Title: Single‐Molecule Protein Encapsulation in a Rigid DNA Cage
Abstract: Angewandte Chemie International EditionVolume 45, Issue 44 p. 7414-7417 Communication Single-Molecule Protein Encapsulation in a Rigid DNA Cage† Christoph M. Erben, Christoph M. Erben Clarendon Laboratory, Department of Physics, University of Oxford, Parks Road, Oxford, OX1 3PU, UK, Fax: (+44) 1865-272-400Search for more papers by this authorRussell P. Goodman, Russell P. Goodman Clarendon Laboratory, Department of Physics, University of Oxford, Parks Road, Oxford, OX1 3PU, UK, Fax: (+44) 1865-272-400Search for more papers by this authorAndrew J. Turberfield Prof., Andrew J. Turberfield Prof. [email protected] Clarendon Laboratory, Department of Physics, University of Oxford, Parks Road, Oxford, OX1 3PU, UK, Fax: (+44) 1865-272-400Search for more papers by this author Christoph M. Erben, Christoph M. Erben Clarendon Laboratory, Department of Physics, University of Oxford, Parks Road, Oxford, OX1 3PU, UK, Fax: (+44) 1865-272-400Search for more papers by this authorRussell P. Goodman, Russell P. Goodman Clarendon Laboratory, Department of Physics, University of Oxford, Parks Road, Oxford, OX1 3PU, UK, Fax: (+44) 1865-272-400Search for more papers by this authorAndrew J. Turberfield Prof., Andrew J. Turberfield Prof. [email protected] Clarendon Laboratory, Department of Physics, University of Oxford, Parks Road, Oxford, OX1 3PU, UK, Fax: (+44) 1865-272-400Search for more papers by this author First published: 06 November 2006 https://doi.org/10.1002/anie.200603392Citations: 230 † We thank Jonathan Bath for helpful discussions. This work was supported by the UK research councils BBSRC, EPSRC, MRC, and the MoD through the UK Bionanotechnology Interdisciplinary Research Collaboration, by the Rhodes Trust and the Oxford Life Sciences Interface Doctoral Training Centre. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Behind bars: A single molecule of the protein cytochrome c has been incarcerated within a rigid tetrahedral DNA cage (see picture). The central cavity is estimated to be large enough to accommodate a sphere of approximately 2.6 nm in radius, such as a 60-kDa globular protein (Mr of cytochrome c: 12.4 kDa). The finding demonstrates the potential of DNA containers as a new kind of drug-delivery system. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z603392_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume45, Issue44November 13, 2006Pages 7414-7417 RelatedInformation
Publication Year: 2006
Publication Date: 2006-11-06
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 270
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