Publication Information

{'id': 'https://openalex.org/W2144846362', 'doi': 'https://doi.org/10.2174/092986707781696609', 'title': 'Sublingual Allergen Immunotherapy: Immunological Mechanisms and Prospects for Refined Vaccine Preparations', 'display_name': 'Sublingual Allergen Immunotherapy: Immunological Mechanisms and Prospects for Refined Vaccine Preparations', 'publication_year': 2007, 'publication_date': '2007-08-30', 'ids': {'openalex': 'https://openalex.org/W2144846362', 'doi': 'https://doi.org/10.2174/092986707781696609', 'mag': '2144846362', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17896972'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/092986707781696609', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33159018', 'display_name': 'Current Medicinal Chemistry', 'issn_l': '0929-8673', 'issn': ['0929-8673', '1875-533X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034240834', 'display_name': 'Robyn E. O’Hehir', 'orcid': 'https://orcid.org/0000-0002-3489-7595'}, 'institutions': [{'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': "R. O'Hehir", 'raw_affiliation_strings': ['Department of Immunology, Monash University, Melbourne, Australia,'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Monash University, Melbourne, Australia,', 'institution_ids': ['https://openalex.org/I56590836']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064784990', 'display_name': 'Alessandra Sandrini', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A. Sandrini', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008084743', 'display_name': 'Gary P. Anderson', 'orcid': 'https://orcid.org/0000-0001-6580-3398'}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'G. Anderson', 'raw_affiliation_strings': ['University of Melbourne'], 'affiliations': [{'raw_affiliation_string': 'University of Melbourne', 'institution_ids': ['https://openalex.org/I165779595']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029225979', 'display_name': 'Jennifer M. Rolland', 'orcid': 'https://orcid.org/0000-0002-7891-983X'}, 'institutions': [{'id': 'https://openalex.org/I2801993434', 'display_name': 'The Alfred Hospital', 'ror': 'https://ror.org/01wddqe20', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801993434', 'https://openalex.org/I4210163178']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'J. Rolland', 'raw_affiliation_strings': ['Immunology Alfred Hospital'], 'affiliations': [{'raw_affiliation_string': 'Immunology Alfred Hospital', 'institution_ids': ['https://openalex.org/I2801993434']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.517, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 28, 'citation_normalized_percentile': {'value': 0.311037, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '14', 'issue': '21', 'first_page': '2235', 'last_page': '2244'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10877', 'display_name': 'Allergic Rhinitis and Sensitization', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10877', 'display_name': 'Allergic Rhinitis and Sensitization', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12438', 'display_name': 'Urticaria and Related Conditions', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10634', 'display_name': 'Food Allergy and Anaphylaxis Research', 'score': 0.989, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sublingual-immunotherapy', 'display_name': 'Sublingual Immunotherapy', 'score': 0.72426903}, {'id': 'https://openalex.org/keywords/allergen-immunotherapy', 'display_name': 'Allergen Immunotherapy', 'score': 0.5816983}], 'concepts': [{'id': 'https://openalex.org/C2777037608', 'wikidata': 'https://www.wikidata.org/wiki/Q1641412', 'display_name': 'Sublingual immunotherapy', 'level': 4, 'score': 0.72426903}, {'id': 'https://openalex.org/C2780510475', 'wikidata': 'https://www.wikidata.org/wiki/Q186752', 'display_name': 'Allergen', 'level': 3, 'score': 0.6809567}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.64378124}, {'id': 'https://openalex.org/C2779787640', 'wikidata': 'https://www.wikidata.org/wiki/Q1641412', 'display_name': 'Allergen immunotherapy', 'level': 4, 'score': 0.5816983}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.53142476}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.44334224}, {'id': 'https://openalex.org/C2779779143', 'wikidata': 'https://www.wikidata.org/wiki/Q3493547', 'display_name': 'Desensitization (medicine)', 'level': 3, 'score': 0.41622695}, {'id': 'https://openalex.org/C207480886', 'wikidata': 'https://www.wikidata.org/wiki/Q42982', 'display_name': 'Allergy', 'level': 2, 'score': 0.36206186}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.15483582}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0382998}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000485', 'descriptor_name': 'Allergens', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000485', 'descriptor_name': 'Allergens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003888', 'descriptor_name': 'Desensitization, Immunologic', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D012130', 'descriptor_name': 'Respiratory Hypersensitivity', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000286', 'descriptor_name': 'Administration, Sublingual', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000485', 'descriptor_name': 'Allergens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D003888', 'descriptor_name': 'Desensitization, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007136', 'descriptor_name': 'Immunoglobulins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007136', 'descriptor_name': 'Immunoglobulins', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D012130', 'descriptor_name': 'Respiratory Hypersensitivity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012130', 'descriptor_name': 'Respiratory Hypersensitivity', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D014612', 'descriptor_name': 'Vaccines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/092986707781696609', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33159018', 'display_name': 'Current Medicinal Chemistry', 'issn_l': '0929-8673', 'issn': ['0929-8673', '1875-533X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17896972', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.68, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4246587793', 'https://openalex.org/W4237140026', 'https://openalex.org/W2989824091', 'https://openalex.org/W2607590955', 'https://openalex.org/W2592751581', 'https://openalex.org/W2409605539', 'https://openalex.org/W2383002280', 'https://openalex.org/W2101014936', 'https://openalex.org/W2032428509', 'https://openalex.org/W1972171744'], 'abstract_inverted_index': {'Allergic': [0], 'diseases': [1], 'constitute': [2], 'a': [3, 95, 187], 'major': [4], 'health': [5], 'issue': [6], 'worldwide.': [7], 'Mainstay': [8], 'treatment': [9, 25, 274], 'constitutes': [10], 'allergen': [11, 19, 51, 59, 106, 116, 195, 214, 248, 266], 'avoidance': [12], 'and': [13, 30, 77, 79, 99, 121, 129, 148, 250, 268], 'pharmacotherapy': [14], 'for': [15, 71, 80, 118, 156, 223, 256, 271], 'symptom': [16], 'relief,': [17], 'but': [18, 53], 'immunotherapy': [20, 41, 107, 117, 158], 'offers': [21], 'advantages': [22], 'of': [23, 37, 46, 50, 56, 66, 90, 103, 105, 140, 150, 230, 234, 251, 264, 273], 'specific': [24], 'with': [26, 218, 227], 'long': [27], 'lasting': [28], 'efficacy,': [29], 'being': [31], 'able': [32], 'to': [33, 85, 160, 163, 220, 241], 'modify': [34], 'the': [35, 38, 43, 54, 64, 100, 161, 173, 231, 235, 257, 262], 'course': [36], 'disease.': [39], 'Conventional': [40], 'involves': [42], 'subcutaneous': [44], 'injection': [45, 132, 157], 'gradually': [47], 'increasing': [48], 'amounts': [49], 'extract': [52], 'use': [55], 'current': [57], 'whole': [58], 'extracts': [60], 'is': [61, 94, 108, 126, 169, 196, 239], 'restricted': [62], 'by': [63], 'risk': [65], 'adverse': [67, 278], 'IgE-mediated': [68, 277], 'events': [69], 'especially': [70, 193], 'potent': [72], 'allergens': [73], 'such': [74], 'as': [75, 154], 'peanut': [76], 'latex': [78], 'asthmatics.': [81], 'This': [82, 204], 'has': [83], 'lead': [84], 'interest': [86], 'in': [87, 190], 'alternative': [88], 'routes': [89], 'immunotherapy.': [91, 133], 'Oral': [92], 'tolerance': [93, 192], 'well-documented': [96], 'immune': [97, 144], 'process': [98], 'sublingual': [101, 115, 258], 'route': [102, 259], 'administration': [104], 'attracting': [109], 'interest.': [110], 'Recent': [111], 'meta-analyses': [112], 'show': [113, 136], 'that': [114, 172, 182, 206], 'grass': [119], 'pollen': [120], 'house': [122], 'dust': [123], 'mite': [124], 'allergy': [125], 'clinically': [127], 'effective': [128], 'safer': [130], 'than': [131], 'Some': [134], 'studies': [135], 'SLIT': [137, 225], 'induces': [138], 'changes': [139], 'T': [141, 152, 166, 212, 286], 'cell': [142, 287, 295], 'anergy,': [143], 'deviation,': [145], 'blocking': [146], 'antibodies,': [147], 'induction': [149], 'regulatory': [151, 178], 'cells,': [153, 167, 213], 'described': [155], 'pointing': [159], 'need': [162], 'target': [164, 210], 'allergen-specific': [165, 211], 'there': [168], 'emergent': [170], 'evidence': [171], 'oral': [174, 183, 284], 'mucosa': [175], 'presents': [176], 'distinct': [177], 'features.': [179], 'Evidence': [180], 'suggests': [181, 205], 'dendritic': [184, 294], 'cells': [185], 'play': [186], 'key': [188], 'role': [189], 'inducing': [191], 'when': [194], 'taken': [197], 'up': [198], 'via': [199], 'Fc': [200], 'receptor': [201, 237], 'bound': [202], 'IgE.': [203], 'although': [207], 'both': [208], 'would': [209], 'formulations': [215, 267], 'may': [216], 'differ': [217], 'respect': [219], 'IgE': [221, 292], 'epitopes': [222], 'optimal': [224], 'compared': [226], 'SCIT.': [228], 'Identification': [229], 'molecular': [232], 'nature': [233], 'allergen-DC': [236], 'interaction': [238], 'required': [240], 'determine': [242], 'whether': [243], 'short': [244], 'peptides': [245], 'or': [246], 'recombinant': [247, 290], 'preparations': [249], 'suitable': [252], 'adjuvants': [253], 'specifically': [254], 'tailored': [255], 'will': [260], 'allow': [261], 'development': [263], 'improved': [265], 'delivery': [269], 'strategies': [270], 'efficacy': [272], 'whilst': [275], 'decreasing': [276], 'effects.': [279], 'Keywords:': [280], 'Allergen,': [281], 'immunotherapy,': [282], 'sublingual,': [283], 'tolerance,': [285], 'epitope,': [288], 'peptide,': [289], 'allergen,': [291], 'antibody,': [293]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2144846362', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T07:53:45.363771', 'created_date': '2016-06-24'}