, 3044, 3076, 3182, 3213, 3217, 3252, 3290, 3315, 3329, 3490, 3502, 3509, 3544, 3619, 3767, 3796], 'Molecular': [20, 41, 213, 270, 291, 312, 353, 575, 600, 1032, 1039, 1090, 1121, 1142, 1314, 1371, 1392, 1413, 1454, 1676, 1701, 2133, 2140, 2191, 2309, 2484, 2600, 2625, 2644], 'Epidemiology,': [21, 42, 112, 214, 271, 292, 313, 354, 414, 625, 734, 756, 819, 1006, 1023, 1091, 1122, 1143, 1213, 1315, 1372, 1393, 1414, 1455, 1515, 1726, 1835, 1857, 1920, 2107, 2124, 2192, 2310, 2345, 2436, 2498, 2589, 2626], 'Helmholtz': [22, 43, 94, 172, 194, 215, 251, 272, 293, 314, 334, 355, 375, 395, 415, 438, 460, 654, 787, 848, 888, 908, 928, 995, 1062, 1092, 1123, 1144, 1195, 1273, 1295, 1316, 1352, 1373, 1394, 1415, 1435, 1456, 1476, 1496, 1516, 1539, 1561, 1755, 1888, 1949, 1989, 2009, 2029, 2096, 2163, 2193, 2311, 2338, 2383, 2394, 2419, 2428, 2437, 2449, 2516, 2627], 'Zentrum': [23, 44, 95, 173, 195, 216, 252, 273, 294, 315, 335, 356, 376, 396, 416, 439, 461, 655, 788, 849, 889, 909, 929, 996, 1063, 1093, 1124, 1145, 1196, 1274, 1296, 1317, 1353, 1374, 1395, 1416, 1436, 1457, 1477, 1497, 1517, 1540, 1562, 1756, 1889, 1950, 1990, 2010, 2030, 2097, 2164, 2194, 2312, 2339, 2384, 2395, 2420, 2429, 2438, 2450, 2517, 2628], 'München,': [24, 45, 96, 174, 196, 217, 233, 253, 274, 295, 316, 336, 357, 377, 397, 417, 440, 462, 656, 789, 798, 850, 890, 910, 930, 977, 997, 1064, 1073, 1094, 1125, 1146, 1197, 1275, 1297, 1318, 1334, 1354, 1375, 1396, 1417, 1437, 1458, 1478, 1498, 1518, 1541, 1563, 1757, 1890, 1899, 1951, 1991, 2011, 2031, 2078, 2098, 2165, 2174, 2195, 2313, 2340, 2385, 2396, 2412, 2421, 2430, 2439, 2451, 2518, 2542, 2580, 2629], 'Neuherberg,': [25, 46, 97, 175, 197, 218, 254, 275, 296, 317, 337, 358, 378, 398, 418, 441, 463, 657, 790, 851, 891, 911, 931, 998, 1065, 1095, 1126, 1147, 1198, 1276, 1298, 1319, 1355, 1376, 1397, 1418, 1438, 1459, 1479, 1499, 1519, 1542, 1564, 1758, 1891, 1952, 1992, 2012, 2032, 2099, 2166, 2196, 2314, 2341, 2386, 2397, 2422, 2431, 2440, 2452, 2519], 'Germany': [26, 47, 76, 98, 120, 176, 198, 219, 235, 255, 276, 297, 318, 338, 359, 379, 399, 419, 442, 464, 493, 581, 606, 636, 658, 742, 764, 791, 800, 830, 852, 858, 892, 912, 932, 941, 970, 979, 999, 1009, 1031, 1043, 1066, 1075, 1096, 1104, 1127, 1148, 1177, 1199, 1221, 1277, 1299, 1320, 1336, 1356, 1377, 1398, 1419, 1439, 1460, 1480, 1500, 1520, 1543, 1565, 1594, 1682, 1707, 1737, 1759, 1843, 1865, 1892, 1901, 1931, 1953, 1959, 1993, 2013, 2033, 2042, 2071, 2080, 2100, 2110, 2132, 2144, 2167, 2176, 2197, 2205, 2315, 2333, 2342, 2353, 2387, 2398, 2414, 2423, 2432, 2441, 2453, 2490, 2509, 2520, 2544, 2550, 2573, 2582, 2592, 2604, 2612], 'Search': [27, 48, 77, 99, 121, 157, 177, 199, 236, 256, 277, 298, 319, 339, 360, 380, 400, 420, 443, 465, 494, 512, 538, 557, 582, 607, 637, 659, 685, 721, 743, 765, 801, 831, 873, 893, 913, 942, 980, 1010, 1044, 1076, 1105, 1128, 1149, 1178, 1200, 1222, 1258, 1278, 1300, 1337, 1357, 1378, 1399, 1420, 1440, 1461, 1481, 1501, 1521, 1544, 1566, 1595, 1613, 1639, 1658, 1683, 1708, 1738, 1760, 1786, 1822, 1844, 1866, 1902, 1932, 1974, 1994, 2014, 2043, 2081, 2111, 2145, 2177, 2206], 'more': [29, 50, 79, 101, 123, 159, 179, 201, 238, 258, 279, 300, 321, 341, 362, 382, 402, 422, 445, 467, 496, 514, 540, 559, 584, 609, 639, 661, 687, 723, 745, 767, 803, 833, 875, 895, 915, 944, 982, 1012, 1046, 1078, 1107, 1130, 1151, 1180, 1202, 1224, 1260, 1280, 1302, 1339, 1359, 1380, 1401, 1422, 1442, 1463, 1483, 1503, 1523, 1546, 1568, 1597, 1615, 1641, 1660, 1685, 1710, 1740, 1762, 1788, 1824, 1846, 1868, 1904, 1934, 1976, 1996, 2016, 2045, 2083, 2113, 2147, 2179, 2208], 'papers': [30, 51, 80, 102, 124, 160, 180, 202, 239, 259, 280, 301, 322, 342, 363, 383, 403, 423, 446, 468, 497, 515, 541, 560, 585, 610, 640, 662, 688, 724, 746, 768, 804, 834, 876, 896, 916, 945, 983, 1013, 1047, 1079, 1108, 1131, 1152, 1181, 1203, 1225, 1261, 1281, 1303, 1340, 1360, 1381, 1402, 1423, 1443, 1464, 1484, 1504, 1524, 1547, 1569, 1598, 1616, 1642, 1661, 1686, 1711, 1741, 1763, 1789, 1825, 1847, 1869, 1905, 1935, 1977, 1997, 2017, 2046, 2084, 2114, 2148, 2180, 2209], 'this': [32, 53, 82, 104, 126, 162, 182, 204, 241, 261, 282, 303, 324, 344, 365, 385, 405, 425, 448, 470, 499, 517, 543, 562, 587, 612, 642, 664, 690, 726, 748, 770, 806, 836, 878, 898, 918, 947, 985, 1015, 1049, 1081, 1110, 1133, 1154, 1183, 1205, 1227, 1263, 1283, 1305, 1342, 1362, 1383, 1404, 1425, 1445, 1466, 1486, 1506, 1526, 1549, 1571, 1600, 1618, 1644, 1663, 1688, 1713, 1743, 1765, 1791, 1827, 1849, 1871, 1907, 1937, 1979, 1999, 2019, 2048, 2086, 2116, 2150, 2182, 2211, 2618], 'author': [33, 54, 83, 105, 127, 163, 183, 205, 242, 262, 283, 304, 325, 345, 366, 386, 406, 426, 449, 471, 500, 518, 544, 563, 588, 613, 643, 665, 691, 727, 749, 771, 807, 837, 879, 899, 919, 948, 986, 1016, 1050, 1082, 1111, 1134, 1155, 1184, 1206, 1228, 1264, 1284, 1306, 1343, 1363, 1384, 1405, 1426, 1446, 1467, 1487, 1507, 1527, 1550, 1572, 1601, 1619, 1645, 1664, 1689, 1714, 1744, 1766, 1792, 1828, 1850, 1872, 1908, 1938, 1980, 2000, 2020, 2049, 2087, 2117, 2151, 2183, 2212, 2672], 'Zhonghao': [34, 36, 1135, 1137, 2218], 'Yu': [35, 37, 1136, 1138], 'Christian': [55, 57, 407, 409, 1156, 1158, 1508, 1510, 2220, 2251], 'Herder': [56, 58, 1157, 1159], 'German': [59, 113, 476, 618, 735, 757, 812, 953, 1024, 1160, 1214, 1577, 1719, 1836, 1858, 1913, 2054, 2125, 2346], 'Diabetes': [60, 69, 477, 486, 550, 619, 629, 650, 813, 823, 954, 963, 1161, 1170, 1578, 1587, 1651, 1720, 1730, 1751, 1914, 1924, 2055, 2064, 2317, 2326, 2470, 2492, 2502, 2512], 'Center,': [61, 145, 433, 478, 620, 709, 782, 814, 955, 1057, 1162, 1246, 1534, 1579, 1721, 1810, 1883, 1915, 2056, 2158, 2318, 2367, 2444, 2493], 'Institute': [62, 90, 114, 168, 188, 247, 330, 371, 391, 411, 434, 454, 479, 527, 568, 593, 621, 648, 670, 736, 758, 783, 815, 842, 884, 904, 924, 956, 991, 1000, 1025, 1058, 1163, 1191, 1215, 1269, 1289, 1348, 1431, 1472, 1492, 1512, 1535, 1555, 1580, 1628, 1669, 1694, 1722, 1749, 1771, 1837, 1859, 1884, 1916, 1943, 1985, 2005, 2025, 2057, 2092, 2101, 2126, 2159, 2319, 2347, 2445, 2458, 2494], 'Clinical': [64, 481, 525, 572, 597, 958, 1165, 1582, 1626, 1673, 1698, 2059, 2321, 2456, 2481, 3626], 'Diabetology,': [65, 482, 959, 1166, 1583, 2060, 2322], 'Leibniz': [66, 483, 626, 820, 960, 1167, 1584, 1727, 1921, 2061, 2323, 2499], 'Center': [67, 133, 484, 506, 627, 697, 821, 961, 1037, 1168, 1234, 1585, 1607, 1728, 1798, 1922, 2062, 2138, 2324, 2355, 2500, 2598], 'at': [71, 488, 631, 825, 965, 1172, 1589, 1732, 1926, 2066, 2328, 2504, 3481, 3506, 3527, 3563, 3804, 3808, 3813, 3817, 3821, 3825], 'Heinrich': [72, 489, 632, 826, 966, 1173, 1590, 1733, 1927, 2067, 2329, 2505], 'Heine': [73, 490, 633, 827, 967, 1174, 1591, 1734, 1928, 2068, 2330, 2506], 'University,': [74, 491, 634, 828, 968, 1175, 1592, 1735, 1929, 2069, 2331, 2507], 'Düsseldorf,': [75, 492, 635, 829, 939, 940, 969, 1176, 1593, 1736, 1930, 2040, 2041, 2070, 2332, 2508, 2571, 2572], 'Ana': [84, 87, 1185, 1188, 2222], 'C': [85, 88, 1186, 1189, 2223], 'Messias': [86, 89, 1187, 1190], 'Structural': [92, 1193, 2336], 'Biology,': [93, 143, 193, 459, 707, 847, 855, 1194, 1244, 1294, 1560, 1808, 1948, 1956, 2337, 2365, 2393, 2547], 'Anna': [106, 108, 1207, 1209, 2225], 'Floegel': [107, 109, 1208, 1210], 'Department': [110, 523, 732, 754, 859, 933, 1021, 1211, 1624, 1833, 1855, 1960, 2034, 2122], 'Human': [116, 170, 738, 760, 886, 926, 1027, 1217, 1271, 1839, 1861, 1987, 2027, 2128, 2349, 2381], 'Nutrition': [117, 739, 761, 1028, 1218, 1840, 1862, 2129, 2350, 2830], 'Potsdam-Rehbruecke,': [118, 740, 762, 1029, 1219, 1841, 1863, 2130, 2351], 'Nuthetal,': [119, 741, 763, 1030, 1220, 1842, 1864, 2131, 2352], 'Ying': [128, 130, 1229, 1231, 2227], 'He': [129, 131, 1230, 1232], 'Shanghai': [132, 146, 505, 674, 696, 710, 1233, 1247, 1606, 1775, 1797, 1811, 2368, 2525], 'Bioinformation': [135, 508, 699, 1236, 1609, 1800, 2357], 'Technology,': [136, 509, 700, 1237, 1610, 1801, 2358], 'Shanghai,': [137, 155, 510, 683, 701, 719, 1238, 1256, 1611, 1784, 1802, 1820, 2359, 2377, 2534], 'China': [138, 156, 511, 556, 684, 702, 720, 1239, 1257, 1612, 1657, 1785, 1803, 1821, 2360, 2378, 2476, 2535], 'Key': [139, 703, 1240, 1804], 'Lab': [140, 704, 1241, 1805, 2362], 'Systems': [142, 192, 458, 706, 846, 1243, 1293, 1559, 1807, 1947, 2364, 2392, 2645], 'Bioinformatics': [144, 190, 456, 708, 844, 1245, 1291, 1557, 1809, 1945, 2366, 2390], 'Institutes': [147, 675, 711, 1248, 1776, 1812, 2369, 2526], 'Biological': [149, 677, 713, 1250, 1778, 1814, 2371, 2528], 'Sciences,': [150, 154, 673, 678, 682, 714, 718, 1251, 1255, 1774, 1779, 1783, 1815, 1819, 2372, 2376, 2524, 2529, 2533], 'Chinese': [151, 679, 715, 1252, 1780, 1816, 2373, 2530], 'Academy': [152, 680, 716, 1253, 1781, 1817, 2374, 2531], 'Katharina': [164, 166, 1265, 1267, 2229], 'Heim': [165, 167, 1266, 1268], 'Genetics,': [171, 437, 786, 795, 887, 927, 1061, 1070, 1272, 1538, 1887, 1896, 1988, 2028, 2162, 2171, 2382, 2448, 2539], 'Monica': [184, 186, 1285, 1287, 2231], 'Campillos': [185, 187, 1286, 1288], 'and': [191, 457, 574, 599, 624, 651, 818, 845, 862, 1005, 1292, 1558, 1675, 1700, 1725, 1752, 1919, 1946, 1963, 2106, 2303, 2391, 2483, 2497, 2513, 2554, 2588, 2653, 2671, 2760, 2770, 2803, 2818, 2829, 2909, 2919, 2939, 2949, 2963, 2981, 3015, 3039, 3089, 3174, 3244, 3297, 3318, 3331, 3357, 3372, 3383, 3440, 3453, 3483, 3570, 3573, 3599, 3609, 3627, 3776, 3782], 'Christina': [206, 208, 1307, 1309, 2233], 'Holzapfel': [207, 209, 1308, 1310], 'Else': [220, 1321], 'Kroener-Fresenius-Center': [221, 1322, 2400], 'Nutritional': [223, 672, 1324, 1773, 2402, 2523], 'Medicine,': [224, 571, 596, 1325, 1672, 1697, 2403, 2480], 'University': [225, 531, 577, 602, 937, 1326, 1632, 1678, 1703, 2038, 2404, 2462, 2486, 2569], 'Hospital': [226, 578, 603, 938, 1327, 1679, 1704, 2039, 2405, 2487, 2570], "'Klinikum": [227, 1328, 2406], 'rechts': [228, 972, 1329, 2073, 2407, 2575], 'der': [229, 973, 1330, 2074, 2408, 2576], "Isar',": [230, 1331, 2409], 'Technische': [231, 796, 975, 1071, 1332, 1897, 2076, 2172, 2410, 2540, 2578], 'Universität': [232, 797, 976, 1072, 1333, 1898, 2077, 2173, 2411, 2541, 2579], 'Munich,': [234, 799, 978, 1008, 1074, 1335, 1900, 2079, 2109, 2175, 2413, 2543, 2581, 2591], 'Barbara': [243, 245, 1344, 1346, 2235], 'Thorand': [244, 246, 1345, 1347], 'Epidemiology': [249, 332, 373, 393, 906, 993, 1033, 1350, 1433, 1474, 1494, 2007, 2094, 2134, 2417, 2426, 2594], 'II,': [250, 333, 394, 907, 1351, 1434, 1495, 2008, 2418], 'Harald': [263, 265, 1364, 1366, 2237], 'Grallert': [264, 266, 1365, 1367], 'Tao': [284, 286, 1385, 1387, 2239], 'Xu': [285, 287, 666, 668, 1386, 1388, 1767, 1769, 2273], 'Erik': [305, 307, 1406, 1408, 2241], 'Bader': [306, 308, 1407, 1409], 'Cornelia': [326, 328, 427, 429, 1427, 1429, 1528, 1530, 2243, 2253], 'Huth': [327, 329, 1428, 1430], 'Kirstin': [346, 348, 1447, 1449, 2245], 'Mittelstrass': [347, 349, 1448, 1450], 'Angela': [367, 369, 1468, 1470, 2247], 'Döring': [368, 370, 1469, 1471], 'I,': [374, 994, 1475, 2095, 2427], 'Christa': [387, 389, 1488, 1490, 2249], 'Meisinger': [388, 390, 1489, 1491, 3305, 3426], 'Gieger': [408, 410, 1509, 1511], 'Genetic': [413, 1514, 2435], 'Prehn': [428, 430, 1529, 1531], 'Genome': [431, 780, 1055, 1532, 1881, 2156], 'Analysis': [432, 781, 1056, 1533, 1882, 2157, 2443], 'Experimental': [436, 785, 794, 1060, 1069, 1537, 1886, 1895, 2161, 2170, 2447, 2538], 'Werner': [450, 452, 1551, 1553, 2255], 'Roemisch-Margl': [451, 453, 1552, 1554], 'Maren': [472, 474, 1573, 1575, 2257], 'Carstensen': [473, 475, 1574, 1576], 'Lu': [501, 503, 1602, 1604, 2259], 'Xie': [502, 504, 1603, 1605], 'Hisami': [519, 521, 1620, 1622, 2261], 'Yamanaka-Okumura': [520, 522, 1621, 1623], 'Nutrition,': [526, 1627, 2457], 'Health': [529, 1630, 2460, 2727, 3285], 'Biosciences,': [530, 1631, 2461], 'Tokushima': [533, 1634, 2464], 'Graduate': [534, 1635, 2465], 'School,': [535, 1102, 1636, 2203, 2466, 2610], 'Tokushima,': [536, 1637, 2467], 'Japan': [537, 1638, 2468], 'Guihong': [545, 547, 1646, 1648, 2263], 'Xing': [546, 548, 1647, 1649], 'Benxi': [549, 552, 1650, 1653, 2472], 'Clinic,': [551, 1652, 2471], 'Central': [553, 1654, 2473], 'Hospital,': [554, 1655, 2474], 'Benxi,': [555, 1656, 2475], 'Uta': [564, 566, 1665, 1667, 2265], 'Ceglarek': [565, 567, 1666, 1668], 'Laboratory': [570, 595, 1671, 1696, 2479], 'Chemistry': [573, 598, 1674, 1699, 2482], 'Diagnostics,': [576, 601, 1677, 1702, 2485], 'Leipzig,': [579, 580, 604, 605, 1680, 1681, 1705, 1706, 2488, 2489], 'Joachim': [589, 591, 1690, 1692, 2267], 'Thiery': [590, 592, 1691, 1693], 'Guido': [614, 616, 1715, 1717, 2269], 'Giani': [615, 617, 1716, 1718], 'Biometrics': [623, 817, 1724, 1918, 2496], 'Heiko': [644, 646, 1745, 1747, 2271], 'Lickert': [645, 647, 1746, 1748], 'Regeneration': [652, 1753, 2514], 'Research,': [653, 1754, 2515], 'Lin': [667, 669, 1768, 1770], 'Yixue': [692, 694, 1793, 1795, 2275], 'Li': [693, 695, 1794, 1796], 'Heiner': [728, 730, 1829, 1831, 2277], 'Boeing': [729, 731, 1830, 1832], 'Hans-Georg': [750, 752, 1851, 1853, 2279], 'Joost': [751, 753, 1852, 1854], 'Martin': [772, 776, 1873, 1877, 2281], 'Hrabé': [773, 777, 1874, 1878, 2282], 'de': [774, 778, 1875, 1879, 2283], 'Angelis': [775, 779, 1876, 1880], 'Chair': [792, 1067, 1893, 2168], 'Wolfgang': [808, 810, 1909, 1911, 2285], 'Rathmann': [809, 811, 1910, 1912, 3422], 'Karsten': [838, 840, 1939, 1941, 2287], 'Suhre': [839, 841, 1940, 1942], 'Faculty': [853, 1954], 'Ludwig-Maximilians-Universität,': [856, 1007, 1957, 2108, 2548, 2590], 'Planegg-Martinsried,': [857, 1958, 2549], 'Physiology': [861, 1962, 2553], 'Biophysics,': [863, 1964, 2555], 'Weill': [864, 1965, 2556], 'Cornell': [865, 1966, 2557], 'Medical': [866, 1002, 1101, 1967, 2103, 2202, 2558, 2585, 2609], 'College': [867, 1968, 2559], 'in': [868, 1969, 2560, 2693, 2723, 2729, 2742, 2777, 2822, 2865, 2928, 3078, 3116, 3127, 3273, 3287, 3457, 3468, 3475, 3497, 3551, 3559], 'Qatar': [869, 872, 1970, 1973, 2561, 2564], '(WCMC-Q),': [870, 1971, 2562], 'Doha,': [871, 1972, 2563], 'Holger': [880, 882, 1981, 1983, 2289], 'Prokisch': [881, 883, 1982, 1984], 'Annette': [900, 902, 2001, 2003, 2291], 'Peters': [901, 903, 2002, 2004], 'Thomas': [920, 922, 1083, 1085, 2021, 2023, 2184, 2186, 2293, 2304], 'Meitinger': [921, 923, 2022, 2024], 'Metabolic': [935, 2036, 2567], 'Diseases,': [936, 2037, 2568], 'Michael': [949, 951, 2050, 2052, 2295], 'Roden': [950, 952, 2051, 2053], 'Klinikum': [971, 2072], 'Isar,': [974, 2075, 2577], 'H-Erich': [987, 989, 2088, 2090, 2297], 'Wichmann': [988, 990, 2089, 2091, 3280], 'Informatics,': [1003, 2104, 2586], 'Biometry': [1004, 2105, 2587], 'Tobias': [1017, 1019, 2118, 2120, 2299], 'Pischon': [1018, 1020, 2119, 2121], 'Group,': [1034, 2135, 2595], 'Max': [1035, 2136, 2596], 'Delbrueck': [1036, 2137, 2597], 'Medicine': [1040, 2141, 2601], '(MDC),': [1041, 2142, 2602], 'Berlin-Buch,': [1042, 2143, 2603], 'Jerzy': [1051, 1053, 2152, 2154, 2301], 'Adamski': [1052, 1054, 2153, 2155], 'Illig': [1084, 1086, 2185, 2187], 'Hannover': [1097, 1100, 2198, 2201, 2608], 'Unified': [1098, 2199, 2606], 'Biobank,': [1099, 2200, 2607], 'Hannover,': [1103, 2204, 2611], 'Information': [2214], '1,‡,': [2217], 'Yu1,‡,': [2219], 'Herder2,‡,': [2221], 'Messias3,‡,': [2224], 'Floegel4,': [2226], 'He5,6,': [2228], 'Heim7,': [2230], 'Campillos8,': [2232], 'Holzapfel1,9,': [2234], 'Thorand10,': [2236], 'Grallert1,': [2238], 'Xu1,': [2240], 'Bader1,': [2242], 'Huth10,': [2244], 'Mittelstrass1,': [2246], 'Döring11,': [2248], 'Meisinger10,': [2250], 'Gieger12,': [2252], 'Prehn13,': [2254], 'Roemisch-Margl8,': [2256], 'Carstensen2,': [2258], 'Xie5,': [2260], 'Yamanaka-Okumura14,': [2262], 'Xing15,': [2264], 'Ceglarek16,': [2266], 'Thiery16,': [2268], 'Giani17,': [2270], 'Lickert18,': [2272], 'Lin19,': [2274], 'Li5,6,': [2276], 'Boeing4,': [2278], 'Joost4,': [2280], 'Angelis13,20,': [2284], 'Rathmann17,': [2286], 'Suhre8,21,22,': [2288], 'Prokisch7,': [2290], 'Peters10,': [2292], 'Meitinger7,23,': [2294], 'Roden2,24,': [2296], 'Wichmann11,25,': [2298], 'Pischon4,26,': [2300], 'Adamski13,20': [2302], 'Illig1,27': [2305], '1Research': [2306], '2German': [2316], '3Institute': [2334], '4Department': [2343], '5Shanghai': [2354], '6Key': [2361], '7Institute': [2379], '8Institute': [2388], '9Else': [2399], '10Institute': [2415], '11Institute': [2424], '12Institute': [2433], '13Genome': [2442], '14Department': [2454], '15Benxi': [2469], '16Institute': [2477], '17German': [2491], '18Institute': [2510], '19Institute': [2521], '20Chair': [2536], '21Faculty': [2545], '22Department': [2551], '23Department': [2565], '24Klinikum': [2574], '25Institute': [2583], '26Molecular': [2593], '27Hannover': [2605], '‡These': [2613], 'authors': [2614], 'contributed': [2615], 'equally': [2616], 'to': [2617, 2674, 2677, 2708, 2782, 2795, 2807, 2870, 2879, 2889, 2944, 3011, 3119, 3323, 3336, 3362, 3400, 3405], 'work': [2619], '*Corresponding': [2620], 'author.': [2621], '85764': [2630], 'Munich-Neuherberg,': [2631], 'Germany.': [2632], 'Tel.:+49': [2633], '89': [2634, 2638], '3187': [2635, 2639], '3978;': [2636], 'Fax:+49': [2637], '2428;': [2640], 'E-mail:': [2641], '[email': [2642], 'protected]': [2643], 'Biology': [2646], '(2012)8:615https://doi.org/10.1038/msb.2012.43': [2647], 'PDFDownload': [2648], 'PDF': [2649], 'article': [2651], 'text': [2652], 'main': [2654], 'figures.': [2655], 'Peer': [2656], 'ReviewDownload': [2657], 'a': [2658, 2705, 2905, 3476, 3784], 'summary': [2659], 'the': [2661, 2724, 2730, 2823, 2866, 2898, 2969, 2992, 2995, 3211, 3274, 3288, 3401, 3458, 3472, 3491, 3522, 3545, 3560, 3620, 3797], 'editorial': [2662, 2666], 'decision': [2663, 2667], 'process': [2664], 'including': [2665, 2978, 3445], 'letters,': [2668], 'reviewer': [2669], 'comments': [2670], 'responses': [2673], 'feedback.': [2675], 'ToolsAdd': [2676], 'favoritesDownload': [2678], 'CitationsTrack': [2679], 'CitationsPermissions': [2680], 'ShareFacebookTwitterLinked': [2681], 'InMendeleyWechatReddit': [2682], 'Figures': [2683], '&': [2684], 'Info': [2685], 'Type': [2686, 2999], '2': [2687, 2951, 3000, 3388, 3595, 3755], 'diabetes': [2688, 2750, 2952, 3001, 3077, 3596], '(T2D)': [2689, 3002, 3598], 'can': [2690, 3081], 'be': [2691, 2808, 3082, 3120], 'prevented': [2692, 3083], 'pre-diabetic': [2694, 2743, 2929, 3079], 'individuals': [2695, 2744, 2779, 2930, 3080, 3129, 3373, 3396, 3442, 3474, 3524, 3605, 3768], 'with': [2696, 2784, 2788, 2845, 2853, 2863, 2904, 2924, 2932, 2968, 3056, 3131, 3230, 3345, 3369, 3374, 3443, 3448, 3451, 3455, 3525], 'impaired': [2697, 3047, 3052, 3586, 3590, 3744, 3748], 'glucose': [2698, 2759, 2786, 3008, 3049, 3053, 3061, 3385, 3394, 3408, 3582, 3588, 3591, 3718, 3740, 3749, 3910], 'tolerance': [2699, 3054, 3409, 3583, 3592], '(IGT).': [2700], 'Here,': [2701, 3258], 'we': [2702, 2837, 3264], 'have': [2703, 3108, 3406], 'used': [2704, 2888], 'approach': [2707, 2886], 'identify': [2709, 2890, 3326], 'candidate': [2710, 2891, 3327], 'pre-diabetes.': [2713, 2894], 'We': [2714, 2762], 'quantified': [2715], '140': [2716], 'metabolites': [2717, 2765, 2849, 2900, 2914, 3114], '4297': [2719], 'fasting': [2720, 2758, 3048, 3382, 3477, 3587, 3745], 'serum': [2721], 'samples': [2722, 3233, 3802], 'population-based': [2725, 2980, 3275], 'Cooperative': [2726, 3284], 'Region': [2731, 3289], 'Augsburg': [2733, 3291], '(KORA)': [2734, 3292], 'cohort.': [2735, 2832], 'Our': [2736, 2872], 'study': [2737, 3464, 3488, 3542, 3624, 3801], 'revealed': [2738], 'significant': [2739], 'metabolic': [2740, 3339], 'variation': [2741], 'that': [2745, 2772, 2842, 3105], 'are': [2746, 2843, 2965, 3466, 3495, 3549, 3579, 3771], 'distinct': [2747], 'from': [2748, 2791, 3359, 3366], 'known': [2749, 3346], 'risk': [2751, 3215], 'indicators,': [2752], 'such': [2753, 3023], 'as': [2754, 2780, 2984, 2986, 3024, 3171, 3250], 'glycosylated': [2755], 'hemoglobin': [2756], 'levels,': [2757], 'insulin.': [2761], 'three': [2764, 2847, 2970], '(glycine,': [2766, 2915], 'lysophosphatidylcholine': [2767, 2916], '(LPC)': [2768, 2917], '(18:2)': [2769, 2918, 2941], 'acetylcarnitine)': [2771], 'had': [2773], 'significantly': [2774, 2925], 'altered': [2775, 2926], 'levels': [2776, 2800, 2858, 2927, 2936, 3009, 3062, 3168], 'IGT': [2778, 2813, 3414, 3531, 3610, 3632, 3781, 3816], 'compared': [2781, 2931, 3130], 'those': [2783], 'normal': [2785, 2933, 3407, 3739], 'tolerance,': [2787], 'P-values': [2789], 'ranging': [2790], '2.4': [2792], '×': [2793, 2797], '10−4': [2794], '2.1': [2796], '10−13.': [2798], 'Lower': [2799, 2935], 'glycine': [2802, 2938], 'LPC': [2804, 2940], 'were': [2805, 2819, 2922, 2942, 3184, 3248, 3348, 3397, 3504], 'found': [2806, 2923, 2943], 'predictors': [2809, 3251], 'not': [2810, 3209], 'only': [2811, 3057], 'but': [2814], 'also': [2815], 'T2D,': [2817], 'independently': [2820], 'confirmed': [2821], 'European': [2824], 'Prospective': [2825], 'Investigation': [2826], 'into': [2827], 'Cancer': [2828], '(EPIC)-Potsdam': [2831], 'Using': [2833], 'metabolite–protein': [2834, 3334], 'network': [2835, 2908], 'analysis,': [2836, 3361], 'seven': [2839], 'T2D-related': [2840, 2955], 'genes': [2841, 2956], 'associated': [2844, 2967], 'these': [2846, 2860, 3316], 'IGT-specific': [2848], 'multiple': [2851], 'interactions': [2852], 'four': [2854], 'enzymes.': [2855], 'The': [2856, 2895, 2973, 3074, 3313, 3433, 3541], 'expression': [2857, 2911], 'enzymes': [2861], 'correlate': [2862], 'changes': [2864, 3088, 3126], 'metabolite': [2867, 3124, 3167, 3266], 'concentrations': [2868], 'linked': [2869], 'diabetes.': [2871], 'results': [2873, 3314], 'may': [2874, 3063, 3169], 'help': [2875], 'developing': [2876], 'novel': [2877], 'strategies': [2878], 'prevent': [2880], 'T2D.': [2881], 'Synopsis': [2882], 'A': [2883, 3042], 'targeted': [2884], 'was': [2887, 2989], 'relevance': [2896], 'is': [2901, 3003], 'further': [2902], 'corroborated': [2903], 'protein-metabolite': [2906], 'interaction': [2907], 'gene': [2910], 'data.': [2912], 'Three': [2913], 'acetylcarnitine': [2920], 'C2)': [2921], 'controls.': [2934], 'predict': [2945], 'risks': [2946], 'type': [2950, 3594, 3754], '(T2D).': [2953], 'Seven': [2954], '(PPARG,': [2957], 'TCF7L2,': [2958], 'HNF1A,': [2959], 'GCK,': [2960], 'IGF1,': [2961], 'IRS1': [2962], 'IDE)': [2964], 'functionally': [2966], 'metabolites.': [2972], 'unique': [2974], 'combination': [2975], 'methodologies,': [2977], 'prospective': [2979, 3226, 3319, 3546, 3574, 3800], 'nested': [2982, 3227], 'case–control,': [2983], 'well': [2985], 'cross-sectional': [2987, 3179, 3317, 3459, 3623], 'studies,': [2988], 'essential': [2990], 'identification': [2993], 'reported': [2996], 'biomarkers.': [2997], 'Introduction': [2998], 'defined': [3004, 3398], 'increased': [3006, 3090], 'blood': [3007, 3060, 3758], 'due': [3010], 'pancreatic': [3012, 3028], 'β-cell': [3013], 'dysfunction': [3014], 'insulin': [3016, 3732, 3924], 'resistance': [3017], 'without': [3018], 'evidence': [3019], 'specific': [3021, 3103], 'causes,': [3022], 'autoimmune': [3025], 'destruction': [3026], 'β-cells': [3029], '(Krebs': [3030], 'et': [3031, 3035, 3071, 3094, 3098, 3135, 3139, 3143, 3147, 3151, 3155, 3159, 3163, 3192, 3196, 3200, 3204, 3220, 3235, 3239, 3255, 3270, 3277, 3281, 3302, 3306, 3310, 3354, 3423, 3427], 'al,': [3032, 3036, 3072, 3095, 3099, 3136, 3140, 3144, 3148, 3152, 3156, 3160, 3164, 3193, 3197, 3201, 3205, 3221, 3236, 3240, 3256, 3271, 3278, 3282, 3303, 3307, 3311, 3355, 3424, 3428], '2002;': [3033, 3069], 'Stumvoll': [3034], '2005;': [3037, 3279], 'Muoio': [3038], 'Newgard,': [3040], '2008).': [3041], 'state': [3043, 3478], '(i.e.,': [3046, 3387, 3515, 3532], '(IFG)': [3050], 'and/or': [3051], '(IGT))': [3055], 'slightly': [3058], 'elevated': [3059], 'precede': [3064], 'T2D': [3065, 3183, 3218, 3253, 3347, 3418, 3514, 3602, 3824], 'years': [3067, 3537], '(McGarry,': [3068], 'Tabak': [3070], '2012).': [3073, 3165, 3312], 'development': [3075], 'or': [3084, 3207, 3415, 3769], 'delayed': [3085], 'dietary': [3087], 'physical': [3091], 'activity': [3092, 3659, 3852], '(Tuomilehto': [3093], '2001;': [3096], 'Knowler': [3097], '2002).': [3100], 'However,': [3101], 'no': [3102], 'enable': [3106, 3175], 'prevention': [3107], 'been': [3109], 'reported.': [3110], 'Metabolomics': [3111, 3557], 'studies': [3112, 3181, 3229, 3300, 3320], 'allow': [3113], 'involved': [3115], 'disease': [3117], 'mechanisms': [3118], 'discovered': [3121], 'monitoring': [3123], 'level': [3125], 'predisposed': [3128], 'healthy': [3132], 'ones': [3133], '(Shaham': [3134, 3191], '2008;': [3137, 3194], 'Newgard': [3138], '2009;': [3141, 3198, 3304, 3425], 'Zhao': [3142, 3199], '2010;': [3145, 3202, 3308, 3429], 'Pietilainen': [3146, 3203], '2011;': [3149, 3153, 3157, 3237], 'Rhee': [3150], 'Wang': [3154, 3238], 'Cheng': [3158], '2012;': [3161], 'Goek': [3162], 'Altered': [3166], 'serve': [3170], 'diagnostic': [3172, 3403], 'preventive': [3176], 'action.': [3177], 'Previous': [3178], 'either': [3185], 'based': [3186, 3224], 'on': [3187, 3225, 3380], 'small': [3188], 'sample': [3189, 3434, 3625], 'sizes': [3190], 'Wopereis': [3195], '2011)': [3206], 'did': [3208], 'consider': [3210], 'influence': [3212, 3365], 'common': [3214], 'factors': [3216], '(Newgard': [3219], '2009).': [3222], 'Recently,': [3223], 'case–control': [3228], 'relative': [3231], 'large': [3232], '(Rhee': [3234], '2011),': [3241], 'five': [3242], 'branched-chain': [3243], 'aromatic': [3245], 'amino': [3246], 'acids': [3247], '(Wang': [3254], '2011).': [3257], 'using': [3259], 'various': [3260], 'comprehensive': [3261], 'large-scale': [3262], 'approaches,': [3263], 'measured': [3265], 'concentration': [3267], 'profiles': [3268], '(Yu': [3269], '2012)': [3272], '(Holle': [3276], '2005)': [3283], 'baseline': [3293, 3482, 3564, 3805, 3809], '(survey': [3294], '4': [3295], '(S4))': [3296], 'follow-up': [3298, 3484, 3814, 3818, 3822, 3826], '(F4)': [3299], '(Rathmann': [3301, 3353], 'Jourdan': [3309], 'allowed': [3321], 'us': [3322], '(i)': [3324], 'reliably': [3325], '(ii)': [3332], 'build': [3333], 'networks': [3335], 'understand': [3337], 'diabetes-related': [3338], 'pathways.': [3340], 'Results': [3341], 'Study': [3342], 'participants': [3343, 3371, 3447], 'Individuals': [3344], 'physician-validated': [3351], 'self-reporting': [3352], '2010)': [3356], 'excluded': [3358], 'our': [3360], 'avoid': [3363], 'potential': [3364], 'anti-diabetic': [3367], 'medication': [3368], 'non-fasting': [3370], 'missing': [3375], 'values': [3376, 3386], '(Figure': [3377, 3462, 3486, 3519, 3539], '1A).': [3378], 'Based': [3379], 'both': [3381], '2-h': [3384, 3724, 3916], 'h': [3389, 3662, 3855], 'post': [3390], 'oral': [3391], '75': [3392], 'g': [3393], 'load),': [3395], 'according': [3399], 'WHO': [3402], 'criteria': [3404], '(NGT),': [3410, 3584], 'isolated': [3411, 3585, 3743], 'IFG': [3412], '(i-IFG),': [3413, 3589], 'newly': [3416, 3600, 3752], 'diagnosed': [3417, 3601, 3753], '(dT2D)': [3419], '(WHO,': [3420], '1999;': [3421], 'Supplementary': [3430, 3498], 'Table': [3431, 3469, 3499, 3552, 3616, 3793], 'S1).': [3432], 'sets': [3435], 'include': [3436, 3606], '91': [3437, 3516, 3638, 3831], 'dT2D': [3438, 3633], 'patients': [3439], '1206': [3441], 'non-T2D,': [3444], '866': [3446, 3635], 'NGT,': [3449, 3607, 3738], '102': [3450, 3636], 'i-IFG': [3452, 3608, 3631], '238': [3454, 3637], 'IGT,': [3456, 3747], 'KORA': [3460, 3492, 3547, 3561, 3621, 3798], 'S4': [3461, 3565, 3569, 3622], 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