Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2142841527', 'doi': 'https://doi.org/10.18632/oncotarget.3139', 'title': 'Computational prediction and experimental validation of a novel synthesized pan-PIM inhibitor PI003 and its apoptosis-inducing mechanisms in cervical cancer', 'display_name': 'Computational prediction and experimental validation of a novel synthesized pan-PIM inhibitor PI003 and its apoptosis-inducing mechanisms in cervical cancer', 'publication_year': 2015, 'publication_date': '2015-02-04', 'ids': {'openalex': 'https://openalex.org/W2142841527', 'doi': 'https://doi.org/10.18632/oncotarget.3139', 'mag': '2142841527', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25749522', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4480732'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3139', 'pdf_url': 'https://www.oncotarget.com/article/3139/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/3139/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101918196', 'display_name': 'Zhongyu Liu', 'orcid': 'https://orcid.org/0000-0002-2016-2424'}, 'institutions': [{'id': 'https://openalex.org/I4210101382', 'display_name': "People's Liberation Army No. 150 Hospital", 'ror': 'https://ror.org/014nsap67', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101382']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhongyu Liu', 'raw_affiliation_strings': ['Anal-Colorectal Surgery Institute, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.'], 'affiliations': [{'raw_affiliation_string': 'Anal-Colorectal Surgery Institute, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.', 'institution_ids': ['https://openalex.org/I4210101382']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003577397', 'display_name': 'Weihua He', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210101382', 'display_name': "People's Liberation Army No. 150 Hospital", 'ror': 'https://ror.org/014nsap67', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101382']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weihua He', 'raw_affiliation_strings': ['Anal-Colorectal Surgery Institute, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.'], 'affiliations': [{'raw_affiliation_string': 'Anal-Colorectal Surgery Institute, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.', 'institution_ids': ['https://openalex.org/I4210101382']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060421878', 'display_name': 'Jianglin Gao', 'orcid': 'https://orcid.org/0000-0001-9546-8391'}, 'institutions': [{'id': 'https://openalex.org/I4210101382', 'display_name': "People's Liberation Army No. 150 Hospital", 'ror': 'https://ror.org/014nsap67', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101382']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianglin Gao', 'raw_affiliation_strings': ['Anal-Colorectal Surgery Institute, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.'], 'affiliations': [{'raw_affiliation_string': 'Anal-Colorectal Surgery Institute, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.', 'institution_ids': ['https://openalex.org/I4210101382']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101523059', 'display_name': 'Junhua Luo', 'orcid': 'https://orcid.org/0000-0002-1885-4595'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Junhua Luo', 'raw_affiliation_strings': ['Department of Obstetrics & Gynecology, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics & Gynecology, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021005715', 'display_name': 'Xian Huang', 'orcid': 'https://orcid.org/0000-0001-9406-4483'}, 'institutions': [{'id': 'https://openalex.org/I4210101382', 'display_name': "People's Liberation Army No. 150 Hospital", 'ror': 'https://ror.org/014nsap67', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101382']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xian Huang', 'raw_affiliation_strings': ['Anal-Colorectal Surgery Institute, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.'], 'affiliations': [{'raw_affiliation_string': 'Anal-Colorectal Surgery Institute, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.', 'institution_ids': ['https://openalex.org/I4210101382']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046938200', 'display_name': 'Chunfang Gao', 'orcid': 'https://orcid.org/0000-0001-6979-4871'}, 'institutions': [{'id': 'https://openalex.org/I4210101382', 'display_name': "People's Liberation Army No. 150 Hospital", 'ror': 'https://ror.org/014nsap67', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101382']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunfang Gao', 'raw_affiliation_strings': ['Anal-Colorectal Surgery Institute, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.'], 'affiliations': [{'raw_affiliation_string': 'Anal-Colorectal Surgery Institute, No.150 Central Hospital of PLA, Luoyang, Henan 471031, China.', 'institution_ids': ['https://openalex.org/I4210101382']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.777, 'has_fulltext': False, 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.791844, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '6', 'issue': '10', 'first_page': '8019', 'last_page': '8035'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.965, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13188', 'display_name': 'Synthesis and bioactivity of alkaloids', 'score': 0.9616, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pim1', 'display_name': 'PIM1', 'score': 0.82760596}, {'id': 'https://openalex.org/keywords/hela', 'display_name': 'HeLa', 'score': 0.63526994}], 'concepts': [{'id': 'https://openalex.org/C98175054', 'wikidata': 'https://www.wikidata.org/wiki/Q18030550', 'display_name': 'PIM1', 'level': 4, 'score': 0.82760596}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.6870262}, {'id': 'https://openalex.org/C2777366897', 'wikidata': 'https://www.wikidata.org/wiki/Q847482', 'display_name': 'HeLa', 'level': 3, 'score': 0.63526994}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.53877634}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.530151}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5166719}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5083186}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.41042393}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.33449113}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.30421084}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2561498}, {'id': 'https://openalex.org/C2776414213', 'wikidata': 'https://www.wikidata.org/wiki/Q183290', 'display_name': 'Serine', 'level': 3, 'score': 0.25166732}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.20346987}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.13204262}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12987542}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09968969}], 'mesh': [{'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D051573', 'descriptor_name': 'Proto-Oncogene Proteins c-pim-1', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D002583', 'descriptor_name': 'Uterine Cervical Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001499', 'descriptor_name': 'Bayes Theorem', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062105', 'descriptor_name': 'Molecular Docking Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051573', 'descriptor_name': 'Proto-Oncogene Proteins c-pim-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054852', 'descriptor_name': 'Small Molecule Libraries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054852', 'descriptor_name': 'Small Molecule Libraries', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002583', 'descriptor_name': 'Uterine Cervical Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002583', 'descriptor_name': 'Uterine Cervical Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D002583', 'descriptor_name': 'Uterine Cervical Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3139', 'pdf_url': 'https://www.oncotarget.com/article/3139/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4480732', 'pdf_url': 'https://europepmc.org/articles/pmc4480732?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480732', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25749522', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3139', 'pdf_url': 'https://www.oncotarget.com/article/3139/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.86, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W1965857762', 'https://openalex.org/W1973500525', 'https://openalex.org/W1984354659', 'https://openalex.org/W1985395773', 'https://openalex.org/W1988129252', 'https://openalex.org/W1991336366', 'https://openalex.org/W2000324597', 'https://openalex.org/W2005279720', 'https://openalex.org/W2013494309', 'https://openalex.org/W2016415795', 'https://openalex.org/W2021446088', 'https://openalex.org/W2026256416', 'https://openalex.org/W2028207573', 'https://openalex.org/W2033341978', 'https://openalex.org/W2038074812', 'https://openalex.org/W2039473152', 'https://openalex.org/W2040191060', 'https://openalex.org/W2050869737', 'https://openalex.org/W2056392169', 'https://openalex.org/W2058448050', 'https://openalex.org/W2075586116', 'https://openalex.org/W2077255729', 'https://openalex.org/W2083381199', 'https://openalex.org/W2088552818', 'https://openalex.org/W2089142809', 'https://openalex.org/W2094253263', 'https://openalex.org/W2097698606', 'https://openalex.org/W2099825600', 'https://openalex.org/W2101117089', 'https://openalex.org/W2103307139', 'https://openalex.org/W2103935957', 'https://openalex.org/W2107432340', 'https://openalex.org/W2110336366', 'https://openalex.org/W2114367386', 'https://openalex.org/W2114461118', 'https://openalex.org/W2114918609', 'https://openalex.org/W2121323579', 'https://openalex.org/W2127444054', 'https://openalex.org/W2132582966', 'https://openalex.org/W2137786672', 'https://openalex.org/W2149785901', 'https://openalex.org/W2151410975', 'https://openalex.org/W2152653671', 'https://openalex.org/W2157795344', 'https://openalex.org/W2159793493', 'https://openalex.org/W2160066010', 'https://openalex.org/W2160544821', 'https://openalex.org/W2166240615', 'https://openalex.org/W2171218023', 'https://openalex.org/W2171528238', 'https://openalex.org/W2333608599', 'https://openalex.org/W2916288174', 'https://openalex.org/W29325754', 'https://openalex.org/W4236956086', 'https://openalex.org/W4294107304'], 'related_works': ['https://openalex.org/W2984941165', 'https://openalex.org/W2899084033', 'https://openalex.org/W2898600811', 'https://openalex.org/W2748952813', 'https://openalex.org/W2580790955', 'https://openalex.org/W2379924649', 'https://openalex.org/W2372231441', 'https://openalex.org/W2370495375', 'https://openalex.org/W2190220707', 'https://openalex.org/W1990610379'], 'abstract_inverted_index': {'//': [0], 'Zhongyu': [1], 'Liu': [2], '1,': [3, 8], '*': [4, 9, 54], ',': [5, 10, 14, 18, 22], 'Weihua': [6], 'He': [7], 'Jianglin': [11], 'Gao': [12, 24], '1': [13, 21, 25, 26], 'Junhua': [15], 'Luo': [16], '2': [17, 39], 'Xian': [19], 'Huang': [20], 'Chunfang': [23, 65], 'Anal-Colorectal': [27], 'Surgery': [28], 'Institute,': [29], 'No.150': [30, 45], 'Central': [31, 46], 'Hospital': [32, 47], 'of': [33, 41, 48, 115, 155], 'PLA,': [34, 49], 'Luoyang,': [35, 50], 'Henan': [36, 51], '471031,': [37, 52], 'China': [38, 53], 'Department': [40], 'Obstetrics': [42], '&': [43], 'Gynecology,': [44], 'These': [55], 'authors': [56], 'have': [57], 'contributed': [58], 'equally': [59], 'to': [60, 108, 136, 146], 'this': [61], 'work': [62], 'Correspondence': [63], 'to:': [64], 'Gao,': [66], 'e-mail:': [67], '[email protected]': [68], 'Keywords:': [69], 'PIM': [70, 93, 139], 'kinase': [71], 'family,': [72, 95], 'Pan-PIM': [73], 'inhibitor': [74, 119], '(PI003),': [75], 'HeLa': [76], 'cell,': [77], 'Apoptosis,': [78], 'MicroRNA': [79], 'Received:': [80], 'December': [81], '20,': [82], '2014': [83], 'Accepted:': [84], 'January': [85], '10,': [86], '2015': [87, 91], 'Published:': [88], 'February': [89], '04,': [90], 'ABSTRACT': [92], 'protein': [94], 'short-lived': [96], 'serine/threonine': [97], 'kinases': [98], '(PIM1,': [99], 'PIM2': [100], 'and': [101, 141, 144, 161, 187, 193, 196, 211, 229, 253, 260, 266], 'PIM3),': [102], 'are': [103], 'weak': [104], 'oncogenes': [105], 'but': [106], 'contribute': [107], 'tumorigenesis': [109], 'as': [110, 209, 244], 'cancer': [111, 126, 175, 288], 'targets.': [112], 'Thus,': [113, 271], 'design': [114], 'a': [116, 122, 132, 153, 164, 245], 'novel': [117, 165, 246], 'pan-PIM': [118, 248, 283], 'is': [120], 'still': [121], 'challenge': [123], 'for': [124], 'current': [125], 'drug': [127], 'discovery.': [128], 'Herein,': [129], 'we': [130, 151, 178, 203, 221], 'used': [131], 'Naïve': [133], 'Bayesian': [134], 'model': [135], 'construct': [137], 'the': [138, 185, 251], 'network': [140], 'identified': [142], 'Bad': [143, 195], 'Hsp90': [145], 'interact': [147], 'with': [148, 169, 199], 'PIMs.': [149], 'Then,': [150], 'screened': [152], 'series': [154], 'candidate': [156], 'small-molecule': [157, 166, 282], 'compounds': [158], 'targeting': [159, 191], 'PIMs,': [160], 'subsequently': [162], 'synthesized': [163, 247], 'compound': [167], 'PI003': [168, 181, 224], 'remarkable': [170, 226, 263], 'anti-proliferative': [171], 'activities': [172], 'in': [173, 217, 232, 233, 257, 269, 285], 'cervical': [174, 287], 'cells.': [176], 'Moreover,': [177], 'found': [179], 'that': [180, 205, 223, 242], 'induced': [182], 'apoptosis': [183, 255], 'via': [184], 'death-receptor': [186, 252], 'mitochondrial': [188, 254], 'pathways': [189], 'by': [190], 'PIMs': [192], 'affecting': [194], 'Hsp90.': [197], 'Combined': [198], 'microRNA': [200, 258], 'microarray': [201], 'analyses,': [202], 'demonstrated': [204], 'some': [206], 'microRNAs': [207], 'such': [208], 'miR-1296': [210], 'miR-1299': [212], 'could': [213], 'affect': [214], 'PIM1-STAT3': [215], 'pathway': [216], 'PI003-induced': [218], 'apoptosis.': [219], 'Finally,': [220], 'reported': [222], 'had': [225], 'anti-tumor': [227, 264], 'activity': [228, 265], 'apoptosis-inducing': [230, 267], 'effect': [231, 268], 'vivo': [234], 'mouse': [235], 'model.': [236], 'In': [237], 'conclusion,': [238], 'these': [239, 272], 'results': [240], 'demonstrate': [241], 'PI003,': [243], 'inhibitor,': [249], 'induces': [250], 'involved': [256], 'regulation,': [259], 'also': [261], 'possessed': [262], 'vivo.': [270], 'findings': [273], 'would': [274], 'shed': [275], 'light': [276], 'on': [277], 'discovering': [278], 'more': [279], 'potential': [280], 'new': [281], 'inhibitors': [284], 'future': [286], 'therapy.': [289]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2142841527', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-12-16T15:25:42.954261', 'created_date': '2016-06-24'}