AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2011 Update

Name: Work Video:
Duration: 3 min 30 s
Sidney C. Smith; Emelia J. Benjamin; Robert O. Bonow; Lynne T. Braun; Mark A. Creager; Barry A. Franklin; Raymond J. Gibbons; Scott M. Grundy; Loren F. Hiratzka; Daniel W. Jones; Donald M. Lloyd‐Jones; Margo Minissian; Lori Mosca; Eric D. Peterson; Ralph L. Sacco; John A. Spertus; James H. Stein; Kathryn A. Taubert
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4036, 4066, 4103], 'not': [575, 723, 970, 1329, 1358, 1433, 1866, 2426, 2576, 2856, 3151, 3235, 3251, 3565, 3682, 3729, 3754, 3764], 'only': [576], 'healthcare': [579, 590], 'provider': [580], 'implement': [581], 'these': [582, 712, 759, 4060], 'recommendations': [583, 621, 629, 698, 975, 993, 1132, 3314, 3685, 3776, 3798, 3821, 3883, 3890, 3911, 4020], 'but': [587, 722, 2864, 3480], 'also': [588, 3873], 'systems': [591], 'support': [592, 3328], 'implementation': [594], 'maximize': [596], 'benefit': [598, 2314, 3432, 3645, 3977], 'patient.Compelling': [601], 'evidence-based': [602, 623], 'results': [603, 669, 3926, 3969, 3990], 'revised': [609], 'practice': [610, 652, 663, 3877], 'provide': [612], 'impetus': [614], 'results2–165': [624], '(Table': [625], '1).': [626], 'Classification': [627, 3210, 3219], 'level': [631, 3668, 3709, 3749], 'expressed': [635], 'ACCF/AHA': [637, 662], 'format,': [638], 'detailed': [640], 'Table': [642], '2.': [643, 3208, 3217], 'Recommendations': [644, 837, 1802], 'made': [645, 3795, 3823], 'herein': [646], 'largely': [648], 'based': [649, 1882], 'major': [651, 3081, 3876], 'National': [656, 813, 3016, 3023, 3379, 3809, 3842, 3849], 'Institutes': [657, 814], 'Health': [659], 'updated': [661, 999, 1138, 3815, 3838], 'guidelines,': [664, 3861], 'well': [666, 2427, 2577], 'trials.': [673, 3256], 'Thus,': [674, 3651, 3888], 'development': [676, 908], 'present': [679, 3886, 3958], 'involved': [681], 'process': [683], 'partial': [685], 'adaptation': [686], 'statements': [690], 'reports': [692], 'supplemental': [694, 714], 'literature': [695, 715], 'searches.': [696], 'The': [697, 966, 987, 1126, 1422, 1615, 1764, 2410, 2514, 2565, 3497, 3786, 3957, 3968, 3989], 'listed': [699, 3662], 'document': [702], 'are,': [703], 'whenever': [704], 'possible,': [705], 'based.': [707], 'Writing': [708], 'members': [710], 'performed': [711], 'relevant': [713], 'searches': [716, 757, 775], 'key': [718], 'search': [719], 'phrases': [720], 'limited': [724, 777, 1939, 2668], 'tobacco/smoking/smoking': [726], 'cessation;': [727], 'blood': [728, 977, 1043, 1054, 1074, 1837, 1879], 'pressure': [729, 961, 978, 1044, 1055, 1838], 'control/hypertension;': [730], 'cholesterol/hypercholesterolemia/lipids/lipoproteins/dyslipidemia;': [731], 'physical': [732, 1019, 1174, 1598, 1701, 1833], 'activity/exercise/exercise': [733], 'training;': [734], 'weight': [735, 1016, 1177, 1693, 1759, 1768, 1776, 1787, 1835], 'management/overweight/obesity;': [736], 'type': [737], '2': [738, 1648, 1798, 3427, 3716], 'diabetes': [739, 1799, 1813, 2632, 3699], 'mellitus': [740, 1800, 3700], 'management;': [741], 'antiplatelet': [742, 2174], 'agents/anticoagulants;': [743], 'renin/angiotensin/aldosterone': [744], 'system': [745, 2460, 4114], 'blockers;': [746], 'β-blockers;': [747], 'influenza': [748, 2804, 4086, 4101], 'vaccination;': [749], 'depression/depression': [751], 'screening;': [752], 'cardiac/cardiovascular': [754], 'rehabilitation.': [755], 'Additional': [756], 'cross-referenced': [758], 'topics': [760], 'subtopics': [763], 'trials,': [766], 'prevention,': [768], 'atherosclerosis,': [769], 'coronary/cerebral/peripheral': [771], 'These': [774, 3391, 3449], 'were': [776, 3371, 3822, 3904], 'studies,': [779], 'reviews,': [780], 'conducted': [784], 'human': [786], 'subjects': [787], 'published': [789, 805, 3354], 'English.': [791], 'addition,': [793, 3482], 'reviewed': [797, 996, 1135], 'documents': [798], 'related': [799, 1627], 'subject': [802], 'matter': [803], 'previously': [804], 'AHA,': [808], 'ACCF,': [810], 'Health.Table': [816], '1.': [817], 'AHA/ACCF': [818], 'Update:': [835], 'Intervention': [836], 'Class': [839, 4061], 'Recommendation': [841, 3212, 3221], 'Level': [843, 3214, 3223, 3228, 3319], 'EvidenceArea': [845], 'InterventionRecommendationsSmoking': [847], 'Goal:': [848, 1511], 'Complete': [849], 'cessation.': [850], 'No': [851], 'exposure': [852, 947, 3195], 'environmental': [854, 949], 'tobacco': [855, 862, 873, 886, 950], 'smokeClass': [856], 'IPatients': [857], 'should': [858, 875, 891, 901, 938, 981, 1007, 1048, 1111, 1150, 1162, 1193, 1228, 1248, 1275, 1295, 1530, 1617, 1681, 1690, 1753, 1771, 1814, 2057, 2078, 2154, 2186, 2242, 2256, 2265, 2296, 2467, 2642, 2666, 2687, 2800, 2895, 2956, 3176, 3187, 3200, 3204, 3334, 3464, 3523, 3606], 'asked': [860], 'about': [861, 3286, 3736], 'use': [863, 1084, 1423, 2364, 2502, 2515, 2552, 2566, 3127, 3330, 3893], 'status': [864, 2885], 'at': [865, 878, 894, 941, 952, 984, 1259, 1398, 1544, 1565, 1646, 1684, 1732, 2061, 3494, 3528, 4001, 4118], 'every': [866, 879, 895, 942, 1685], 'office': [867, 943, 2915], 'visit.2,3,4,5,7)': [868], '(Level': [869, 897, 933, 1310, 1446, 1474, 1630, 1794, 1825, 1850, 1892, 1908, 1920, 1964, 2329, 2405, 2768, 2790, 2934, 2940, 2948], 'Evidence:': [871, 884, 899, 926, 935, 959, 1039, 1077, 1168, 1186, 1218, 1241, 1267, 1287, 1312, 1352, 1372, 1392, 1417, 1448, 1469, 1476, 1507, 1589, 1613, 1632, 1653, 1725, 1762, 1796, 1827, 1852, 1869, 1894, 1910, 1922, 1966, 1986, 2007, 2029, 2066, 2109, 2160, 2192, 2216, 2246, 2278, 2301, 2331, 2378, 2407, 2430, 2458, 2495, 2510, 2545, 2562, 2586, 2637, 2683, 2711, 2742, 2770, 2792, 2807, 2849, 2874, 2918, 2936, 2942, 2950, 2983, 3009], 'B)Every': [872], 'user': [874], 'advised': [877, 940], 'visit': [880, 944], 'quit.4,5,7,9(Level': [882], 'A)The': [885], "user's": [887], 'willingness': [888], 'quit': [890], 'visit.': [896], 'C)Patients': [900], 'assisted': [903], 'counseling': [905], 'plan': [911], 'quitting': [913], 'may': [915, 1426, 1478, 1485, 1905, 1917, 1928, 2447, 2774, 2865, 3263, 3543], 'include': [916, 1194], 'pharmacotherapy': [917, 1860, 1899], 'and/or': [918, 1061, 1367, 1444, 1601, 1678, 1823, 2286, 2944, 4046], 'referral': [919], 'smoking': [922], 'cessation': [923], 'program.4–9(Level': [924], 'A)Arrangement': [927], 'follow': [929], 'up': [930], 'recommended.': [932], 'C)All': [936], 'avoid': [946, 3733], 'smoke': [951], 'work,': [953, 1566], 'home,': [954], 'public': [956], 'places.10,11(Level': [957], 'B)Blood': [960], 'controlGoal:': [962], '<140/90': [963], 'mm': [964, 1046], 'HgNote:': [965], 'committee': [968, 989, 1128], 'did': [969], 'think': [971], 'control': [979], '(below)': [980], 'modified': [983], 'time.': [986], 'anticipates': [990, 1129], 'will': [994, 1133], 'when': [997, 1136, 1711, 3135, 3143, 3511], 'JNC': [1000], 'released.Class': [1003, 1142], 'I1.': [1004, 1143, 1674, 1810, 1969, 2464, 2513, 2590, 2639, 2795, 2877], 'All': [1005, 2878, 2920], 'counseled': [1009], 'regarding': [1010, 3912], 'lifestyle': [1014, 1224, 1560, 1700, 1751], 'modification:': [1015], 'control;': [1017], 'increased': [1018, 1028, 2291, 4119], 'activity;': [1020], 'alcohol': [1021], 'moderation;': [1022], 'sodium': [1023], 'reduction;': [1024], 'emphasis': [1026], 'consumption': [1029], 'fresh': [1031], 'fruits,': [1032], 'vegetables,': [1033], 'low-fat': [1035], 'dairy': [1036], 'products.12–16(Level': [1037], 'B)2.': [1040, 1169, 1353, 1590, 1726, 2008, 2431, 2743], '≥140/90': [1045], 'Hg': [1047], 'treated,': [1050], 'tolerated,': [1052], 'medication,': [1056], 'treating': [1057], 'initially': [1058], 'β-blockers': [1060, 2719], 'ACE': [1062, 2462, 2465, 2503, 2573, 2616], 'inhibitors,': [1063], 'addition': [1065, 1221, 1302], 'drugs': [1068], 'needed': [1070], 'achieve': [1072, 1088, 1330, 1436, 1902, 2269, 3527, 3583], 'goal': [1073, 1332, 1410, 1766, 1955, 3440, 3724], 'pressure.12,17,18(Level': [1075], 'A)Lipid': [1078], 'managementGoal:': [1079], 'Treatment': [1080, 2852, 3030, 3041, 3386, 3856], 'statin': [1082, 1085, 1226, 1247, 1304, 1319, 1383, 1462, 3163, 3521, 3548], 'therapy;': [1083], 'therapy': [1086, 1158, 1189, 1227, 1300, 1305, 1341, 1362, 1384, 1770, 2175, 2195, 2202, 2264, 2318, 2433, 2641, 2686, 2725, 2750, 2779, 3275, 3501, 3522, 3549, 3981, 3998, 4023, 4065], 'an': [1089, 1099, 1456, 1556, 1602, 1696, 1857, 1994, 2572, 2615, 2802, 3517], 'LDL-C': [1090, 1100, 1253, 1387, 1438, 3489, 3512, 3569, 3584, 3626, 3639, 3723], '<100': [1092, 1117, 1255, 1412, 3466, 3726], 'mg/dL;': [1093], 'very': [1095, 1120, 1379, 1399, 3266, 3400], 'high': [1096, 1121, 1400, 3106, 3575], 'risk*': [1097, 1401], '<70': [1101, 1389, 3490, 3537, 3570, 3751], 'mg/dL': [1102, 1118, 1256, 1274, 1294, 1413, 3109, 3113, 3139, 3467, 3491, 3538, 3571, 3727, 3752], 'reasonable;': [1104], 'if': [1105, 1792, 1865, 2829, 3562], 'triglycerides': [1106, 1272, 1292, 1405, 3107, 3136, 3144], '≥200': [1108, 1273, 1406, 3108, 3138, 3600], 'mg/dL,': [1109, 1114, 1407, 3516, 3601], 'non–HDL-C†': [1110], '<130': [1113, 1284], 'whereas': [1115], 'non–HDL-C': [1116, 1282, 1409, 1458, 3111, 3628], 'reasonableNote:': [1125], 'ATP': [1139, 3425, 3689, 3781, 3816], 'A': [1144, 1912, 2009, 2966, 2986, 3322], 'lipid': [1145, 1841, 3351, 3434], 'profile': [1146], 'all': [1148, 1183, 1191, 1482, 1526, 1592, 1846, 1977, 2474, 2506, 2646, 2696, 2727, 2781, 3469], 'established,': [1152], 'hospitalized': [1155], 'patients,': [1156, 1483, 1527, 1593, 3406, 3720], 'lipid-lowering': [1157, 3500], 'recommended': [1160, 1181, 1606, 1844, 1975, 1992, 2197, 2271, 2519, 2605, 3722, 4104], 'below': [1161, 1803, 3437], 'initiated': [1164], 'before': [1165], 'discharge.20(Level': [1166], 'Lifestyle': [1170, 1829], 'modifications': [1171, 1830], 'daily': [1173, 1559, 1832, 1973, 1990, 2056, 2100, 2441, 2446], 'activity': [1175, 1599], 'strongly': [1180], 'patients.19,29(Level': [1184], 'B)3.': [1187, 1373, 1614, 1763, 2379], 'Dietary': [1188], 'intake': [1196, 3190], 'saturated': [1198], 'fats': [1199], '(to': [1200, 1207, 1214], '<7%': [1201], 'total': [1203, 1210], 'calories),': [1204, 1211], 'transfatty': [1205], 'acids': [1206, 1492], '<1%': [1208], 'cholesterol': [1213, 3124, 3397, 3439, 3462, 3604, 3737, 3748], '<200': [1215], 'mg/d).21–24,29(Level': [1216], 'B)4.': [1219], 'therapeutic': [1223, 1750, 1962, 2612, 3368], 'changes,': [1225], 'prescribed': [1230], 'absence': [1233], 'contraindications': [1235], 'or': [1236, 1347, 1435, 1465, 1471, 1495, 1944, 1947, 1950, 2002, 2023, 2036, 2051, 2116, 2124, 2138, 2181, 2205, 2236, 2401, 2488, 2526, 2633, 2659, 2673, 2708, 2739, 2764, 2786, 2819, 2883, 2893, 2910, 2932, 3232, 3274, 3278, 3284, 3341, 3591, 3701, 3767, 3898, 4070], 'documented': [1237], 'adverse': [1238], 'effects.25–29(Level': [1239], 'A)5.': [1242, 2161], 'An': [1243], 'adequate': [1244, 1461, 3518], 'dose': [1245, 2252, 3519], 'used': [1250, 2644, 3153, 3525, 3608, 3647, 3879], 'AND': [1257], 'achieves': [1258], 'least': [1260, 1513, 1545, 1580, 1582, 1647, 2062, 3529], '30%': [1262, 3531], 'lowering': [1263, 3435, 3532], 'LDL-C.25–29(Level': [1265], 'C)6.': [1268], 'who': [1270, 1290, 1356, 1396, 1403, 1431, 1452, 1998, 2119, 2397, 2522, 2527, 2540, 2557, 2608, 2620, 2629, 2703, 2734, 3697, 3762, 4107], 'have': [1271, 1291, 1404, 1455, 2120, 2523, 2528, 2621, 2630, 2676, 2704, 2735, 2801, 2831, 3617, 3698, 3765, 3874, 3973, 4024, 4108], 'treated': [1277], 'statins': [1279, 1324, 3590], 'lower': [1281, 1386, 2172, 2423, 3395], 'mg/dL.25–27,30(Level': [1285], 'B)7.': [1288], '>500': [1293], 'started': [1297, 2080, 2156, 2188, 2469, 2689], 'fibrate': [1299, 3165], 'prevent': [1307], 'acute': [1308, 3055, 3410], 'pancreatitis.': [1309], 'C)Class': [1313, 1633, 1895, 2408, 2771], 'IIa1.': [1314, 1634, 1854, 2303, 2497, 2547, 2713, 2809, 2985], 'If': [1315, 1727, 2304], 'treatment': [1316, 2126, 3620, 3800, 3826], '(including': [1320], 'higher-dose': [1323], 'higher-potency': [1326], 'statins)': [1327], 'does': [1328, 3234, 3681, 3753], 'selected': [1333], 'patient,': [1336], 'intensification': [1337], 'LDL-C–lowering': [1339, 1361, 3592], 'drug': [1340, 3417, 3593], 'bile': [1344, 1364, 1441, 3129], 'acid': [1345, 1365, 1442, 3130], 'sequestrant‡`': [1346], 'niacin§`': [1348, 1368, 1464], 'reasonable.31–33(Level': [1350], 'For': [1354, 1450, 1481, 1525, 1591, 2070, 2162, 2380, 2810, 3595, 4056], 'do': [1357, 1432, 3250, 3763], 'tolerate': [1359, 1434], 'statins,': [1360, 1440], 'sequestrants‡`': [1366], 'reasonable.35,36(Level': [1370], 'reasonable': [1376, 1487, 1637, 1873, 2362, 2393, 2500, 2550, 2716, 2746, 2824, 2867, 3485, 3747], 'treat': [1378, 2211, 3487], 'high-risk': [1380, 1584, 3401, 3719], 'patients*': [1381], 'mg/dL.26–28,37,38,166(Level': [1390], 'C)4.': [1393], 'reasonable.25–27,30(Level': [1415], 'B)Lipid': [1418], "cont'dClass": [1420], 'IIb1.': [1421, 1896, 2409, 2564, 2772, 2851], 'ezetimibe': [1425], 'considered': [1428, 1930, 2449, 2776, 3666], 'target': [1437, 1903, 1913, 3396, 3539, 3622, 3625], 'sequestrants,‡`': [1443], 'niacin.§`': [1445], 'C)2.': [1449, 1828], 'continue': [1453, 2257, 2718], 'elevated': [1457], 'while': [1459], 'therapy,': [1463, 2225], 'fibrate∥`': [1466], 'therapy32,41,41(Level': [1467], 'B)': [1470, 2511], 'fish': [1472, 1496, 3192], 'oil': [1473, 1497], 'C)': [1477, 2332], 'reasonable.3.': [1480], 'recommend': [1489, 1642, 3962], 'omega-3': [1490], 'fatty': [1491], 'fish¶`': [1494], 'capsules': [1498], '(1': [1499], 'g/d)': [1500], 'cardiovascular': [1502, 1808, 2338, 2798, 2861, 2902, 2963, 3431, 4113, 4136], 'disease': [1503, 1982, 2169, 2420, 2799, 2862, 2947, 3404, 3680, 3696, 4008], 'reduction.44–46(Level': [1505], 'B)Physical': [1508], 'activityClass': [1509], 'I': [1510, 3316, 4062], 'At': [1512], '30': [1514, 1532], 'minutes,': [1515], '7': [1516, 1550], 'days': [1517, 1522, 1547, 1551, 1649], 'per': [1518, 1523, 1552, 1650, 2369], 'week': [1519], '(minimum': [1520], '5': [1521, 1546], 'week)1.': [1524], 'clinician': [1529, 1616, 1640, 1689], 'encourage': [1531, 1692], '60': [1534], 'minutes': [1535], 'moderate-intensity': [1537], 'aerobic': [1538], 'activity,': [1539, 1702, 1834], 'such': [1540, 2226, 3292, 3458, 3774], 'brisk': [1542], 'walking,': [1543], 'preferably': [1549], 'week,': [1553], 'supplemented': [1554], 'increase': [1557, 3169, 3547], 'activities': [1561], '(eg,': [1562, 2324], 'walking': [1563], 'breaks': [1564], 'gardening,': [1567], 'household': [1568], 'work)': [1569], 'improve': [1571, 2860], 'cardiorespiratory': [1572], 'fitness': [1573], 'move': [1575], 'out': [1577], 'fit,': [1581], 'active': [1583], 'cohort': [1585], '(bottom': [1586], '20%).54,58,58(Level': [1587], 'assessment': [1595], 'history': [1600, 1935, 3004, 3296, 3299, 3304], 'exercise': [1603], 'test': [1604, 3273], 'guide': [1608, 3611], 'prognosis': [1609], 'prescription.47–52,58(Level': [1611], 'counsel': [1618], 'report': [1621, 3013, 3839], 'evaluated': [1624], 'symptoms': [1626], 'exercise.': [1629], 'complementary': [1643], 'resistance': [1644], 'training': [1645], 'week.59(Level': [1651], 'C)Weight': [1654], 'managementGoals:': [1655], 'Body': [1656, 1675], 'mass': [1657, 1676, 1717], 'index:': [1658], '18.5': [1659, 1720], '24.9': [1661, 1722], 'kg/m2Waist': [1662], 'circumference:': [1663], 'women': [1664, 1742, 3186], '<35': [1665], 'inches': [1666, 1671, 1738, 1745], '(<89': [1667], 'cm),': [1668], 'men': [1669], '<40': [1670, 3117], '(<102': [1672], 'cm)Class': [1673], 'index': [1677, 1718], 'waist': [1679, 1728], 'circumference': [1680, 1729], 'visit,': [1686], 'consistently': [1691], 'maintenance/reduction': [1694], 'through': [1695], 'balance': [1698], 'structured': [1703], 'exercise,': [1704], 'caloric': [1705], 'intake,': [1706], 'formal': [1708], 'behavioral': [1709], 'programs': [1710], 'indicated': [1712, 2018], 'maintain/achieve': [1714], 'between': [1719, 3355], 'kg/m2.60–62,65–70(Level': [1723], '(measured': [1730], 'horizontally': [1731], 'iliac': [1734], 'crest)': [1735], '≥35': [1737], '(≥89': [1739], 'cm)': [1740, 1747], '≥40': [1744], '(≥102': [1746], 'men,': [1749], 'interventions': [1752, 1881, 1900], 'intensified': [1755], 'focused': [1757], 'management.66–70(Level': [1760], 'initial': [1765], 'loss': [1769, 1788], 'reduce': [1774, 2087, 2680], 'approximately': [1778], '5%': [1779], '10%': [1781], 'baseline.': [1783], 'success,': [1785], 'can': [1789, 1862, 2971, 2993, 3168], 'attempted': [1791], 'indicated.': [1793], 'C)Type': [1797], 'managementNote:': [1801], 'prevention': [1806, 3871], 'complications.Class': [1809], 'Care': [1811], 'coordinated': [1816], "patient's": [1819, 1886, 3557], 'primary': [1820, 2840], 'care': [1821, 2841], 'physician': [1822, 2842], 'endocrinologist.': [1824], 'management,': [1836, 2835], 'control,': [1839], 'diabetes.19,22–24,29,56,58,59,62,66,74,162': [1849], 'B)Class': [1853, 2563, 2712, 2850], 'Metformin': [1855], 'effective': [1858], 'first-line': [1859], 'useful': [1864, 3277], 'contraindicated.74–76(Level': [1867], 'A)2.': [1870, 1911, 2684, 2919], 'individualize': [1875], 'intensity': [1877], 'sugar–lowering': [1880], 'individual': [1885], 'hypoglycemia': [1889], 'during': [1890, 2039, 2911], 'treatment.': [1891, 3418], 'Initiation': [1897], 'HbA1c': [1904, 1914, 1926], 'reasonable.71,72,74–80': [1907], '≤7%': [1916], 'considered.': [1919], 'C)3.': [1923], 'Less': [1924], 'stringent': [1925], 'goals': [1927], 'severe': [1937, 3087, 3172], 'hypoglycemia,': [1938], 'life': [1940], 'expectancy,': [1941], 'advanced': [1942], 'microvascular': [1943], 'macrovascular': [1945], 'complications,': [1946], 'extensive': [1948], 'comorbidities,': [1949], 'those': [1951, 2354, 2484, 2580, 3408, 3443, 4057], 'whom': [1953], 'difficult': [1957], 'attain': [1959, 3568], 'despite': [1960], 'interventions.': [1963], 'C)Antiplatelet': [1967], 'agents/anticoagulantsClass': [1968], 'Aspirin': [1970], '75–162': [1971], 'mg': [1972, 1989, 2045, 2049, 2054, 2099, 2131, 2136, 2147, 2150, 2179, 2184, 2366, 2389, 2440, 2445], 'unless': [1983, 2492, 2663], 'contraindicated.64,81,82,116(Level': [1984], 'A)Clopidogrel': [1987], '75': [1988, 2044, 2437, 2444], 'alternative': [1995, 2394], 'intolerant': [2000, 2399], 'allergic': [2003, 2402], 'aspirin.117(Level': [2005], 'P2Y12': [2010], 'receptor': [2011, 3073], 'antagonist': [2012, 3980], 'combination': [2014, 2140, 2570, 3160], 'aspirin': [2016, 2077, 2128, 2142, 2177, 2253, 2285, 2368, 2413, 2436, 3310, 3964], 'after': [2021, 2084, 2319], 'ACS': [2022, 2882], 'PCI': [2024, 2040, 2933], 'stent': [2026, 2035, 2038, 2320], 'placement.83–85(Level': [2027], 'A)For': [2030], 'receiving': [2032, 2250, 2611], 'bare-metal': [2034, 2356], 'drug-eluting': [2037, 2351], 'ACS,': [2042, 2927, 3054], 'clopidogrel': [2043, 2133, 2182, 2287, 2387, 2443, 3892], 'daily,': [2046, 2050, 2152], 'prasugrel': [2047, 3913], '10': [2048], 'ticagrelor': [2052, 3915], '90': [2053], 'twice': [2055, 2151], 'given': [2059], '12': [2063], 'months.84,86,113,114(Level': [2064], 'A)Antiplatelet': [2067], 'agents/anticoagulants': [2068], "cont'd3.": [2069], 'undergoing': [2072, 2382], 'bypass': [2075, 2385, 2816, 2891, 2930], 'grafting,': [2076, 2386], 'within': [2081, 2952], '6': [2082], 'hours': [2083], 'surgery': [2085, 2818, 2892, 2931], 'saphenous': [2088], 'vein': [2089], 'graft': [2090, 2817], 'closure.': [2091], 'Dosing': [2092], 'regimens': [2093], 'ranging': [2094], '100': [2096, 3515], '325': [2098], 'year': [2103, 2955], 'appear': [2104], 'efficacious.87–90(Level': [2107], 'A)4.': [2110], 'extracranial': [2114], 'vertebral': [2117], 'atherosclerosis': [2118, 2255], 'had': [2121, 2529, 2705, 2736], 'ischemic': [2122, 3064], 'stroke': [2123], 'TIA,': [2125, 3062], 'alone': [2129, 2134], '(75–325': [2130, 2178], 'daily),': [2132, 2137], '(75': [2135, 2183, 2388], 'plus': [2143, 3078, 3110, 3164], 'extended-release': [2144], 'dipyridamole': [2145], '(25': [2146], '200': [2149], 'respectively)': [2153], 'continued.91,116,116(Level': [2158], 'symptomatic': [2165], 'extremity,': [2173], 'daily)': [2180, 2185, 2390], 'continued.92,107,116,117(Level': [2190], 'A)6.': [2193], 'Antiplatelet': [2194], 'preference': [2199, 2372], 'anticoagulant': [2201, 2224], 'warfarin': [2204, 2241, 2281], 'vitamin': [2207], 'K': [2208], 'antagonists': [2209], 'atherosclerosis.93,94,105,110(Level': [2214], 'A)If': [2217], 'there': [2218, 3262], 'compelling': [2221], 'indication': [2222], 'atrial': [2228], 'fibrillation,': [2229], 'prosthetic': [2230], 'heart': [2231, 2524, 2583, 2634, 2657, 2762, 3006, 3306, 3403, 3447], 'valve,': [2232], 'left': [2233, 2477, 2534, 2623, 2649, 2700, 2731, 2754, 3986, 4011, 4047], 'ventricular': [2234, 2478, 2535, 2624, 2650, 2701, 2732, 2755, 3987, 4012, 4048, 4052], 'thrombus,': [2235], 'concomitant': [2237], 'venous': [2238], 'thromboembolic': [2239], 'administered.95,99–102(Level': [2244], 'A)': [2247, 2587], '(NOTE:': [2248], 'low': [2251, 3115, 3180, 4003], 'receive': [2259], 'it.)For': [2260], 'requiring': [2262], 'warfarin,': [2263], 'administered': [2267], 'INR': [2272], 'specific': [2275, 3889], 'condition.81,96,110(Level': [2276], 'B)Use': [2279], 'conjunction': [2283], 'associated': [2289], 'bleeding': [2294, 2310], 'monitored': [2298], 'closely.97,110,110(Level': [2299], 'A)Class': [2302, 2496, 2546, 2984], 'morbidity': [2308], 'outweighs': [2311], 'anticipated': [2313], 'afforded': [2315], 'thienopyridine': [2317], 'implantation,': [2321], 'earlier': [2322], 'discontinuation': [2323, 2343], '<12': [2325], 'months)': [2326], 'reasonable.': [2328], '(Note:': [2333], 'serious': [2337], 'events': [2339], 'because': [2340, 3572, 4115], 'early': [2342], 'thienopyridines': [2345], 'greater': [2347], 'stents': [2352], 'than': [2353], 'stents.)2.': [2357], 'After': [2358], 'PCI,': [2359, 3058], '81': [2365], 'day': [2370], 'higher': [2374], 'maintenance': [2375], 'doses.84,85,118–122(Level': [2376], 'aspirin.': [2404], 'benefits': [2411, 3498], 'asymptomatic': [2417], 'extremities': [2424], 'established.108,109(Level': [2428], 'Combination': [2432], 'both': [2435], '162': [2439], 'stable': [2453, 3000, 4006], 'disease.112(Level': [2456], 'B)Renin-angiotensin-aldosterone': [2459], 'blockers': [2461], 'inhibitorsClass': [2463], 'inhibitors': [2466, 2504], 'continued': [2471, 2691, 3094], 'indefinitely': [2472], 'ejection': [2479, 2536, 2625, 4053], 'fraction': [2480, 2537, 2626, 2654, 2759, 4054], '≤40%': [2481, 2538], 'hypertension,': [2486], 'diabetes,': [2487, 3298], 'chronic': [2489, 2724, 2778, 2938, 3445, 3966, 4109], 'kidney': [2490], 'contraindicated.124,125(Level': [2493], 'patients.126(Level': [2508], 'ARBsClass': [2512], 'ARBs': [2517, 2553, 2568], 'failure': [2525, 2658, 2763], 'myocardial': [2531, 2661, 2706, 2737, 2766, 2820, 3302, 4042], 'infarction': [2532, 2597, 2707, 2738, 4043], 'ACE-inhibitor': [2542, 2559], 'intolerant.130–132(Level': [2543], 'intolerant.133(Level': [2560], 'inhibitor': [2574, 2617, 3997], 'systolic': [2582, 2651, 2756, 4049], 'failure.132,134(Level': [2584], 'Aldosterone': [2588], 'blockadeClass': [2589], 'Use': [2591], 'aldosterone': [2593, 3979], 'blockade': [2594], 'post–myocardial': [2596], 'without': [2599, 2761, 3694, 4059], 'significant': [2600], 'renal': [2601], 'dysfunction#`or': [2602], 'hyperkalemia**': [2603], 'already': [2610], 'doses': [2613, 3175], 'β-blocker,': [2619], '≤40%,': [2627], 'either': [2631, 2905, 3589], 'failure.136,137(Level': [2635], 'A)β-BlockersClass': [2638], 'β-Blocker': [2640, 2685], 'dysfunction': [2652, 2757, 4050], '(ejection': [2653, 2758], '≤40%)': [2655, 2760], 'prior': [2660, 2765, 2906, 3301, 3309], 'infarction,': [2662, 2821, 3303], 'contraindicated.': [2664], '(Use': [2665], 'carvedilol,': [2670], 'metoprolol': [2671], 'succinate,': [2672], 'bisoprolol,': [2674], 'which': [2675, 3370, 3657], 'been': [2677, 2857, 4025], 'shown': [2678, 2858], 'mortality.)138,141,141(Level': [2681], '3': [2693, 2721], 'years': [2694, 2722], 'normal': [2699, 2730, 4010], 'function': [2702, 2733, 4013], 'ACS.139,143,143(Level': [2709, 2740], 'beyond': [2720], 'give': [2748], 'β-blocker': [2749, 4022, 4064], 'infarction.': [2767], 'β-Blockers': [2773], 'C)Influenza': [2793], 'vaccinationClass': [2794], 'annual': [2803], 'vaccination.144–147(Level': [2805], 'B)DepressionClass': [2808], 'screen': [2826], 'depression': [2828, 2854, 4133], 'access': [2832], 'case': [2834], 'collaboration': [2837], 'their': [2839, 3189, 4034], 'mental': [2845], 'health': [2846], 'specialist.148–152(Level': [2847], 'outcomes': [2863], 'benefits.(Level': [2872], 'C)Cardiac': [2875], 'rehabilitationClass': [2876], 'eligible': [2879, 2921], 'whose': [2884], 'immediately': [2887], 'post': [2888], 'post-PCI': [2894], 'referred': [2897, 2958], 'outpatient': [2901, 2962, 2989], 'rehabilitation': [2903, 2964, 2969, 2991], 'program': [2904, 2970, 2978, 2992], 'hospital': [2908], 'discharge': [2909], 'first': [2913], 'follow-up': [2914], 'visit.55,154,161,163(Level': [2916], 'outpatients': [2922, 3001], 'diagnosis': [2925], 'A),55,154,155,161': [2937], 'angina': [2939], 'B),161,163': [2943], 'A)(158,164': [2951], 'past': [2954], 'program.3.': [2965], 'home-based': [2967], 'cardiac': [2968, 2990], 'substituted': [2973], 'supervised,': [2976], 'center-based': [2977], 'low-risk': [2980], 'patients.153,160,160(Level': [2981], 'exercise-based': [2988], 'safe': [2995], 'beneficial': [2997], 'clinically': [2999], 'failure.159,159a–159c(Level': [3007], 'B)JNC': [3010], 'indicates': [3011], 'Heart,': [3017, 3380, 3810, 3843], 'Lung,': [3018, 3381, 3811, 3844], 'Blood': [3020, 3033, 3383, 3813, 3846, 3859], "Institute's": [3021, 3384, 3814, 3847], 'Joint': [3022, 3848], 'Committee': [3024, 3850], 'Prevention,': [3026, 3852, 4097], 'Detection,': [3027, 3853], 'Evaluation,': [3028, 3854], 'High': [3032, 3858], 'Pressure': [3034, 3860], 'guidelines;': [3035], 'ACE,': [3036], 'angiotensin-converting': [3037, 3995], 'enzyme;': [3038], 'ATP,': [3039], 'Adult': [3040, 3385], 'Panel;': [3042], 'LDL-C,': [3043, 3509, 3577], 'low-density': [3044, 3460], 'lipoprotein': [3045, 3049, 3461, 3603], 'cholesterol;': [3046, 3050], 'HDL-C,': [3047], 'high-density': [3048], 'HbA1c,': [3051], 'hemoglobin': [3052], 'A1c;': [3053], 'syndrome;': [3057], 'percutaneous': [3059], 'intervention;': [3061], 'transient': [3063], 'attack;': [3065], 'INR,': [3066], 'international': [3067], 'normalized': [3068], 'ratio;': [3069], 'ARB,': [3071], 'angiotensin': [3072], 'blocker.*Presence': [3074], 'CVD': [3077], '(1)': [3079], 'multiple': [3080, 3098, 3702], 'factors': [3083, 3092, 3100, 3704], '(especially': [3084, 3093, 3105, 3166], 'diabetes),': [3085], '(2)': [3086], 'poorly': [3089], 'controlled': [3090, 3635], 'cigarette': [3095], 'smoking),': [3096], '(3)': [3097], 'metabolic': [3103], 'syndrome': [3104, 3897], '≥130': [3112], 'HDL-C': [3116], 'mg/dL),': [3118], '(4)': [3120], 'ACSs.†Non–HDL-C=total': [3123], 'minus': [3125], 'HDL-C.‡The': [3126], 'sequestrants': [3131], 'relatively': [3133, 3179, 4002], 'contraindicated': [3134, 3142], '≥500': [3146], 'mg/dL.§Dietary': [3147], 'supplement': [3148], 'niacin': [3149], 'must': [3150, 3742], 'substitute': [3156], 'prescription': [3158], 'niacin.∥The': [3159], 'high-dose': [3162], 'gemfibrozil)': [3167], 'myopathy.': [3173], 'Statin': [3174], 'kept': [3178], 'combination.¶Pregnant': [3183], 'lactating': [3185], 'limit': [3188], 'minimize': [3194], 'methylmercury.#Estimated': [3197], 'creatinine': [3198], 'clearance': [3199], '>30': [3202], 'mL/min.**Potassium': [3203], '<5.0': [3206], 'mEq/L.Table': [3207], 'Applying': [3209, 3218], 'EvidenceTable': [3216], 'EvidenceA': [3225], 'recommendation': [3226, 3239, 4076], 'Evidence': [3230, 3321], 'B': [3231, 3324], 'C': [3233], 'imply': [3236], 'weak.': [3241], 'Many': [3242], 'questions': [3245], 'addressed': [3246], 'lend': [3252], 'themselves': [3253], 'Although': [3257, 3614], 'randomized': [3258, 3634], 'unavailable,': [3261], 'clear': [3267], 'consensus': [3269], 'particular': [3272], 'effective.*Data': [3279], 'available': [3280], 'registries': [3285], 'usefulness/efficacy': [3288], 'different': [3290], 'subpopulations,': [3291], 'sex,': [3294], 'age,': [3295], 'failure,': [3307], 'use.†For': [3311], 'comparative': [3312], 'effectiveness': [3313], '(Class': [3315, 4068], 'IIa;': [3318], 'only),': [3325], 'studies': [3326, 3616, 3655, 3972], 'comparator': [3332], 'verbs': [3333], 'involve': [3335], 'direct': [3336], 'comparisons': [3337], 'treatments': [3340], 'strategies': [3342], 'being': [3343], 'evaluated.With': [3344], 'regard': [3345, 4084], 'lipids': [3347], 'dyslipidemias,': [3349], 'reduction': [3352, 3507], '2002': [3356], '200618,25,166–168': [3358], 'included': [3359, 3905], '>50': [3360], '000': [3361], 'resulted': [3364], 'new': [3366, 4130], 'optional': [3367, 3394, 4067], 'targets,': [3369], 'outlined': [3372], '2004': [3375, 3422, 3688, 3780], 'Panel': [3387], '(ATP)': [3388], 'III': [3389, 3690, 3782], 'report.169': [3390], 'changes': [3392, 3793], 'defined': [3393], 'levels': [3398, 3441, 3599, 3629, 3640], '(CHD)': [3405], 'especially': [3407], 'syndromes,': [3412], 'expanded': [3414], 'indications': [3415], 'Subsequent': [3419], 'III,': [3426], 'additional': [3428, 3971], 'trials26,27': [3429], 'demonstrated': [3430], 'significantly': [3436], 'current': [3438, 4016], 'allowed': [3451], 'alterations': [3453], 'guideline,': [3457], '(LDL-C)': [3463], 'CHD': [3472, 3711, 3766], 'forms': [3476, 3769], 'highest': [3495], 'risk.': [3496], 'proportion': [3504], 'above': [3514], 'LDL-C.': [3534], 'When': [3535], 'chosen,': [3541], 'prudent': [3545], 'graded': [3552], 'fashion': [3553], 'determine': [3555], 'response': [3558], 'tolerance.': [3560], 'Furthermore,': [3561], 'possible': [3566, 3581], 'baseline': [3576], 'generally': [3579], 'reductions': [3585], '>50%': [3587], 'combinations.': [3594], 'triglyceride': [3598], 'non–high-density': [3602], 'values': [3605], 'therapy.': [3613, 3967], 'no': [3615, 3791], 'directly': [3618], 'tested': [3619], 'strategies,': [3623], 'derived': [3631, 3660], 'several': [3633, 3992], 'where': [3637], 'achieved': [3641], 'showing': [3644], 'suggest': [3649], 'targets.': [3650], 'references': [3652], 'targets': [3658, 3664], 'Importantly,': [3672], 'statement': [3675], 'modify': [3683], '10-year': [3707], '>20%.': [3712], 'latter': [3715], 'types': [3717, 3758], 'changed.': [3730], 'Finally,': [3731, 4018], 'any': [3734], 'misunderstanding': [3735], 'general,': [3740], 'emphasized': [3744], 'apply': [3755], 'lower-risk': [3760], 'individuals': [3761, 4106], 'disease;': [3772], 'cases,': [3775], 'contained': [3777], 'still': [3784], 'pertain.': [3785], 'agreed': [3789], 'dyslipidemia': [3802], 'pending': [3803, 3833], 'expected': [3805, 3862], 'publication': [3806, 3835], '2012.': [3819], 'Similar': [3820], 'hypertension': [3828], 'spring': [3865], '2012.Trials': [3867], 'involving': [3868, 3994], 'influenced': [3875, 4014], 'formulate': [3881], 'update.': [3887], 'post–acute': [3895], 'post–percutaneous': [3899], 'intervention': [3901], 'stented': [3902], 'update,': [3909], 'added': [3917, 4129], 'basis': [3923], 'TRITON-TIMI': [3929], '38': [3930], 'trial': [3931], '(Trial': [3932], 'Assess': [3934], 'Improvement': [3935], 'Therapeutic': [3937], 'Outcomes': [3938], 'Optimizing': [3940], 'Platelet': [3941, 3952], 'Inhibition': [3942, 3953], 'Prasugrel–Thrombolysis': [3944], 'Myocardial': [3946], 'Infarction)': [3947], 'PLATO': [3949], '(Study': [3950], 'Patient': [3955], 'Outcomes).': [3956], 'continues': [3960, 4140], 'lower-dose': [3963], 'confirmed': [3975], 'among': [3982, 3999, 4038], 'impaired': [3985], 'function.': [3988], 'enzyme': [3996], 'recommendations.32': [4017], 'clarified': [4026], 'reflect': [4028], 'fact': [4030], 'supporting': [4033], 'efficacy': [4035], 'greatest': [4037], '(<3': [4044], 'years)': [4045], '(left': [4051], '≤40%).': [4055], 'indications,': [4063], 'IIa': [4069], 'IIb).The': [4071], 'introduced': [4077], 'vaccination.': [4087], 'According': [4088], 'US': [4091], 'Centers': [4092], 'Disease': [4094], 'Control': [4095], 'vaccination': [4098], 'inactivated': [4100], 'vaccine': [4102], 'disorders': [4110], 'they': [4116], 'complications': [4122], 'influenza.147': [4124], 'Additionally,': [4125], 'sections': [4131], 'rehabilitation.The': [4137], 'emphasize': [4142], 'importance': [4144], 'giv': [4146]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2144663588', 'counts_by_year': [{'year': 2024, 'cited_by_count': 56}, {'year': 2023, 'cited_by_count': 76}, {'year': 2022, 'cited_by_count': 99}, {'year': 2021, 'cited_by_count': 103}, {'year': 2020, 'cited_by_count': 115}, {'year': 2019, 'cited_by_count': 126}, {'year': 2018, 'cited_by_count': 141}, {'year': 2017, 'cited_by_count': 163}, {'year': 2016, 'cited_by_count': 145}, {'year': 2015, 'cited_by_count': 163}, {'year': 2014, 'cited_by_count': 171}, {'year': 2013, 'cited_by_count': 174}, {'year': 2012, 'cited_by_count': 112}], 'updated_date': '2024-12-18T13:13:49.055826', 'created_date': '2016-06-24'}
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