Publication Information

{'id': 'https://openalex.org/W2142793416', 'doi': 'https://doi.org/10.1242/jcs.141689', 'title': 'Rab5 is required for Caveolin-1-enhanced Rac1 activation, migration and invasion of metastatic cancer cells', 'display_name': 'Rab5 is required for Caveolin-1-enhanced Rac1 activation, migration and invasion of metastatic cancer cells', 'publication_year': 2014, 'publication_date': '2014-01-01', 'ids': {'openalex': 'https://openalex.org/W2142793416', 'doi': 'https://doi.org/10.1242/jcs.141689', 'mag': '2142793416', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24659799', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4074264'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.141689', 'pdf_url': 'https://jcs.biologists.org/content/joces/127/11/2401.full.pdf', 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://jcs.biologists.org/content/joces/127/11/2401.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051655820', 'display_name': 'Jorge Díaz', 'orcid': 'https://orcid.org/0000-0002-0830-6122'}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}, {'id': 'https://openalex.org/I4210131520', 'display_name': 'Advanced Center for Chronic Diseases', 'ror': 'https://ror.org/036mwh061', 'country_code': 'CL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210131520']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'Jorge Díaz', 'raw_affiliation_strings': ['Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'Center for Molecular Studies of the Cell, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Calle Sergio Livingstone 943, Santiago, Chile'], 'affiliations': [{'raw_affiliation_string': 'Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025', 'https://openalex.org/I4210131520']}, {'raw_affiliation_string': 'Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Calle Sergio Livingstone 943, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025']}, {'raw_affiliation_string': 'Center for Molecular Studies of the Cell, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103031646', 'display_name': 'Pablo Mendoza', 'orcid': 'https://orcid.org/0009-0008-3624-3457'}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'Pablo Mendoza', 'raw_affiliation_strings': ['Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Calle Sergio Livingstone 943, Santiago, Chile'], 'affiliations': [{'raw_affiliation_string': 'Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Calle Sergio Livingstone 943, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061653559', 'display_name': 'Rina Ortiz', 'orcid': 'https://orcid.org/0000-0002-9326-5862'}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}, {'id': 'https://openalex.org/I4210131520', 'display_name': 'Advanced Center for Chronic Diseases', 'ror': 'https://ror.org/036mwh061', 'country_code': 'CL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210131520']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'Rina Ortiz', 'raw_affiliation_strings': ['Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'Center for Molecular Studies of the Cell, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile'], 'affiliations': [{'raw_affiliation_string': 'Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025', 'https://openalex.org/I4210131520']}, {'raw_affiliation_string': 'Center for Molecular Studies of the Cell, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024235580', 'display_name': 'Natalia Díaz‐Valdivia', 'orcid': 'https://orcid.org/0000-0002-8063-2598'}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}, {'id': 'https://openalex.org/I4210131520', 'display_name': 'Advanced Center for Chronic Diseases', 'ror': 'https://ror.org/036mwh061', 'country_code': 'CL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210131520']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'Natalia Díaz', 'raw_affiliation_strings': ['Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'Center for Molecular Studies of the Cell, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile'], 'affiliations': [{'raw_affiliation_string': 'Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025', 'https://openalex.org/I4210131520']}, {'raw_affiliation_string': 'Center for Molecular Studies of the Cell, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029827243', 'display_name': 'Lisette Leyton', 'orcid': 'https://orcid.org/0000-0001-9690-9638'}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}, {'id': 'https://openalex.org/I4210131520', 'display_name': 'Advanced Center for Chronic Diseases', 'ror': 'https://ror.org/036mwh061', 'country_code': 'CL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210131520']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'Lisette Leyton', 'raw_affiliation_strings': ['Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'Program of Cell and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile'], 'affiliations': [{'raw_affiliation_string': 'Program of Cell and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025']}, {'raw_affiliation_string': 'Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I4210131520', 'https://openalex.org/I69737025']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057799963', 'display_name': 'Dwayne G. Stupack', 'orcid': 'https://orcid.org/0000-0003-4396-5745'}, 'institutions': [{'id': 'https://openalex.org/I4390039236', 'display_name': 'Moores Cancer Center', 'ror': 'https://ror.org/01qkmtm61', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800935791', 'https://openalex.org/I4390039236']}, {'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dwayne Stupack', 'raw_affiliation_strings': ['Moores UCSD Cancer Center, University of California, La Jolla, CA 92093, USA'], 'affiliations': [{'raw_affiliation_string': 'Moores UCSD Cancer Center, University of California, La Jolla, CA 92093, USA', 'institution_ids': ['https://openalex.org/I4390039236', 'https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039658579', 'display_name': 'Andrew F. G. Quest', 'orcid': 'https://orcid.org/0000-0001-8755-1590'}, 'institutions': [{'id': 'https://openalex.org/I4210131520', 'display_name': 'Advanced Center for Chronic Diseases', 'ror': 'https://ror.org/036mwh061', 'country_code': 'CL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210131520']}, {'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'Andrew F. G. Quest', 'raw_affiliation_strings': ['Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'Center for Molecular Studies of the Cell, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'Program of Cell and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile'], 'affiliations': [{'raw_affiliation_string': 'Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I4210131520', 'https://openalex.org/I69737025']}, {'raw_affiliation_string': 'Program of Cell and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025']}, {'raw_affiliation_string': 'Center for Molecular Studies of the Cell, Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5023614126', 'display_name': 'Vicente A. Torres', 'orcid': 'https://orcid.org/0000-0002-5973-7248'}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}, {'id': 'https://openalex.org/I4210131520', 'display_name': 'Advanced Center for Chronic Diseases', 'ror': 'https://ror.org/036mwh061', 'country_code': 'CL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210131520']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'Vicente A. Torres', 'raw_affiliation_strings': ['Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Calle Sergio Livingstone 943, Santiago, Chile'], 'affiliations': [{'raw_affiliation_string': 'Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Calle Sergio Livingstone 943, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025']}, {'raw_affiliation_string': 'Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile', 'institution_ids': ['https://openalex.org/I4210131520', 'https://openalex.org/I69737025']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.497, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 74, 'citation_normalized_percentile': {'value': 0.99988, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12793', 'display_name': 'Caveolin-1 and cellular processes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12793', 'display_name': 'Caveolin-1 and cellular processes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9942, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/caveolin-1', 'display_name': 'Caveolin 1', 'score': 0.55020803}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.92581666}, {'id': 'https://openalex.org/C2779717556', 'wikidata': 'https://www.wikidata.org/wiki/Q15325735', 'display_name': 'RAC1', 'level': 3, 'score': 0.77120167}, {'id': 'https://openalex.org/C2780870201', 'wikidata': 'https://www.wikidata.org/wiki/Q17855958', 'display_name': 'Caveolin 1', 'level': 2, 'score': 0.55020803}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.48346382}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.46947512}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.42006493}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37567404}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.16138023}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07169235}], 'mesh': [{'descriptor_ui': 'D051242', 'descriptor_name': 'Caveolin 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020696', 'descriptor_name': 'rab5 GTP-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020830', 'descriptor_name': 'rac1 GTP-Binding Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000634', 'descriptor_name': 'Aminoquinolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000634', 'descriptor_name': 'Aminoquinolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051242', 'descriptor_name': 'Caveolin 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051242', 'descriptor_name': 'Caveolin 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058543', 'descriptor_name': 'Class Ia Phosphatidylinositol 3-Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019073', 'descriptor_name': 'HT29 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000075684', 'descriptor_name': 'T-Lymphoma Invasion and Metastasis-inducing Protein 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020696', 'descriptor_name': 'rab5 GTP-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020696', 'descriptor_name': 'rab5 GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020830', 'descriptor_name': 'rac1 GTP-Binding Protein', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D020830', 'descriptor_name': 'rac1 GTP-Binding Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.141689', 'pdf_url': 'https://jcs.biologists.org/content/joces/127/11/2401.full.pdf', 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074264', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4074264', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24659799', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.141689', 'pdf_url': 'https://jcs.biologists.org/content/joces/127/11/2401.full.pdf', 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1907484284', 'https://openalex.org/W1966081925', 'https://openalex.org/W1986808936', 'https://openalex.org/W1994668150', 'https://openalex.org/W2013175272', 'https://openalex.org/W2035127729', 'https://openalex.org/W2035640799', 'https://openalex.org/W2073296814', 'https://openalex.org/W2077318471', 'https://openalex.org/W2080647249', 'https://openalex.org/W2083623111', 'https://openalex.org/W2087879163', 'https://openalex.org/W2090121925', 'https://openalex.org/W2097807909', 'https://openalex.org/W2106586483', 'https://openalex.org/W2117911674', 'https://openalex.org/W2121337367', 'https://openalex.org/W2135226348', 'https://openalex.org/W2139419679', 'https://openalex.org/W2141552214', 'https://openalex.org/W2142685635', 'https://openalex.org/W2149397564', 'https://openalex.org/W2152494039', 'https://openalex.org/W2154565292', 'https://openalex.org/W2160025503', 'https://openalex.org/W2164443997', 'https://openalex.org/W2166135064', 'https://openalex.org/W2166645311', 'https://openalex.org/W2169364099'], 'related_works': ['https://openalex.org/W4390984186', 'https://openalex.org/W3204477002', 'https://openalex.org/W2805185066', 'https://openalex.org/W2418239294', 'https://openalex.org/W2370087273', 'https://openalex.org/W2165467938', 'https://openalex.org/W2055781207', 'https://openalex.org/W2034971176', 'https://openalex.org/W1996953995', 'https://openalex.org/W1976350481'], 'abstract_inverted_index': {'Rab5': [0, 20, 61, 105, 176, 195], 'is': [1, 30], 'a': [2, 187], 'small': [3], 'GTPase': [4], 'that': [5, 41, 58, 171], 'regulates': [6], 'early': [7, 135], 'endosome': [8], 'trafficking': [9], 'and': [10, 17, 24, 50, 68, 78, 111, 118, 150, 156, 178, 202, 207], 'other': [11], 'cellular': [12], 'processes,': [13], 'including': [14], 'cell': [15, 26, 69, 109, 151, 180, 205], 'adhesion': [16], 'migration.': [18, 70, 181], 'Specifically,': [19], 'promotes': [21, 47], 'Rac1': [22, 48, 66, 107, 148, 200], 'activation': [23, 49, 149], 'cancer': [25, 53, 96], 'migration,': [27], 'but': [28], 'little': [29], 'known': [31], 'about': [32], 'upstream': [33], 'regulators': [34], 'of': [35, 52, 72, 90, 104, 122, 129], 'Rab5.': [36, 157], 'We': [37], 'have': [38], 'previously': [39], 'shown': [40, 143], 'the': [42, 130, 138, 163], 'scaffolding': [43], 'protein': [44], 'Caveolin-1': [45], '(CAV1)': [46], 'migration': [51, 110, 152, 206], 'cells.': [54, 120], 'Here,': [55], 'we': [56, 159], 'hypothesized': [57], 'CAV1': [59, 73, 92, 115, 123, 155, 172, 193], 'stimulates': [60], 'activation,': [62, 108], 'leading': [63, 197], 'to': [64, 114, 133, 144, 198], 'increased': [65, 84, 127, 199], 'activity': [67, 201], 'Expression': [71, 121], 'in': [74, 93, 116, 166], 'B16-F10': [75, 117], 'mouse': [76], 'melanoma': [77], 'HT-29(US)': [79, 119], 'human': [80], 'colon': [81], 'adenocarcinoma': [82], 'cells': [83, 97], 'Rab5-GTP': [85, 99], 'loading,': [86], 'whereas': [87], 'shRNA-mediated': [88, 102], 'targeting': [89], 'endogenous': [91], 'MDA-MB-231': [94], 'breast': [95], 'decreased': [98, 106], 'levels.': [100], 'Accordingly,': [101], 'down-regulation': [103], 'invasion': [112], 'due': [113], 'was': [124, 142], 'accompanied': [125], 'by': [126, 154, 169], 'recruitment': [128], 'Rac1-GEF': [131], 'Tiam1': [132, 141], 'Rab5-positive': [134], 'endosomes.': [136], 'Using': [137], 'inhibitor': [139], 'NSC23766,': [140], 'be': [145], 'required': [146], 'for': [147], 'induced': [153], 'Mechanistically,': [158], 'provide': [160], 'evidence': [161], 'implicating': [162], 'Rab5-GAP': [164], 'p85α': [165], 'CAV1-dependent': [167], 'effects,': [168], 'showing': [170], 'recruits': [173], 'p85α,': [174], 'precluding': [175], 'inactivation': [177], 'increasing': [179], 'In': [182], 'summary,': [183], 'these': [184], 'studies': [185], 'identify': [186], 'novel': [188], 'CAV1-Rab5-Rac1': [189], 'signaling': [190], 'axis,': [191], 'whereby': [192], 'prevents': [194], 'inactivation,': [196], 'enhanced': [203], 'tumor': [204], 'invasion.': [208]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2142793416', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}], 'updated_date': '2024-12-15T10:44:41.924976', 'created_date': '2016-06-24'}