Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2145057484', 'doi': None, 'title': 'Regulated poly(A) tail shortening in somatic cells mediated by cap-proximal translational repressor proteins and ribosome association.', 'display_name': 'Regulated poly(A) tail shortening in somatic cells mediated by cap-proximal translational repressor proteins and ribosome association.', 'publication_year': 1997, 'publication_date': '1997-09-01', 'ids': {'openalex': 'https://openalex.org/W2145057484', 'mag': '2145057484', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9292498', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1369545'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9292498', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5060970793', 'display_name': 'Martina U. Muckenthaler', 'orcid': 'https://orcid.org/0000-0002-3778-510X'}, 'institutions': [{'id': 'https://openalex.org/I4210138560', 'display_name': 'European Molecular Biology Laboratory', 'ror': 'https://ror.org/03mstc592', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I4210138560']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'M Muckenthaler', 'raw_affiliation_strings': ['Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany.', 'institution_ids': ['https://openalex.org/I4210138560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021967550', 'display_name': 'Nikolas Gunkel', 'orcid': 'https://orcid.org/0000-0001-8116-2690'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'N Gunkel', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007570262', 'display_name': 'Renata Stripecke', 'orcid': 'https://orcid.org/0000-0001-7756-8460'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R Stripecke', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000270755', 'display_name': 'Matthias W. Hentze', 'orcid': 'https://orcid.org/0000-0002-4023-7876'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M W Hentze', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.552, 'has_fulltext': False, 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.679959, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '3', 'issue': '9', 'first_page': '983', 'last_page': '95'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9854, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9163, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/translational-regulation', 'display_name': 'Translational regulation', 'score': 0.70560217}, {'id': 'https://openalex.org/keywords/translational-efficiency', 'display_name': 'Translational efficiency', 'score': 0.63805}, {'id': 'https://openalex.org/keywords/puromycin', 'display_name': 'Puromycin', 'score': 0.5151297}, {'id': 'https://openalex.org/keywords/p-bodies', 'display_name': 'P-bodies', 'score': 0.5111721}, {'id': 'https://openalex.org/keywords/polysome', 'display_name': 'Polysome', 'score': 0.47092527}, {'id': 'https://openalex.org/keywords/eif4e', 'display_name': 'EIF4E', 'score': 0.466533}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.752555}, {'id': 'https://openalex.org/C39685955', 'wikidata': 'https://www.wikidata.org/wiki/Q3455905', 'display_name': 'Translational regulation', 'level': 5, 'score': 0.70560217}, {'id': 'https://openalex.org/C149364088', 'wikidata': 'https://www.wikidata.org/wiki/Q185917', 'display_name': 'Translation (biology)', 'level': 4, 'score': 0.69635934}, {'id': 'https://openalex.org/C88478588', 'wikidata': 'https://www.wikidata.org/wiki/Q42244', 'display_name': 'Ribosome', 'level': 4, 'score': 0.67674387}, {'id': 'https://openalex.org/C2775992057', 'wikidata': 'https://www.wikidata.org/wiki/Q16956568', 'display_name': 'Translational efficiency', 'level': 5, 'score': 0.63805}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.6101128}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5668436}, {'id': 'https://openalex.org/C142575336', 'wikidata': 'https://www.wikidata.org/wiki/Q412148', 'display_name': 'Polyadenylation', 'level': 4, 'score': 0.5217182}, {'id': 'https://openalex.org/C158448853', 'wikidata': 'https://www.wikidata.org/wiki/Q425218', 'display_name': 'Repressor', 'level': 4, 'score': 0.52071553}, {'id': 'https://openalex.org/C2779200571', 'wikidata': 'https://www.wikidata.org/wiki/Q424696', 'display_name': 'Puromycin', 'level': 3, 'score': 0.5151297}, {'id': 'https://openalex.org/C162419368', 'wikidata': 'https://www.wikidata.org/wiki/Q14864908', 'display_name': 'P-bodies', 'level': 5, 'score': 0.5111721}, {'id': 'https://openalex.org/C3675279', 'wikidata': 'https://www.wikidata.org/wiki/Q211935', 'display_name': 'Protein biosynthesis', 'level': 2, 'score': 0.4856633}, {'id': 'https://openalex.org/C65666806', 'wikidata': 'https://www.wikidata.org/wiki/Q970614', 'display_name': 'Polysome', 'level': 5, 'score': 0.47092527}, {'id': 'https://openalex.org/C161295673', 'wikidata': 'https://www.wikidata.org/wiki/Q5408696', 'display_name': 'EIF4E', 'level': 5, 'score': 0.466533}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.42167997}, {'id': 'https://openalex.org/C2778128677', 'wikidata': 'https://www.wikidata.org/wiki/Q412895', 'display_name': 'Cycloheximide', 'level': 3, 'score': 0.41602513}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.27809328}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.22347683}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.17756215}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09989759}], 'mesh': [{'descriptor_ui': 'D011061', 'descriptor_name': 'Poly A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012270', 'descriptor_name': 'Ribosomes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005293', 'descriptor_name': 'Ferritins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005293', 'descriptor_name': 'Ferritins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005293', 'descriptor_name': 'Ferritins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019382', 'descriptor_name': 'Human Growth Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019382', 'descriptor_name': 'Human Growth Hormone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019382', 'descriptor_name': 'Human Growth Hormone', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007501', 'descriptor_name': 'Iron', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007501', 'descriptor_name': 'Iron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008322', 'descriptor_name': 'Mammals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011061', 'descriptor_name': 'Poly A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011061', 'descriptor_name': 'Poly A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012315', 'descriptor_name': 'RNA Caps', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012270', 'descriptor_name': 'Ribosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012270', 'descriptor_name': 'Ribosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9292498', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4211013306', 'https://openalex.org/W3034594433', 'https://openalex.org/W2227815800', 'https://openalex.org/W2147685819', 'https://openalex.org/W2145057484', 'https://openalex.org/W2141325721', 'https://openalex.org/W2114762985', 'https://openalex.org/W2004943023', 'https://openalex.org/W1630550847', 'https://openalex.org/W1522814088'], 'abstract_inverted_index': {'The': [0, 33], 'poly(A)': [1, 26, 68, 78, 118, 138, 172], 'tail': [2, 27, 69, 119, 173], 'plays': [3], 'an': [4, 83], 'important': [5], 'role': [6, 182], 'in': [7, 19, 171, 186], 'translation': [8, 31, 100, 126], 'initiation.': [9], 'We': [10], 'report': [11], 'the': [12, 61, 72, 108, 112, 130, 141, 145, 150, 187], 'identification': [13], 'of': [14, 35, 63, 74, 111, 144, 159, 165, 183, 189], 'a': [15, 156, 163], 'mechanism': [16, 158, 185], 'that': [17, 102, 128], 'operates': [18], 'mammalian': [20], 'somatic': [21], 'cells,': [22], 'and': [23, 44, 97, 123, 134, 177], 'couples': [24], 'mRNA': [25, 39, 66, 146], 'length': [28], 'with': [29, 76], 'its': [30], 'state.': [32], 'regulation': [34], 'human': [36], 'ferritin': [37, 64], 'L-chain': [38, 65], 'by': [40, 57], 'iron-responsive': [41], 'elements': [42], '(IREs)': [43], 'iron': [45], 'regulatory': [46], 'proteins': [47, 116], '(IRPs)': [48], 'is': [49, 87, 192], 'subject': [50], 'to': [51, 60, 82, 148], 'this': [52, 184], 'mechanism:': [53], 'translational': [54, 93, 114, 166, 190], 'repression': [55, 191], 'imposed': [56], 'IRP': [58, 80], 'binding': [59, 81], 'IRE': [62, 84], 'induces': [67], 'shortening.': [70], 'For': [71], 'accumulation': [73], 'mRNAs': [75, 104, 133], 'short': [77], 'tails,': [79], 'per': [85], 'se': [86], 'not': [88], 'sufficient,': [89], 'but': [90], 'must': [91], 'cause': [92], 'repression.': [94], 'Interestingly,': [95], 'puromycin': [96], 'verrucarin': [98], '(general': [99, 125], 'inhibitors': [101, 127], 'dissociate': [103], 'from': [105], 'ribosomes)': [106, 135], 'mimick': [107], 'negative': [109], 'effect': [110], 'specific': [113], 'repressor': [115], 'on': [117], 'length,': [120], 'whereas': [121], 'cycloheximide': [122], 'anisomycin': [124], 'maintain': [129], 'association': [131, 143], 'between': [132, 175], 'preserve': [136], 'long': [137], 'tails.': [139], 'Thus,': [140], 'ribosome': [142], 'appears': [147], 'represent': [149], 'critical': [151], 'determinant.': [152], 'These': [153], 'findings': [154], 'identify': [155], 'novel': [157], 'regulated': [160], 'polyadenylation': [161], 'as': [162], 'consequence': [164], 'control.': [167], 'They': [168], 'reveal': [169], 'differences': [170], 'metabolism': [174], 'polysomal': [176], 'mRNP-associated': [178], 'mRNAs.': [179], 'A': [180], 'possible': [181], 'maintenance': [188], 'discussed.': [193]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2145057484', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-14T18:32:52.239905', 'created_date': '2016-06-24'}