Publication Information

{'id': 'https://openalex.org/W2142495381', 'doi': 'https://doi.org/10.1164/rccm.200308-1094oc', 'title': 'Continuous Exposure to House Dust Mite Elicits Chronic Airway Inflammation and Structural Remodeling', 'display_name': 'Continuous Exposure to House Dust Mite Elicits Chronic Airway Inflammation and Structural Remodeling', 'publication_year': 2003, 'publication_date': '2003-11-04', 'ids': {'openalex': 'https://openalex.org/W2142495381', 'doi': 'https://doi.org/10.1164/rccm.200308-1094oc', 'mag': '2142495381', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14597485'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1164/rccm.200308-1094oc', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S93356601', 'display_name': 'American Journal of Respiratory and Critical Care Medicine', 'issn_l': '1073-449X', 'issn': ['1073-449X', '1535-4970'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316311', 'host_organization_name': 'American Thoracic Society', 'host_organization_lineage': ['https://openalex.org/P4310316311'], 'host_organization_lineage_names': ['American Thoracic Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062315448', 'display_name': 'Jill R. Johnson', 'orcid': 'https://orcid.org/0000-0002-5149-0084'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}, {'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jill R. Johnson', 'raw_affiliation_strings': ['Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732', 'https://openalex.org/I4210147799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056268748', 'display_name': 'Ryan E. Wiley', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}, {'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Ryan E. Wiley', 'raw_affiliation_strings': ['Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732', 'https://openalex.org/I4210147799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031575617', 'display_name': 'Ramzi Fattouh', 'orcid': 'https://orcid.org/0000-0001-6573-6367'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}, {'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Ramzi Fattouh', 'raw_affiliation_strings': ['Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732', 'https://openalex.org/I4210147799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034311334', 'display_name': 'Filip K. Świrski', 'orcid': 'https://orcid.org/0000-0002-3163-9152'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}, {'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Filip K. Swirski', 'raw_affiliation_strings': ['Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732', 'https://openalex.org/I4210147799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004137739', 'display_name': 'Beata Gajewska', 'orcid': 'https://orcid.org/0000-0003-4105-0306'}, 'institutions': [{'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}, {'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Beata U. Gajewska', 'raw_affiliation_strings': ['Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I4210147799', 'https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037034997', 'display_name': 'Anthony J. Coyle', 'orcid': 'https://orcid.org/0000-0001-8802-985X'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}, {'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Anthony J. Coyle', 'raw_affiliation_strings': ['Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732', 'https://openalex.org/I4210147799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111532539', 'display_name': 'Jose‐Carlos Gutierrez‐Ramos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}, {'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'José-Carlos Gutierrez-Ramos', 'raw_affiliation_strings': ['Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732', 'https://openalex.org/I4210147799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057545023', 'display_name': 'Russ Ellis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}, {'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Russ Ellis', 'raw_affiliation_strings': ['Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732', 'https://openalex.org/I4210147799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077189765', 'display_name': 'Mark D. Inman', 'orcid': 'https://orcid.org/0000-0003-4111-7654'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}, {'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Mark D. Inman', 'raw_affiliation_strings': ['Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732', 'https://openalex.org/I4210147799']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065277319', 'display_name': 'Manel Jordana', 'orcid': 'https://orcid.org/0000-0002-5861-5994'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}, {'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Manel Jordana', 'raw_affiliation_strings': ['Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts; and Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732', 'https://openalex.org/I4210147799']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.539, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 410, 'citation_normalized_percentile': {'value': 0.94736, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '169', 'issue': '3', 'first_page': '378', 'last_page': '385'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10877', 'display_name': 'Allergic Rhinitis and Sensitization', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11651', 'display_name': 'Inhalation and Respiratory Drug Delivery', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aeroallergen', 'display_name': 'Aeroallergen', 'score': 0.44542825}, {'id': 'https://openalex.org/keywords/allergic-inflammation', 'display_name': 'Allergic Inflammation', 'score': 0.416166}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8164817}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.7336289}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.66462576}, {'id': 'https://openalex.org/C2778166374', 'wikidata': 'https://www.wikidata.org/wiki/Q29938', 'display_name': 'House dust mite', 'level': 4, 'score': 0.66138977}, {'id': 'https://openalex.org/C2776946954', 'wikidata': 'https://www.wikidata.org/wiki/Q420291', 'display_name': 'Ovalbumin', 'level': 3, 'score': 0.63707423}, {'id': 'https://openalex.org/C2778391694', 'wikidata': 'https://www.wikidata.org/wiki/Q4688176', 'display_name': 'Aeroallergen', 'level': 4, 'score': 0.44542825}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.4184574}, {'id': 'https://openalex.org/C2779675166', 'wikidata': 'https://www.wikidata.org/wiki/Q4732119', 'display_name': 'Allergic inflammation', 'level': 3, 'score': 0.416166}, {'id': 'https://openalex.org/C207480886', 'wikidata': 'https://www.wikidata.org/wiki/Q42982', 'display_name': 'Allergy', 'level': 2, 'score': 0.2778852}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.23705018}, {'id': 'https://openalex.org/C2780510475', 'wikidata': 'https://www.wikidata.org/wiki/Q186752', 'display_name': 'Allergen', 'level': 3, 'score': 0.15387094}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.150929}], 'mesh': [{'descriptor_ui': 'D000485', 'descriptor_name': 'Allergens', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016535', 'descriptor_name': 'Bronchial Hyperreactivity', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D000403', 'descriptor_name': 'Airway Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000485', 'descriptor_name': 'Allergens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001707', 'descriptor_name': 'Biopsy, Needle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016535', 'descriptor_name': 'Bronchial Hyperreactivity', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D016535', 'descriptor_name': 'Bronchial Hyperreactivity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002908', 'descriptor_name': 'Chronic Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004391', 'descriptor_name': 'Dust', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007136', 'descriptor_name': 'Immunoglobulins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D007136', 'descriptor_name': 'Immunoglobulins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008925', 'descriptor_name': 'Mites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011336', 'descriptor_name': 'Probability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011657', 'descriptor_name': 'Pulmonary Eosinophilia', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D011657', 'descriptor_name': 'Pulmonary Eosinophilia', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011657', 'descriptor_name': 'Pulmonary Eosinophilia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012680', 'descriptor_name': 'Sensitivity and Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1164/rccm.200308-1094oc', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S93356601', 'display_name': 'American Journal of Respiratory and Critical Care Medicine', 'issn_l': '1073-449X', 'issn': ['1073-449X', '1535-4970'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316311', 'host_organization_name': 'American Thoracic Society', 'host_organization_lineage': ['https://openalex.org/P4310316311'], 'host_organization_lineage_names': ['American Thoracic Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14597485', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1504820480', 'https://openalex.org/W1752886302', 'https://openalex.org/W1967714707', 'https://openalex.org/W2002799490', 'https://openalex.org/W2014913710', 'https://openalex.org/W2028411179', 'https://openalex.org/W2030106405', 'https://openalex.org/W2032955706', 'https://openalex.org/W2033425354', 'https://openalex.org/W2041464595', 'https://openalex.org/W2055811366', 'https://openalex.org/W2088137078', 'https://openalex.org/W2089725956', 'https://openalex.org/W2096843723', 'https://openalex.org/W2097490698', 'https://openalex.org/W2100792873', 'https://openalex.org/W2113246580', 'https://openalex.org/W2124287494', 'https://openalex.org/W2128085654', 'https://openalex.org/W2144633578', 'https://openalex.org/W2145611796', 'https://openalex.org/W2164402028', 'https://openalex.org/W2165484058', 'https://openalex.org/W2169495508', 'https://openalex.org/W4254570903', 'https://openalex.org/W72669700'], 'related_works': ['https://openalex.org/W4225552239', 'https://openalex.org/W2753206231', 'https://openalex.org/W2398764584', 'https://openalex.org/W2161698623', 'https://openalex.org/W2108263321', 'https://openalex.org/W2104362381', 'https://openalex.org/W2079537492', 'https://openalex.org/W2029986739', 'https://openalex.org/W2020565652', 'https://openalex.org/W1582663428'], 'abstract_inverted_index': {'It': [0], 'is': [1, 7], 'now': [2], 'fully': [3], 'appreciated': [4], 'that': [5, 188], 'asthma': [6], 'a': [8, 11, 92, 101], 'disease': [9], 'of': [10, 53, 80, 89, 94, 99, 103, 117, 126, 136, 141, 158, 183], 'chronic': [12], 'nature': [13], 'resulting': [14], 'from': [15], 'intermittent': [16], 'or': [17, 42], 'continued': [18], 'aeroallergen': [19], 'exposure': [20, 62], 'leading': [21], 'to': [22, 28, 35, 57, 63, 147, 169, 178], 'airway': [23, 72, 142, 167, 190, 201], 'inflammation.': [24, 73], 'To': [25], 'investigate': [26], 'responses': [27, 173], 'continuous': [29], 'antigen': [30], 'exposure,': [31], 'mice': [32, 128, 145, 164], 'were': [33, 174], 'exposed': [34, 146], 'either': [36], 'house': [37], 'dust': [38], 'mite': [39], 'extract': [40], '(HDM)': [41], 'ovalbumin': [43], 'intranasally': [44], 'for': [45, 55, 176], 'five': [46], 'consecutive': [47, 59], 'days,': [48], 'followed': [49], 'by': [50, 124], '2': [51, 107], 'days': [52], 'rest,': [54], 'up': [56, 177], 'seven': [58], 'weeks.': [60], 'Continuous': [61], 'HDM,': [64, 148], 'unlike': [65], 'ovalbumin,': [66], 'elicited': [67], 'severe': [68, 166], 'and': [69, 98, 114, 155, 200], 'persistent': [70], 'eosinophilic': [71], 'Flow': [74], 'cytometric': [75], 'analysis': [76, 135], 'demonstrated': [77, 165], 'an': [78], 'accumulation': [79, 157], 'CD4+': [81], 'lymphocytes': [82], 'in': [83, 130, 144], 'the': [84, 137, 194], 'lung': [85, 138], 'with': [86, 149], 'elevated': [87], 'expression': [88], 'inducible': [90], 'costimulator': [91], 'marker': [93, 102], 'T': [95, 105, 119], 'cell': [96, 120, 151], 'activation,': [97], 'T1/ST2,': [100], 'helper': [104, 118], 'Type': [106, 121], 'effector': [108], 'cells.': [109], 'We': [110, 186], 'also': [111], 'detected': [112], 'increased': [113], 'sustained': [115], 'production': [116], '2-associated': [122], 'cytokines': [123], 'splenocytes': [125], 'HDM-exposed': [127, 163], 'on': [129], 'vitro': [131], 'HDM': [132, 184], 'recall.': [133], 'Histologic': [134], 'showed': [139], 'evidence': [140], 'remodeling': [143, 195], 'goblet': [150], 'hyperplasia,': [152], 'collagen': [153], 'deposition,': [154], 'peribronchial': [156], 'contractile': [159], 'tissue.': [160], 'In': [161], 'addition,': [162], 'hyperreactivity': [168, 202], 'methacholine.': [170], 'Finally,': [171], 'these': [172], 'studied': [175], '9': [179], 'weeks': [180], 'after': [181], 'cessation': [182], 'exposure.': [185], 'observed': [187], 'whereas': [189], 'inflammation': [191], 'resolved': [192, 203], 'fully,': [193], 'changes': [196], 'did': [197], 'not': [198], 'resolve': [199], 'only': [204], 'partly.': [205]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2142495381', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 24}, {'year': 2017, 'cited_by_count': 27}, {'year': 2016, 'cited_by_count': 24}, {'year': 2015, 'cited_by_count': 22}, {'year': 2014, 'cited_by_count': 19}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 22}], 'updated_date': '2025-01-11T20:54:14.669376', 'created_date': '2016-06-24'}