Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2143203840', 'doi': 'https://doi.org/10.1093/nar/gku1335', 'title': 'Molecular crowding overcomes the destabilizing effects of mutations in a bacterial ribozyme', 'display_name': 'Molecular crowding overcomes the destabilizing effects of mutations in a bacterial ribozyme', 'publication_year': 2014, 'publication_date': '2014-12-24', 'ids': {'openalex': 'https://openalex.org/W2143203840', 'doi': 'https://doi.org/10.1093/nar/gku1335', 'mag': '2143203840', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25541198', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4333387'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gku1335', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/43/2/1170/17434798/gku1335.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://academic.oup.com/nar/article-pdf/43/2/1170/17434798/gku1335.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079291132', 'display_name': 'Hui-Ting Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hui-Ting Lee', 'raw_affiliation_strings': ['Johns Hopkins Univ., Baltimore, MD (United States). Thomas C. Jenkins Dept. of Biophysics'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins Univ., Baltimore, MD (United States). Thomas C. Jenkins Dept. of Biophysics', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043561068', 'display_name': 'Duncan Kilburn', 'orcid': 'https://orcid.org/0000-0002-0772-7195'}, 'institutions': [{'id': 'https://openalex.org/I4210159838', 'display_name': 'NIST Center for Neutron Research', 'ror': 'https://ror.org/05qgcra83', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1321296531', 'https://openalex.org/I1343035065', 'https://openalex.org/I4210159838']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Duncan Kilburn', 'raw_affiliation_strings': ['Johns Hopkins Univ., Baltimore, MD (United States). Thomas C. Jenkins Dept. of Biophysics', 'National Inst. of Standards and Technology, Gaithersburg, MD (United States). Center for Neutron Scattering Research'], 'affiliations': [{'raw_affiliation_string': 'National Inst. of Standards and Technology, Gaithersburg, MD (United States). Center for Neutron Scattering Research', 'institution_ids': ['https://openalex.org/I4210159838']}, {'raw_affiliation_string': 'Johns Hopkins Univ., Baltimore, MD (United States). Thomas C. Jenkins Dept. of Biophysics', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031072649', 'display_name': 'Reza Behrouzi', 'orcid': 'https://orcid.org/0000-0003-3064-9743'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Reza Behrouzi', 'raw_affiliation_strings': ['Johns Hopkins Univ., Baltimore, MD (United States). Thomas C. Jenkins Dept. of Biophysics'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins Univ., Baltimore, MD (United States). Thomas C. Jenkins Dept. of Biophysics', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055168582', 'display_name': 'Robert M. Briber', 'orcid': 'https://orcid.org/0000-0002-8358-5942'}, 'institutions': [{'id': 'https://openalex.org/I66946132', 'display_name': 'University of Maryland, College Park', 'ror': 'https://ror.org/047s2c258', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I66946132']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert M. Briber', 'raw_affiliation_strings': ['Univ. of Maryland, College Park, MD (United States). Dept. of Materials Science and Engineering'], 'affiliations': [{'raw_affiliation_string': 'Univ. of Maryland, College Park, MD (United States). Dept. of Materials Science and Engineering', 'institution_ids': ['https://openalex.org/I66946132']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5078281937', 'display_name': 'Sarah A. Woodson', 'orcid': 'https://orcid.org/0000-0003-0170-1987'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sarah A. Woodson', 'raw_affiliation_strings': ['Johns Hopkins Univ., Baltimore, MD (United States). Thomas C. Jenkins Dept. of Biophysics'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins Univ., Baltimore, MD (United States). Thomas C. Jenkins Dept. of Biophysics', 'institution_ids': ['https://openalex.org/I145311948']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'fwci': 0.686, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 28, 'citation_normalized_percentile': {'value': 0.881649, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '43', 'issue': '2', 'first_page': '1170', 'last_page': '1176'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11048', 'display_name': 'Ecology and Evolution of Viruses in Ecosystems', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10015', 'display_name': 'RNA Sequencing Data Analysis', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vs-ribozyme', 'display_name': 'VS ribozyme', 'score': 0.5421366}, {'id': 'https://openalex.org/keywords/protein-tertiary-structure', 'display_name': 'Protein tertiary structure', 'score': 0.46128482}, {'id': 'https://openalex.org/keywords/secondary-structure-prediction', 'display_name': 'Secondary Structure Prediction', 'score': 0.455102}, {'id': 'https://openalex.org/keywords/hairpin-ribozyme', 'display_name': 'Hairpin ribozyme', 'score': 0.43749022}, {'id': 'https://openalex.org/keywords/crowding', 'display_name': 'Crowding', 'score': 0.41317952}], 'concepts': [{'id': 'https://openalex.org/C76346623', 'wikidata': 'https://www.wikidata.org/wiki/Q205858', 'display_name': 'Ribozyme', 'level': 4, 'score': 0.9299434}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.86844754}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.7375329}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.54627866}, {'id': 'https://openalex.org/C66144319', 'wikidata': 'https://www.wikidata.org/wiki/Q7907583', 'display_name': 'VS ribozyme', 'level': 5, 'score': 0.5421366}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.5041324}, {'id': 'https://openalex.org/C75599170', 'wikidata': 'https://www.wikidata.org/wiki/Q898483', 'display_name': 'Protein tertiary structure', 'level': 2, 'score': 0.46128482}, {'id': 'https://openalex.org/C107745601', 'wikidata': 'https://www.wikidata.org/wiki/Q3934265', 'display_name': 'Hairpin ribozyme', 'level': 5, 'score': 0.43749022}, {'id': 'https://openalex.org/C149333683', 'wikidata': 'https://www.wikidata.org/wiki/Q5189188', 'display_name': 'Crowding', 'level': 2, 'score': 0.41317952}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35834163}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.323286}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20312032}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016337', 'descriptor_name': 'RNA, Catalytic', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D020627', 'descriptor_name': 'Azoarcus', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009690', 'descriptor_name': 'Nucleic Acid Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011092', 'descriptor_name': 'Polyethylene Glycols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059370', 'descriptor_name': 'RNA Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gku1335', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/43/2/1170/17434798/gku1335.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.osti.gov/biblio/1170030', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402487', 'display_name': 'OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I139351228', 'host_organization_name': 'Office of Scientific and Technical Information', 'host_organization_lineage': ['https://openalex.org/I139351228'], 'host_organization_lineage_names': ['Office of Scientific and Technical Information'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4333387', 'pdf_url': 'https://europepmc.org/articles/pmc4333387?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333387', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1017.4489', 'pdf_url': 'http://nar.oxfordjournals.org/content/early/2014/12/24/nar.gku1335.full.pdf', 'source': {'id': 'https://openalex.org/S4306400349', 'display_name': 'CiteSeer X (The Pennsylvania State University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130769515', 'host_organization_name': 'Pennsylvania State University', 'host_organization_lineage': ['https://openalex.org/I130769515'], 'host_organization_lineage_names': ['Pennsylvania State University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25541198', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gku1335', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/43/2/1170/17434798/gku1335.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1489623410', 'https://openalex.org/W1540350243', 'https://openalex.org/W1595708470', 'https://openalex.org/W1967090211', 'https://openalex.org/W1968897791', 'https://openalex.org/W1969379377', 'https://openalex.org/W1974259661', 'https://openalex.org/W1976281789', 'https://openalex.org/W1977038370', 'https://openalex.org/W1980579966', 'https://openalex.org/W1986112182', 'https://openalex.org/W1991187323', 'https://openalex.org/W1991525022', 'https://openalex.org/W1993619986', 'https://openalex.org/W2000813466', 'https://openalex.org/W2004641057', 'https://openalex.org/W2007781782', 'https://openalex.org/W2010855589', 'https://openalex.org/W2012706554', 'https://openalex.org/W2025696272', 'https://openalex.org/W2026161183', 'https://openalex.org/W2027065950', 'https://openalex.org/W2036363965', 'https://openalex.org/W2043656813', 'https://openalex.org/W2044235066', 'https://openalex.org/W2045194452', 'https://openalex.org/W2048538856', 'https://openalex.org/W2052944914', 'https://openalex.org/W2055572015', 'https://openalex.org/W2058276221', 'https://openalex.org/W2069122773', 'https://openalex.org/W2069779808', 'https://openalex.org/W2073406862', 'https://openalex.org/W2079532263', 'https://openalex.org/W2085158278', 'https://openalex.org/W2090365398', 'https://openalex.org/W2091976510', 'https://openalex.org/W2106198894', 'https://openalex.org/W2114616777', 'https://openalex.org/W2116199447', 'https://openalex.org/W2122829132', 'https://openalex.org/W2131187223', 'https://openalex.org/W2133173870', 'https://openalex.org/W2133296358', 'https://openalex.org/W2134816300', 'https://openalex.org/W2141228121', 'https://openalex.org/W2142096557', 'https://openalex.org/W2148176300', 'https://openalex.org/W2154878591', 'https://openalex.org/W2163358451', 'https://openalex.org/W2164552624'], 'related_works': ['https://openalex.org/W2379344035', 'https://openalex.org/W2085851730', 'https://openalex.org/W2067162089', 'https://openalex.org/W2055702166', 'https://openalex.org/W2052928878', 'https://openalex.org/W2029667257', 'https://openalex.org/W2021185362', 'https://openalex.org/W2009723196', 'https://openalex.org/W2006140659', 'https://openalex.org/W1607687794'], 'abstract_inverted_index': {'The': [0], 'native': [1, 64], 'structure': [2, 105], 'of': [3, 15, 30, 106, 140, 169], 'the': [4, 12, 50, 57, 89, 103, 107, 125, 129, 137, 157, 167], 'Azoarcus': [5, 58], 'group': [6], 'I': [7], 'ribozyme': [8, 34, 118], 'is': [9], 'stabilized': [10, 102], 'by': [11, 147, 160], 'cooperative': [13], 'formation': [14], 'tertiary': [16, 31], 'interactions': [17, 32], 'between': [18], 'double': [19, 148], 'helical': [20], 'domains.': [21], 'Thus,': [22], 'even': [23], 'single': [24], 'mutations': [25, 55, 119], 'that': [26, 43, 48, 154], 'break': [27], 'this': [28], 'network': [29], 'reduce': [33], 'activity': [35, 69], 'in': [36, 49, 56, 78, 124, 128], 'physiological': [37, 111], 'Mg2+': [38, 99], 'concentrations.': [39], 'Here,': [40], 'we': [41], 'report': [42], 'molecular': [44], 'crowding': [45, 133, 155], 'comparable': [46], 'to': [47, 73, 94], 'cell': [51, 126], 'compensates': [52], 'for': [53], 'destabilizing': [54], 'ribozyme.': [59], 'Small': [60], 'angle': [61], 'X-ray': [62], 'scattering,': [63], 'polyacrylamide': [65], 'gel': [66], 'electrophoresis': [67], 'and': [68, 80, 91, 101, 149], 'assays': [70], 'were': [71], 'used': [72], 'compare': [74], 'folding': [75], 'free': [76], 'energies': [77], 'dilute': [79], 'crowded': [81], 'solutions': [82], 'containing': [83], '18%': [84], 'PEG1000.': [85], 'Crowder': [86], 'molecules': [87], 'allowed': [88], 'wild-type': [90], 'mutant': [92, 108], 'ribozymes': [93, 109], 'fold': [95], 'at': [96], 'similarly': [97], 'low': [98], 'concentrations': [100], 'active': [104, 144], 'under': [110], 'conditions.': [112], 'This': [113], 'compensation': [114], 'helps': [115], 'explains': [116], 'why': [117], 'are': [120], 'often': [121], 'less': [122, 143], 'deleterious': [123], 'than': [127], 'test': [130], 'tube.': [131], 'Nevertheless,': [132], 'did': [134], 'not': [135], 'rescue': [136], 'high': [138], 'fraction': [139], 'folded': [141], 'but': [142], 'structures': [145, 164], 'formed': [146], 'triple': [150], 'mutants.': [151], 'We': [152], 'conclude': [153], 'broadens': [156], 'fitness': [158], 'landscape': [159], 'stabilizing': [161], 'compact': [162], 'RNA': [163], 'without': [165], 'improving': [166], 'specificity': [168], 'self-assembly.': [170]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2143203840', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-09-10T04:33:52.264439', 'created_date': '2016-06-24'}