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'transduction': [47], 'directly': [48], 'promotes': [49], 'any': [50], 'the': [52, 71, 105, 122, 154], 'conditions': [53], 'that': [54, 149], 'frequently': [55], 'complicate': [56], 'Abnormalities': [58], 'tumor': [60], 'necrosis': [61], 'factor': [62], 'alpha': [63], 'have': [65], 'been': [66], 'noted': [67], 'each': [69], 'above': [72], 'comorbid': [73], 'conditions,': [74], 'so': [75], 'deficiency': [77], 'could': [78], 'promote': [79], 'these': [80], 'complications': [81, 156], 'if': [82], 'had': [84], 'immunoregulatory': [85], 'activity.': [86], 'Studies': [87], 'rodents': [89], 'genetic': [91], 'abnormalities': [92], 'revealed': [98], 'deficits': [100], 'macrophage': [102], 'phagocytosis': [103, 120], 'proinflammatory': [108, 125], 'cytokines': [109], 'both': [110, 119], 'vivo': [112], 'vitro.': [115], 'Exogenous': [116], 'up-regulated': [118], 'production': [123], 'cytokines.': [126], 'These': [127], 'identify': [129], 'important': [131], 'novel': [133], 'function': [134], 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