Mathematical modeling of pathogenicity of <i>Cryptococcus neoformans</i>

Name: Work Video:
Duration: 3 min 30 s
Jacqueline García; John M. Shea; Fernando Alvarez‐Vasquez; Asfia Qureshi; Chiara Luberto; Eberhard O. Voit; Maurizio Del Poeta
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2910, 2931, 2965, 2988, 3008, 3086, 3102, 3108, 3163, 3190, 3198, 3205, 3247, 3251, 3265, 3269, 3275, 3297, 3302, 3313, 3317, 3323, 3344, 3392, 3412, 3422, 3430, 3442, 3462, 3483, 3495, 3543, 3558, 3582, 3594, 3652, 3655, 3695, 3707, 3710, 3719, 3748, 3757, 3775, 3931, 3942, 3991, 4081, 4102, 4172, 4186], 'pathogenicity': [7], 'Cryptococcus': [9, 590, 721, 1342], 'neoformans': [10, 591, 722, 1343], 'Jacqueline': [11, 13, 230, 232, 451], 'Garcia': [12, 14, 231, 233], 'Department': [15, 40, 65, 79, 104, 129, 158, 184, 198, 234, 259, 284, 298, 323, 348, 377, 403, 417, 499, 537], 'Biochemistry': [17, 42, 67, 106, 131, 186, 236, 261, 286, 325, 350, 405, 471, 539], 'and': [18, 43, 68, 83, 107, 132, 187, 201, 237, 262, 287, 302, 326, 351, 406, 420, 464, 472, 487, 513, 540, 577, 638, 649, 669, 687, 702, 712, 734, 746, 769, 812, 881, 1043, 1060, 1068, 1118, 1282, 1331, 1388, 1415, 1438, 1455, 1484, 1488, 1495, 1555, 1561, 1607, 1612, 1619, 1631, 1656, 1660, 1701, 1704, 1745, 1753, 1813, 1858, 1872, 1881, 1981, 1992, 2009, 2015, 2019, 2037, 2053, 2135, 2167, 2184, 2192, 2222, 2239, 2252, 2268, 2304, 2327, 2338, 2369, 2387, 2395, 2406, 2412, 2422, 2426, 2443, 2521, 2531, 2550, 2581, 2620, 2640, 2894, 2914, 3021, 3039, 3073, 3166, 3219, 3292, 3334, 3386, 3402, 3414, 3444, 3506, 3514, 3549, 3567, 3601, 3605, 3610, 3638, 3640, 3643, 3660, 3685, 3714, 3750, 3786, 3825, 3844, 3849, 3944, 4001, 4012, 4027, 4033, 4035, 4039, 4048, 4058, 4085, 4104, 4199, 4210, 4222, 4240, 4242], 'Molecular': [19, 44, 69, 108, 133, 188, 238, 263, 288, 327, 352, 407, 473, 541, 568], 'Biology,': [20, 45, 70, 109, 134, 189, 239, 264, 289, 328, 353, 408, 474, 542], 'Medical': [21, 46, 71, 85, 110, 135, 190, 203, 215, 240, 265, 290, 304, 329, 354, 409, 422, 434, 475, 489, 515, 527, 543], 'University': [22, 47, 72, 86, 111, 136, 191, 204, 216, 241, 266, 291, 305, 330, 355, 410, 423, 435, 476, 490, 516, 528, 544], 'South': [24, 49, 74, 88, 113, 138, 193, 206, 218, 243, 268, 293, 307, 332, 357, 412, 425, 437, 478, 492, 518, 530, 546], 'Carolina,': [25, 50, 75, 89, 114, 139, 194, 207, 219, 244, 269, 294, 308, 333, 358, 413, 426, 438, 479, 493, 519, 531, 547], 'Charleston,': [26, 51, 76, 90, 115, 140, 195, 208, 220, 245, 270, 295, 309, 334, 359, 414, 427, 439, 480, 494, 520, 532, 553], 'SC,': [27, 52, 77, 91, 116, 141, 196, 209, 221, 246, 271, 296, 310, 335, 360, 415, 428, 440, 481, 495, 521, 533], 'USA': [28, 53, 78, 92, 117, 142, 168, 197, 210, 222, 247, 272, 297, 311, 336, 361, 387, 416, 429, 441, 482, 496, 509, 522, 534], 'Search': [29, 54, 93, 118, 143, 169, 223, 248, 273, 312, 337, 362, 388, 442], 'for': [30, 55, 94, 119, 144, 170, 224, 249, 274, 313, 338, 363, 389, 443, 1057, 1088, 1188, 1514, 1629, 1668, 1719, 1724, 1819, 1845, 2035, 2181, 2626, 2632, 2643, 3216, 3473, 3529, 3541, 3555, 3753, 3780, 4226], 'more': [31, 56, 95, 120, 145, 171, 225, 250, 275, 314, 339, 364, 390, 444], 'papers': [32, 57, 96, 121, 146, 172, 226, 251, 276, 315, 340, 365, 391, 445], 'by': [33, 58, 97, 122, 147, 173, 227, 252, 277, 316, 341, 366, 392, 446, 809, 820, 949, 992, 1035, 1123, 1232, 1516, 1590, 2160, 3575, 3633, 3680, 3874, 3958, 3979, 4054, 4147, 4151], 'this': [34, 59, 98, 123, 148, 174, 228, 253, 278, 317, 342, 367, 393, 447, 625, 998, 1119, 1152, 1245, 1290, 1541, 1912, 2119, 3283], 'author': [35, 60, 99, 124, 149, 175, 229, 254, 279, 318, 343, 368, 394, 448], 'John': [36, 38, 255, 257, 453], 'Shea': [37, 39, 256, 258, 2063, 2504], 'Fernando': [61, 63, 280, 282, 455], 'Alvarez-Vasquez': [62, 64, 281, 283], 'Biostatistic,': [81, 300, 485], 'Bioinformatics': [82, 301, 486], 'Epidemiology,': [84, 303, 488], 'Asfia': [100, 102, 319, 321, 457], 'Qureshi': [101, 103, 320, 322], 'Chiara': [125, 127, 344, 346, 459], 'Luberto': [126, 128, 345, 347, 2014], 'Eberhard': [150, 153, 369, 372, 461], 'O': [151, 154, 370, 373, 462], 'Voit': [152, 155, 371, 374], 'W.C.': [156, 375], 'Coulter': [157, 376, 498], 'Biomedical': [160, 379, 501], 'Engineering,': [161, 380, 502], 'Georgia': [162, 381, 503], 'Institute': [163, 382, 504], 'Technology,': [165, 384, 506], 'Atlanta,': [166, 385, 507], 'Georgia,': [167, 386, 508], 'Maurizio': [176, 181, 395, 400, 465], 'Del': [177, 182, 396, 401, 466, 2372], 'Poeta': [178, 183, 397, 402, 467], 'Corresponding': [179, 398], 'Author': [180, 399, 449], 'Microbiology': [200, 419, 512], 'Immunology,': [202, 421, 514], 'Division': [211, 430], 'Infectious': [213, 432, 525], 'Diseases,': [214, 433, 526], 'Information': [450], 'Garcia1,': [452], 'Shea1,': [454], 'Alvarez-Vasquez1,2,': [456], 'Qureshi1,': [458], 'Luberto1,': [460], 'Voit3': [463], '1,4,5': [468], '1Department': [469], '2Department': [483], '3W.C.': [497], '4Department': [510], '5Division': [523], '*Corresponding': [535], 'author.': [536], '173': [548], 'Ashley': [549], 'Avenue,': [550], 'BSB': [551], '503,': [552], 'SC': [554], '29425,': [555], 'USA.': [556], 'Tel.:': [557], '+843': [558, 562], '792': [559, 563], '8381;': [560], 'Fax:': [561], '8565;': [564], 'E-mail:': [565], '[email': [566], 'protected]': [567], 'Systems': [569], 'Biology': [570], '(2008)4:183https://doi.org/10.1038/msb.2008.17': [571], 'PDFDownload': [572], 'PDF': [573], 'article': [575], 'text': [576, 2639], 'main': [578, 1766, 2638], 'figures.': [579], 'ToolsAdd': [580], 'to': [581, 633, 636, 675, 801, 908, 942, 977, 1015, 1019, 1025, 1029, 1085, 1092, 1113, 1272, 1321, 1333, 1403, 1427, 1433, 1508, 1510, 1538, 1586, 1599, 1640, 1710, 1907, 1933, 1957, 1967, 2087, 2114, 2144, 2150, 2230, 2235, 2283, 2291, 2383, 2417, 2448, 2453, 2489, 2586, 2594, 2928, 2945, 2958, 2969, 2979, 2994, 3001, 3030, 3047, 3095, 3182, 3195, 3278, 3326, 3348, 3382, 3480, 3527, 3591, 3599, 3648, 3700, 3889, 3915, 3982, 4022, 4045, 4074, 4089, 4121, 4125, 4165, 4195, 4201, 4234], 'favoritesDownload': [582], 'CitationsTrack': [583], 'CitationsPermissions': [584], 'ShareFacebookTwitterLinked': [585], 'InMendeleyWechatReddit': [586], 'Figures': [587], '&': [588], 'Info': [589], '(Cn)': [592, 723, 1344], 'is': [593, 627, 724, 786, 912, 947, 1131, 1183, 1226, 1265, 1270, 1345, 1357, 1430, 1479, 1624, 1643, 1770, 1799, 1817, 1890, 2354, 2399, 2436, 2463, 2613, 3245, 3380, 3449, 3451, 3624, 3778, 3795, 3865, 3956, 3966, 4145, 4207, 4245], 'the': [594, 607, 612, 643, 656, 710, 732, 736, 758, 763, 767, 771, 795, 797, 805, 813, 817, 842, 866, 883, 900, 906, 909, 918, 921, 933, 943, 950, 959, 962, 983, 993, 1004, 1031, 1046, 1049, 1076, 1093, 1124, 1133, 1149, 1169, 1176, 1189, 1216, 1252, 1256, 1277, 1283, 1314, 1323, 1328, 1353, 1393, 1397, 1400, 1404, 1425, 1442, 1457, 1467, 1518, 1553, 1564, 1573, 1576, 1602, 1632, 1636, 1638, 1646, 1651, 1658, 1669, 1676, 1694, 1717, 1725, 1729, 1740, 1747, 1751, 1754, 1765, 1771, 1784, 1796, 1835, 1848, 1854, 1860, 1908, 1927, 1942, 1998, 2085, 2093, 2115, 2131, 2155, 2158, 2170, 2231, 2245, 2249, 2263, 2286, 2305, 2314, 2360, 2404, 2487, 2535, 2555, 2627, 2633, 2794, 2908, 2929, 2962, 2971, 2985, 3009, 3084, 3203, 3238, 3248, 3263, 3273, 3287, 3321, 3349, 3420, 3439, 3447, 3459, 3481, 3492, 3498, 3537, 3547, 3550, 3556, 3579, 3592, 3606, 3631, 3653, 3708, 3727, 3738, 3746, 3754, 3771, 3781, 3792, 3805, 3823, 3826, 3831, 3835, 3840, 3851, 3854, 3863, 3867, 3882, 3895, 3901, 3919, 3923, 3932, 3938, 3945, 3973, 3985, 3989, 4066, 4079, 4100, 4108, 4113, 4126, 4130, 4184, 4193, 4196, 4202, 4216, 4248], 'most': [595, 3678], 'common': [596, 1959], 'cause': [597, 640, 1428], 'fungal': [599, 707, 726, 845, 1347, 1743, 1759, 2356, 3303, 3793, 3841, 3855], 'meningitis': [600], 'worldwide.': [601], 'In': [602, 642, 823, 997, 1096, 1192, 1312, 1502, 1761, 1809, 1984, 2026, 2118, 3525, 3760, 3972, 4065, 4215], 'infected': [603], 'patients,': [604], 'growth': [605, 846, 1160, 1209, 1257, 2036, 2342, 2462, 2891, 3109, 3463], 'fungus': [608, 759, 798, 1426, 1752, 2133, 2159, 3832, 3864], 'can': [609, 698, 760, 1373, 1485, 3976], 'occur': [610], 'within': [611, 1045, 1466, 1532, 2169], 'phagolysosome': [613, 818, 1468, 2094, 3868], 'phagocytic': [615, 775, 1471, 2096, 2161], 'cells,': [616, 757, 776, 1764, 1986, 2097], 'especially': [617, 3645], 'in': [618, 660, 731, 735, 743, 762, 770, 794, 841, 848, 865, 882, 923, 969, 1244, 1327, 1363, 1392, 1411, 1435, 1452, 1456, 1487, 1552, 1572, 1614, 1650, 1675, 1757, 1780, 1814, 1833, 1840, 1847, 1853, 1950, 1955, 1972, 1979, 1997, 2013, 2039, 2130, 2242, 2298, 2313, 2345, 2359, 2363, 2403, 2433, 2477, 2486, 2540, 2567, 2570, 2793, 2886, 2907, 2954, 2973, 2996, 3064, 3174, 3234, 3438, 3453, 3517, 3626, 3664, 3682, 3702, 3712, 3737, 3853, 3937, 4107, 4112, 4119, 4129, 4247], 'non-activated': [619], 'macrophages': [620, 779, 1036], 'immunocompromised': [622, 926, 1412], 'subjects.': [623], 'Since': [624, 3560], 'environment': [626, 733, 773, 2456, 2492, 2976, 3871], 'characteristically': [628, 1463], 'acidic,': [629], 'Cn': [630, 661, 752, 785, 869, 903, 937, 968, 989, 1009, 1034, 1091, 1326, 1478, 2073, 2134, 2234, 2344, 2370, 2887, 2955, 3082, 3176, 3347, 3443, 3520, 3583, 3697, 4173], 'must': [631, 799], 'adapt': [632, 800, 1509, 2449], 'low': [634, 1212, 1260, 3028, 3045], 'pH': [635, 811, 1115, 1164, 1213, 1261, 1768, 1786, 1798, 2332, 2542, 2896, 2998, 3049, 3058, 3071, 3126, 3140, 3184, 3354, 3357, 4122], 'survive': [637], 'efficiently': [639], 'disease.': [641], 'present': [644, 1362], 'work,': [645], 'we': [646, 826, 2069, 2121, 2310, 3260, 3285, 3486, 3628, 3887], 'designed,': [647], 'tested,': [648], 'experimentally': [650, 2312], 'validated': [651], 'a': [652, 725, 788, 830, 836, 924, 1000, 1020, 1143, 1159, 1172, 1204, 1208, 1273, 1334, 1346, 1407, 1480, 1511, 1544, 1688, 1830, 1843, 1891, 1904, 1930, 1973, 2076, 2101, 2110, 2124, 2145, 2279, 2355, 2431, 2459, 2474, 2484, 2490, 2519, 2529, 2943, 2959, 2974, 3093, 3175, 3299, 3378, 3396, 3798, 3890, 3980, 3992, 4002, 4093, 4178], 'theoretical': [653], 'model': [654, 1002, 1040, 1077, 1253, 1316, 2126, 2164, 2282, 2297, 2320, 3448, 3472, 3500, 3539, 3581, 3616, 3632, 3739, 3838, 3860, 4097, 4141, 4158], 'sphingolipid': [657, 1005, 1017, 1102, 1177, 1318, 1948, 2107, 2128, 2142, 2565, 3440, 3471, 3584, 3758, 3933], 'biochemical': [658, 696, 1050, 2102, 2141, 2513], 'pathway': [659, 1007, 1178, 3441, 3585, 3934], 'under': [662, 1132, 3988], 'acidic': [663, 821, 859, 1027, 1094, 1114, 1163, 1439, 1460, 1800, 2054, 2089, 2152, 2346, 2455, 2895, 2947, 3097, 3186, 3465, 3523, 3761], 'conditions.': [664], 'Simulations': [665], 'metabolic': [667, 1006, 1699, 2112], 'fluxes': [668], 'enzyme': [670, 2357, 2401, 2634, 3515, 3649], 'deletions': [671], 'or': [672, 754, 858, 1267, 1366, 1528, 1713, 1898, 1920, 2084, 2631, 3067, 3185, 3267, 3315], 'downregulation': [673, 1194, 2337, 3268, 3316], 'led': [674, 2927], 'predictions': [676, 701, 2138, 2301], 'that': [677, 729, 829, 964, 1101, 1180, 1228, 1255, 1296, 1349, 1423, 1696, 1827, 2071, 2211, 2445, 2575, 2904, 2953, 2995, 3014, 3081, 3311, 3331, 3434, 3490, 3608, 3862, 4099, 4143, 4181, 4252], 'show': [678, 2598], 'good': [679], 'agreement': [680], 'with': [681, 1078, 1368, 1926, 2105, 2109, 2450, 2511, 2605, 3224, 3531, 3646, 3671, 3726, 3783, 3877, 3881, 4017], 'experimental': [682, 1079, 1098, 1284, 2209], 'results': [683, 1779, 2197, 3079, 3654], 'generated': [684], 'post': [685], 'hoc': [686], 'reconcile': [688], 'intuitively': [689], 'puzzling': [690, 2545], 'results.': [691], 'This': [692, 2296, 2544, 2925, 3954], 'study': [693], 'demonstrates': [694], 'how': [695, 2285, 3696], 'yield': [699], 'testable': [700], 'aid': [703], 'our': [704, 1250, 2199], 'understanding': [705, 960, 1336], 'pathogenesis': [708, 1744], 'through': [709, 1300, 1307, 1399, 1601, 1914, 2578], 'design': [711], 'computational': [713], 'simulation': [714], 'hypothetical': [716], 'experiments.': [717, 3208, 3425], 'Synopsis': [718, 720], 'Extended': [719], 'microbial': [727, 1698], 'pathogen': [728, 1348, 1483], 'lives': [730], 'gastrointestinal': [737], 'tract': [738], 'several': [740, 1610, 3488, 3509], 'birds,': [741], 'pigeons': [742], 'particular': [744, 3589, 3683], '(Casadevall': [745, 1414], 'Perfect,': [747, 1416, 1418], '1998).': [748], 'Upon': [749], 'inhalation': [750], 'spores': [753], 'desiccated': [755], 'yeast': [756, 3276, 3324, 3474], 'grow': [761, 1434], 'extracellular': [764, 806, 907, 1797, 2081], 'space': [765, 807], 'alveoli': [768], 'intracellular': [772, 790, 814, 910, 1482, 1767, 1785, 1836, 2705, 3252], 'particularly': [777, 913, 1361, 1410], 'alveolar': [778, 1453, 2082], '(Levitz': [780], 'et': [781, 851, 855, 862, 877, 888, 892, 896, 929, 955, 1474, 1499, 1680, 1789, 1802, 1806, 1823, 1864, 1868, 1876, 2023, 2042, 2046, 2050, 2056, 2060, 2064, 2366, 2391, 2470, 2497, 2501, 2505, 2921, 3255, 3306, 3476, 3564, 3570, 3962, 4062, 4137, 4154, 4175], 'al,': [782, 852, 856, 863, 878, 889, 893, 897, 930, 956, 1475, 1500, 1681, 1790, 1803, 1807, 1824, 1865, 1869, 1877, 2024, 2043, 2047, 2051, 2057, 2061, 2065, 2367, 2392, 2471, 2498, 2502, 2506, 2922, 3256, 3307, 3477, 3565, 3571, 3963, 4063, 4138, 4155, 4176], '1999).': [783, 2428], 'Hence,': [784], 'considered': [787], 'facultative': [789, 1481], 'pathogen.': [791], 'Thus,': [792, 1684, 2068, 2508], 'once': [793, 3872], 'lung,': [796, 1394], 'two': [802, 2509, 3620], 'different': [803, 1173, 1521, 2225, 2287, 3010, 3164, 3225, 3532], 'environments:': [804], 'characterized': [808, 819], 'neutral/alkaline': [810, 849, 2077, 3094], 'milieu': [815], 'pH.': [822, 1837, 2243, 3187, 3398, 3466, 3524, 3703, 3788], 'recent': [824], 'years,': [825], 'have': [827, 1964, 1994, 2029, 2534], 'found': [828, 1084, 1448, 1464, 2444, 3063, 3310, 4164], 'class': [831], 'lipids,': [833], 'sphingolipids,': [834], 'represents': [835], 'reservoir': [837], 'molecules': [839, 1971, 2033], 'implicated': [840], 'regulation': [843, 884, 1703, 1849, 1999], 'either': [847], '(Rittershaus': [850], '2006;': [853, 1497, 1879, 2048], 'Kechichian': [854], '2007)': [857], 'environments': [860, 1330, 1440, 1446, 1461, 2347], '(Shea': [861], '2006),': [864], 'modulation': [867], 'virulence': [870], 'factors,': [871], 'such': [872, 1234, 1450, 1595, 1988, 2079, 2091], 'as': [873, 1203, 1235, 1451, 1596, 1969, 1989, 2031, 2080, 2092, 2227, 2319, 2329, 2458, 2518, 2528, 2615, 2799, 3213, 3596, 3598, 3741, 3763, 3797, 4133], 'melanin': [874], 'production': [875, 1127, 1554], '(Heung': [876], '2004,': [879, 2923, 3478], '2005),': [880, 4177], 'phagocytosis': [886, 1032], '(Luberto': [887, 954, 2469], '2003;': [890], 'Mare': [891], '2005;': [894, 2044, 2062, 2503], 'Tommasino': [895], '2008).': [898], 'Interestingly,': [899, 932, 1126], 'shift': [901, 1021, 2146], 'cells': [904, 1108, 1472, 1493, 1953, 2898, 2939, 2956, 3277, 3325], 'from': [905, 1022, 1111, 1376, 2075, 2147, 2380, 2584, 2592, 2942, 3092, 3912, 3949, 4087, 4192, 4232], 'compartment': [911, 4115], 'important': [914, 988, 1421, 1625, 2032, 2228, 3437, 3779], 'because': [915, 1142, 1548, 1562, 1626, 2256], 'it': [916, 1225, 1372, 1505, 1627, 2098, 2446, 3507, 3623, 4206], 'changes': [917, 1551, 1649, 3083, 3681], 'outcome': [919, 944], 'infection': [922, 946, 1398, 4171], 'severely': [925], 'host': [927, 951, 994, 1329, 1470, 1492, 1755, 3875, 3883], '(Kechichian': [928], '2007).': [931, 1883], 'contribution': [934], 'each': [936, 1664, 3191, 3199], 'population': [938], '(extracellular': [939, 972], 'versus': [940, 973, 3158, 3376], 'intracellular)': [941, 974], 'determined': [948, 991, 3511], 'immune': [952, 995, 2010], 'status': [953], '2003).': [957], 'Therefore,': [958, 1224], 'mechanism(s)': [963], 'regulate': [965, 3338, 3612], 'survival': [966, 3557], 'both': [970, 3332], 'compartments': [971, 3735], 'may': [975, 1240, 1706, 1735, 3336, 4007, 4015, 4041, 4070], 'lead': [976, 2290], 'novel': [978], 'therapeutic': [979], 'interventions': [980], 'based': [981, 3450], 'on': [982, 1249, 1693, 2139, 2341, 2440, 2538, 3406, 3445, 3810, 3900], 'fine': [984], 'tune': [985], 'up': [986], 'switches': [990, 1571], 'status.': [996], 'paper,': [999], 'mathematical': [1001, 1073, 1315, 2125, 2280, 3580], 'representing': [1003], 'was': [1010, 1013, 1041, 1121, 2165, 2480, 2547, 3193, 3501, 4163], 'developed.': [1011], 'It': [1012, 1356, 1534, 2376], 'tested': [1014, 2430], 'simulate': [1016], 'adaptation': [1018, 1089, 1190, 1246, 1324, 1542, 1598, 1677, 2113, 2143, 2488], 'an': [1023, 1026, 1358, 1584, 1915, 1938, 2088, 2148, 2151, 2292, 2400, 2454, 2946, 3096, 3390, 3469, 4117], 'alkaline': [1024, 1112, 2149, 3057], 'pH,': [1028, 2153, 3032], 'mimic': [1030], '(Figure': [1037, 1292], '1).': [1038, 1167, 1293], 'The': [1039, 1621, 1884, 1901, 1945, 2163, 2196, 2205, 2273, 2610, 3188, 3209, 3399, 3428, 3615, 3667, 3733, 3773, 3928, 3940, 4096, 4110, 4140, 4157], 'designed': [1042, 2166], 'analyzed': [1044, 2168], 'framework': [1047, 2171], 'system': [1051, 1685], 'theory,': [1052], 'which': [1053, 1200, 2177, 2309, 2434, 2478, 3446, 3552, 3675, 4051, 4162], 'uses': [1054, 1201, 2178, 2516, 2526], 'power-law': [1055, 2179], 'representations': [1056, 2180], 'all': [1058, 1672, 1762, 1951, 2182, 3431], 'enzymatic': [1059, 2183], 'transport': [1061, 2185, 2729, 2732, 2839, 2842, 2867, 3686, 3747, 3777, 3802, 3814, 3892, 3916, 4080, 4255], 'processes': [1062, 2186], '(Savageau,': [1063, 2187], '1969a,': [1064, 2188], 'b,': [1065], '1976;': [1066, 2190], 'Torres': [1067, 2191], 'Voit,': [1069, 2193], '2002).': [1070, 2194, 4156], 'By': [1071, 3704, 3904], 'coupling': [1072], 'simulations': [1074], 'using': [1075, 1543], 'determinations,': [1080], 'multiple': [1081], 'factors': [1082], 'were': [1083, 3024, 3041, 3053, 3062, 3435, 3724], 'be': [1086, 1242, 1374, 1536, 3977, 4071, 4166], 'required': [1087, 2034, 3752], 'environment.': [1095, 1574, 2117, 2948, 3098], 'particular,': [1097, 1193], 'determinations': [1099], 'showed': [1100, 1179, 2483, 3410], 'phytoceramide': [1103, 1129, 1181, 1202, 1219, 1301, 2267, 2328, 2517, 2675, 2679, 2683, 2786, 2884, 2903, 2933, 2967, 3011, 3065, 3068, 3088, 3165, 3169, 4075, 4103, 4148], 'C26': [1104, 1130, 1182, 1220, 3019, 4034, 4040, 4069, 4086, 4149, 4223], 'significantly': [1105, 2464, 2992, 3025, 3042, 3319], 'increases': [1106, 2991, 3320], 'when': [1107, 1263, 2072, 2938, 3090, 3894], 'are': [1109, 1221, 1447, 1462, 1924, 2576, 2582, 2590, 2624, 2940, 3181, 3202, 3211, 3419, 3553, 3573, 3658, 3661, 3677, 3740, 4052, 4224, 4254], 'shifted': [1110, 2941, 3091], '(Table': [1116, 1286, 3005, 3328], 'I),': [1117], 'result': [1120], 'predicted': [1122], 'model.': [1125], 'control': [1134], 'inositol': [1136, 1196, 2213, 2217, 2269, 2378, 2419, 2692, 2697, 2702, 2806, 2815, 4230], 'phosphosphingolipid': [1137, 2218, 2807], 'phospholipase': [1138, 2219, 2808], 'C': [1139, 2220], '(Isc1)': [1140], 'enzyme,': [1141], 'Δisc1': [1144, 1156, 3363, 3400], 'mutant': [1145, 1157, 1174, 2432, 2475, 3236, 3401], 'strain': [1146, 2476, 3404], 'dramatically': [1147], 'reduces': [1148], 'level': [1150, 2557, 2964, 2972, 2987], 'sphingolipid.': [1153], 'As': [1154, 3237, 3622], 'expected,': [1155], 'has': [1158, 1687, 1829, 4116], 'defect': [1161, 1210, 1258], 'at': [1162, 1211, 1259, 1663, 1859, 1941, 2554, 2892, 3027, 3044, 3056, 3105, 3389, 3395, 3464, 3522], '(Supplementary': [1165, 2466, 2493, 3846], 'Figure': [1166, 2467, 2494, 2561, 3454], 'Moreover,': [1168], 'use': [1170, 1577], 'necessary': [1184], 'but': [1185, 1371, 3833], 'not': [1186, 1222, 3076, 3691], 'sufficient': [1187, 2451], 'process.': [1191, 1247, 4095], 'phosphorylceramide': [1197, 2214, 2693, 2698, 2703, 2816], 'synthase': [1198, 2215, 2351, 2629, 2636, 2772, 2784, 2855, 3995], '(Ipc1),': [1199, 2216], 'substrate,': [1205], 'shows': [1206], 'also': [1207, 1241, 3054, 4159], 'even': [1214, 1794], 'though': [1215], 'levels': [1217, 2935, 3066, 3197, 3513], 'altered.': [1223], 'proposed': [1227, 1842, 3586], 'other': [1229], 'lipids': [1230, 1531], 'regulated': [1231], 'Ipc1,': [1233, 2325], 'complex': [1236, 1310, 1565, 1748], 'sphingolipids': [1237, 1846, 1889, 1923, 1987, 2028], 'and/or': [1238, 1309], 'diacylglycerol,': [1239], 'involved': [1243, 3736], 'Based': [1248], 'simulations,': [1251], 'suggests': [1254], 'observed': [1262], 'Isc1': [1264, 1297, 2253, 2339, 2398, 2479, 2525, 2804, 3235, 3266, 3314, 3333, 3345, 3715, 4152], 'deleted': [1266], 'Ipc1': [1268, 1304, 2251, 2336, 2435, 2813, 3270, 3318, 3335, 3713, 4228, 4244], 'downregulated': [1269], 'due': [1271], 'decreased': [1274, 3043], 'activity': [1275, 4118], 'plasma': [1278, 1772, 1861, 2831, 3239, 3924, 4131, 4203], 'membrane': [1279, 1773, 1862, 2832, 2852, 3240, 4204], 'H+ATPase': [1280, 1774, 2236, 3243, 3784], '(Pma1),': [1281], 'findings': [1285], 'V)': [1287], 'indeed': [1288, 2951], 'support': [1289], 'prediction': [1291], 'We': [1294, 2429, 3309, 3467, 3744], 'hypothesize': [1295, 2070], 'regulates': [1298, 1305], 'Pma1': [1299, 1306, 1816, 1828, 1851, 2303, 2685, 2792, 3279, 3304, 3339, 3350, 3561, 3906, 4105, 4111, 4127, 4144, 4187, 4190], 'C26,': [1302], 'whereas': [1303, 1459, 2524, 2984, 3033, 3804], 'DAG': [1308, 2713], 'sphingolipids.': [1311], 'conclusion,': [1313], 'metabolism': [1319, 2129, 2566, 3085], 'helps': [1320], 'predict': [1322, 1711], 'contributes': [1332], 'better': [1335], 'its': [1338, 1431, 2106, 2140, 2461, 3636], 'pathogenic': [1339, 2132], 'traits.': [1340], 'Introduction': [1341], 'infects': [1350], 'humans': [1351], 'via': [1352, 1937], 'respiratory': [1354], 'tract.': [1355], 'environmental': [1359, 1661], 'microorganism': [1360], 'pigeon': [1364], 'droppings': [1365], 'associated': [1367, 2104, 2604], 'eucalyptus': [1369], 'tree': [1370], 'isolated': [1375], 'soil,': [1377], 'water,': [1378], 'milk,': [1379], 'fruits,': [1380], 'horse': [1381], 'intestinal': [1382], 'flora,': [1383], 'bird': [1384], 'nests,': [1385], 'bats,': [1386], 'burns,': [1387], 'cockroaches.': [1389], 'Once': [1390, 4077], 'inhaled': [1391], 'dissemination': [1395], 'bloodstream': [1401], 'leads': [1402], 'development': [1405], 'life-threatening': [1408], 'meningoencephalitis,': [1409], 'patients': [1413], '1998;': [1417], '2005).': [1419, 2924], 'An': [1420], 'characteristic': [1422], 'enables': [1424], 'disease': [1429], 'ability': [1432], 'alkaline,': [1436], 'neutral,': [1437], 'human': [1443], 'body.': [1444], 'Alkaline/neutral': [1445], 'extracellularly,': [1449], 'spaces': [1454, 2083], 'bloodstream,': [1458, 2086], 'intracellularly,': [1465], '(Feldmesser': [1473], '2001).': [1476, 2472], 'Indeed,': [1477], 'move': [1486, 3769], 'out': [1489], 'without': [1490, 1716], 'killing': [1491], '(Alvarez': [1494], 'Casadevall,': [1496], 'Ma': [1498], '2006).': [1501, 2025, 2507], 'doing': [1503], 'so,': [1504], 'constantly': [1506], 'needs': [1507], 'new': [1512, 2116, 3499, 3538], 'environment,': [1513, 2078, 2090, 2961], 'instance,': [1515, 3886], 'changing': [1517, 2541], 'organization': [1519], 'cellular': [1522, 1559, 1597, 1659, 1712, 2001, 3734], 'components,': [1523], 'gene': [1524], 'expression,': [1525], 'protein': [1526], 'activities,': [1527], 'arrangements': [1529], 'membranes.': [1533], 'might': [1535, 1582, 2289], 'impossible': [1537], 'fully': [1539], 'understand': [1540], 'purely': [1545], 'reductionistic': [1546, 1588], 'approach': [1547], 'continual': [1550], 'degradation': [1556, 3845], 'key': [1558, 1831, 1995], 'components': [1560, 1569, 1673, 1960], 'interplay': [1566, 1749], 'among': [1567, 1635], 'these': [1568, 2257, 2623, 3656], 'during': [1570, 1654, 2890, 3171, 3503, 4168], 'Instead,': [1575], 'systems': [1579, 1732, 2281, 2556], 'biological': [1580, 1714, 1733], 'methods': [1581], 'offer': [1583], 'opportunity': [1585], 'complement': [1587], 'insights': [1589, 1738, 3673], 'explaining': [1591], 'complex,': [1592], 'systemic': [1593], 'behaviors,': [1594], 'environments,': [1600], 'simultaneous': [1603], 'investigation': [1604], 'stimuli': [1606], 'responses': [1608, 3699], 'enzymes': [1611, 2250, 2258, 2510, 3607, 3684], 'metabolites': [1613, 3676], 'terms': [1615], 'space,': [1617], 'time,': [1618, 3987], 'context.': [1620], 'spatial': [1622], 'aspect': [1623], 'accounts': [1628, 1667, 3540], 'compartmentalization': [1630], 'topographic': [1633], 'relationships': [1634, 3782], 'components;': [1637], 'need': [1639, 1718], 'consider': [1641], 'time': [1642, 1665], 'evident,': [1644], 'given': [1645], 'dramatic': [1647], 'dynamic': [1648], 'molecular': [1652], 'characteristics': [1653], 'adaptation;': [1655], 'addressing': [1657], 'context': [1662], 'point': [1666], 'interdependencies': [1670], 'between': [1671, 1750, 2266, 3070, 3546, 3819], 'partaking': [1674], 'process': [1678, 3815, 3893], '(Ahn': [1679], '2006a,': [1682], '2006b).': [1683], 'biology': [1686], 'chance': [1689], 'shedding': [1691], 'light': [1692], 'complexities': [1695], 'govern': [1697], 'pathways,': [1700], 'their': [1702, 2911, 2915, 3613], 'adaptations': [1705], 'ultimately': [1707], 'allow': [1708], 'us': [1709, 3670], 'phenotypes': [1715], 'large-scale': [1720], 'wet': [1721], 'experimentation.': [1722], 'Specifically': [1723], 'case': [1726], 'Cn,': [1728, 1815, 2027], 'application': [1730], 'concepts': [1734], 'provide': [1736], 'significant': [1737], 'into': [1739, 1746, 2202, 3619, 3674, 3770, 3791, 3969, 4188], 'mechanisms': [1741, 3542, 3718], 'immunity': [1756], 'chronic': [1758], 'diseases.': [1760], 'eukaryotic': [1763, 1952], 'regulator': [1769], '(Pma1)': [1775, 2238, 3244, 3785], 'pump,': [1776], 'whose': [1777], 'activation': [1778], 'proton': [1781, 2844, 3241, 3776, 3820, 3828, 3896], 'extrusion,': [1782], 'maintaining': [1783], 'neutral': [1787, 2944, 2975, 2997, 3031, 3048, 3183, 3397], '(Serrano': [1788, 3254], '1986;': [1791, 3257], 'Serrano,': [1792, 3258], '1988)': [1793], 'if': [1795], '(Perona': [1801], '1990;': [1804], 'Portillo': [1805], '1991).': [1808, 3964, 4212], 'Saccharomyces': [1810], 'cerevisiae': [1811], '(Sc)': [1812], 'essential': [1818], 'cell': [1820, 2005], 'viability': [1821, 2539], '(Soteropoulos': [1822], '2000),': [1825], 'suggesting': [1826, 3330], 'role': [1832, 1844, 2306], 'regulating': [1834], 'Many': [1838], 'studies': [1839, 2200, 2210, 2277, 2318, 2323, 3427], 'Sc': [1841, 2364], 'function': [1852, 1968, 3568], 'endoplasmic': [1855], 'reticulum': [1856, 3927], '(ER)': [1857], '(Patton': [1863], '1992;': [1866], 'Lee': [1867], '2002;': [1870, 1874], 'Wang': [1871], 'Chang,': [1873], 'Gaigg': [1875], '2005,': [1878], 'Toulmay': [1880], 'Schneiter,': [1882], 'basic': [1885], 'structural': [1886], 'component': [1887], 'long-chain': [1892, 2741, 3016, 3577, 3603, 4003, 4018], 'sphingoid': [1893], 'base': [1894, 3997], 'backbone': [1895, 1913], '(e.g.,': [1896], 'sphingosine': [1897], 'phytosphingosine': [1899], '(PHS)).': [1900], 'linkage': [1902], 'fatty': [1905, 2742, 2747, 2752, 3227, 3533, 4004, 4019], 'acid': [1906, 2743, 2748, 2753, 3228, 3534, 4005, 4020], 'two-amino': [1909], 'group': [1910, 1932, 3947], 'amide': [1916], 'bond': [1917, 1940], 'yields': [1918], 'ceramide': [1919, 1934, 2271, 2350, 2415, 3103, 3994], 'phytoceramide.': [1921], 'Complex': [1922], 'formed': [1925], 'addition': [1928, 1956, 3526], 'polar': [1931], '(or': [1935], 'phytoceramide)': [1936, 2533, 3223], 'ester': [1939], 'C-1': [1943], 'position.': [1944], 'synthesis': [1946, 3494, 3843], 'occurs': [1949, 4106], 'and,': [1954, 2457], 'being': [1958], 'membranes,': [1962], 'they': [1963, 3689, 3764], 'been': [1965], 'recognized': [1966], 'signaling': [1970, 1976, 2038], 'variety': [1974], 'pathways': [1977], '(reviewed': [1978, 2012], 'Futerman': [1980], 'Hannun,': [1982, 2016], '2004).': [1983], 'mammalian': [1985], 'ceramide,': [1990], 'ceramide-1-phosphate,': [1991], 'sphingosine-1-phosphate': [1993], 'roles': [1996, 2247], 'proliferation,': [2002], 'stress': [2003, 2294], 'responses,': [2004], 'cycle,': [2006], 'apoptosis,': [2007], 'inflammation,': [2008], 'response': [2011, 2103, 2232, 2333, 4120], '1999;': [2017, 2393], 'Hannun': [2018], 'Luberto,': [2020], '2000;': [2021, 4060], 'McQuiston': [2022], 'emerged': [2030], 'alkaline/neutral': [2040, 2893], '(Liu': [2041], 'Rittershaus': [2045], 'Saito': [2049], '2006)': [2052, 2066], '(Buede': [2055, 2496, 3961], '1991;': [2058, 2499], 'Berne': [2059, 2500], 'environments.': [2067, 2543], 'shifts': [2074, 2241, 3701], 'should': [2099], 'promote': [2100], 'pathway,': [2108], 'consequent': [2111], 'study,': [2120], 'thus': [2122], 'developed': [2123, 3502], 'made': [2136, 2300], 'reliable': [2137], 'mimicking': [2154], 'internalization': [2156], 'cells.': [2162], 'Biochemical': [2173], 'System': [2174], 'Theory': [2175], '(BST),': [2176], '1969b,': [2189], 'Results': [2195, 3201, 3418], 'fall': [2201, 3618], 'three': [2203, 3206, 3423], 'categories.': [2204, 3621], 'first': [2206, 3629, 3755, 3929], 'set': [2207, 2275, 2316], 'describes': [2208], 'identified': [2212], '(Isc1),': [2221], 'phytoceramides': [2223, 2990, 3017, 3036, 3604, 4024, 4036, 4082, 4219, 4253], 'lengths': [2226, 2909], 'contributors': [2229, 2288], 'pump': [2237, 3242], 'ATP-mediated': [2240], 'Especially': [2244], 'putative': [2246], 'seem': [2254], 'puzzling,': [2255], 'catalyze': [2259], 'opposite': [2260], 'directions': [2261], 'reversible': [2264], 'reaction': [2265, 2630, 3432, 3955], 'phosphoryl': [2270, 2349], '(IPC).': [2272], 'second': [2274], 'used': [2278], 'elucidate': [2284], 'appropriate': [2293], 'response.': [2295], 'turn': [2299], 'regarding': [2302], 'ATP,': [2308], 'investigated': [2311], 'third': [2315], 'validation.': [2321], 'Experimental': [2322], 'identifying': [2324], 'Isc1,': [2326], 'drivers': [2330], 'Effect': [2334], 'deletion': [2340], 'Inositol': [2348], '1': [2352], '(Ipc1)': [2353], 'localized': [2358, 2402, 4246], 'Golgi': [2361, 2851, 4090, 4197, 4213, 4217, 4249], 'apparatus': [2362, 4091, 4198, 4214], '(Levine': [2365], '2000)': [2368], '(M': [2371], 'Poeta,': [2373], 'unpublished': [2374], 'data).': [2375], 'transfers': [2377, 4229], 'phosphate': [2379, 2420, 4231], 'phosphatidylinositol': [2381], '(PI)': [2382], 'phytoceramide,': [2384, 2418], 'producing': [2385, 4236], 'IPC': [2386, 2527, 4237], '1,2-sn-diacylglycerol': [2388], '(DAG)': [2389], '(Kuroda': [2390], 'Heidler': [2394], 'Radding,': [2396], '2000).': [2397, 3732, 4064], 'ER': [2405, 2801, 4088, 4114, 4194], 'breaks': [2407], 'down': [2408], 'IPC,': [2409, 2523], 'mannosyl-IPC': [2410], '(MIPC),': [2411], 'mannosyl': [2413], 'diphosphoryl': [2414], '(M(IP)2C)': [2416], '(MIP),': [2421], 'M(IP)2,': [2423], 'respectively': [2424], '(Dickson': [2425], 'Lester,': [2427], 'downregulated,': [2437], 'GAL7:IPC1,': [2438], 'grown': [2439, 3405, 3521], 'glucose': [2441, 3407], 'medium,': [2442], 'fails': [2447], 'speed': [2452], 'consequence,': [2460], 'retarded': [2465], '1A)': [2468], 'Similarly,': [2473], 'deleted,': [2481], 'Δisc1,': [2482, 3384], 'delay': [2485], 'low-pH': [2491, 2960], '1B)': [2495], "'opposite'": [2512], 'activities': [2514, 3516], '(Ipc1': [2515, 3408], 'substrate': [2520, 2530], 'produces': [2522, 2532], 'same': [2536, 3986], 'effect': [2537], 'finding': [2546], 'quite': [2548], 'intriguing': [2549], 'warranted': [2551], 'further': [2552], 'investigations': [2553], '(see': [2558, 2637], "'Computational": [2559], "studies').": [2560], '1.Model': [2562], 'diagram': [2563, 3429], 'Cn.': [2568, 3484, 3559], 'Metabolites': [2569], 'boxes': [2571], 'represent': [2572, 2608], 'dependent': [2573], 'variables': [2574, 2589], 'defined': [2577], 'differential': [2579], 'equations': [2580], 'numbered': [2583, 2591], 'X1': [2585], 'X19.': [2587], 'Independent': [2588, 2716], 'X100': [2593], 'X136.': [2595], 'Solid': [2596], 'arrows': [2597, 2607], 'flow': [2599], 'material.': [2601], 'Plus': [2602], 'signs': [2603], 'dotted': [2606], 'activation.': [2609], 'acylation': [2611], 'state': [2612], 'coded': [2614], '(1)': [2616], 'C26-CoA,': [2617], '(2)': [2618], 'C18-CoA,': [2619], '(3)': [2621], 'C24-CoA;': [2622], 'substrates': [2625, 4225], 'DH-Cer': [2628, 2771], 'P-Cer': [2635, 2783], 'Supplementary': [2641, 3665], 'information': [2642], 'details).': [2644], 'Dependent': [2645], 'variables:': [2646, 2717], 'Pal-CoA': [2647, 2854], '(X1),': [2648], 'palmitoyl-CoA;': [2649], 'serine': [2650, 2723, 2726, 2731, 2755, 2848, 3943, 3959], '(X2);': [2651], 'KDHS': [2652, 2766, 3965], '(X3),': [2653], '3-ketodihydrosphingosine;': [2654], 'DHS': [2655, 3975, 4000, 4047], '(X4),': [2656], 'dihydrosphingosine;': [2657], 'dihydro-C24': [2658], '(X5),': [2659], 'dihydroceramide': [2660, 2664, 2668, 2764, 2774, 4068], 'C24;': [2661, 2680, 2699], 'dihydro-C26': [2662], '(X6),': [2663], 'C26;': [2665, 2676, 2694], 'dihydro-C18': [2666], '(X7),': [2667], 'C18;': [2669, 2684, 2704], 'PHS': [2670, 4014], '(X8),': [2671], 'phytosphingosine;': [2672], 'phyto-C26': [2673], '(X9),': [2674], 'phyto-C24': [2677], '(X10),': [2678], 'phyto-C18': [2681], '(X11),': [2682], '(X12),': [2686], 'newly': [2687, 2790, 3510], 'synthesized': [2688, 2791, 2830], 'Pma1;': [2689], 'IPC-C26': [2690], '(X13),': [2691], 'IPC-C24': [2695], '(X14),': [2696], 'IPC-C18': [2700], '(X15),': [2701], 'protons': [2706, 2836, 3545, 3768, 3917], '(X16);': [2707], 'ATP': [2708, 2859, 3842, 3913], '(X17),': [2709], 'adenosine-5′-triphosphate;': [2710], 'palmitate': [2711, 2718, 2721, 2728, 3749], '(X18);': [2712], '(X19),': [2714], 'sn-1,2-diacylglycerol.': [2715], 'ext': [2719, 2724], '(X100),': [2720], 'external;': [2722, 2727, 2837], '(X101),': [2725], '(X102);': [2730], '(X103);': [2733], 'Ac-CoA': [2734], '(X104),': [2735], 'acetyl': [2736], 'CoA;': [2737], 'C26-CoA': [2738], '(X105),': [2739], 'very': [2740, 3015, 3576, 3602], '(C26-CoA);': [2744], 'C18-CoA': [2745], '(X106),': [2746], '(C18-CoA);': [2749], 'C24-CoA': [2750], '(X107),': [2751], '(C24-CoA);': [2754], 'palmitoyltransferase': [2756, 3960], '(X108);': [2757], 'ADP,': [2758], 'adenosine': [2759, 2864], 'biphosphate': [2760], '(X109);': [2761], 'dihydro-CDase': [2762], '(X110),': [2763], 'ceramidase;': [2765], 'reductase': [2767], '(X111),': [2768], '3-ketodihydrosphingosine': [2769, 3952], 'reductase;': [2770], '(X112),': [2773], 'synthase;': [2775, 2787, 2817, 2858, 2872], 'phyto-CDase': [2776], '(X113),': [2777], 'phytoceramidase;': [2778], 'hydroxylase': [2779, 2781, 3981], '(X114);': [2780], '(X115);': [2782], '(X116),': [2785], 'Pma1p': [2788], '(X117),': [2789], 'ER;': [2795], 'Sec61': [2796, 2798], '(X118),': [2797], 'probable': [2800], 'insertion': [2802, 4185], 'protein;': [2803], '(X119),': [2805], 'C;': [2809], 'PI': [2810, 4233], '(X120),': [2811], 'phosphatidylinositol;': [2812], '(X121),': [2814], 'alternative': [2818], 'respiration': [2819], '(X122);': [2820], 'NADHm': [2821], '(X123),': [2822], 'nicotinamide': [2823], 'adenine': [2824], 'dinucleotide;': [2825], 'oxygen': [2826], '(X124);': [2827], 'Pma1-H+ATPase': [2828], '(X125),': [2829], 'H+-ATPase;': [2833], 'H+': [2834, 2841, 2873, 3253], '(X126),': [2835], 'ER–Golgi': [2838], '(X127);': [2840], '(X128),': [2843], 'transport;': [2845], 'SHMT': [2846], '(X129)': [2847], 'hydroxymethyl': [2849], 'transferase;': [2850], '(X130);': [2853], '(X131),': [2856], 'palmitoyl-CoA': [2857, 3950], 'total': [2860, 2963, 2986], '(X132);': [2861], 'AMP': [2862], '(X133),': [2863], 'monophosphate;': [2865], 'Golgi–ER': [2866], '(X134);': [2868], 'F0F1-ATPase': [2869, 3852], '(X135),': [2870], 'F0F1-ATP': [2871], 'm': [2874], '(X136),': [2875], 'mitochondrial': [2876], 'protons.': [2877, 3721], 'Download': [2878, 2880], 'figure': [2879], 'PowerPoint': [2881], 'Measurement': [2882], 'subspecies': [2885, 2934, 3012, 3069, 3089], 'wild': [2888], 'type': [2889], 'Fungal': [2897], 'produce': [2899], 'variant': [2900], 'species': [2901, 3104, 3111, 3170, 3192], 'differ': [2905], 'principally': [2906], 'acyl': [2912, 3946], 'chains': [2913], 'hydroxylation': [2916], 'states': [2917], '(Vaena': [2918], 'de': [2919], 'Avalos': [2920], 'variability': [2926], 'question': [2930], 'whether': [2932, 3262], 'would': [2936, 3271], 'change': [2937], 'Targeted': [2949], 'experiments': [2950], 'revealed': [2952, 3013], 'exposed': [2957], 'non-hydroxylated': [2966, 3022, 3035], 'decreases': [2968], 'half': [2970], '(from': [2977, 2999], '3862.7±6.34': [2978], '1588.7±6.32': [2980], 'pmol/pmol': [2981, 3003, 3214], 'Pi;': [2982], 'P<0.05),': [2983], 'hydroxylated': [2989, 3020, 4072], 'compared': [2993, 3029, 3046], '1244.1±3.2': [3000], '2147.2±3.5': [3002], 'Pi)': [3004, 3113], 'I).': [3006], 'Analysis': [3007], '(both': [3018], 'forms)': [3023], 'elevated': [3026, 3232], 'short-chain': [3034, 3600], '(C14,': [3037], 'C16,': [3038], 'C18)': [3040], '(P<0.05).': [3050], 'Phytoceramide': [3051], 'measurements': [3052], 'performed': [3055], '(7.4).': [3059], 'No': [3060], 'differences': [3061, 3921], '7.0': [3072], '7.4': [3074], '(data': [3075], 'shown).': [3077], 'These': [3078], 'suggest': [3080], 'certain': [3087], 'Table': [3099, 3341, 3847], '1.': [3100, 3455], 'Identification': [3101], '48': [3106], 'h': [3107], 'Ceramide': [3110], '(pmol/pmol': [3112], 'Phyto-C18': [3114], 'Phyto-C18;1': [3115], 'Phyto-C20': [3116], 'Phyto-C24': [3117], 'Phyto-C24:1': [3118], 'Phyto-C26': [3119], 'Phyto-C26:1': [3120], 'α-OH-phyto-C18': [3121], 'α-OH-phyto-C18:1': [3122], 'α-OH-phyto-C24': [3123], 'α-OH-phyto-C26': [3124], 'α-OH-phyto-C26:1': [3125], '7': [3127, 3355], '406.6': [3128], '230': [3129], '60': [3130], '2260': [3131], '640.1': [3132], '170': [3133], '96': [3134], '3.1': [3135], '1.04': [3136], '570': [3137], '360': [3138], '310': [3139], '4': [3141, 3157, 3358, 3375], '215.3': [3142], '180': [3143], '4.5*': [3144], '396*': [3145], '400': [3146], '222.5': [3147], '170.4*': [3148], '4.2': [3149], '3': [3150], '810': [3151], '710*': [3152], '620': [3153], '*': [3154, 3372], 'P<0.05': [3155, 3373], '(pH': [3156, 3374], '7).': [3159, 3377], 'Mass': [3160], 'spectrometric': [3161], 'analysis': [3162], 'alpha': [3167], 'hydroxyl': [3168, 3222], 'late-log': [3172, 3460, 3504], 'phase': [3173, 3461, 3505], 'H99': [3177], 'WT': [3178, 3360], 'strain.': [3179], 'Determinations': [3180], 'mass': [3189], 'normalized': [3194], 'phosphorous': [3196], 'sample.': [3200], 'means': [3204, 3421], 'separate': [3207, 3424, 3491], 'concentrations': [3210], 'reported': [3212], 'Pi': [3215], 'phyto-': [3217], '(phytoceramide)': [3218], 'α-OH-phyto': [3220], '(alpha': [3221], 'length': [3226], 'chains.': [3229], 'Ebselen': [3230, 3379], 'causes': [3231], 'inhibition': [3233], 'one': [3246], 'major': [3249], 'regulators': [3250], '1988),': [3259], 'wondered': [3261], 'absence': [3264], 'affect': [3272], 'susceptibility': [3274, 3322], 'inhibitors.': [3280], 'To': [3281], 'address': [3282], 'question,': [3284], 'examined': [3286], 'minimal': [3288, 3293], 'inhibitory': [3289], 'concentration': [3290, 3295, 3829], '(MIC)': [3291], 'fungicidal': [3294, 3381], '(MFC)': [3296], 'ebselen,': [3298], 'well-established': [3300], 'inhibitor': [3301, 3351], '(Perlin': [3305], '1997).': [3308], 'loss': [3312], 'ebselen': [3327], 'II),': [3329], 'potentially': [3337], 'function.': [3340], '2.': [3342], 'Loss': [3343], 'sensitizes': [3346], 'ebselena': [3352], 'Strain': [3353], '(μM)': [3356, 3359], '3.12': [3361, 3364, 3367, 3368, 3370, 3393], '2.48': [3362], '0.78*': [3365], 'Δisc1REC': [3366], 'GAL7:IPC1-glucose': [3369], '0.39*': [3371], 'WT,': [3383], 'Δisc1REC,': [3385], 'GAL7:IPC1': [3387, 3403], 'strains': [3388], 'MFC': [3391], 'μM': [3394], 'downregulated)': [3409], 'MFCs': [3411], '0.78': [3413], '0.39': [3415], 'μM,': [3416], 'respectively.': [3417], 'Computational': [3426], 'steps': [3433, 3930], 'deemed': [3436], 'presented': [3452, 3663], 'Most': [3456, 3651], 'analyses': [3457, 3617, 3657, 3723], 'reflect': [3458], 'adapted': [3468], 'earlier': [3470], '(Alvarez-Vasquez': [3475], '2005)': [3479, 3566], 'peculiarities': [3482], 'Importantly,': [3485], 'incorporated': [3487], 'organelles': [3489], 'physical': [3493], 'metabolites.': [3496], 'Also': [3497], 'contains': [3508], 'metabolite': [3512], 'wild-type': [3518], '(WT)': [3519], 'allowing': [3528], 'ceramides': [3530], 'chain': [3535], 'lengths,': [3536], 'transporting': [3544], 'cytosol': [3548, 3794], 'phagolysosome,': [3551], 'crucial': [3554], 'trafficking': [3562], '(Gaigg': [3563], '(Lee': [3569, 4153], '2002)': [3572], 'controlled': [3574], 'phytoceramides,': [3578], 'here': [3587], 'pays': [3588], 'attention': [3590], 'dynamics': [3593], 'Pma1,': [3595], 'well': [3597], 'directly': [3609, 3899, 3911, 4073], 'indirectly': [3611], 'production.': [3614], 'standard': [3625], 'BST,': [3627], 'diagnosed': [3630], 'thoroughly': [3634], 'investigating': [3635], 'stability': [3637], 'robustness': [3639], 'evaluating': [3641], 'sensitivities': [3642], 'gains,': [3644], 'respect': [3647], 'activities.': [3650], 'unremarkable': [3659], 'therefore': [3662], 'information.': [3666], 'gains': [3668], 'provided': [3669], 'some': [3672], 'affected': [3679], 'steps.': [3687], 'However,': [3688], 'did': [3690], 'reveal': [3692], 'compelling': [3693], 'explanations': [3694], 'coordinates': [3698], 'contrast,': [3705, 3905], 'exploration': [3706], 'consequences': [3709], 'alterations': [3711], 'suggested': [3716, 4135], 'interesting': [3717], 'handling': [3720], 'All': [3722], 'executed': [3725], 'free': [3728], 'software': [3729], 'PLAS©': [3730], '(Ferreira,': [3731], 'follows.': [3742], 'Cytoplasm': [3743], 'include': [3745], 'serine,': [3751], 'step': [3756], 'biosynthesis.': [3759], 'conditions,': [3762], 'exist': [3765], 'inside': [3766, 3834, 3866], 'macrophages,': [3767], 'cell.': [3772], 'inclusion': [3774], 'cytoplasmic': [3787], 'Proton': [3789], 'import': [3790], 'modeled': [3796], 'simple': [3799, 3813, 3891], '(first': [3800], 'order)': [3801], 'process,': [3803], 'export': [3806], 'mechanism': [3807], 'depends': [3808, 3898], 'highly': [3809], 'Pma1.': [3811], 'A': [3812], 'implies': [3816], 'direct': [3817, 3879], 'proportionality': [3818], 'influx': [3821, 3897], '(inside': [3822], 'fungus)': [3824], 'external': [3827], '(outside': [3830], 'phagolysosome).': [3836], 'Our': [3837, 3859], 'considers': [3839, 4098, 4160], 'S7)': [3848], 'includes': [3850], 'mitochondria': [3856], '(equation': [3857], '17).': [3858], 'assumes': [3861], '(its': [3869], 'physiological': [3870], 'internalized': [3873], 'macrophages)': [3876], 'no': [3878], 'contact': [3880], 'mitochondria.': [3884], 'For': [3885], 'refer': [3888], 'electrochemical': [3902, 3920], 'gradient.': [3903], '(X125)': [3907], 'utilizes': [3908], 'energy': [3909], 'obtained': [3910], 'hydrolysis': [3914], 'against': [3918], 'across': [3922], 'membrane.': [3925], 'Endoplasmic': [3926], 'take': [3935], 'place': [3936], 'ER.': [3939, 4109], 'condensation': [3941], 'transferred': [3948], 'form': [3951, 4008, 4023, 4046], '(KDHS).': [3953], 'catalyzed': [3957, 4053], 'rapidly': [3967], 'converted': [3968, 3978], 'dihydrosphingosine': [3970], '(DHS).': [3971], 'model,': [3974, 4067], 'PHS.': [3983], 'At': [3984], 'action': [3990], 'specific': [3993, 4055], '(sphingoid': [3996], 'N-acyl': [3998], 'transferase),': [3999], 'CoA': [4006, 4021], 'dihydroceramides': [4009, 4030], 'C18,': [4010, 4025, 4031, 4037, 4083, 4220], 'C24,': [4011, 4026, 4032, 4038, 4084, 4221], 'C26.': [4013, 4028, 4076], 'combine': [4016], 'Both': [4029], 'undergo': [4042], 'hydrolytic': [4043], 'reactions': [4044], 'PHS,': [4049], 'respectively,': [4050], 'ceramidases': [4056], '(Mao': [4057], 'Obeid,': [4059], 'Mao': [4061], 'produced,': [4078], 'follows': [4092], 'first-order': [4094], 'biosynthesis': [4101], 'signals': [4123], 'similar': [4124], 'inserted': [4128, 4208], 'membrane,': [4132], 'previously': [4134], '(Portillo': [4136], '1989).': [4139], 'predicts': [4142], 'stabilized': [4146], 'produced': [4150], 'Sec61,': [4161], 'upregulated': [4167], 'murine': [4169], 'macrophage': [4170], '(Fan': [4174], 'secretory': [4179], 'factor': [4180], 'could': [4182], 'mediate': [4183], 'vesicles.': [4189], 'travels': [4191], 'finally': [4200], 'where': [4205], '(Chang': [4209], 'Slayman,': [4211], 'apparatus,': [4218, 4250], 'Ipc1.': [4227], 'phytoceramide(s),': [4235], '(IPC-C18,': [4238], '-C24,': [4239], '-C26)': [4241], 'DAG.': [4243], 'implying': [4251]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2145544634', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2025-01-12T19:14:49.864707', 'created_date': '2016-06-24'}
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