Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2143918249', 'doi': 'https://doi.org/10.1161/hypertensionaha.112.191452', 'title': 'Possible Involvement of Angiotensin-Converting Enzyme 2 and Mas Activation in Inhibitory Effects of Angiotensin II Type 1 Receptor Blockade on Vascular Remodeling', 'display_name': 'Possible Involvement of Angiotensin-Converting Enzyme 2 and Mas Activation in Inhibitory Effects of Angiotensin II Type 1 Receptor Blockade on Vascular Remodeling', 'publication_year': 2012, 'publication_date': '2012-07-01', 'ids': {'openalex': 'https://openalex.org/W2143918249', 'doi': 'https://doi.org/10.1161/hypertensionaha.112.191452', 'mag': '2143918249', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22665126'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hypertensionaha.112.191452', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.112.191452', 'source': {'id': 'https://openalex.org/S67880631', 'display_name': 'Hypertension', 'issn_l': '0194-911X', 'issn': ['0194-911X', '1524-4563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.112.191452', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049688470', 'display_name': 'Masaru Iwai', 'orcid': 'https://orcid.org/0000-0001-6121-7543'}, 'institutions': [{'id': 'https://openalex.org/I43545212', 'display_name': 'Ehime University', 'ror': 'https://ror.org/017hkng22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I43545212']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masaru Iwai', 'raw_affiliation_strings': ['From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.', 'institution_ids': ['https://openalex.org/I43545212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035200578', 'display_name': 'Hirotomo Nakaoka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43545212', 'display_name': 'Ehime University', 'ror': 'https://ror.org/017hkng22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I43545212']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirotomo Nakaoka', 'raw_affiliation_strings': ['From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.', 'institution_ids': ['https://openalex.org/I43545212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053464779', 'display_name': 'Izumi Senba', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43545212', 'display_name': 'Ehime University', 'ror': 'https://ror.org/017hkng22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I43545212']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Izumi Senba', 'raw_affiliation_strings': ['From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.', 'institution_ids': ['https://openalex.org/I43545212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035704745', 'display_name': 'Hiroaki Kanno', 'orcid': 'https://orcid.org/0000-0001-7933-5492'}, 'institutions': [{'id': 'https://openalex.org/I43545212', 'display_name': 'Ehime University', 'ror': 'https://ror.org/017hkng22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I43545212']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Harumi Kanno', 'raw_affiliation_strings': ['From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.', 'institution_ids': ['https://openalex.org/I43545212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071626514', 'display_name': 'Tomozo Moritani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43545212', 'display_name': 'Ehime University', 'ror': 'https://ror.org/017hkng22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I43545212']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tomozo Moritani', 'raw_affiliation_strings': ['From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.', 'institution_ids': ['https://openalex.org/I43545212']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001563356', 'display_name': 'Masatsugu Horiuchi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43545212', 'display_name': 'Ehime University', 'ror': 'https://ror.org/017hkng22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I43545212']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masatsugu Horiuchi', 'raw_affiliation_strings': ['From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.', 'institution_ids': ['https://openalex.org/I43545212']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.142, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 40, 'citation_normalized_percentile': {'value': 0.887122, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '60', 'issue': '1', 'first_page': '137', 'last_page': '144'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14486', 'display_name': 'Role of Urotensin II in Cardiovascular Physiology and Disease', 'score': 0.9884, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11917', 'display_name': 'Hereditary Angioedema: Molecular Mechanisms and Clinical Management', 'score': 0.9861, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neointima', 'display_name': 'Neointima', 'score': 0.6390392}, {'id': 'https://openalex.org/keywords/angiotensin-ii-receptor', 'display_name': 'Angiotensin II Receptor', 'score': 0.546854}, {'id': 'https://openalex.org/keywords/olmesartan', 'display_name': 'Olmesartan', 'score': 0.5388327}, {'id': 'https://openalex.org/keywords/ace2', 'display_name': 'ACE2', 'score': 0.534291}, {'id': 'https://openalex.org/keywords/angiotensin-converting-enzyme-2', 'display_name': 'Angiotensin-converting enzyme 2', 'score': 0.5281848}, {'id': 'https://openalex.org/keywords/knockout-mouse', 'display_name': 'Knockout mouse', 'score': 0.49477452}, {'id': 'https://openalex.org/keywords/immunostaining', 'display_name': 'Immunostaining', 'score': 0.44515806}], 'concepts': [{'id': 'https://openalex.org/C2908929049', 'wikidata': 'https://www.wikidata.org/wiki/Q65963433', 'display_name': 'Angiotensin II', 'level': 3, 'score': 0.8219005}, {'id': 'https://openalex.org/C2777339539', 'wikidata': 'https://www.wikidata.org/wiki/Q6993039', 'display_name': 'Neointima', 'level': 4, 'score': 0.6390392}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6389334}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6301254}, {'id': 'https://openalex.org/C2778468042', 'wikidata': 'https://www.wikidata.org/wiki/Q273976', 'display_name': 'Blockade', 'level': 3, 'score': 0.62728786}, {'id': 'https://openalex.org/C2777387769', 'wikidata': 'https://www.wikidata.org/wiki/Q155472', 'display_name': 'Valsartan', 'level': 3, 'score': 0.6042242}, {'id': 'https://openalex.org/C198710026', 'wikidata': 'https://www.wikidata.org/wiki/Q898218', 'display_name': 'Renin–angiotensin system', 'level': 3, 'score': 0.5938425}, {'id': 'https://openalex.org/C2779766728', 'wikidata': 'https://www.wikidata.org/wiki/Q421156', 'display_name': 'Olmesartan', 'level': 3, 'score': 0.5388327}, {'id': 'https://openalex.org/C123915805', 'wikidata': 'https://www.wikidata.org/wiki/Q15332826', 'display_name': 'Angiotensin II receptor type 1', 'level': 4, 'score': 0.5383213}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5375006}, {'id': 'https://openalex.org/C2775946041', 'wikidata': 'https://www.wikidata.org/wiki/Q14875321', 'display_name': 'Angiotensin-converting enzyme 2', 'level': 5, 'score': 0.5281848}, {'id': 'https://openalex.org/C182704531', 'wikidata': 'https://www.wikidata.org/wiki/Q1364740', 'display_name': 'Knockout mouse', 'level': 3, 'score': 0.49477452}, {'id': 'https://openalex.org/C104849204', 'wikidata': 'https://www.wikidata.org/wiki/Q24778533', 'display_name': 'Angiotensin receptor', 'level': 4, 'score': 0.4835517}, {'id': 'https://openalex.org/C4224716', 'wikidata': 'https://www.wikidata.org/wiki/Q10859258', 'display_name': 'Immunostaining', 'level': 3, 'score': 0.44515806}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.43404567}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34251958}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.07230079}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.070601225}, {'id': 'https://openalex.org/C2778283817', 'wikidata': 'https://www.wikidata.org/wiki/Q6590597', 'display_name': 'Restenosis', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C2778583881', 'wikidata': 'https://www.wikidata.org/wiki/Q1325542', 'display_name': 'Stent', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005263', 'descriptor_name': 'Femoral Artery', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007703', 'descriptor_name': 'Peptidyl-Dipeptidase A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D044140', 'descriptor_name': 'Receptor, Angiotensin, Type 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000803', 'descriptor_name': 'Angiotensin I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000803', 'descriptor_name': 'Angiotensin I', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D047228', 'descriptor_name': 'Angiotensin II Type 1 Receptor Blockers', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D047228', 'descriptor_name': 'Angiotensin II Type 1 Receptor Blockers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000085962', 'descriptor_name': 'Angiotensin-Converting Enzyme 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005263', 'descriptor_name': 'Femoral Artery', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D005263', 'descriptor_name': 'Femoral Artery', 'qualifier_ui': 'Q000293', 'qualifier_name': 'injuries', 'is_major_topic': False}, {'descriptor_ui': 'D005263', 'descriptor_name': 'Femoral Artery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058426', 'descriptor_name': 'Neointima', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058426', 'descriptor_name': 'Neointima', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D058426', 'descriptor_name': 'Neointima', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007703', 'descriptor_name': 'Peptidyl-Dipeptidase A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007703', 'descriptor_name': 'Peptidyl-Dipeptidase A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000090063', 'descriptor_name': 'Proto-Oncogene Mas', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D044140', 'descriptor_name': 'Receptor, Angiotensin, Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044140', 'descriptor_name': 'Receptor, Angiotensin, Type 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017539', 'descriptor_name': 'Tunica Intima', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017539', 'descriptor_name': 'Tunica Intima', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D017539', 'descriptor_name': 'Tunica Intima', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017539', 'descriptor_name': 'Tunica Intima', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hypertensionaha.112.191452', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.112.191452', 'source': {'id': 'https://openalex.org/S67880631', 'display_name': 'Hypertension', 'issn_l': '0194-911X', 'issn': ['0194-911X', '1524-4563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22665126', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hypertensionaha.112.191452', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.112.191452', 'source': {'id': 'https://openalex.org/S67880631', 'display_name': 'Hypertension', 'issn_l': '0194-911X', 'issn': ['0194-911X', '1524-4563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.72, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1520957183', 'https://openalex.org/W1983190423', 'https://openalex.org/W1988742278', 'https://openalex.org/W2004840558', 'https://openalex.org/W2011974109', 'https://openalex.org/W2023262160', 'https://openalex.org/W2024162107', 'https://openalex.org/W2029269323', 'https://openalex.org/W2043908786', 'https://openalex.org/W2060629558', 'https://openalex.org/W2063597031', 'https://openalex.org/W2066971442', 'https://openalex.org/W2088673900', 'https://openalex.org/W2097362788', 'https://openalex.org/W2101576799', 'https://openalex.org/W2109740270', 'https://openalex.org/W2117373831', 'https://openalex.org/W2123368332', 'https://openalex.org/W2128206934', 'https://openalex.org/W2134074925', 'https://openalex.org/W2137329488', 'https://openalex.org/W2152016477', 'https://openalex.org/W2154841519', 'https://openalex.org/W2157363415', 'https://openalex.org/W2164686130', 'https://openalex.org/W2169328873'], 'related_works': ['https://openalex.org/W3147378870', 'https://openalex.org/W2382874935', 'https://openalex.org/W2360138754', 'https://openalex.org/W2348979301', 'https://openalex.org/W2228585698', 'https://openalex.org/W2143579217', 'https://openalex.org/W2131780348', 'https://openalex.org/W2056893352', 'https://openalex.org/W1983010996', 'https://openalex.org/W1973222295'], 'abstract_inverted_index': {'We': [0], 'explored': [1], 'the': [2, 32, 39, 68, 74, 134, 151, 177, 186], 'roles': [3], 'of': [4, 21, 42, 60, 78, 88, 129, 159, 176, 189], 'angiotensin-converting': [5], 'enzyme': [6], '2': [7], '(ACE2),': [8], 'angiotensin-(1-7),': [9, 90], 'and': [10, 45, 62, 70, 127, 131], 'Mas': [11, 46, 63, 92, 132], 'activation': [12, 175], 'in': [13, 50, 67, 73, 113, 133, 144, 150, 185], 'angiotensin': [14, 118, 164, 190], 'II': [15, 119, 165, 191], 'type': [16, 120, 166, 192], '1': [17, 167, 193], 'receptor': [18, 122, 168, 194], 'blockade-mediated': [19], 'attenuation': [20], 'vascular': [22, 197], 'remodeling.': [23, 198], 'Vascular': [24], 'injury': [25], 'was': [26, 47, 56, 64, 71, 110, 154], 'induced': [27, 106], 'by': [28, 107, 157], 'polyethylene-cuff': [29], 'placement': [30, 109], 'around': [31], 'mouse': [33], 'femoral': [34], 'artery.': [35, 76], 'After': [36], 'cuff': [37, 84, 108], 'placement,': [38, 85], 'mRNA': [40, 55, 125], 'level': [41], 'both': [43], 'ACE2': [44, 61, 114, 130, 148], 'markedly': [48], 'decreased': [49, 80], 'wild-type': [51, 145, 160], 'mice,': [52, 124], 'whereas': [53, 86], 'ACE': [54], 'not': [57], 'changed.': [58], 'Immunostaining': [59], 'observed': [65, 156], 'mainly': [66], 'media': [69], 'reduced': [72], 'injured': [75, 135, 152], 'Administration': [77], 'angiotensin-(1-7)': [79], 'neointimal': [81, 104, 141], 'formation': [82, 105, 142], 'after': [83], 'administration': [87], '[D-Ala(7)]': [89], 'a': [91], 'antagonist,': [93], 'increased': [94, 112], 'it.': [95], 'Consistent': [96], 'with': [97, 139, 162], 'these': [98], 'results,': [99], 'we': [100], 'also': [101, 155], 'demonstrated': [102], 'that': [103, 174], 'further': [111], 'knockout': [115, 123], 'mice.': [116, 146], 'In': [117], '1a': [121], 'expression': [126, 149], 'immunostaining': [128], 'artery': [136, 153], 'were': [137], 'greater,': [138], 'less': [140], 'than': [143], 'Increased': [147], 'treatment': [158], 'mice': [161], 'an': [163], 'blocker,': [169], 'olmesartan.': [170], 'These': [171], 'results': [172], 'suggested': [173], 'ACE2-angiotensin-(1-7)-Mas': [178], 'axis': [179], 'is': [180], 'at': [181], 'least': [182], 'partly': [183], 'involved': [184], 'beneficial': [187], 'effects': [188], 'blockade': [195], 'on': [196]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2143918249', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-09-10T04:39:37.954320', 'created_date': '2016-06-24'}