Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2145014826', 'doi': 'https://doi.org/10.1128/aem.01138-14', 'title': 'Analysis of Strains Lacking Known Osmolyte Accumulation Mechanisms Reveals Contributions of Osmolytes and Transporters to Protection against Abiotic Stress', 'display_name': 'Analysis of Strains Lacking Known Osmolyte Accumulation Mechanisms Reveals Contributions of Osmolytes and Transporters to Protection against Abiotic Stress', 'publication_year': 2014, 'publication_date': '2014-09-01', 'ids': {'openalex': 'https://openalex.org/W2145014826', 'doi': 'https://doi.org/10.1128/aem.01138-14', 'mag': '2145014826', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24951793', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4136119'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aem.01138-14', 'pdf_url': 'https://aem.asm.org/content/aem/80/17/5366.full.pdf', 'source': {'id': 'https://openalex.org/S158228368', 'display_name': 'Applied and Environmental Microbiology', 'issn_l': '0099-2240', 'issn': ['0099-2240', '1070-6291', '1098-5336'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://aem.asm.org/content/aem/80/17/5366.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079492749', 'display_name': 'Lindsay Murdock', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Lindsay Murdock', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada', 'institution_ids': ['https://openalex.org/I79817857']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055017013', 'display_name': 'Tangi Burke', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Tangi Burke', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada', 'institution_ids': ['https://openalex.org/I79817857']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039781813', 'display_name': 'Chelsea Coumoundouros', 'orcid': 'https://orcid.org/0000-0001-5539-974X'}, 'institutions': [{'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Chelsea Coumoundouros', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada', 'institution_ids': ['https://openalex.org/I79817857']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036039634', 'display_name': 'Doreen E. Culham', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Doreen E. Culham', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada', 'institution_ids': ['https://openalex.org/I79817857']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083362309', 'display_name': 'Charles E. Deutch', 'orcid': 'https://orcid.org/0000-0002-2182-854X'}, 'institutions': [{'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}, {'id': 'https://openalex.org/I55732556', 'display_name': 'Arizona State University', 'ror': 'https://ror.org/03efmqc40', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55732556']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Charles E. Deutch', 'raw_affiliation_strings': ['aDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada', 'bSchool of Mathematical and Natural Sciences, Arizona State University at the West Campus, Phoenix, Arizona, USA'], 'affiliations': [{'raw_affiliation_string': 'aDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada', 'institution_ids': ['https://openalex.org/I79817857']}, {'raw_affiliation_string': 'bSchool of Mathematical and Natural Sciences, Arizona State University at the West Campus, Phoenix, Arizona, USA', 'institution_ids': ['https://openalex.org/I55732556']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070831180', 'display_name': 'James J. Ellinger', 'orcid': 'https://orcid.org/0000-0002-8477-901X'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James Ellinger', 'raw_affiliation_strings': ['Department of Biochemistry, University of Wisconsin, Madison, Madison, Wisconsin, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Wisconsin, Madison, Madison, Wisconsin, USA', 'institution_ids': ['https://openalex.org/I135310074']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004117199', 'display_name': 'Craig H. Kerr', 'orcid': 'https://orcid.org/0000-0002-4793-2855'}, 'institutions': [{'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Craig H. Kerr', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada', 'institution_ids': ['https://openalex.org/I79817857']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064157402', 'display_name': 'Samantha M. Plater', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Samantha M. Plater', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada', 'institution_ids': ['https://openalex.org/I79817857']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001438410', 'display_name': 'Eric To', 'orcid': 'https://orcid.org/0000-0001-7812-823X'}, 'institutions': [{'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Eric To', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada', 'institution_ids': ['https://openalex.org/I79817857']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013556483', 'display_name': 'Geordie Wright', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Geordie Wright', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada', 'institution_ids': ['https://openalex.org/I79817857']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048414850', 'display_name': 'Janet M. Wood', 'orcid': 'https://orcid.org/0000-0002-0349-4638'}, 'institutions': [{'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Janet M. Wood', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada', 'institution_ids': ['https://openalex.org/I79817857']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.509, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.881649, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '80', 'issue': '17', 'first_page': '5366', 'last_page': '5378'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10724', 'display_name': 'Molecular Mechanisms of Aquaporins in Physiology and Disease', 'score': 0.9579, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10724', 'display_name': 'Molecular Mechanisms of Aquaporins in Physiology and Disease', 'score': 0.9579, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Transport and Metabolism in Health and Disease', 'score': 0.9556, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10066', 'display_name': 'Diversity and Function of Gut Microbiome', 'score': 0.9555, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/osmolyte', 'display_name': 'Osmolyte', 'score': 0.9911287}, {'id': 'https://openalex.org/keywords/betaine', 'display_name': 'Betaine', 'score': 0.94602156}, {'id': 'https://openalex.org/keywords/dimethylsulfoniopropionate', 'display_name': 'Dimethylsulfoniopropionate', 'score': 0.88231546}, {'id': 'https://openalex.org/keywords/obesity-associated-microbiome', 'display_name': 'Obesity-associated Microbiome', 'score': 0.516449}, {'id': 'https://openalex.org/keywords/osmotic-shock', 'display_name': 'Osmotic shock', 'score': 0.4996009}, {'id': 'https://openalex.org/keywords/ectoine', 'display_name': 'Ectoine', 'score': 0.42614505}], 'concepts': [{'id': 'https://openalex.org/C127160389', 'wikidata': 'https://www.wikidata.org/wiki/Q415608', 'display_name': 'Osmolyte', 'level': 2, 'score': 0.9911287}, {'id': 'https://openalex.org/C26448091', 'wikidata': 'https://www.wikidata.org/wiki/Q176686', 'display_name': 'Osmoprotectant', 'level': 4, 'score': 0.9658426}, {'id': 'https://openalex.org/C2777248517', 'wikidata': 'https://www.wikidata.org/wiki/Q72052841', 'display_name': 'Betaine', 'level': 2, 'score': 0.94602156}, {'id': 'https://openalex.org/C2777593447', 'wikidata': 'https://www.wikidata.org/wiki/Q3817447', 'display_name': 'Dimethylsulfoniopropionate', 'level': 4, 'score': 0.88231546}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.67322797}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.6206144}, {'id': 'https://openalex.org/C2778452849', 'wikidata': 'https://www.wikidata.org/wiki/Q421773', 'display_name': 'Trehalose', 'level': 2, 'score': 0.5241285}, {'id': 'https://openalex.org/C168529131', 'wikidata': 'https://www.wikidata.org/wiki/Q13656562', 'display_name': 'Osmotic shock', 'level': 3, 'score': 0.4996009}, {'id': 'https://openalex.org/C2777756961', 'wikidata': 'https://www.wikidata.org/wiki/Q620730', 'display_name': 'Glycine', 'level': 3, 'score': 0.47915286}, {'id': 'https://openalex.org/C89519541', 'wikidata': 'https://www.wikidata.org/wiki/Q4667893', 'display_name': 'Abiotic stress', 'level': 3, 'score': 0.47872493}, {'id': 'https://openalex.org/C2780929338', 'wikidata': 'https://www.wikidata.org/wiki/Q414414', 'display_name': 'Ectoine', 'level': 5, 'score': 0.42614505}, {'id': 'https://openalex.org/C2779815552', 'wikidata': 'https://www.wikidata.org/wiki/Q484583', 'display_name': 'Proline', 'level': 3, 'score': 0.40347046}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.24215874}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.056738555}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2780892065', 'wikidata': 'https://www.wikidata.org/wiki/Q184755', 'display_name': 'Phytoplankton', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C142796444', 'wikidata': 'https://www.wikidata.org/wiki/Q181394', 'display_name': 'Nutrient', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001622', 'descriptor_name': 'Betaine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003470', 'descriptor_name': 'Culture Media', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008744', 'descriptor_name': 'Methylamines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009997', 'descriptor_name': 'Osmotic Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011392', 'descriptor_name': 'Proline', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012965', 'descriptor_name': 'Sodium Chloride', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013312', 'descriptor_name': 'Stress, Physiological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013452', 'descriptor_name': 'Sulfonium Compounds', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013696', 'descriptor_name': 'Temperature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014508', 'descriptor_name': 'Urea', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aem.01138-14', 'pdf_url': 'https://aem.asm.org/content/aem/80/17/5366.full.pdf', 'source': {'id': 'https://openalex.org/S158228368', 'display_name': 'Applied and Environmental Microbiology', 'issn_l': '0099-2240', 'issn': ['0099-2240', '1070-6291', '1098-5336'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4136119', 'pdf_url': 'https://europepmc.org/articles/pmc4136119?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136119', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24951793', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aem.01138-14', 'pdf_url': 'https://aem.asm.org/content/aem/80/17/5366.full.pdf', 'source': {'id': 'https://openalex.org/S158228368', 'display_name': 'Applied and Environmental Microbiology', 'issn_l': '0099-2240', 'issn': ['0099-2240', '1070-6291', '1098-5336'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 74, 'referenced_works': ['https://openalex.org/W139261800', 'https://openalex.org/W1512810258', 'https://openalex.org/W1538213312', 'https://openalex.org/W1546783991', 'https://openalex.org/W1549818014', 'https://openalex.org/W1564269649', 'https://openalex.org/W1581978506', 'https://openalex.org/W1596478298', 'https://openalex.org/W1642602682', 'https://openalex.org/W1694960344', 'https://openalex.org/W1781531090', 'https://openalex.org/W1824289027', 'https://openalex.org/W185570573', 'https://openalex.org/W1918140755', 'https://openalex.org/W1930253951', 'https://openalex.org/W1967039644', 'https://openalex.org/W1977306382', 'https://openalex.org/W1982088862', 'https://openalex.org/W1982762997', 'https://openalex.org/W1986678287', 'https://openalex.org/W1991157642', 'https://openalex.org/W1993032194', 'https://openalex.org/W1995264942', 'https://openalex.org/W2000863036', 'https://openalex.org/W2006265229', 'https://openalex.org/W2008481607', 'https://openalex.org/W2010321216', 'https://openalex.org/W2017539531', 'https://openalex.org/W2018746058', 'https://openalex.org/W2023002165', 'https://openalex.org/W2030007840', 'https://openalex.org/W2039501073', 'https://openalex.org/W2049645892', 'https://openalex.org/W2059356919', 'https://openalex.org/W2062028366', 'https://openalex.org/W2063968553', 'https://openalex.org/W2067350232', 'https://openalex.org/W2073641569', 'https://openalex.org/W2073644005', 'https://openalex.org/W2077707986', 'https://openalex.org/W2099338122', 'https://openalex.org/W2102021856', 'https://openalex.org/W2102954241', 'https://openalex.org/W2104368889', 'https://openalex.org/W2111967267', 'https://openalex.org/W2116038970', 'https://openalex.org/W2116137883', 'https://openalex.org/W2116307528', 'https://openalex.org/W2123779514', 'https://openalex.org/W2126040811', 'https://openalex.org/W2134153749', 'https://openalex.org/W2135684970', 'https://openalex.org/W2136252045', 'https://openalex.org/W2143019272', 'https://openalex.org/W2144962786', 'https://openalex.org/W2146648724', 'https://openalex.org/W2148874125', 'https://openalex.org/W2153139855', 'https://openalex.org/W2155031737', 'https://openalex.org/W2155144946', 'https://openalex.org/W2156349857', 'https://openalex.org/W2156424600', 'https://openalex.org/W2157531772', 'https://openalex.org/W2158774060', 'https://openalex.org/W2164103857', 'https://openalex.org/W2167322308', 'https://openalex.org/W2169821755', 'https://openalex.org/W2322957911', 'https://openalex.org/W2332972504', 'https://openalex.org/W2411489959', 'https://openalex.org/W393356442', 'https://openalex.org/W4232534952', 'https://openalex.org/W4234493244', 'https://openalex.org/W93876421'], 'related_works': ['https://openalex.org/W3111003289', 'https://openalex.org/W3008656054', 'https://openalex.org/W2739387798', 'https://openalex.org/W2150961695', 'https://openalex.org/W2113203114', 'https://openalex.org/W2112622077', 'https://openalex.org/W2088293635', 'https://openalex.org/W2014458954', 'https://openalex.org/W1642602682', 'https://openalex.org/W1530026900'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Osmolyte': [1], 'accumulation': [2, 20, 37, 114], 'and': [3, 41, 55, 79, 88, 109, 121, 143, 152, 179, 187, 199, 214, 226], 'release': [4], 'can': [5], 'protect': [6], 'cells': [7], 'from': [8, 235], 'abiotic': [9, 46], 'stresses.': [10], 'In': [11], 'Escherichia': [12], 'coli': [13], ',': [14], 'known': [15, 61, 100, 136], 'mechanisms': [16, 38], 'mediate': [17, 168], 'osmotic': [18], 'stress-induced': [19], 'of': [21, 50, 99, 127, 222], 'K': [22], '+': [23], 'glutamate,': [24], 'trehalose,': [25], 'or': [26, 101, 176], 'zwitterions': [27], 'like': [28], 'glycine': [29, 223], 'betaine.': [30], 'Previous': [31], 'observations': [32], 'suggested': [33], 'that': [34], 'additional': [35], 'osmolyte': [36, 113], '(OAMs)': [39], 'exist': [40], 'their': [42, 232, 240, 247, 254], 'impacts': [43], 'may': [44], 'be': [45], 'stress': [47, 250], 'specific.': [48], 'Derivatives': [49], 'the': [51, 56, 128, 203, 258], 'uropathogenic': [52], 'strain': [53, 58], 'CFT073': [54, 65, 78, 105], 'laboratory': [57], 'MG1655': [59, 130, 158], 'lacking': [60], 'OAMs': [62, 162], 'were': [63, 156, 163, 170, 192, 202], 'created.': [64, 164], 'grew': [66, 83], 'without': [67, 175], 'osmoprotectants': [68, 139, 229], 'in': [69, 86, 117, 189], 'minimal': [70], 'medium': [71], 'with': [72, 148, 177, 231, 239, 253], 'up': [73], 'to': [74, 115, 167, 242, 256], '0.9': [75], 'M': [76], 'NaCl.': [77], 'its': [80], 'OAM-deficient': [81, 129], 'derivative': [82, 131], 'equally': [84], 'well': [85], 'high-': [87], 'low-osmolality': [89], 'urine': [90], 'pools.': [91], 'Urine-grown': [92], 'bacteria': [93], 'did': [94, 110, 140], 'not': [95, 111, 184, 238], 'accumulate': [96], 'large': [97], 'amounts': [98], 'novel': [102, 154], 'osmolytes.': [103], 'Thus,': [104, 246], 'showed': [106], 'unusual': [107], 'osmotolerance': [108], 'require': [112], 'grow': [116], 'urine.': [118], 'Yeast': [119], 'extract': [120], 'brain': [122], 'heart': [123], 'infusion': [124], 'stimulated': [125], 'growth': [126, 147], 'at': [132, 172], 'high': [133], 'salinity.': [134], 'Neither': [135], 'nor': [137], 'putative': [138], 'so.': [141], 'Glutamate': [142], 'glutamine': [144], 'accumulated': [145], 'after': [146], 'either': [149], 'organic': [150], 'mixture,': [151], 'no': [153], 'osmolytes': [155], 'detected.': [157], 'derivatives': [159], 'retaining': [160], 'individual': [161], 'Their': [165], 'abilities': [166], 'osmoprotection': [169], 'compared': [171], '15°C,': [173], '37°C': [174], 'urea,': [178], '42°C.': [180], 'Stress': [181], 'protection': [182], 'was': [183, 210], 'OAM': [185], 'specific,': [186], 'variations': [188], 'osmoprotectant': [190, 213], 'effectiveness': [191, 221, 248], 'similar': [193], 'under': [194], 'all': [195], 'conditions.': [196], 'Glycine': [197], 'betaine': [198], 'dimethylsulfoniopropionate': [200], '(DMSP)': [201], 'most': [204], 'effective.': [205], 'Trimethylamine-': [206], 'N': [207], '-oxide': [208], '(TMAO)': [209], 'a': [211, 215], 'weak': [212], 'particularly': [216], 'effective': [217], 'urea': [218], 'protectant.': [219], 'The': [220], 'betaine,': [224], 'TMAO,': [225], 'proline': [227], 'as': [228, 249], 'correlated': [230, 252], 'preferential': [233], 'exclusion': [234], 'protein': [236, 244], 'surfaces,': [237], 'propensity': [241], 'prevent': [243], 'denaturation.': [245], 'protectants': [251], 'ability': [255], 'rehydrate': [257], 'cytoplasm.': [259]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2145014826', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-09-01T12:06:44.428296', 'created_date': '2016-06-24'}