Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2142408209', 'doi': 'https://doi.org/10.1128/mcb.00939-10', 'title': 'Selective Abrogation of BiP/GRP78 Blunts Activation of NF-κB through the ATF6 Branch of the UPR: Involvement of C/EBPβ and mTOR-Dependent Dephosphorylation of Akt', 'display_name': 'Selective Abrogation of BiP/GRP78 Blunts Activation of NF-κB through the ATF6 Branch of the UPR: Involvement of C/EBPβ and mTOR-Dependent Dephosphorylation of Akt', 'publication_year': 2011, 'publication_date': '2011-04-01', 'ids': {'openalex': 'https://openalex.org/W2142408209', 'doi': 'https://doi.org/10.1128/mcb.00939-10', 'mag': '2142408209', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21300786', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3126329'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00939-10', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1128/mcb.00939-10', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078775589', 'display_name': 'Shotaro Nakajima', 'orcid': 'https://orcid.org/0000-0002-9339-3792'}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shotaro Nakajima', 'raw_affiliation_strings': ['Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi 409-3898, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi 409-3898, Japan.', 'institution_ids': ['https://openalex.org/I66906201']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102077843', 'display_name': 'Nobuhiko Hiramatsu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nobuhiko Hiramatsu', 'raw_affiliation_strings': ['1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan'], 'affiliations': [{'raw_affiliation_string': '1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan', 'institution_ids': ['https://openalex.org/I66906201']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014821521', 'display_name': 'Kunihiro Hayakawa', 'orcid': 'https://orcid.org/0000-0002-8053-746X'}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kunihiro Hayakawa', 'raw_affiliation_strings': ['1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan'], 'affiliations': [{'raw_affiliation_string': '1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan', 'institution_ids': ['https://openalex.org/I66906201']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005045379', 'display_name': 'Youhei Saito', 'orcid': 'https://orcid.org/0000-0002-8545-6925'}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yukinori Saito', 'raw_affiliation_strings': ['1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan'], 'affiliations': [{'raw_affiliation_string': '1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan', 'institution_ids': ['https://openalex.org/I66906201']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059619340', 'display_name': 'Hironori Kato', 'orcid': 'https://orcid.org/0000-0002-5543-5816'}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hironori Kato', 'raw_affiliation_strings': ['1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan'], 'affiliations': [{'raw_affiliation_string': '1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan', 'institution_ids': ['https://openalex.org/I66906201']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101867241', 'display_name': 'Tao Huang', 'orcid': 'https://orcid.org/0000-0002-9703-3604'}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tao Huang', 'raw_affiliation_strings': ['1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan'], 'affiliations': [{'raw_affiliation_string': '1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan', 'institution_ids': ['https://openalex.org/I66906201']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080600205', 'display_name': 'Jian Yao', 'orcid': 'https://orcid.org/0000-0003-2622-0215'}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Jian Yao', 'raw_affiliation_strings': ['1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan'], 'affiliations': [{'raw_affiliation_string': '1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan', 'institution_ids': ['https://openalex.org/I66906201']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038494526', 'display_name': 'Adrienne W. Paton', 'orcid': 'https://orcid.org/0000-0002-2996-5733'}, 'institutions': [{'id': 'https://openalex.org/I5681781', 'display_name': 'University of Adelaide', 'ror': 'https://ror.org/00892tw58', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I5681781']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Adrienne W. Paton', 'raw_affiliation_strings': ['2Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia'], 'affiliations': [{'raw_affiliation_string': '2Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia', 'institution_ids': ['https://openalex.org/I5681781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055597053', 'display_name': 'James C. Paton', 'orcid': 'https://orcid.org/0000-0001-9807-5278'}, 'institutions': [{'id': 'https://openalex.org/I5681781', 'display_name': 'University of Adelaide', 'ror': 'https://ror.org/00892tw58', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I5681781']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'James C. Paton', 'raw_affiliation_strings': ['2Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia'], 'affiliations': [{'raw_affiliation_string': '2Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia', 'institution_ids': ['https://openalex.org/I5681781']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058680290', 'display_name': 'Masanori Kitamura', 'orcid': 'https://orcid.org/0000-0002-8087-1855'}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masanori Kitamura', 'raw_affiliation_strings': ['1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan'], 'affiliations': [{'raw_affiliation_string': '1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan', 'institution_ids': ['https://openalex.org/I66906201']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.385, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 104, 'citation_normalized_percentile': {'value': 0.999879, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '31', 'issue': '8', 'first_page': '1710', 'last_page': '1718'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11051', 'display_name': 'Role of Sirtuins in Health and Aging', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dephosphorylation', 'display_name': 'Dephosphorylation', 'score': 0.75135356}, {'id': 'https://openalex.org/keywords/unfolded-protein-response', 'display_name': 'Unfolded Protein Response', 'score': 0.494006}], 'concepts': [{'id': 'https://openalex.org/C181912034', 'wikidata': 'https://www.wikidata.org/wiki/Q1101143', 'display_name': 'Dephosphorylation', 'level': 4, 'score': 0.75135356}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7094891}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.6433582}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.5758792}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.55011225}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.5449542}, {'id': 'https://openalex.org/C2777730290', 'wikidata': 'https://www.wikidata.org/wiki/Q411114', 'display_name': 'NF-κB', 'level': 3, 'score': 0.46564898}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4127109}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3750714}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.35001945}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.33409828}, {'id': 'https://openalex.org/C178666793', 'wikidata': 'https://www.wikidata.org/wiki/Q422476', 'display_name': 'Phosphatase', 'level': 3, 'score': 0.20096198}], 'mesh': [{'descriptor_ui': 'D051702', 'descriptor_name': 'Activating Transcription Factor 6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D022782', 'descriptor_name': 'CCAAT-Enhancer-Binding Protein-beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051702', 'descriptor_name': 'Activating Transcription Factor 6', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051702', 'descriptor_name': 'Activating Transcription Factor 6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022782', 'descriptor_name': 'CCAAT-Enhancer-Binding Protein-beta', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D022782', 'descriptor_name': 'CCAAT-Enhancer-Binding Protein-beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058767', 'descriptor_name': 'Protein Unfolding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00939-10', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3126329', 'pdf_url': 'https://europepmc.org/articles/pmc3126329?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126329', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21300786', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00939-10', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.63, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 61, 'referenced_works': ['https://openalex.org/W1499597566', 'https://openalex.org/W1515372146', 'https://openalex.org/W1518126931', 'https://openalex.org/W1567375657', 'https://openalex.org/W1573490928', 'https://openalex.org/W1617532721', 'https://openalex.org/W1933156589', 'https://openalex.org/W1966664870', 'https://openalex.org/W1973882490', 'https://openalex.org/W1975133676', 'https://openalex.org/W1981844658', 'https://openalex.org/W1984736455', 'https://openalex.org/W1990425294', 'https://openalex.org/W1998641189', 'https://openalex.org/W2008683065', 'https://openalex.org/W2011994162', 'https://openalex.org/W2013207691', 'https://openalex.org/W2024445551', 'https://openalex.org/W2024531819', 'https://openalex.org/W2027077104', 'https://openalex.org/W2027166251', 'https://openalex.org/W2031405609', 'https://openalex.org/W2039358381', 'https://openalex.org/W2040651817', 'https://openalex.org/W2044332034', 'https://openalex.org/W2045242604', 'https://openalex.org/W2047842452', 'https://openalex.org/W2061129733', 'https://openalex.org/W2062250284', 'https://openalex.org/W2062918974', 'https://openalex.org/W2063826476', 'https://openalex.org/W2066538173', 'https://openalex.org/W2072199399', 'https://openalex.org/W2072714194', 'https://openalex.org/W2079473693', 'https://openalex.org/W2079768195', 'https://openalex.org/W2079944569', 'https://openalex.org/W2086189875', 'https://openalex.org/W2110048751', 'https://openalex.org/W2110445055', 'https://openalex.org/W2115311570', 'https://openalex.org/W2117445500', 'https://openalex.org/W2117614106', 'https://openalex.org/W2120383034', 'https://openalex.org/W2123960570', 'https://openalex.org/W2124179501', 'https://openalex.org/W2127906377', 'https://openalex.org/W2128547513', 'https://openalex.org/W2129011493', 'https://openalex.org/W2129058679', 'https://openalex.org/W2135801991', 'https://openalex.org/W2140487984', 'https://openalex.org/W2145112854', 'https://openalex.org/W2147950253', 'https://openalex.org/W2150247687', 'https://openalex.org/W2150684620', 'https://openalex.org/W2158589169', 'https://openalex.org/W2160670580', 'https://openalex.org/W2162076197', 'https://openalex.org/W2163411496', 'https://openalex.org/W2167435864'], 'related_works': ['https://openalex.org/W4205189596', 'https://openalex.org/W3183179750', 'https://openalex.org/W3116479654', 'https://openalex.org/W2982360817', 'https://openalex.org/W2916964185', 'https://openalex.org/W2422815049', 'https://openalex.org/W2098584395', 'https://openalex.org/W2070783513', 'https://openalex.org/W2024933597', 'https://openalex.org/W2019551003'], 'abstract_inverted_index': {'AbstractSubtilase': [0], 'cytotoxin': [1], '(SubAB)': [2], 'that': [3, 24, 89, 134, 147, 162], 'selectively': [4], 'cleaves': [5], 'BiP/GRP78': [6], 'triggers': [7], 'the': [8, 46, 61, 80, 90, 94, 101, 119, 125, 148, 274], 'unfolded': [9], 'protein': [10], 'response': [11], '(UPR)': [12], 'and': [13, 19, 38, 50, 75, 113, 129, 176, 255, 281], 'protects': [14], 'mice': [15], 'from': [16, 273], 'endotoxic': [17], 'lethality': [18], 'collagen': [20], 'arthritis.': [21], 'We': [22, 87], 'found': [23], 'pretreatment': [25], 'of': [26, 36, 48, 54, 60, 69, 77, 83, 93, 103, 116, 127, 132, 138, 142, 166, 174, 179, 186, 194, 203, 212, 227, 234, 243, 253, 276], 'cells': [27], 'with': [28, 262], 'SubAB': [29, 64, 84, 110, 163], 'suppressed': [30, 71], 'tumor': [31], 'necrosis': [32], 'alpha': [33], '(TNF-α)-induced': [34], 'activation': [35, 131, 141, 165], 'NF-κB': [37, 73, 143, 157, 167], 'NF-κB-dependent': [39], 'chemokine': [40], 'expression.': [41], 'To': [42], 'elucidate': [43], 'underlying': [44], 'mechanisms,': [45, 170], 'involvement': [47], 'C/EBP': [49, 62], 'Akt,': [51], 'putative': [52], 'regulators': [53], 'NF-κB,': [55], 'was': [56, 122, 266], 'investigated.': [57], 'Among': [58], 'members': [59], 'family,': [63], 'preferentially': [65], 'induced': [66], 'C/EBPβ.': [67, 104], 'Overexpression': [68], 'C/EBPβ': [70, 78, 175], 'TNF-α-induced': [72, 114], 'activation,': [74], 'knockdown': [76], 'attenuated': [79, 140], 'suppressive': [81], 'effect': [82], 'on': [85], 'NF-κB.': [86], 'identified': [88], 'ATF6': [91, 128], 'branch': [92], 'UPR': [95], 'plays': [96], 'a': [97], 'crucial': [98], 'role': [99], 'in': [100], 'induction': [102, 126, 173], 'In': [105], 'addition': [106], 'to': [107, 286], 'this': [108], 'effect,': [109], 'depressed': [111], 'basal': [112], 'phosphorylation': [115], 'Akt': [117, 139], 'via': [118], 'UPR.': [120], 'It': [121], 'mediated': [123], 'by': [124, 144, 268], 'consequent': [130], 'mTOR': [133], 'dephosphorylated': [135], 'Akt.': [136, 180], 'Inhibition': [137], 'TNF-α,': [145], 'suggesting': [146], 'mTOR-Akt': [149], 'pathway': [150], 'is': [151], 'another': [152], 'target': [153], 'for': [154, 259, 270], 'SubAB-initiated,': [155], 'UPR-mediated': [156], 'suppression.': [158], 'These': [159], 'results': [160], 'elucidated': [161], 'blunts': [164], 'through': [168], 'ATF6-dependent': [169], 'i.e.,': [171], 'preferential': [172], 'mTOR-dependent': [177], 'dephosphorylation': [178], 'ACKNOWLEDGMENTSWe': [181], 'thank': [182], 'Masayuki': [183], 'Miura': [184], '(University': [185, 202, 242, 252], 'Tokyo),': [187], 'Ronald': [188], 'C.': [189], 'Wek': [190], '(Indiana': [191], 'University': [192, 211, 225, 232], 'School': [193, 226, 233], 'Medicine),': [195, 228, 235], 'Kazutoshi': [196], 'Mori': [197], '(Kyoto': [198], 'University),': [199, 239], 'Antonio': [200], 'Leonardi': [201], 'Naples),': [204], 'Ez-Zoubir': [205], 'Amri': [206], '(CNRS),': [207], 'Yoshihiko': [208], 'Nishio': [209], '(Shiga': [210], 'Medical': [213, 219], 'Science),': [214], 'Laurie': [215], 'H.': [216], 'Glimcher': [217], '(Harvard': [218], 'School),': [220], 'David': [221], 'Ron': [222], '(New': [223], 'York': [224], 'Kenneth': [229], 'Walsh': [230], '(Boston': [231], 'Satoshi': [236], 'Ogawa': [237], '(Kanazawa': [238], 'Kazunori': [240], 'Imaizumi': [241], 'Miyazaki),': [244], 'Pierre': [245], 'Fafournoux': [246], '(INRA': [247], 'de': [248], 'Theix),': [249], 'Jacob': [250], 'Friedman': [251], 'Colorado),': [254], 'Takao': [256], 'Iwawaki': [257], '(RIKEN)': [258], 'providing': [260], 'us': [261], 'expression': [263], 'plasmids.This': [264], 'work': [265], 'supported': [267], 'Grant-in-Aids': [269], 'Scientific': [271], 'Research': [272], 'Ministry': [275], 'Education,': [277], 'Culture,': [278], 'Sports,': [279], 'Science': [280], 'Technology,': [282], 'Japan': [283], '(no.': [284], '20390235)': [285], 'M.': [287], 'Kitamura.': [288]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2142408209', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-09-13T01:15:15.796158', 'created_date': '2016-06-24'}