Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2145180842', 'doi': 'https://doi.org/10.1146/annurev-pharmtox-010611-134517', 'title': 'The Chemical Biology of Naphthoquinones and Its Environmental Implications', 'display_name': 'The Chemical Biology of Naphthoquinones and Its Environmental Implications', 'publication_year': 2012, 'publication_date': '2012-02-10', 'ids': {'openalex': 'https://openalex.org/W2145180842', 'doi': 'https://doi.org/10.1146/annurev-pharmtox-010611-134517', 'mag': '2145180842', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21942631'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev-pharmtox-010611-134517', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S163849586', 'display_name': 'The Annual Review of Pharmacology and Toxicology', 'issn_l': '0362-1642', 'issn': ['0362-1642', '1545-4304'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013567557', 'display_name': 'Yoshito Kumagai', 'orcid': 'https://orcid.org/0000-0003-4523-8234'}, 'institutions': [{'id': 'https://openalex.org/I146399215', 'display_name': 'University of Tsukuba', 'ror': 'https://ror.org/02956yf07', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146399215']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshito Kumagai', 'raw_affiliation_strings': ['Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, Japan.', 'institution_ids': ['https://openalex.org/I146399215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004496411', 'display_name': 'Yasuhiro Shinkai', 'orcid': 'https://orcid.org/0000-0003-1772-5342'}, 'institutions': [{'id': 'https://openalex.org/I146399215', 'display_name': 'University of Tsukuba', 'ror': 'https://ror.org/02956yf07', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146399215']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuhiro Shinkai', 'raw_affiliation_strings': ['Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, Japan'], 'affiliations': [{'raw_affiliation_string': 'Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, Japan', 'institution_ids': ['https://openalex.org/I146399215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103426589', 'display_name': 'Takashi Miura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I146399215', 'display_name': 'University of Tsukuba', 'ror': 'https://ror.org/02956yf07', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146399215']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takashi Miura', 'raw_affiliation_strings': ['Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, Japan'], 'affiliations': [{'raw_affiliation_string': 'Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, Japan', 'institution_ids': ['https://openalex.org/I146399215']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035062742', 'display_name': 'Arthur K. Cho', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74022624', 'display_name': 'Oklahoma State University Center for Health Sciences', 'ror': 'https://ror.org/02mfxdp77', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I74022624']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Arthur K. Cho', 'raw_affiliation_strings': ['Departments of Molecular and Medical Pharmacology and Environmental Health Sciences, UCLA Center for Health Sciences, Los Angeles, California 90095;'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular and Medical Pharmacology and Environmental Health Sciences, UCLA Center for Health Sciences, Los Angeles, California 90095;', 'institution_ids': ['https://openalex.org/I74022624']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.252, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 288, 'citation_normalized_percentile': {'value': 0.977778, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '52', 'issue': '1', 'first_page': '221', 'last_page': '247'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12356', 'display_name': 'Role of Quinones in Toxicology and Pharmacology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12356', 'display_name': 'Role of Quinones in Toxicology and Pharmacology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13792', 'display_name': 'Therapeutic Properties of Morinda citrifolia', 'score': 0.9819, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11332', 'display_name': 'Role of Nrf2 Signaling in Oxidative Stress Response', 'score': 0.9768, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/anthraquinones', 'display_name': 'Anthraquinones', 'score': 0.499185}], 'concepts': [{'id': 'https://openalex.org/C2780643102', 'wikidata': 'https://www.wikidata.org/wiki/Q412382', 'display_name': 'Quinone', 'level': 2, 'score': 0.70165616}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6739224}, {'id': 'https://openalex.org/C50027330', 'wikidata': 'https://www.wikidata.org/wiki/Q908086', 'display_name': 'Electrophile', 'level': 3, 'score': 0.55872154}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5340589}, {'id': 'https://openalex.org/C114246631', 'wikidata': 'https://www.wikidata.org/wiki/Q187661', 'display_name': 'Carcinogen', 'level': 2, 'score': 0.5160741}, {'id': 'https://openalex.org/C178907741', 'wikidata': 'https://www.wikidata.org/wiki/Q745930', 'display_name': 'Nucleophile', 'level': 3, 'score': 0.4566433}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.44081926}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004777', 'descriptor_name': 'Environment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009285', 'descriptor_name': 'Naphthoquinones', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D009285', 'descriptor_name': 'Naphthoquinones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000393', 'descriptor_name': 'Air Pollutants', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D000393', 'descriptor_name': 'Air Pollutants', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000393', 'descriptor_name': 'Air Pollutants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002273', 'descriptor_name': 'Carcinogens', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D002273', 'descriptor_name': 'Carcinogens', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D002273', 'descriptor_name': 'Carcinogens', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D002273', 'descriptor_name': 'Carcinogens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003545', 'descriptor_name': 'Cysteine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003545', 'descriptor_name': 'Cysteine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004781', 'descriptor_name': 'Environmental Exposure', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D004781', 'descriptor_name': 'Environmental Exposure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005987', 'descriptor_name': 'Glyceraldehyde-3-Phosphate Dehydrogenases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005987', 'descriptor_name': 'Glyceraldehyde-3-Phosphate Dehydrogenases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009285', 'descriptor_name': 'Naphthoquinones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009285', 'descriptor_name': 'Naphthoquinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054562', 'descriptor_name': 'Protein Tyrosine Phosphatase, Non-Receptor Type 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054562', 'descriptor_name': 'Protein Tyrosine Phosphatase, Non-Receptor Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011809', 'descriptor_name': 'Quinones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011809', 'descriptor_name': 'Quinones', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D011809', 'descriptor_name': 'Quinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev-pharmtox-010611-134517', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S163849586', 'display_name': 'The Annual Review of Pharmacology and Toxicology', 'issn_l': '0362-1642', 'issn': ['0362-1642', '1545-4304'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21942631', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.8, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 155, 'referenced_works': ['https://openalex.org/W1417333514', 'https://openalex.org/W1506117495', 'https://openalex.org/W1530401629', 'https://openalex.org/W1534343559', 'https://openalex.org/W1546500257', 'https://openalex.org/W1548836679', 'https://openalex.org/W1553375567', 'https://openalex.org/W1560670296', 'https://openalex.org/W1565481119', 'https://openalex.org/W1592311769', 'https://openalex.org/W1606366915', 'https://openalex.org/W1643210644', 'https://openalex.org/W1785455093', 'https://openalex.org/W1805538867', 'https://openalex.org/W1809748389', 'https://openalex.org/W1953090218', 'https://openalex.org/W1965087471', 'https://openalex.org/W1968580657', 'https://openalex.org/W1970714744', 'https://openalex.org/W1971135682', 'https://openalex.org/W1972090433', 'https://openalex.org/W1972873115', 'https://openalex.org/W1973081886', 'https://openalex.org/W1973195211', 'https://openalex.org/W1974755487', 'https://openalex.org/W1975351296', 'https://openalex.org/W1975488757', 'https://openalex.org/W1976300978', 'https://openalex.org/W1976459269', 'https://openalex.org/W1978387073', 'https://openalex.org/W1979424160', 'https://openalex.org/W1980464741', 'https://openalex.org/W1981346154', 'https://openalex.org/W1982140654', 'https://openalex.org/W1982258251', 'https://openalex.org/W1982467853', 'https://openalex.org/W1984465237', 'https://openalex.org/W1984791592', 'https://openalex.org/W1985131241', 'https://openalex.org/W1985368964', 'https://openalex.org/W1987364666', 'https://openalex.org/W1987633665', 'https://openalex.org/W1990827723', 'https://openalex.org/W1992394390', 'https://openalex.org/W1992989755', 'https://openalex.org/W1994262781', 'https://openalex.org/W1994724497', 'https://openalex.org/W1995101219', 'https://openalex.org/W1996939535', 'https://openalex.org/W1997610850', 'https://openalex.org/W1998316952', 'https://openalex.org/W1998431913', 'https://openalex.org/W2002617338', 'https://openalex.org/W2003132433', 'https://openalex.org/W2005220795', 'https://openalex.org/W2006151386', 'https://openalex.org/W2006531657', 'https://openalex.org/W2007054316', 'https://openalex.org/W2008096537', 'https://openalex.org/W2010205595', 'https://openalex.org/W2017741142', 'https://openalex.org/W2018230189', 'https://openalex.org/W2021907601', 'https://openalex.org/W2022246252', 'https://openalex.org/W2024540523', 'https://openalex.org/W2025030616', 'https://openalex.org/W2029914749', 'https://openalex.org/W2030969794', 'https://openalex.org/W2031109095', 'https://openalex.org/W2032153758', 'https://openalex.org/W2033275653', 'https://openalex.org/W2033652458', 'https://openalex.org/W2034286442', 'https://openalex.org/W2034925881', 'https://openalex.org/W2037016203', 'https://openalex.org/W2038805839', 'https://openalex.org/W2039560924', 'https://openalex.org/W2040309005', 'https://openalex.org/W2040379417', 'https://openalex.org/W2042968475', 'https://openalex.org/W2043405307', 'https://openalex.org/W2044271936', 'https://openalex.org/W2046005857', 'https://openalex.org/W2046970075', 'https://openalex.org/W2049119654', 'https://openalex.org/W2050831651', 'https://openalex.org/W2051581244', 'https://openalex.org/W2053728486', 'https://openalex.org/W2056017024', 'https://openalex.org/W2057579884', 'https://openalex.org/W2061699184', 'https://openalex.org/W2064298888', 'https://openalex.org/W2066661679', 'https://openalex.org/W2066669057', 'https://openalex.org/W2068769189', 'https://openalex.org/W2069149537', 'https://openalex.org/W2069159655', 'https://openalex.org/W2069401676', 'https://openalex.org/W2069785858', 'https://openalex.org/W2070331619', 'https://openalex.org/W2073972309', 'https://openalex.org/W2076038104', 'https://openalex.org/W2076935230', 'https://openalex.org/W2080138855', 'https://openalex.org/W2081932427', 'https://openalex.org/W2083592314', 'https://openalex.org/W2086317499', 'https://openalex.org/W2086592404', 'https://openalex.org/W2089790390', 'https://openalex.org/W2089810082', 'https://openalex.org/W2090990681', 'https://openalex.org/W2091781796', 'https://openalex.org/W2093178531', 'https://openalex.org/W2095699993', 'https://openalex.org/W2097158481', 'https://openalex.org/W2101444644', 'https://openalex.org/W2106171481', 'https://openalex.org/W2107235167', 'https://openalex.org/W2113163706', 'https://openalex.org/W2115558737', 'https://openalex.org/W2118755647', 'https://openalex.org/W2119660622', 'https://openalex.org/W2120807382', 'https://openalex.org/W2125762200', 'https://openalex.org/W2125778454', 'https://openalex.org/W2125935300', 'https://openalex.org/W2127140861', 'https://openalex.org/W2130448184', 'https://openalex.org/W2130872185', 'https://openalex.org/W2132878122', 'https://openalex.org/W2133148204', 'https://openalex.org/W2136782457', 'https://openalex.org/W2146558971', 'https://openalex.org/W2150269465', 'https://openalex.org/W2152164517', 'https://openalex.org/W2152976919', 'https://openalex.org/W2153145014', 'https://openalex.org/W2153343124', 'https://openalex.org/W2155314275', 'https://openalex.org/W2156251634', 'https://openalex.org/W2160378405', 'https://openalex.org/W2161982997', 'https://openalex.org/W2167424396', 'https://openalex.org/W2169925593', 'https://openalex.org/W2171475249', 'https://openalex.org/W2172046850', 'https://openalex.org/W2206183556', 'https://openalex.org/W2269187270', 'https://openalex.org/W2335883500', 'https://openalex.org/W268092627', 'https://openalex.org/W3005433546', 'https://openalex.org/W4236412125', 'https://openalex.org/W4236940115', 'https://openalex.org/W74553655', 'https://openalex.org/W74990001'], 'related_works': ['https://openalex.org/W2952378758', 'https://openalex.org/W2949551219', 'https://openalex.org/W2111978725', 'https://openalex.org/W2100457900', 'https://openalex.org/W2051290316', 'https://openalex.org/W2049917615', 'https://openalex.org/W2046236137', 'https://openalex.org/W1997700499', 'https://openalex.org/W1954521139', 'https://openalex.org/W1893761061'], 'abstract_inverted_index': {'Quinones': [0, 88], 'are': [1, 44, 73], 'a': [2], 'group': [3], 'of': [4, 35, 45, 49, 65, 77, 175, 203], 'highly': [5], 'reactive': [6, 100], 'organic': [7], 'chemical': [8], 'species': [9], 'that': [10, 154], 'interact': [11], 'with': [12, 109, 167, 184], 'biological': [13], 'systems': [14], 'to': [15, 23, 99, 177, 214], 'promote': [16, 155], 'inflammatory,': [17], 'anti-inflammatory,': [18], 'and': [19, 22, 32, 37, 39, 55, 67, 71, 103, 136, 156, 161, 171], 'anticancer': [20], 'actions': [21, 91, 144, 165], 'induce': [24], 'toxicities.': [25], 'This': [26], 'review': [27], 'describes': [28], 'the': [29, 61, 79, 129, 137, 168, 185, 190, 198], 'chemistry,': [30], 'biochemistry,': [31], 'cellular': [33], 'effects': [34], '1,2-': [36, 70], '1,4-naphthoquinones': [38, 72], 'their': [40, 50, 90, 143], 'derivatives.': [41], 'The': [42, 112, 201], 'naphthoquinones': [43, 178], 'particular': [46], 'interest': [47], 'because': [48], 'prevalence': [51], 'as': [52, 56, 63, 95, 104, 121, 179], 'natural': [53], 'products': [54, 64], 'environmental': [57, 180], 'chemicals,': [58], 'present': [59, 84], 'in': [60, 85, 197, 210], 'atmosphere': [62], 'fuel': [66], 'tobacco': [68], 'combustion.': [69], 'also': [74], 'toxic': [75], 'metabolites': [76], 'naphthalene,': [78], 'major': [80], 'polynuclear': [81], 'aromatic': [82], 'hydrocarbon': [83], 'ambient': [86], 'air.': [87], 'exert': [89], 'through': [92], 'two': [93], 'reactions:': [94], 'prooxidants,': [96], 'reducing': [97], 'oxygen': [98, 101], 'species;': [102], 'electrophiles,': [105], 'forming': [106], 'covalent': [107], 'bonds': [108], 'tissue': [110], 'nucleophiles.': [111], 'targets': [113], 'for': [114, 132], 'these': [115], 'reactions': [116], 'include': [117], 'regulatory': [118, 130, 146], 'proteins': [119], 'such': [120], 'protein': [122, 127, 131], 'tyrosine': [123], 'phosphatases;': [124], 'Kelch-like': [125], 'ECH-associated': [126], '1,': [128], 'NF-E2-related': [133], 'factor': [134], '2;': [135], 'glycolysis': [138], 'enzyme': [139], 'glyceraldehyde-3-phosphate': [140], 'dehydrogenase.': [141], 'Through': [142], 'on': [145], 'proteins,': [147], 'quinones': [148], 'affect': [149], 'various': [150], 'cell': [151, 162], 'signaling': [152], 'pathways': [153], 'protect': [157], 'against': [158], 'inflammatory': [159], 'responses': [160], 'damage.': [163], 'These': [164], 'vary': [166, 183], 'specific': [169], 'quinone': [170, 191, 215], 'its': [172], 'concentration.': [173], 'Effects': [174], 'exposure': [176], 'chemicals': [181], 'can': [182], 'physical': [186], 'state,': [187], 'i.e.,': [188], 'whether': [189], 'is': [192, 196], 'particle': [193], 'bound': [194], 'or': [195], 'vapor': [199], 'state.': [200], 'exacerbation': [202], 'pulmonary': [204], 'diseases': [205], 'by': [206], 'air': [207], 'pollutants': [208], 'can,': [209], 'part,': [211], 'be': [212], 'attributed': [213], 'action.': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2145180842', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 34}, {'year': 2021, 'cited_by_count': 30}, {'year': 2020, 'cited_by_count': 30}, {'year': 2019, 'cited_by_count': 18}, {'year': 2018, 'cited_by_count': 30}, {'year': 2017, 'cited_by_count': 23}, {'year': 2016, 'cited_by_count': 27}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-09-16T19:26:01.082937', 'created_date': '2016-06-24'}